ENSG00000130560

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371756 ENSG00000130560 HEK293_OSMI2_6hA HEK293_TMG_6hB UBAC1 protein_coding protein_coding 62.8599 84.0923 37.97016 6.909599 1.655838 -1.146899 50.736748 70.865899 28.120061 6.2924271 1.8054167 -1.3331825 0.78424583 0.84170000 0.7392333 -0.10246667 0.009542709 0.009542709 FALSE TRUE
ENST00000465873 ENSG00000130560 HEK293_OSMI2_6hA HEK293_TMG_6hB UBAC1 protein_coding processed_transcript 62.8599 84.0923 37.97016 6.909599 1.655838 -1.146899 2.812249 2.989949 3.438950 0.6274361 0.2617926 0.2012192 0.05299583 0.03740000 0.0915000 0.05410000 0.137956184 0.009542709 TRUE FALSE
MSTRG.33615.3 ENSG00000130560 HEK293_OSMI2_6hA HEK293_TMG_6hB UBAC1 protein_coding   62.8599 84.0923 37.97016 6.909599 1.655838 -1.146899 6.248871 6.853144 4.054281 1.2388499 0.5245605 -0.7558695 0.10800833 0.08006667 0.1062333 0.02616667 0.631319819 0.009542709 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000130560 E001 5.3082301 0.0050026864 1.430265e-01 0.3520172533 9 135924826 135924861 36 - 0.573 0.800 0.953
ENSG00000130560 E002 85.6056439 0.0005902179 2.726771e-05 0.0004965349 9 135924862 135925187 326 - 2.004 1.825 -0.601
ENSG00000130560 E003 133.0361491 0.0022584189 6.697783e-01 0.8161338684 9 135932969 135933041 73 - 2.055 2.069 0.049
ENSG00000130560 E004 147.1663564 0.0004830261 3.934644e-01 0.6231226163 9 135933042 135933056 15 - 2.091 2.116 0.085
ENSG00000130560 E005 886.1140737 0.0008651206 7.415317e-01 0.8614303845 9 135933057 135933515 459 - 2.895 2.885 -0.031
ENSG00000130560 E006 480.8632535 0.0001300577 5.063876e-01 0.7051977239 9 135938222 135938339 118 - 2.615 2.622 0.026
ENSG00000130560 E007 229.7589678 0.0002073978 8.950529e-02 0.2629112844 9 135938340 135938360 21 - 2.269 2.311 0.139
ENSG00000130560 E008 356.6907515 0.0001642020 1.542411e-01 0.3683339139 9 135939673 135939731 59 - 2.471 2.497 0.088
ENSG00000130560 E009 254.1290757 0.0020755898 9.313702e-01 0.9677558870 9 135939732 135939759 28 - 2.349 2.343 -0.017
ENSG00000130560 E010 4.0455374 0.0063663194 6.791143e-03 0.0436588525 9 135942162 135942289 128 - 0.910 0.516 -1.646
ENSG00000130560 E011 746.7517377 0.0001640812 2.821277e-03 0.0223208788 9 135945028 135945250 223 - 2.781 2.822 0.135
ENSG00000130560 E012 57.5200653 0.0645885959 1.200522e-03 0.0114358675 9 135945251 135945673 423 - 1.974 1.560 -1.400
ENSG00000130560 E013 646.4676762 0.0001461039 3.750997e-02 0.1483316760 9 135945889 135945997 109 - 2.728 2.757 0.096
ENSG00000130560 E014 598.0142371 0.0007008556 8.606361e-01 0.9306737912 9 135946269 135946371 103 - 2.721 2.713 -0.027
ENSG00000130560 E015 7.3282419 0.1311661704 1.276374e-01 0.3281067892 9 135947516 135947797 282 - 1.061 0.768 -1.111
ENSG00000130560 E016 460.4072837 0.0002836184 5.838562e-01 0.7595135116 9 135947798 135947876 79 - 2.596 2.602 0.021
ENSG00000130560 E017 274.6937965 0.0002743713 3.950914e-01 0.6244705386 9 135947877 135947905 29 - 2.397 2.372 -0.084
ENSG00000130560 E018 1.6922099 0.3690546327 4.370918e-01 0.6565211285 9 135947906 135948044 139 - 0.190 0.424 1.589
ENSG00000130560 E019 304.1789471 0.0001943873 5.305373e-01 0.7224300276 9 135953680 135953753 74 - 2.435 2.416 -0.064
ENSG00000130560 E020 0.2027342 0.0341457891 1.000000e+00   9 135953754 135953893 140 - 0.001 0.076 7.164
ENSG00000130560 E021 298.7794782 0.0001818561 1.852451e-03 0.0160717697 9 135955295 135955415 121 - 2.471 2.395 -0.252
ENSG00000130560 E022 186.2954426 0.0012416003 4.227341e-01 0.6456803373 9 135961025 135961373 349 - 2.236 2.205 -0.101