ENSG00000130717

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372210 ENSG00000130717 HEK293_OSMI2_6hA HEK293_TMG_6hB UCK1 protein_coding protein_coding 63.19459 87.44529 38.04809 10.34379 1.143135 -1.200342 3.426400 4.695762 1.162407 0.1717416 0.1931043 -2.0049541 0.05151250 0.05526667 0.03066667 -0.02460000 0.315900629 0.009342177 FALSE TRUE
ENST00000372215 ENSG00000130717 HEK293_OSMI2_6hA HEK293_TMG_6hB UCK1 protein_coding protein_coding 63.19459 87.44529 38.04809 10.34379 1.143135 -1.200342 41.714963 58.827523 22.110511 9.9433331 0.4253560 -1.4113518 0.63740833 0.66330000 0.58160000 -0.08170000 0.588719809 0.009342177 FALSE TRUE
ENST00000482398 ENSG00000130717 HEK293_OSMI2_6hA HEK293_TMG_6hB UCK1 protein_coding processed_transcript 63.19459 87.44529 38.04809 10.34379 1.143135 -1.200342 3.158090 4.226663 4.545450 0.1353715 0.3823606 0.1046653 0.05702083 0.05013333 0.11970000 0.06956667 0.009342177 0.009342177   FALSE
ENST00000484876 ENSG00000130717 HEK293_OSMI2_6hA HEK293_TMG_6hB UCK1 protein_coding processed_transcript 63.19459 87.44529 38.04809 10.34379 1.143135 -1.200342 3.779501 5.245550 3.694882 0.4363001 0.3223325 -0.5044142 0.06577083 0.06276667 0.09710000 0.03433333 0.463846932 0.009342177   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000130717 E001 1118.832344 0.0002833929 0.0001024232 0.001526041 9 131523801 131524720 920 - 2.945 2.995 0.167
ENSG00000130717 E002 284.893393 0.0003847047 0.3385838015 0.576729124 9 131524721 131524737 17 - 2.409 2.385 -0.083
ENSG00000130717 E003 775.427311 0.0006912347 0.3714023641 0.605060565 9 131524738 131525062 325 - 2.836 2.820 -0.056
ENSG00000130717 E004 390.449224 0.0002056787 0.2868904688 0.527610406 9 131525063 131525147 85 - 2.544 2.521 -0.077
ENSG00000130717 E005 360.926943 0.0004880388 0.0760343899 0.236850674 9 131525148 131525221 74 - 2.524 2.483 -0.137
ENSG00000130717 E006 241.177260 0.0006849420 0.0613078118 0.205744141 9 131525929 131525944 16 - 2.358 2.305 -0.176
ENSG00000130717 E007 301.621063 0.0002533335 0.4364279404 0.656086504 9 131525945 131525977 33 - 2.429 2.410 -0.065
ENSG00000130717 E008 29.697110 0.0257489412 0.3047201033 0.545313517 9 131525978 131526159 182 - 1.505 1.394 -0.384
ENSG00000130717 E009 15.931279 0.0463320516 0.0949532333 0.272880311 9 131526445 131526503 59 - 1.318 1.092 -0.799
ENSG00000130717 E010 37.070126 0.0185652818 0.3663038483 0.600950774 9 131526952 131527148 197 - 1.582 1.497 -0.291
ENSG00000130717 E011 22.538646 0.0151232110 0.0010754138 0.010494771 9 131528795 131528943 149 - 1.521 1.208 -1.088
ENSG00000130717 E012 384.183916 0.0002154064 0.4618666814 0.674407462 9 131528944 131529038 95 - 2.509 2.524 0.049
ENSG00000130717 E013 21.677790 0.0489050123 0.3229364286 0.562240195 9 131529039 131529127 89 - 1.398 1.258 -0.486
ENSG00000130717 E014 333.056272 0.0001900884 0.7741390023 0.881243894 9 131529128 131529201 74 - 2.453 2.458 0.018
ENSG00000130717 E015 291.658228 0.0018306137 0.7246042080 0.850869580 9 131529202 131529260 59 - 2.408 2.394 -0.048
ENSG00000130717 E016 212.926026 0.0027885126 0.1801627056 0.404219407 9 131529261 131529270 10 - 2.302 2.248 -0.180
ENSG00000130717 E017 1.870006 0.2155937775 0.3446141049 0.582161182 9 131529480 131529487 8 - 0.196 0.441 1.629
ENSG00000130717 E018 337.730055 0.0023432434 0.9704901566 0.987100511 9 131529488 131529556 69 - 2.465 2.460 -0.017
ENSG00000130717 E019 247.227807 0.0003514510 0.9626181146 0.983259128 9 131529557 131529584 28 - 2.328 2.327 -0.002
ENSG00000130717 E020 439.920175 0.0003144307 0.2123700306 0.444516511 9 131530486 131530645 160 - 2.559 2.583 0.079
ENSG00000130717 E021 19.610524 0.0047462662 0.4157829040 0.640369538 9 131530646 131530687 42 - 1.305 1.228 -0.271
ENSG00000130717 E022 165.355015 0.0005743608 0.1615674427 0.379084974 9 131531067 131531093 27 - 2.122 2.169 0.155
ENSG00000130717 E023 209.633056 0.0006446061 0.0046069501 0.032509187 9 131531094 131531264 171 - 2.192 2.279 0.291