ENSG00000130779

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302528 ENSG00000130779 HEK293_OSMI2_6hA HEK293_TMG_6hB CLIP1 protein_coding protein_coding 10.66217 6.607694 19.01071 0.3856263 0.3770394 1.52317 2.3916649 1.7964981 3.010853 0.2329104 0.8322671 0.7417604 0.25053333 0.26953333 0.1593333 -0.11020000 5.188746e-01 1.711907e-09 FALSE TRUE
ENST00000361654 ENSG00000130779 HEK293_OSMI2_6hA HEK293_TMG_6hB CLIP1 protein_coding protein_coding 10.66217 6.607694 19.01071 0.3856263 0.3770394 1.52317 2.2084381 2.3667607 3.922463 0.2829709 0.6205816 0.7264365 0.24814583 0.35550000 0.2059333 -0.14956667 1.446117e-01 1.711907e-09 FALSE TRUE
ENST00000537178 ENSG00000130779 HEK293_OSMI2_6hA HEK293_TMG_6hB CLIP1 protein_coding protein_coding 10.66217 6.607694 19.01071 0.3856263 0.3770394 1.52317 1.9009825 0.0000000 2.986390 0.0000000 0.5263474 8.2270815 0.12032917 0.00000000 0.1582000 0.15820000 1.711907e-09 1.711907e-09 FALSE TRUE
ENST00000648993 ENSG00000130779 HEK293_OSMI2_6hA HEK293_TMG_6hB CLIP1 protein_coding protein_coding 10.66217 6.607694 19.01071 0.3856263 0.3770394 1.52317 2.2194586 1.6148955 5.049195 0.1067888 0.4448120 1.6385608 0.19625417 0.24440000 0.2650333 0.02063333 9.070798e-01 1.711907e-09 FALSE TRUE
MSTRG.8209.15 ENSG00000130779 HEK293_OSMI2_6hA HEK293_TMG_6hB CLIP1 protein_coding   10.66217 6.607694 19.01071 0.3856263 0.3770394 1.52317 0.7937554 0.1810998 2.101167 0.1415738 0.6224493 3.4656428 0.05174167 0.03023333 0.1097333 0.07950000 3.555588e-01 1.711907e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000130779 E001 0.0000000       12 122271432 122271433 2 -      
ENSG00000130779 E002 4.8205616 0.1265094457 7.239540e-02 0.2295659530 12 122271434 122271468 35 - 0.568 0.962 1.596
ENSG00000130779 E003 96.5682783 1.2104789025 2.791248e-01 0.5192499435 12 122271469 122272042 574 - 1.767 2.209 1.486
ENSG00000130779 E004 69.0796453 0.8841305142 2.905650e-01 0.5312156612 12 122272043 122272460 418 - 1.676 2.016 1.148
ENSG00000130779 E005 40.7530050 0.7485550627 3.291220e-01 0.5681343392 12 122272461 122272598 138 - 1.478 1.762 0.969
ENSG00000130779 E006 29.8443202 0.6000753097 2.090030e-01 0.4406831410 12 122272599 122272660 62 - 1.309 1.673 1.251
ENSG00000130779 E007 18.0818114 0.4494300494 2.374876e-01 0.4736837865 12 122272661 122272667 7 - 1.135 1.430 1.038
ENSG00000130779 E008 57.1772362 0.8409874010 3.196563e-01 0.5594275930 12 122272668 122272805 138 - 1.614 1.915 1.018
ENSG00000130779 E009 113.7387968 1.3212608148 3.959469e-01 0.6251516232 12 122272806 122273100 295 - 1.901 2.219 1.066
ENSG00000130779 E010 74.4089208 0.0633240929 4.683218e-02 0.1721437949 12 122274038 122274143 106 - 1.738 2.017 0.942
ENSG00000130779 E011 38.9276431 0.0087303096 1.042848e-03 0.0102381573 12 122274144 122274162 19 - 1.461 1.752 0.991
ENSG00000130779 E012 14.3445396 0.0378840388 1.257988e-01 0.3251553132 12 122274163 122275823 1661 - 1.193 1.041 -0.547
ENSG00000130779 E013 2.1404016 0.1590710204 8.111349e-01 0.9029432754 12 122276439 122276444 6 - 0.432 0.542 0.541
ENSG00000130779 E014 9.9438622 0.1911675578 1.992025e-01 0.4287110915 12 122276445 122277367 923 - 1.054 0.853 -0.754
ENSG00000130779 E015 8.1387942 0.1324431586 1.441406e-01 0.3535893627 12 122277368 122278153 786 - 0.979 0.749 -0.888
ENSG00000130779 E016 62.6282164 0.0060767657 7.419641e-03 0.0466486110 12 122278154 122278203 50 - 1.694 1.910 0.727
ENSG00000130779 E017 2.1895425 0.0559000646 7.142241e-01 0.8444849037 12 122278204 122278472 269 - 0.431 0.542 0.547
ENSG00000130779 E018 63.8157528 0.0009392552 1.632501e-02 0.0829949008 12 122278792 122278942 151 - 1.719 1.892 0.582
ENSG00000130779 E019 61.6199423 0.0030489640 4.146939e-01 0.6395895123 12 122279028 122279145 118 - 1.757 1.776 0.063
ENSG00000130779 E020 0.9146696 0.9300241047 9.900766e-01   12 122279146 122280878 1733 - 0.278 0.182 -0.784
ENSG00000130779 E021 51.0998192 0.0085195894 4.128423e-01 0.6382583188 12 122288489 122288541 53 - 1.677 1.685 0.027
ENSG00000130779 E022 67.0729187 0.0027573222 1.973205e-01 0.4262759319 12 122309762 122309882 121 - 1.798 1.794 -0.013
ENSG00000130779 E023 70.9103255 0.0153461304 3.899910e-01 0.6204519159 12 122316749 122316855 107 - 1.820 1.820 0.001
ENSG00000130779 E024 76.5412694 0.0195044581 5.338480e-01 0.7248242274 12 122319232 122319348 117 - 1.847 1.865 0.059
ENSG00000130779 E025 2.5030290 0.0443017411 9.156077e-01 0.9599529069 12 122322114 122324381 2268 - 0.519 0.540 0.097
ENSG00000130779 E026 114.5084308 0.0030142337 7.747647e-01 0.8816133526 12 122327947 122328162 216 - 2.009 2.060 0.170
ENSG00000130779 E027 100.6914347 0.0036536662 3.137103e-02 0.1314173860 12 122328261 122328426 166 - 1.982 1.944 -0.127
ENSG00000130779 E028 101.6641463 0.0025614690 3.405807e-02 0.1390219019 12 122332987 122333143 157 - 1.984 1.954 -0.100
ENSG00000130779 E029 65.6591053 0.0059775726 3.882453e-02 0.1516851411 12 122334027 122334084 58 - 1.803 1.743 -0.203
ENSG00000130779 E030 48.2714572 0.0151204323 3.417057e-01 0.5794741079 12 122334085 122334110 26 - 1.658 1.642 -0.055
ENSG00000130779 E031 57.2061790 0.0298646998 2.961479e-01 0.5366905270 12 122334648 122334705 58 - 1.739 1.695 -0.148
ENSG00000130779 E032 72.1184551 0.0267101687 1.892495e-01 0.4160378656 12 122336632 122336748 117 - 1.843 1.783 -0.203
ENSG00000130779 E033 94.0262446 0.0019939248 6.662992e-03 0.0430108473 12 122340753 122340980 228 - 1.957 1.900 -0.192
ENSG00000130779 E034 67.9199285 0.0010261589 4.573038e-05 0.0007708437 12 122340981 122341087 107 - 1.843 1.706 -0.464
ENSG00000130779 E035 77.5932331 0.0081242091 1.304896e-02 0.0706479197 12 122341088 122341256 169 - 1.884 1.799 -0.286
ENSG00000130779 E036 127.9483844 0.0136001880 8.274491e-02 0.2501956692 12 122341257 122341697 441 - 2.088 2.039 -0.163
ENSG00000130779 E037 0.9172423 0.0419311592 2.296219e-01   12 122341698 122344044 2347 - 0.153 0.397 1.820
ENSG00000130779 E038 3.8826712 0.0112462057 3.510280e-01 0.5881451622 12 122347375 122347479 105 - 0.699 0.598 -0.432
ENSG00000130779 E039 0.6901176 0.0572471642 9.451300e-02   12 122351028 122351110 83 - 0.083 0.397 2.826
ENSG00000130779 E040 0.3751086 0.0261429551 6.890040e-02   12 122351111 122351143 33 - 0.000 0.299 13.831
ENSG00000130779 E041 44.5121277 0.0237157409 2.744415e-01 0.5144050015 12 122352726 122352786 61 - 1.634 1.595 -0.133
ENSG00000130779 E042 59.9714829 0.0120037364 2.198577e-01 0.4533487093 12 122354453 122354556 104 - 1.758 1.734 -0.082
ENSG00000130779 E043 0.7743180 0.0176266990 5.255801e-01   12 122354557 122354909 353 - 0.266 0.174 -0.775
ENSG00000130779 E044 0.6600180 0.0193874923 1.524519e-01   12 122354910 122355114 205 - 0.266 0.000 -12.408
ENSG00000130779 E045 80.1654643 0.0046572678 6.424214e-02 0.2122321426 12 122355115 122355312 198 - 1.886 1.851 -0.116
ENSG00000130779 E046 0.2027342 0.0377185774 2.407852e-01   12 122355313 122356160 848 - 0.000 0.175 12.831
ENSG00000130779 E047 0.0000000       12 122360816 122360958 143 -      
ENSG00000130779 E048 76.8285970 0.0045336509 2.565461e-01 0.4953150247 12 122360959 122361181 223 - 1.857 1.860 0.010
ENSG00000130779 E049 62.5780436 0.0071985922 1.177228e-02 0.0655253271 12 122363983 122364107 125 - 1.795 1.700 -0.319
ENSG00000130779 E050 86.8018163 0.0074214009 1.326181e-02 0.0714835356 12 122377389 122377720 332 - 1.930 1.851 -0.267
ENSG00000130779 E051 32.5237629 0.0338952201 2.164108e-01 0.4491809019 12 122377721 122377795 75 - 1.512 1.449 -0.216
ENSG00000130779 E052 61.7637396 0.0753702579 2.482071e-01 0.4860289414 12 122377796 122377960 165 - 1.784 1.717 -0.226
ENSG00000130779 E053 53.7803511 0.0264761856 2.462198e-01 0.4838425776 12 122380368 122380558 191 - 1.717 1.681 -0.122
ENSG00000130779 E054 0.0000000       12 122380559 122380560 2 -      
ENSG00000130779 E055 0.1614157 0.0325227876 1.000000e+00   12 122395390 122395997 608 - 0.083 0.000 -10.407
ENSG00000130779 E056 1.1328584 0.0179964504 5.905205e-01   12 122399781 122400014 234 - 0.266 0.395 0.814
ENSG00000130779 E057 0.5059767 0.0213709528 1.980697e-02   12 122400132 122400243 112 - 0.000 0.395 14.413
ENSG00000130779 E058 3.0193307 0.0085672736 1.442340e-01 0.3537332302 12 122417327 122417442 116 - 0.462 0.737 1.231
ENSG00000130779 E059 10.6444550 0.0029677567 4.285727e-01 0.6499741065 12 122422521 122422669 149 - 1.046 1.016 -0.108