ENSG00000130224

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317135 ENSG00000130224 HEK293_OSMI2_6hA HEK293_TMG_6hB LRCH2 protein_coding protein_coding 6.927274 1.570792 11.91193 0.3469319 1.238667 2.914898 1.802862 0.6043017 2.583098 0.3237252 0.05774178 2.077658 0.3184917 0.45406667 0.2207667 -0.2333000 8.900852e-01 3.627114e-09 FALSE TRUE
MSTRG.34739.1 ENSG00000130224 HEK293_OSMI2_6hA HEK293_TMG_6hB LRCH2 protein_coding   6.927274 1.570792 11.91193 0.3469319 1.238667 2.914898 1.190958 0.8466083 2.197381 0.5163846 0.33352318 1.365628 0.3312417 0.44766667 0.1940000 -0.2536667 9.130680e-01 3.627114e-09 FALSE TRUE
MSTRG.34739.4 ENSG00000130224 HEK293_OSMI2_6hA HEK293_TMG_6hB LRCH2 protein_coding   6.927274 1.570792 11.91193 0.3469319 1.238667 2.914898 2.240702 0.0000000 3.705941 0.0000000 0.60022058 8.537584 0.1978625 0.00000000 0.3097667 0.3097667 3.627114e-09 3.627114e-09 FALSE TRUE
MSTRG.34739.5 ENSG00000130224 HEK293_OSMI2_6hA HEK293_TMG_6hB LRCH2 protein_coding   6.927274 1.570792 11.91193 0.3469319 1.238667 2.914898 1.692753 0.1198820 3.425505 0.0292248 1.07517763 4.725249 0.1524167 0.09823333 0.2754667 0.1772333 3.172613e-01 3.627114e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000130224 E001 0.0000000       X 115110616 115110625 10 -      
ENSG00000130224 E002 183.0024973 0.0193575850 0.013458412 0.07222461 X 115110626 115113199 2574 - 2.138 2.297 0.530
ENSG00000130224 E003 27.4632457 0.0013245087 0.100762485 0.28314835 X 115113200 115113335 136 - 1.335 1.477 0.491
ENSG00000130224 E004 26.8517892 0.0013686142 0.316331446 0.55636438 X 115122527 115122604 78 - 1.342 1.439 0.336
ENSG00000130224 E005 41.4915448 0.0016069333 0.072684443 0.23015753 X 115122760 115122897 138 - 1.515 1.648 0.453
ENSG00000130224 E006 44.7302931 0.0025289731 0.238672473 0.47509847 X 115123080 115123192 113 - 1.553 1.647 0.322
ENSG00000130224 E007 30.5661038 0.0063538087 0.857756477 0.92921065 X 115123945 115124002 58 - 1.413 1.417 0.016
ENSG00000130224 E008 27.9864059 0.0114646763 0.586494652 0.76125077 X 115126843 115126893 51 - 1.363 1.435 0.250
ENSG00000130224 E009 25.4113929 0.0013959493 0.927053061 0.96559088 X 115130155 115130199 45 - 1.338 1.351 0.043
ENSG00000130224 E010 0.9662812 0.0823979694 0.219134494   X 115136484 115136543 60 - 0.299 0.000 -9.829
ENSG00000130224 E011 2.7821047 0.0137564266 0.006041223 0.03992600 X 115138339 115138442 104 - 0.366 0.824 2.102
ENSG00000130224 E012 35.8702025 0.0009750300 0.654901484 0.80667382 X 115149827 115149943 117 - 1.487 1.477 -0.036
ENSG00000130224 E013 25.8852482 0.0181703581 0.557817072 0.74170631 X 115150022 115150070 49 - 1.336 1.404 0.238
ENSG00000130224 E014 27.9978720 0.0088748124 0.704926470 0.83866766 X 115156602 115156667 66 - 1.371 1.418 0.161
ENSG00000130224 E015 43.6341883 0.0090643286 0.381381035 0.61336709 X 115163676 115163783 108 - 1.578 1.527 -0.175
ENSG00000130224 E016 29.2208508 0.0244824957 0.413659763 0.63874208 X 115165405 115165463 59 - 1.416 1.345 -0.245
ENSG00000130224 E017 38.0992643 0.0009397569 0.090385138 0.26446680 X 115165558 115165655 98 - 1.527 1.429 -0.339
ENSG00000130224 E018 41.3877884 0.0048663915 0.004476520 0.03180421 X 115165841 115165952 112 - 1.581 1.384 -0.677
ENSG00000130224 E019 34.6142042 0.0265165989 0.056777607 0.19546602 X 115166255 115166342 88 - 1.505 1.318 -0.647
ENSG00000130224 E020 34.4638716 0.0259155345 0.021515105 0.10102748 X 115170299 115170432 134 - 1.509 1.267 -0.840
ENSG00000130224 E021 29.0990093 0.0104469497 0.006833735 0.04386204 X 115179427 115179563 137 - 1.439 1.190 -0.872
ENSG00000130224 E022 28.5124587 0.0184168167 0.448002025 0.66424432 X 115179646 115179751 106 - 1.399 1.336 -0.217
ENSG00000130224 E023 29.2985096 0.0068397972 0.076689802 0.23814534 X 115184411 115184537 127 - 1.423 1.284 -0.482
ENSG00000130224 E024 23.7999647 0.0017153624 0.221724940 0.45558372 X 115188226 115188370 145 - 1.328 1.240 -0.309
ENSG00000130224 E025 17.0293248 0.0117203036 0.520094138 0.71503520 X 115233693 115233867 175 - 1.158 1.239 0.289
ENSG00000130224 E026 6.0929340 0.0048135494 0.866942311 0.93432806 X 115233868 115234096 229 - 0.787 0.781 -0.024
ENSG00000130224 E027 0.9598639 0.5141659604 0.207771321   X 115234291 115234350 60 - 0.176 0.459 1.916