ENSG00000130119

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336470 ENSG00000130119 HEK293_OSMI2_6hA HEK293_TMG_6hB GNL3L protein_coding protein_coding 16.26975 16.22561 19.06673 0.7986172 0.3996417 0.2326525 7.357438 7.955633 7.526164 0.9136620 0.4768446 -0.07995877 0.4579917 0.4906000 0.3957333 -0.09486667 6.773549e-01 3.486018e-11 FALSE TRUE
ENST00000360845 ENSG00000130119 HEK293_OSMI2_6hA HEK293_TMG_6hB GNL3L protein_coding protein_coding 16.26975 16.22561 19.06673 0.7986172 0.3996417 0.2326525 2.643836 4.109613 1.101681 0.5137290 0.6362527 -1.88976613 0.1736000 0.2513667 0.0567000 -0.19466667 4.020679e-01 3.486018e-11 FALSE TRUE
MSTRG.34315.13 ENSG00000130119 HEK293_OSMI2_6hA HEK293_TMG_6hB GNL3L protein_coding   16.26975 16.22561 19.06673 0.7986172 0.3996417 0.2326525 4.154745 1.746394 7.868240 0.1465042 0.2784095 2.16525681 0.2405625 0.1090333 0.4124667 0.30343333 3.486018e-11 3.486018e-11 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000130119 E001 0.4349185 0.0217681645 4.471766e-01   X 54530183 54530202 20 + 0.224 0.116 -1.140
ENSG00000130119 E002 0.4349185 0.0217681645 4.471766e-01   X 54530203 54530203 1 + 0.224 0.116 -1.140
ENSG00000130119 E003 1.1728918 0.1616761980 7.757584e-01   X 54530204 54530208 5 + 0.302 0.398 0.575
ENSG00000130119 E004 1.3343075 0.1503570972 9.665033e-01   X 54530209 54530210 2 + 0.370 0.398 0.159
ENSG00000130119 E005 3.5298194 0.0065742195 6.128685e-01 7.788550e-01 X 54530211 54530218 8 + 0.674 0.642 -0.139
ENSG00000130119 E006 7.9633791 0.0037757075 9.195076e-01 9.619857e-01 X 54530219 54530237 19 + 0.909 0.969 0.225
ENSG00000130119 E007 13.9726397 0.0040880732 1.986233e-01 4.279364e-01 X 54530238 54530247 10 + 1.202 1.134 -0.241
ENSG00000130119 E008 27.4706938 0.0037982071 5.838967e-04 6.438066e-03 X 54530248 54530259 12 + 1.539 1.347 -0.659
ENSG00000130119 E009 40.3191052 0.0020350766 7.955840e-04 8.246492e-03 X 54530260 54530278 19 + 1.682 1.542 -0.477
ENSG00000130119 E010 58.4030591 0.0023361787 7.753890e-04 8.075982e-03 X 54530279 54530302 24 + 1.829 1.714 -0.387
ENSG00000130119 E011 24.4209498 0.0048851971 9.771766e-02 2.777748e-01 X 54530303 54530312 10 + 1.437 1.366 -0.247
ENSG00000130119 E012 47.6783262 0.0047373860 2.993996e-02 1.271696e-01 X 54530313 54530419 107 + 1.722 1.649 -0.250
ENSG00000130119 E013 3.5171252 0.0069564002 7.792945e-01 8.843400e-01 X 54532447 54532519 73 + 0.642 0.642 0.001
ENSG00000130119 E014 70.4495766 0.0017562949 1.744099e-04 2.385536e-03 X 54532520 54532523 4 + 1.908 1.792 -0.392
ENSG00000130119 E015 98.0380831 0.0013746025 2.054627e-04 2.735149e-03 X 54532524 54532585 62 + 2.038 1.948 -0.300
ENSG00000130119 E016 88.0128489 0.0004532905 3.850969e-04 4.588068e-03 X 54539040 54539101 62 + 1.987 1.907 -0.271
ENSG00000130119 E017 1.2922489 0.0153528401 8.550129e-02   X 54539102 54539500 399 + 0.481 0.208 -1.722
ENSG00000130119 E018 109.3901356 0.0019521598 2.596448e-04 3.319056e-03 X 54540135 54540238 104 + 2.087 1.999 -0.295
ENSG00000130119 E019 50.8421796 0.0034579975 1.514944e-02 7.864529e-02 X 54540239 54540242 4 + 1.757 1.676 -0.275
ENSG00000130119 E020 116.6679816 0.0020753141 2.278266e-02 1.052508e-01 X 54541273 54541389 117 + 2.086 2.053 -0.110
ENSG00000130119 E021 101.9550424 0.0004167418 9.023482e-04 9.113261e-03 X 54542955 54543038 84 + 2.043 1.980 -0.211
ENSG00000130119 E022 1.3163791 0.5314269392 7.070832e-01   X 54543146 54543206 61 + 0.370 0.356 -0.086
ENSG00000130119 E023 132.7319196 0.0003092655 5.581908e-02 1.932198e-01 X 54543207 54543342 136 + 2.124 2.119 -0.017
ENSG00000130119 E024 0.5474829 0.0302812326 1.246831e-01   X 54544006 54544120 115 + 0.000 0.285 11.798
ENSG00000130119 E025 125.5276006 0.0003558216 5.829095e-04 6.428016e-03 X 54544223 54544326 104 + 2.127 2.072 -0.186
ENSG00000130119 E026 123.3072059 0.0004069500 3.061507e-04 3.792226e-03 X 54548229 54548373 145 + 2.125 2.062 -0.209
ENSG00000130119 E027 11.4672180 0.2492029938 8.959162e-01 9.497504e-01 X 54548374 54550026 1653 + 0.930 1.199 0.979
ENSG00000130119 E028 5.7930065 0.0171170504 7.682389e-01 8.775722e-01 X 54550366 54550616 251 + 0.783 0.873 0.349
ENSG00000130119 E029 88.6653179 0.0022739192 1.542969e-02 7.970535e-02 X 54550963 54551050 88 + 1.977 1.927 -0.170
ENSG00000130119 E030 110.8334051 0.0004913060 1.708303e-02 8.576921e-02 X 54551568 54551742 175 + 2.060 2.032 -0.092
ENSG00000130119 E031 119.5384251 0.0037331541 6.732394e-02 2.190758e-01 X 54551832 54551974 143 + 2.090 2.067 -0.079
ENSG00000130119 E032 158.6292301 0.0006986385 3.212171e-03 2.467659e-02 X 54552292 54552428 137 + 2.218 2.184 -0.113
ENSG00000130119 E033 167.6242854 0.0002997115 1.595316e-05 3.146590e-04 X 54554565 54554692 128 + 2.255 2.189 -0.218
ENSG00000130119 E034 186.0199491 0.0002533876 1.209769e-02 6.684669e-02 X 54558436 54558655 220 + 2.272 2.261 -0.038
ENSG00000130119 E035 129.6628576 0.0004097562 3.854679e-01 6.168227e-01 X 54560520 54560647 128 + 2.064 2.146 0.275
ENSG00000130119 E036 92.3208254 0.0005394584 7.594438e-01 8.722272e-01 X 54560648 54560809 162 + 1.926 1.991 0.221
ENSG00000130119 E037 1803.9694743 0.0016021099 1.687827e-23 7.330738e-21 X 54560810 54567289 6480 + 3.143 3.335 0.637
ENSG00000130119 E038 1.3389166 0.1808634634 7.787666e-01   X 54576501 54576614 114 + 0.302 0.411 0.650
ENSG00000130119 E039 0.6058878 0.1115198180 3.203646e-02   X 54587702 54587727 26 + 0.370 0.000 -12.411
ENSG00000130119 E040 12.0777554 0.0450812497 4.229074e-01 6.457766e-01 X 54620845 54621521 677 + 1.158 1.089 -0.246
ENSG00000130119 E041 1.3325720 0.0128314764 2.601740e-01   X 54636235 54636305 71 + 0.225 0.454 1.448
ENSG00000130119 E042 0.9574634 0.0156183438 5.833583e-01   X 54636394 54636427 34 + 0.225 0.348 0.861
ENSG00000130119 E043 0.3751086 0.0274424043 2.658391e-01   X 54636428 54636445 18 + 0.000 0.209 11.255
ENSG00000130119 E044 1.1368026 0.0639890555 5.464414e-01   X 54642828 54642938 111 + 0.370 0.286 -0.533