ENSG00000129351

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000407004 ENSG00000129351 HEK293_OSMI2_6hA HEK293_TMG_6hB ILF3 protein_coding protein_coding 289.4473 326.8395 291.6334 30.42003 7.054287 -0.1644211 121.19809 131.40057 125.14354 20.680686 3.7028853 -0.07038222 0.41434583 0.39720000 0.4291000 0.03190000 0.85056092 4.222635e-18 FALSE TRUE
ENST00000587928 ENSG00000129351 HEK293_OSMI2_6hA HEK293_TMG_6hB ILF3 protein_coding retained_intron 289.4473 326.8395 291.6334 30.42003 7.054287 -0.1644211 18.07780 19.31483 20.69487 2.472171 0.6015028 0.09951502 0.06454167 0.06160000 0.0710000 0.00940000 0.87045167 4.222635e-18 TRUE TRUE
ENST00000589998 ENSG00000129351 HEK293_OSMI2_6hA HEK293_TMG_6hB ILF3 protein_coding protein_coding 289.4473 326.8395 291.6334 30.42003 7.054287 -0.1644211 37.40006 29.99312 61.77294 3.712471 3.3478732 1.04209584 0.13587917 0.09563333 0.2115000 0.11586667 0.04193405 4.222635e-18 FALSE TRUE
MSTRG.16424.8 ENSG00000129351 HEK293_OSMI2_6hA HEK293_TMG_6hB ILF3 protein_coding   289.4473 326.8395 291.6334 30.42003 7.054287 -0.1644211 31.46163 61.16056 30.52301 13.488990 0.6610763 -1.00246760 0.10822083 0.18256667 0.1047333 -0.07783333 0.15487761 4.222635e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000129351 E001 23.760150 3.962788e-03 8.405340e-07 2.442539e-05 19 10654261 10654303 43 + 1.087 1.521 1.518
ENSG00000129351 E002 86.588782 1.995773e-02 5.593460e-04 6.215390e-03 19 10654304 10654327 24 + 1.737 2.029 0.982
ENSG00000129351 E003 194.658714 1.119436e-02 1.214228e-03 1.154040e-02 19 10654328 10654360 33 + 2.149 2.354 0.685
ENSG00000129351 E004 347.767465 1.084079e-02 1.884254e-01 4.149567e-01 19 10654361 10654381 21 + 2.481 2.566 0.284
ENSG00000129351 E005 1001.196135 3.064846e-03 1.514361e-01 3.644174e-01 19 10654382 10654487 106 + 3.007 2.982 -0.083
ENSG00000129351 E006 12.922011 1.151560e-02 3.132083e-01 5.534516e-01 19 10654938 10655023 86 + 1.060 1.188 0.462
ENSG00000129351 E007 28.352309 5.857925e-03 8.590190e-01 9.298444e-01 19 10655024 10655123 100 + 1.461 1.468 0.022
ENSG00000129351 E008 6.109306 4.780901e-03 9.541889e-01 9.789982e-01 19 10655124 10655147 24 + 0.833 0.856 0.089
ENSG00000129351 E009 6.722683 6.869021e-02 6.837592e-01 8.251169e-01 19 10655496 10655585 90 + 0.830 0.917 0.335
ENSG00000129351 E010 19.770790 3.512528e-03 1.598994e-01 3.766313e-01 19 10666492 10666649 158 + 1.218 1.353 0.473
ENSG00000129351 E011 3.813231 1.803903e-01 7.017962e-01 8.367017e-01 19 10670512 10670515 4 + 0.732 0.624 -0.456
ENSG00000129351 E012 839.530973 1.961546e-03 9.753972e-04 9.720373e-03 19 10670516 10670536 21 + 2.952 2.888 -0.214
ENSG00000129351 E013 1374.237033 2.255285e-04 7.374963e-20 2.129997e-17 19 10670537 10670605 69 + 3.180 3.089 -0.301
ENSG00000129351 E014 904.990383 1.013517e-04 1.694032e-20 5.337394e-18 19 10670606 10670608 3 + 3.004 2.905 -0.328
ENSG00000129351 E015 2.862904 8.225303e-03 5.651077e-01 7.468449e-01 19 10670815 10670973 159 + 0.613 0.534 -0.355
ENSG00000129351 E016 1430.659368 9.072330e-05 1.171162e-20 3.731524e-18 19 10670974 10671036 63 + 3.191 3.113 -0.259
ENSG00000129351 E017 1964.842142 4.917086e-05 1.420945e-27 9.463104e-25 19 10671037 10671133 97 + 3.327 3.253 -0.248
ENSG00000129351 E018 1478.973223 1.001630e-04 3.175275e-21 1.078469e-18 19 10671134 10671169 36 + 3.207 3.128 -0.262
ENSG00000129351 E019 1487.354945 2.869606e-04 1.191403e-12 1.199617e-10 19 10671170 10671203 34 + 3.204 3.136 -0.227
ENSG00000129351 E020 2061.431535 3.710401e-04 2.364612e-07 7.984996e-06 19 10671358 10671480 123 + 3.332 3.288 -0.144
ENSG00000129351 E021 1542.768930 3.728938e-04 2.721904e-02 1.189414e-01 19 10671481 10671535 55 + 3.186 3.176 -0.034
ENSG00000129351 E022 1493.917752 9.734574e-04 1.943095e-02 9.394752e-02 19 10677163 10677204 42 + 3.180 3.157 -0.076
ENSG00000129351 E023 2113.259004 4.497264e-04 8.293726e-03 5.067698e-02 19 10677205 10677310 106 + 3.326 3.310 -0.050
ENSG00000129351 E024 1591.509795 6.110767e-05 6.373168e-01 7.952552e-01 19 10678613 10678652 40 + 3.179 3.202 0.077
ENSG00000129351 E025 1580.557837 5.998688e-05 6.005924e-01 7.706007e-01 19 10678653 10678704 52 + 3.176 3.199 0.079
ENSG00000129351 E026 2079.426596 2.311016e-04 8.056338e-01 8.994665e-01 19 10679097 10679184 88 + 3.296 3.317 0.072
ENSG00000129351 E027 1096.113613 9.907790e-04 7.887241e-01 8.897474e-01 19 10679185 10679192 8 + 3.016 3.041 0.083
ENSG00000129351 E028 1762.734437 5.320160e-04 1.353541e-01 3.403200e-01 19 10679816 10679927 112 + 3.238 3.236 -0.006
ENSG00000129351 E029 1488.216223 7.274311e-05 5.335948e-02 1.875888e-01 19 10680346 10680443 98 + 3.165 3.164 -0.003
ENSG00000129351 E030 1696.829845 7.323516e-05 1.774499e-08 7.882573e-07 19 10681019 10681130 112 + 3.242 3.207 -0.115
ENSG00000129351 E031 1794.195270 7.237380e-05 2.120279e-04 2.808018e-03 19 10681219 10681329 111 + 3.254 3.238 -0.052
ENSG00000129351 E032 643.006259 4.816619e-02 3.073141e-02 1.295355e-01 19 10681330 10681992 663 + 2.908 2.709 -0.663
ENSG00000129351 E033 2806.274230 1.935370e-04 2.371039e-01 4.732075e-01 19 10681993 10682192 200 + 3.435 3.443 0.025
ENSG00000129351 E034 3254.897897 4.198381e-05 1.223306e-02 6.736455e-02 19 10682537 10682704 168 + 3.503 3.505 0.005
ENSG00000129351 E035 657.579312 1.183313e-04 1.130011e-09 6.540621e-08 19 10683125 10683136 12 + 2.851 2.780 -0.236
ENSG00000129351 E036 1394.415925 7.398872e-05 1.290559e-05 2.617540e-04 19 10683137 10683139 3 + 3.151 3.124 -0.088
ENSG00000129351 E037 2841.156218 1.551787e-04 1.031689e-01 2.874938e-01 19 10683140 10683262 123 + 3.442 3.447 0.015
ENSG00000129351 E038 2517.371518 3.965195e-04 5.415658e-01 7.301666e-01 19 10683366 10683517 152 + 3.376 3.403 0.089
ENSG00000129351 E039 1308.087711 9.272275e-05 1.210699e-01 3.175654e-01 19 10683518 10683542 25 + 3.087 3.122 0.117
ENSG00000129351 E040 1795.768707 4.311951e-04 4.827440e-02 1.756423e-01 19 10683636 10683755 120 + 3.218 3.263 0.148
ENSG00000129351 E041 1180.684649 2.945556e-04 6.785025e-02 2.202698e-01 19 10683756 10683789 34 + 3.037 3.080 0.142
ENSG00000129351 E042 1316.279466 3.514455e-04 7.251629e-02 2.298077e-01 19 10683917 10683970 54 + 3.084 3.127 0.142
ENSG00000129351 E043 71.182597 6.857814e-02 7.264429e-01 8.520795e-01 19 10683971 10684415 445 + 1.792 1.884 0.310
ENSG00000129351 E044 865.408047 1.179873e-03 1.033717e-05 2.158477e-04 19 10684416 10684476 61 + 2.970 2.898 -0.240
ENSG00000129351 E045 2407.449414 9.698035e-04 8.330374e-11 6.004623e-09 19 10684477 10684858 382 + 3.423 3.335 -0.293
ENSG00000129351 E046 1010.352874 2.808527e-03 2.183785e-03 1.829766e-02 19 10684859 10684921 63 + 3.033 2.968 -0.216
ENSG00000129351 E047 3616.163884 2.020122e-03 2.608856e-02 1.156108e-01 19 10684922 10685765 844 + 3.566 3.539 -0.090
ENSG00000129351 E048 151.437656 8.057423e-02 6.656445e-01 8.134398e-01 19 10685928 10687345 1418 + 2.095 2.222 0.423
ENSG00000129351 E049 1140.617046 5.318284e-04 2.995074e-26 1.695441e-23 19 10687346 10687604 259 + 2.928 3.115 0.622
ENSG00000129351 E050 1000.588532 1.411815e-03 2.598169e-12 2.491411e-10 19 10687605 10687708 104 + 2.881 3.054 0.575
ENSG00000129351 E051 57.795308 5.881409e-02 3.567220e-01 5.931094e-01 19 10687709 10688114 406 + 1.657 1.820 0.551
ENSG00000129351 E052 1059.423031 1.601302e-04 6.168167e-33 6.426360e-30 19 10688550 10688678 129 + 2.905 3.078 0.576
ENSG00000129351 E053 8159.747571 8.151914e-04 3.005764e-65 2.552239e-61 19 10689179 10692417 3239 + 3.739 3.988 0.828