ENSG00000130559

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312405 ENSG00000130559 HEK293_OSMI2_6hA HEK293_TMG_6hB CAMSAP1 protein_coding protein_coding 10.14131 12.69457 8.438067 1.197129 0.5014809 -0.5886544 4.3473352 5.818192 4.4985806 0.6505175 0.2811551 -0.370375 0.43230000 0.4581667 0.53330000 0.07513333 6.129553e-01 1.302636e-05 FALSE  
ENST00000389532 ENSG00000130559 HEK293_OSMI2_6hA HEK293_TMG_6hB CAMSAP1 protein_coding protein_coding 10.14131 12.69457 8.438067 1.197129 0.5014809 -0.5886544 4.1958592 4.922890 1.8663819 0.8052727 0.9466858 -1.394480 0.41595833 0.3832000 0.20966667 -0.17353333 7.789148e-01 1.302636e-05 FALSE  
ENST00000409386 ENSG00000130559 HEK293_OSMI2_6hA HEK293_TMG_6hB CAMSAP1 protein_coding protein_coding 10.14131 12.69457 8.438067 1.197129 0.5014809 -0.5886544 0.4514950 0.000000 0.5574576 0.0000000 0.1727420 5.826441 0.04202083 0.0000000 0.06750000 0.06750000 1.302636e-05 1.302636e-05 FALSE  
ENST00000482664 ENSG00000130559 HEK293_OSMI2_6hA HEK293_TMG_6hB CAMSAP1 protein_coding retained_intron 10.14131 12.69457 8.438067 1.197129 0.5014809 -0.5886544 0.4589750 1.722401 0.2792647 0.2297551 0.2792647 -2.582310 0.04034583 0.1397000 0.03006667 -0.10963333 2.551402e-01 1.302636e-05 FALSE  
MSTRG.33614.10 ENSG00000130559 HEK293_OSMI2_6hA HEK293_TMG_6hB CAMSAP1 protein_coding   10.14131 12.69457 8.438067 1.197129 0.5014809 -0.5886544 0.1619657 0.000000 1.0239891 0.0000000 1.0239891 6.692077 0.01987083 0.0000000 0.13556667 0.13556667 8.714497e-01 1.302636e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000130559 E001 45.9757236 0.2787768862 0.09795519 0.27819297 9 135808487 135808926 440 - 1.392 1.757 1.246
ENSG00000130559 E002 86.9259070 0.5000369067 0.15763895 0.37316309 9 135808927 135809580 654 - 1.665 2.028 1.227
ENSG00000130559 E003 152.7933092 1.0705147967 0.45532720 0.66975483 9 135809581 135810422 842 - 2.046 2.229 0.612
ENSG00000130559 E004 29.9054701 0.3057897052 0.52935011 0.72159693 9 135810423 135810477 55 - 1.420 1.504 0.287
ENSG00000130559 E005 25.9274427 0.2802879887 0.62451269 0.78701539 9 135810478 135810478 1 - 1.382 1.433 0.176
ENSG00000130559 E006 30.6356345 0.2810663113 0.42375923 0.64639735 9 135810479 135810489 11 - 1.396 1.529 0.458
ENSG00000130559 E007 38.7688566 0.3945753960 0.49122751 0.69479129 9 135810490 135810507 18 - 1.519 1.617 0.336
ENSG00000130559 E008 40.5304071 0.3890701385 0.42645076 0.64835986 9 135810508 135810521 14 - 1.514 1.646 0.453
ENSG00000130559 E009 98.8071193 0.6815953864 0.41351966 0.63866358 9 135810522 135810680 159 - 1.874 2.035 0.539
ENSG00000130559 E010 183.9543958 1.1134196673 0.41496568 0.63978274 9 135810681 135811095 415 - 2.091 2.321 0.770
ENSG00000130559 E011 91.4097232 0.6002102799 0.29318334 0.53389889 9 135811096 135811227 132 - 1.773 2.026 0.849
ENSG00000130559 E012 153.6662428 1.0746404167 0.46180830 0.67437419 9 135811228 135811512 285 - 2.050 2.230 0.604
ENSG00000130559 E013 40.3804831 0.3791008567 0.41461233 0.63952178 9 135811513 135811514 2 - 1.512 1.646 0.457
ENSG00000130559 E014 79.6639325 0.5973907841 0.38032565 0.61245299 9 135811515 135811611 97 - 1.774 1.945 0.576
ENSG00000130559 E015 93.1234464 0.0004381742 0.74274207 0.86212928 9 135815097 135815215 119 - 1.913 1.984 0.240
ENSG00000130559 E016 94.7005357 0.0105758831 0.77137799 0.87944624 9 135815890 135816005 116 - 1.930 1.982 0.175
ENSG00000130559 E017 0.7366858 0.9182311003 0.41886428   9 135817788 135817847 60 - 0.368 0.101 -2.353
ENSG00000130559 E018 80.8463488 0.0191365396 0.81647708 0.90615744 9 135817977 135818079 103 - 1.835 1.927 0.311
ENSG00000130559 E019 0.0000000       9 135818080 135818171 92 -      
ENSG00000130559 E020 104.2282868 0.0193977457 0.53984025 0.72887018 9 135818408 135818616 209 - 1.926 2.045 0.400
ENSG00000130559 E021 0.4536995 0.1397670673 0.28403190   9 135818617 135818647 31 - 0.266 0.095 -1.784
ENSG00000130559 E022 85.4002826 0.0184685726 0.84459666 0.92192227 9 135819010 135819146 137 - 1.878 1.941 0.211
ENSG00000130559 E023 633.5583692 0.0425456511 0.19870135 0.42804836 9 135820839 135823118 2280 - 2.798 2.779 -0.065
ENSG00000130559 E024 62.9107860 0.0240151161 0.01383823 0.07369466 9 135823119 135823260 142 - 1.874 1.732 -0.478
ENSG00000130559 E025 52.0589778 0.0253873928 0.03342507 0.13725898 9 135823950 135824034 85 - 1.781 1.663 -0.400
ENSG00000130559 E026 53.4521292 0.0355915321 0.08008226 0.24500446 9 135824789 135824880 92 - 1.783 1.679 -0.355
ENSG00000130559 E027 0.0000000       9 135826125 135826409 285 -      
ENSG00000130559 E028 76.1146385 0.0238313568 0.12584030 0.32523060 9 135827407 135827584 178 - 1.904 1.851 -0.179
ENSG00000130559 E029 0.0000000       9 135849857 135850136 280 -      
ENSG00000130559 E030 50.8175175 0.0241011339 0.26732656 0.50695572 9 135850137 135850233 97 - 1.714 1.690 -0.081
ENSG00000130559 E031 58.4859316 0.0187089457 0.37372401 0.60712410 9 135850322 135850461 140 - 1.757 1.758 0.006
ENSG00000130559 E032 48.4470454 0.0010362421 0.02528288 0.11306721 9 135862467 135862608 142 - 1.712 1.654 -0.198
ENSG00000130559 E033 0.1308682 0.0315109915 1.00000000   9 135865248 135865331 84 - 0.000 0.096 8.669
ENSG00000130559 E034 0.2922838 0.0262873144 0.62134524   9 135865332 135865364 33 - 0.153 0.096 -0.771
ENSG00000130559 E035 0.0000000       9 135866379 135866455 77 -      
ENSG00000130559 E036 47.1263625 0.0009339520 0.01388651 0.07389263 9 135866456 135866536 81 - 1.708 1.637 -0.243
ENSG00000130559 E037 59.7719592 0.0214319735 0.02098914 0.09931693 9 135881633 135881794 162 - 1.835 1.719 -0.392
ENSG00000130559 E038 52.2438338 0.0344460155 0.12039240 0.31646116 9 135882816 135883078 263 - 1.756 1.677 -0.268
ENSG00000130559 E039 0.0000000       9 135888165 135888273 109 -      
ENSG00000130559 E040 17.2718342 0.0024783767 0.16581581 0.38486658 9 135907000 135907159 160 - 1.281 1.220 -0.215
ENSG00000130559 E041 2.7998854 0.6185658352 0.91958114 0.96200121 9 135907160 135907305 146 - 0.553 0.565 0.055
ENSG00000130559 E042 0.8399544 0.7837951990 0.81210982   9 135907306 135907546 241 - 0.267 0.247 -0.146