ENSG00000129515

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000556303 ENSG00000129515 HEK293_OSMI2_6hA HEK293_TMG_6hB SNX6 protein_coding retained_intron 38.01522 7.413902 71.31511 1.709572 2.592139 3.264161 6.0390474 0.0000000 12.10167 0.0000000 2.300870 10.242182 0.0897625 0.00000000 0.1692000 0.16920000 3.393801e-10 2.880496e-20 FALSE TRUE
ENST00000557265 ENSG00000129515 HEK293_OSMI2_6hA HEK293_TMG_6hB SNX6 protein_coding protein_coding 38.01522 7.413902 71.31511 1.709572 2.592139 3.264161 7.8289333 0.0000000 15.94760 0.0000000 1.553881 10.640028 0.1181667 0.00000000 0.2227667 0.22276667 2.880496e-20 2.880496e-20 FALSE FALSE
ENST00000652385 ENSG00000129515 HEK293_OSMI2_6hA HEK293_TMG_6hB SNX6 protein_coding protein_coding 38.01522 7.413902 71.31511 1.709572 2.592139 3.264161 20.5516187 6.3932788 37.70535 1.4039775 1.644451 2.558269 0.6907083 0.87220000 0.5293000 -0.34290000 3.311993e-03 2.880496e-20 FALSE TRUE
MSTRG.9362.4 ENSG00000129515 HEK293_OSMI2_6hA HEK293_TMG_6hB SNX6 protein_coding   38.01522 7.413902 71.31511 1.709572 2.592139 3.264161 0.2249169 0.4775775 0.00000 0.3195319 0.000000 -5.607560 0.0242750 0.05876667 0.0000000 -0.05876667 1.384723e-06 2.880496e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000129515 E001 0.0000000       14 34561093 34561093 1 -      
ENSG00000129515 E002 0.0000000       14 34561094 34561411 318 -      
ENSG00000129515 E003 2.5208866 0.0244223742 6.099144e-01 0.7768258423 14 34561412 34561945 534 - 0.425 0.536 0.554
ENSG00000129515 E004 212.5683870 0.0114604489 1.924348e-05 0.0003701422 14 34561946 34562639 694 - 2.121 2.380 0.865
ENSG00000129515 E005 45.3633720 0.0439416959 2.109518e-01 0.4429007752 14 34562640 34562659 20 - 1.476 1.651 0.597
ENSG00000129515 E006 310.6338491 0.0002130717 1.439206e-04 0.0020274203 14 34562660 34563175 516 - 2.316 2.429 0.377
ENSG00000129515 E007 159.3501000 0.0003471621 5.589148e-01 0.7424697975 14 34567686 34567762 77 - 2.041 2.076 0.117
ENSG00000129515 E008 95.1213664 0.0005192069 6.000636e-01 0.7702481428 14 34567763 34567771 9 - 1.818 1.856 0.131
ENSG00000129515 E009 120.1940148 0.0003792076 2.285046e-01 0.4635188231 14 34567854 34567891 38 - 1.914 1.980 0.220
ENSG00000129515 E010 203.4903596 0.0002393688 1.544646e-01 0.3687067752 14 34567892 34568013 122 - 2.143 2.203 0.202
ENSG00000129515 E011 0.1426347 0.0328894126 9.199313e-01   14 34575591 34575755 165 - 0.052 0.000 -7.333
ENSG00000129515 E012 155.9982973 0.0003969636 3.176504e-02 0.1325244073 14 34575756 34575842 87 - 2.026 2.120 0.317
ENSG00000129515 E013 109.9622417 0.0003698818 9.010228e-01 0.9523757294 14 34581561 34581600 40 - 1.885 1.903 0.061
ENSG00000129515 E014 179.9596204 0.0003137809 6.299461e-01 0.7903910395 14 34586230 34586305 76 - 2.096 2.126 0.101
ENSG00000129515 E015 0.3453689 0.0283435830 1.827137e-01   14 34586306 34586316 11 - 0.052 0.259 2.675
ENSG00000129515 E016 246.8782334 0.0002431956 3.247648e-01 0.5640135042 14 34593045 34593150 106 - 2.238 2.219 -0.065
ENSG00000129515 E017 244.1650073 0.0002095514 3.498897e-02 0.1415588265 14 34597550 34597645 96 - 2.238 2.181 -0.191
ENSG00000129515 E018 132.3451547 0.0011899892 7.604155e-02 0.2368637715 14 34603348 34603364 17 - 1.978 1.907 -0.241
ENSG00000129515 E019 229.5734022 0.0002666154 6.836953e-02 0.2214307052 14 34603365 34603471 107 - 2.211 2.161 -0.165
ENSG00000129515 E020 1.1630461 0.3647243758 5.055786e-01   14 34604135 34604174 40 - 0.282 0.000 -10.172
ENSG00000129515 E021 1.2043646 0.2255928338 1.000000e+00   14 34604175 34604268 94 - 0.250 0.262 0.086
ENSG00000129515 E022 0.0000000       14 34605487 34605595 109 -      
ENSG00000129515 E023 290.0370691 0.0002045260 8.937862e-04 0.0090439997 14 34605596 34605681 86 - 2.316 2.227 -0.299
ENSG00000129515 E024 227.0876228 0.0002310288 1.605650e-05 0.0003166237 14 34605682 34605717 36 - 2.216 2.073 -0.478
ENSG00000129515 E025 287.1461087 0.0002534544 1.379927e-03 0.0127591133 14 34608030 34608140 111 - 2.312 2.225 -0.290
ENSG00000129515 E026 225.9490851 0.0005222487 2.335375e-01 0.4692274808 14 34609638 34609742 105 - 2.202 2.173 -0.098
ENSG00000129515 E027 0.4952057 0.3909922948 3.623435e-01   14 34629458 34629906 449 - 0.099 0.261 1.679
ENSG00000129515 E028 124.4510891 0.0004002762 9.007534e-01 0.9522509463 14 34629907 34629950 44 - 1.939 1.957 0.059
ENSG00000129515 E029 82.7056933 0.0006382256 6.489183e-01 0.8028127126 14 34629951 34629954 4 - 1.770 1.757 -0.045
ENSG00000129515 E030 5.5489490 0.0062961622 6.636086e-01 0.8121473950 14 34629955 34630109 155 - 0.696 0.629 -0.286
ENSG00000129515 E031 78.9930500 0.0007179837 6.626717e-01 0.8115622146 14 34630111 34630188 78 - 1.751 1.738 -0.044