ENSG00000130772

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373842 ENSG00000130772 HEK293_OSMI2_6hA HEK293_TMG_6hB MED18 protein_coding protein_coding 24.23583 28.69404 15.3903 3.518433 0.608862 -0.8982953 18.1787205 22.9472089 8.775690 2.7196839 0.7166488 -1.3857198 0.7314292 0.800566667 0.57316667 -0.22740000 0.02172085 0.02172085 FALSE TRUE
ENST00000474683 ENSG00000130772 HEK293_OSMI2_6hA HEK293_TMG_6hB MED18 protein_coding processed_transcript 24.23583 28.69404 15.3903 3.518433 0.608862 -0.8982953 1.0743443 0.6645067 1.985791 0.3761457 0.4843155 1.5650561 0.0517500 0.023366667 0.12876667 0.10540000 0.05990374 0.02172085 FALSE TRUE
ENST00000475655 ENSG00000130772 HEK293_OSMI2_6hA HEK293_TMG_6hB MED18 protein_coding processed_transcript 24.23583 28.69404 15.3903 3.518433 0.608862 -0.8982953 0.2256818 0.1466159 1.455395 0.1466159 0.7346955 3.2259871 0.0132625 0.005166667 0.09286667 0.08770000 0.52556680 0.02172085   FALSE
ENST00000479574 ENSG00000130772 HEK293_OSMI2_6hA HEK293_TMG_6hB MED18 protein_coding processed_transcript 24.23583 28.69404 15.3903 3.518433 0.608862 -0.8982953 3.9329660 4.7743765 3.173427 0.7672997 0.6078002 -0.5877502 0.1682958 0.166233333 0.20520000 0.03896667 0.85410127 0.02172085 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000130772 E001 12.970919 0.0510070248 3.891592e-01 0.6198317901 1 28329002 28329039 38 + 1.153 1.045 -0.390
ENSG00000130772 E002 11.041088 0.0365229486 9.131339e-01 0.9586731542 1 28329040 28329040 1 + 1.014 1.009 -0.018
ENSG00000130772 E003 17.839434 0.0024189931 9.340955e-01 0.9691940283 1 28329041 28329054 14 + 1.198 1.206 0.027
ENSG00000130772 E004 23.513822 0.0061001204 2.839426e-01 0.5243949533 1 28329055 28329061 7 + 1.241 1.340 0.347
ENSG00000130772 E005 73.343110 0.0008032716 2.253005e-01 0.4597080865 1 28329062 28329124 63 + 1.759 1.817 0.196
ENSG00000130772 E006 100.856422 0.0004984213 5.553262e-01 0.7399832837 1 28329125 28329180 56 + 1.958 1.934 -0.080
ENSG00000130772 E007 2.410873 0.0883071966 6.065118e-01 0.7745534100 1 28330283 28330375 93 + 0.572 0.483 -0.422
ENSG00000130772 E008 180.654705 0.0002465232 9.415034e-03 0.0556019391 1 28330597 28330735 139 + 2.247 2.175 -0.243
ENSG00000130772 E009 1.029329 0.0156543282 6.869418e-01   1 28330736 28330792 57 + 0.321 0.246 -0.524
ENSG00000130772 E010 464.124451 0.0001757708 1.031376e-04 0.0015352041 1 28334417 28335086 670 + 2.647 2.587 -0.200
ENSG00000130772 E011 68.969177 0.0007446114 4.882032e-06 0.0001128002 1 28335087 28335184 98 + 1.588 1.831 0.823
ENSG00000130772 E012 99.488076 0.0009703606 2.778028e-03 0.0220506252 1 28335185 28335317 133 + 1.841 1.970 0.432
ENSG00000130772 E013 251.341260 0.0003749484 4.067557e-02 0.1564869398 1 28335318 28335793 476 + 2.300 2.351 0.167
ENSG00000130772 E014 71.897565 0.0005511069 6.892235e-01 0.8285738565 1 28335794 28335965 172 + 1.783 1.801 0.061