ENSG00000130758

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253055 ENSG00000130758 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP3K10 protein_coding protein_coding 13.9023 22.4256 7.759939 2.31191 0.6403841 -1.529815 6.3681694 11.156130 2.4060994 1.4004528 0.43522667 -2.2083775 0.44535417 0.49876667 0.32206667 -0.17670000 4.811260e-01 1.927994e-11 FALSE  
ENST00000593502 ENSG00000130758 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP3K10 protein_coding nonsense_mediated_decay 13.9023 22.4256 7.759939 2.31191 0.6403841 -1.529815 0.6566050 1.106055 0.7549730 0.5809206 0.40139536 -0.5449276 0.05432917 0.05430000 0.10690000 0.05260000 9.602147e-01 1.927994e-11 TRUE  
ENST00000594791 ENSG00000130758 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP3K10 protein_coding retained_intron 13.9023 22.4256 7.759939 2.31191 0.6403841 -1.529815 1.9776454 3.456731 0.8400077 0.6440714 0.17358780 -2.0280280 0.13651250 0.15310000 0.10720000 -0.04590000 6.755969e-01 1.927994e-11 FALSE  
ENST00000594951 ENSG00000130758 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP3K10 protein_coding nonsense_mediated_decay 13.9023 22.4256 7.759939 2.31191 0.6403841 -1.529815 2.1278261 3.532919 1.2638918 1.2543371 0.42370227 -1.4756958 0.14837083 0.15003333 0.15563333 0.00560000 1.000000e+00 1.927994e-11 FALSE  
MSTRG.17155.2 ENSG00000130758 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP3K10 protein_coding   13.9023 22.4256 7.759939 2.31191 0.6403841 -1.529815 1.3302068 1.733006 1.5421384 0.1981935 0.50802620 -0.1673202 0.11141250 0.08053333 0.19080000 0.11026667 3.230484e-01 1.927994e-11 FALSE  
MSTRG.17155.3 ENSG00000130758 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP3K10 protein_coding   13.9023 22.4256 7.759939 2.31191 0.6403841 -1.529815 0.2596665 0.000000 0.4273093 0.0000000 0.03183769 5.4505820 0.02259583 0.00000000 0.05576667 0.05576667 1.927994e-11 1.927994e-11 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000130758 E001 66.024856 0.0012209096 4.858393e-02 1.763509e-01 19 40191426 40192137 712 + 1.635 1.763 0.435
ENSG00000130758 E002 51.441357 0.0007226089 8.829621e-04 8.956353e-03 19 40192138 40192228 91 + 1.438 1.673 0.806
ENSG00000130758 E003 35.358892 0.0010933934 6.411024e-03 4.173258e-02 19 40192229 40192244 16 + 1.284 1.515 0.801
ENSG00000130758 E004 73.962075 0.0006185513 8.063503e-01 8.999469e-01 19 40192245 40192382 138 + 1.783 1.787 0.011
ENSG00000130758 E005 66.091028 0.0008284552 2.881313e-01 5.288803e-01 19 40192383 40192454 72 + 1.770 1.730 -0.134
ENSG00000130758 E006 107.686538 0.0004490312 3.197859e-01 5.595026e-01 19 40192455 40192637 183 + 1.967 1.942 -0.085
ENSG00000130758 E007 94.610765 0.0005634790 1.456136e-01 3.558080e-01 19 40192638 40192713 76 + 1.934 1.887 -0.158
ENSG00000130758 E008 74.169581 0.0005947758 1.240965e-01 3.222144e-01 19 40198375 40198396 22 + 1.838 1.780 -0.197
ENSG00000130758 E009 82.027499 0.0004629072 3.805283e-02 1.497615e-01 19 40198397 40198423 27 + 1.894 1.815 -0.265
ENSG00000130758 E010 73.842573 0.0005335576 1.842603e-02 9.045039e-02 19 40198424 40198442 19 + 1.861 1.764 -0.328
ENSG00000130758 E011 98.531612 0.0004441232 1.889100e-02 9.205789e-02 19 40198443 40198511 69 + 1.973 1.891 -0.277
ENSG00000130758 E012 81.240206 0.0005183589 4.766691e-02 1.742196e-01 19 40198512 40198555 44 + 1.887 1.812 -0.253
ENSG00000130758 E013 104.231216 0.0004314996 1.766973e-02 8.789216e-02 19 40204485 40204600 116 + 1.996 1.915 -0.271
ENSG00000130758 E014 73.195160 0.0094505597 1.122904e-01 3.029597e-01 19 40204601 40204633 33 + 1.853 1.756 -0.327
ENSG00000130758 E015 5.016713 0.1894450409 4.895442e-01 6.936898e-01 19 40204634 40205120 487 + 0.829 0.664 -0.669
ENSG00000130758 E016 158.725667 0.0016533218 2.618977e-02 1.158870e-01 19 40205121 40205296 176 + 2.167 2.099 -0.226
ENSG00000130758 E017 8.302754 0.0095816074 2.507635e-01 4.888007e-01 19 40205530 40205599 70 + 0.991 0.853 -0.523
ENSG00000130758 E018 163.819779 0.0003324748 9.511149e-01 9.775393e-01 19 40205911 40206157 247 + 2.116 2.133 0.059
ENSG00000130758 E019 3.354209 0.1624607994 9.153105e-01 9.598015e-01 19 40206158 40206402 245 + 0.548 0.568 0.093
ENSG00000130758 E020 79.263137 0.0005947941 9.667495e-01 9.852864e-01 19 40209103 40209151 49 + 1.809 1.823 0.045
ENSG00000130758 E021 92.284565 0.0004145695 6.462470e-01 8.010215e-01 19 40209152 40209219 68 + 1.887 1.882 -0.015
ENSG00000130758 E022 132.594410 0.0015990094 6.511734e-01 8.043019e-01 19 40212805 40212976 172 + 2.009 2.042 0.109
ENSG00000130758 E023 93.671066 0.0007769868 3.833990e-02 1.504807e-01 19 40213076 40213188 113 + 1.796 1.910 0.381
ENSG00000130758 E024 53.438883 0.0326399182 8.143168e-01 9.048243e-01 19 40213189 40213388 200 + 1.643 1.646 0.010
ENSG00000130758 E025 40.166574 0.0339335296 9.753966e-01 9.895254e-01 19 40213389 40213516 128 + 1.515 1.526 0.036
ENSG00000130758 E026 120.515861 0.0005593207 2.136003e-08 9.317811e-07 19 40213517 40214221 705 + 1.774 2.040 0.895
ENSG00000130758 E027 153.176415 0.4044249520 1.890873e-01 4.158265e-01 19 40214970 40215575 606 + 1.844 2.142 1.001