ENSG00000129625

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379638 ENSG00000129625 HEK293_OSMI2_6hA HEK293_TMG_6hB REEP5 protein_coding protein_coding 161.8531 150.1686 141.4304 11.96435 7.201475 -0.08648424 18.67940 8.936001 26.670642 1.516121 0.5504876 1.57647854 0.11859167 0.0590000 0.1893333 0.13033333 3.583158e-07 3.583158e-07 FALSE TRUE
ENST00000504247 ENSG00000129625 HEK293_OSMI2_6hA HEK293_TMG_6hB REEP5 protein_coding protein_coding 161.8531 150.1686 141.4304 11.96435 7.201475 -0.08648424 37.52213 36.852986 32.084112 3.329574 2.9481485 -0.19986427 0.23207083 0.2449667 0.2264333 -0.01853333 8.403189e-01 3.583158e-07 FALSE FALSE
ENST00000513339 ENSG00000129625 HEK293_OSMI2_6hA HEK293_TMG_6hB REEP5 protein_coding protein_coding 161.8531 150.1686 141.4304 11.96435 7.201475 -0.08648424 8.35618 8.630589 7.159958 1.064056 1.5514690 -0.26916493 0.05137083 0.0571000 0.0498000 -0.00730000 8.824212e-01 3.583158e-07 FALSE FALSE
MSTRG.26755.4 ENSG00000129625 HEK293_OSMI2_6hA HEK293_TMG_6hB REEP5 protein_coding   161.8531 150.1686 141.4304 11.96435 7.201475 -0.08648424 63.11575 55.038874 57.016120 2.799784 4.5034815 0.05090981 0.38985833 0.3686667 0.4025000 0.03383333 8.112139e-01 3.583158e-07 FALSE FALSE
MSTRG.26755.8 ENSG00000129625 HEK293_OSMI2_6hA HEK293_TMG_6hB REEP5 protein_coding   161.8531 150.1686 141.4304 11.96435 7.201475 -0.08648424 27.31092 30.358563 14.734290 4.098346 1.0807445 -1.04242226 0.16612083 0.2003667 0.1044333 -0.09593333 1.880800e-03 3.583158e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000129625 E001 580.6864683 0.0156048916 6.583135e-13 6.984263e-11 5 112876385 112878084 1700 - 2.944 2.495 -1.493
ENSG00000129625 E002 200.5094580 0.0002547414 1.516938e-48 4.519492e-45 5 112878085 112878576 492 - 2.474 2.057 -1.394
ENSG00000129625 E003 938.7804655 0.0022423588 7.279107e-01 8.529828e-01 5 112878577 112878832 256 - 2.982 2.963 -0.064
ENSG00000129625 E004 568.3644934 0.0011353851 9.613172e-01 9.826691e-01 5 112878833 112878835 3 - 2.769 2.739 -0.098
ENSG00000129625 E005 1248.0217971 0.0001085482 2.596347e-04 3.319056e-03 5 112887015 112887183 169 - 3.090 3.097 0.021
ENSG00000129625 E006 8.9077542 0.1273590783 2.509301e-02 1.125144e-01 5 112892450 112892817 368 - 0.752 1.147 1.487
ENSG00000129625 E007 0.7796672 0.0193874923 6.629524e-01   5 112892818 112893382 565 - 0.223 0.286 0.476
ENSG00000129625 E008 1080.0831378 0.0005638946 9.146640e-08 3.425160e-06 5 112902380 112902518 139 - 3.007 3.053 0.154
ENSG00000129625 E009 855.9838998 0.0007436570 1.372875e-08 6.237179e-07 5 112921163 112921256 94 - 2.895 2.960 0.216
ENSG00000129625 E010 4.6311299 0.0468279052 5.293767e-01 7.215984e-01 5 112921257 112921479 223 - 0.700 0.781 0.329
ENSG00000129625 E011 2.6972842 0.0402255186 6.323129e-02 2.099710e-01 5 112921480 112921672 193 - 0.370 0.677 1.482
ENSG00000129625 E012 0.3032425 0.0266273165 2.018955e-01   5 112921720 112922045 326 - 0.000 0.210 9.141
ENSG00000129625 E013 1.6248558 0.0109405160 2.112348e-01 4.432483e-01 5 112922046 112922072 27 - 0.302 0.502 1.113
ENSG00000129625 E014 895.8026759 0.0005573504 1.763458e-10 1.186512e-08 5 112922073 112922289 217 - 2.913 2.981 0.224