ENSG00000130164

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000535915 ENSG00000130164 HEK293_OSMI2_6hA HEK293_TMG_6hB LDLR protein_coding protein_coding 16.8906 17.34963 17.43559 1.088193 0.3334667 0.007126187 2.357258 2.04224137 3.407684 0.35085478 1.0844912 0.7358187 0.13515417 0.1202667 0.1946000 0.07433333 0.80298261 0.01611625 FALSE TRUE
ENST00000558013 ENSG00000130164 HEK293_OSMI2_6hA HEK293_TMG_6hB LDLR protein_coding protein_coding 16.8906 17.34963 17.43559 1.088193 0.3334667 0.007126187 1.105728 0.06086265 1.721860 0.06086265 1.7218596 4.6111527 0.06549583 0.0034000 0.1005667 0.09716667 1.00000000 0.01611625 FALSE TRUE
ENST00000558518 ENSG00000130164 HEK293_OSMI2_6hA HEK293_TMG_6hB LDLR protein_coding protein_coding 16.8906 17.34963 17.43559 1.088193 0.3334667 0.007126187 10.133737 12.30439076 8.369001 1.30842025 0.2724784 -0.5554952 0.60850000 0.7057667 0.4798333 -0.22593333 0.01611625 0.01611625 FALSE TRUE
MSTRG.16438.1 ENSG00000130164 HEK293_OSMI2_6hA HEK293_TMG_6hB LDLR protein_coding   16.8906 17.34963 17.43559 1.088193 0.3334667 0.007126187 1.387623 1.73091060 2.297786 0.28556756 0.6016845 0.4066672 0.08115833 0.0993000 0.1309667 0.03166667 0.87631578 0.01611625 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000130164 E001 7.4859794 0.0044966124 9.892199e-01 0.9963837716 19 11089427 11089461 35 + 0.921 0.923 0.009
ENSG00000130164 E002 7.6168476 0.0043919629 9.138703e-01 0.9590697807 19 11089462 11089462 1 + 0.921 0.938 0.063
ENSG00000130164 E003 14.8176752 0.0027909455 8.336702e-01 0.9158209796 19 11089463 11089477 15 + 1.174 1.198 0.083
ENSG00000130164 E004 79.5092923 0.0012414668 4.919902e-01 0.6953101370 19 11089478 11089615 138 + 1.916 1.893 -0.079
ENSG00000130164 E005 0.3393995 0.0271326751 1.371319e-01   19 11090599 11090919 321 + 0.239 0.000 -11.871
ENSG00000130164 E006 103.1378822 0.0032733427 2.040028e-01 0.4346356456 19 11100223 11100345 123 + 2.041 1.992 -0.165
ENSG00000130164 E007 0.6182515 0.0241791620 4.551563e-01   19 11100346 11100578 233 + 0.136 0.267 1.213
ENSG00000130164 E008 91.0245589 0.0161027271 9.370408e-02 0.2706402805 19 11102664 11102786 123 + 2.021 1.906 -0.384
ENSG00000130164 E009 7.4194779 0.0048554154 5.540198e-01 0.7391392395 19 11102787 11104268 1482 + 0.958 0.893 -0.246
ENSG00000130164 E010 90.1595581 0.0014430696 1.146113e-02 0.0642491203 19 11105220 11105306 87 + 2.008 1.911 -0.326
ENSG00000130164 E011 173.3688163 0.0006748919 8.332935e-03 0.0508525234 19 11105307 11105600 294 + 2.275 2.205 -0.233
ENSG00000130164 E012 1.8814829 0.0146370568 8.965994e-01 0.9501366775 19 11106356 11106564 209 + 0.452 0.433 -0.103
ENSG00000130164 E013 128.9738139 0.0022345259 1.425143e-01 0.3511993763 19 11106565 11106687 123 + 2.138 2.088 -0.165
ENSG00000130164 E014 134.4407310 0.0003866715 7.492004e-02 0.2346409561 19 11107392 11107514 123 + 2.157 2.107 -0.165
ENSG00000130164 E015 1.3549373 0.0481158715 7.232606e-01   19 11107515 11107515 1 + 0.393 0.330 -0.374
ENSG00000130164 E016 86.8695016 0.0004905576 4.873737e-01 0.6921659458 19 11110652 11110712 61 + 1.952 1.930 -0.071
ENSG00000130164 E017 84.0131293 0.0006732915 3.117843e-01 0.5521701285 19 11110713 11110771 59 + 1.946 1.912 -0.114
ENSG00000130164 E018 114.7541261 0.0004764607 4.389295e-01 0.6579051532 19 11111514 11111639 126 + 2.071 2.051 -0.068
ENSG00000130164 E019 104.2477317 0.0004144876 1.743189e-01 0.3962912462 19 11113278 11113370 93 + 2.041 2.000 -0.140
ENSG00000130164 E020 102.8007398 0.0004022530 1.720042e-01 0.3932170102 19 11113371 11113449 79 + 2.037 1.995 -0.142
ENSG00000130164 E021 0.1426347 0.0312270374 3.797721e-01   19 11113450 11113473 24 + 0.136 0.000 -10.868
ENSG00000130164 E022 0.7145081 0.0202238001 7.906130e-01   19 11113474 11113534 61 + 0.239 0.195 -0.371
ENSG00000130164 E023 194.8417239 0.0017943593 2.078002e-02 0.0986201747 19 11113535 11113762 228 + 2.322 2.255 -0.224
ENSG00000130164 E024 144.9547204 0.0070357525 7.967644e-02 0.2441708248 19 11116094 11116212 119 + 2.199 2.121 -0.262
ENSG00000130164 E025 151.1657152 0.0049291194 3.621324e-01 0.5974664570 19 11116859 11116998 140 + 2.192 2.160 -0.108
ENSG00000130164 E026 144.5297050 0.0003059308 4.122615e-01 0.6377856373 19 11120092 11120233 142 + 2.168 2.149 -0.063
ENSG00000130164 E027 146.3446580 0.0003797707 9.722166e-01 0.9880772255 19 11120370 11120522 153 + 2.164 2.169 0.015
ENSG00000130164 E028 150.2688313 0.0021536033 4.364247e-01 0.6560865037 19 11123174 11123344 171 + 2.159 2.192 0.111
ENSG00000130164 E029 0.6901176 0.0493175061 4.550961e-01   19 11127547 11127654 108 + 0.136 0.269 1.224
ENSG00000130164 E030 112.3014719 0.0003943705 8.203319e-01 0.9082869149 19 11128008 11128085 78 + 2.050 2.048 -0.008
ENSG00000130164 E031 1.1431969 0.4680731884 6.298985e-01   19 11129451 11129512 62 + 0.240 0.385 0.954
ENSG00000130164 E032 152.1807780 0.0003563676 4.616885e-02 0.1704315239 19 11129513 11129670 158 + 2.142 2.206 0.215
ENSG00000130164 E033 58.6148214 0.0077378509 3.507383e-01 0.5879149879 19 11131281 11131286 6 + 1.735 1.798 0.214
ENSG00000130164 E034 558.8761656 0.0025088763 8.516108e-03 0.0516787899 19 11131287 11132446 1160 + 2.701 2.774 0.243
ENSG00000130164 E035 152.2900020 0.0031700030 7.226842e-06 0.0001581959 19 11132447 11132922 476 + 2.068 2.253 0.620
ENSG00000130164 E036 133.8411171 0.0004681644 1.530159e-03 0.0138184657 19 11132923 11133094 172 + 2.063 2.169 0.357
ENSG00000130164 E037 215.7090684 0.0047635149 1.367712e-02 0.0730772954 19 11133095 11133846 752 + 2.269 2.375 0.355