ENSG00000130783

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253079 ENSG00000130783 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC62 protein_coding protein_coding 0.2310555 0.1408947 0.3450635 0.03373105 0.009815997 1.234535 0.01818152 0.02810694 0.00000000 0.02810694 0.00000000 -1.930054 0.09178750 0.1370333 0.0000000 -0.1370333 0.6230690482 0.0001024758 FALSE TRUE
ENST00000341952 ENSG00000130783 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC62 protein_coding nonsense_mediated_decay 0.2310555 0.1408947 0.3450635 0.03373105 0.009815997 1.234535 0.10269407 0.00000000 0.30700683 0.00000000 0.02015989 4.986442 0.38470833 0.0000000 0.8881333 0.8881333 0.0001024758 0.0001024758 TRUE TRUE
ENST00000392440 ENSG00000130783 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC62 protein_coding protein_coding 0.2310555 0.1408947 0.3450635 0.03373105 0.009815997 1.234535 0.01802715 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.09461667 0.0000000 0.0000000 0.0000000   0.0001024758 FALSE TRUE
ENST00000392441 ENSG00000130783 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC62 protein_coding protein_coding 0.2310555 0.1408947 0.3450635 0.03373105 0.009815997 1.234535 0.03923507 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.11722083 0.0000000 0.0000000 0.0000000   0.0001024758 FALSE TRUE
ENST00000537566 ENSG00000130783 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC62 protein_coding protein_coding 0.2310555 0.1408947 0.3450635 0.03373105 0.009815997 1.234535 0.05291768 0.11278779 0.03805672 0.01109484 0.01230553 -1.353357 0.31166667 0.8629667 0.1118667 -0.7511000 0.0199145094 0.0001024758 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000130783 E001 0.1779838 0.03865491 1.000000000   12 122774526 122774527 2 + 0.088 0.000 -10.341
ENSG00000130783 E002 0.1779838 0.03865491 1.000000000   12 122774528 122774531 4 + 0.088 0.000 -11.329
ENSG00000130783 E003 0.3559677 0.47503997 0.744803168   12 122774532 122774571 40 + 0.164 0.000 -12.250
ENSG00000130783 E004 0.5283420 0.14886219 0.915695030   12 122774572 122774706 135 + 0.162 0.166 0.047
ENSG00000130783 E005 2.0472677 0.01114049 0.035600847 0.14319357 12 122776558 122777490 933 + 0.326 0.630 1.543
ENSG00000130783 E006 4.3956761 0.03064776 0.234004697 0.46973173 12 122777491 122777683 193 + 0.758 0.524 -1.010
ENSG00000130783 E007 1.1661824 0.01689369 0.943581686   12 122781164 122781294 131 + 0.326 0.286 -0.266
ENSG00000130783 E008 1.4404930 0.01311446 0.181836925 0.40640791 12 122781295 122781330 36 + 0.446 0.166 -1.944
ENSG00000130783 E009 1.5533880 0.01398649 0.015426877 0.07969818 12 122785719 122785820 102 + 0.510 0.000 -14.386
ENSG00000130783 E010 1.0713538 0.01938749 0.055032383   12 122788758 122788784 27 + 0.409 0.000 -13.879
ENSG00000130783 E011 1.7235495 0.01876738 0.098722287 0.27956170 12 122788785 122788929 145 + 0.510 0.166 -2.263
ENSG00000130783 E012 1.2790773 0.01355320 0.251425237   12 122792020 122792121 102 + 0.409 0.166 -1.751
ENSG00000130783 E013 0.6378404 0.02470091 0.883156367   12 122797307 122797395 89 + 0.223 0.166 -0.528
ENSG00000130783 E014 0.9640683 0.01611770 0.082802605   12 122798085 122798200 116 + 0.370 0.000 -13.668
ENSG00000130783 E015 5.6837230 0.22574652 0.328515215 0.56752057 12 122801124 122801852 729 + 0.772 0.867 0.372
ENSG00000130783 E016 1.1562038 0.28269882 1.000000000   12 122806151 122806295 145 + 0.322 0.293 -0.187
ENSG00000130783 E017 0.5177432 0.02392263 0.183350618   12 122813270 122813419 150 + 0.088 0.286 2.060
ENSG00000130783 E018 0.3150090 0.02853056 0.516103562   12 122823366 122823459 94 + 0.088 0.166 1.058
ENSG00000130783 E019 0.8209858 0.01849836 0.019281022   12 122826422 122826617 196 + 0.088 0.457 3.058
ENSG00000130783 E020 1.2563816 0.01784868 0.002001126   12 122826618 122827245 628 + 0.088 0.580 3.647
ENSG00000130783 E021 0.3751086 0.02760680 0.050273865   12 122827246 122827528 283 + 0.000 0.286 13.817