ENSG00000129317

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344862 ENSG00000129317 HEK293_OSMI2_6hA HEK293_TMG_6hB PUS7L protein_coding protein_coding 4.601562 0.5850154 8.756466 0.05333159 0.5699078 3.880996 1.8608563 0.41813300 3.0386187 0.02651330 0.1446820 2.832025 0.63740000 0.72176667 0.3478000 -0.37396667 0.001440142 0.001440142 FALSE TRUE
ENST00000416848 ENSG00000129317 HEK293_OSMI2_6hA HEK293_TMG_6hB PUS7L protein_coding protein_coding 4.601562 0.5850154 8.756466 0.05333159 0.5699078 3.880996 0.7839095 0.12056885 2.1174054 0.06413794 0.1376674 4.026212 0.11723333 0.19150000 0.2421667 0.05066667 0.856116918 0.001440142 FALSE TRUE
ENST00000431332 ENSG00000129317 HEK293_OSMI2_6hA HEK293_TMG_6hB PUS7L protein_coding protein_coding 4.601562 0.5850154 8.756466 0.05333159 0.5699078 3.880996 0.5729724 0.02133816 1.2666407 0.02133816 0.6683615 5.348288 0.06894583 0.03996667 0.1367667 0.09680000 0.878041491 0.001440142 FALSE TRUE
ENST00000551923 ENSG00000129317 HEK293_OSMI2_6hA HEK293_TMG_6hB PUS7L protein_coding protein_coding 4.601562 0.5850154 8.756466 0.05333159 0.5699078 3.880996 0.7794040 0.02497542 0.9904976 0.02497542 0.1857523 4.838233 0.10769167 0.04680000 0.1153667 0.06856667 0.644928784 0.001440142 FALSE TRUE
ENST00000553166 ENSG00000129317 HEK293_OSMI2_6hA HEK293_TMG_6hB PUS7L protein_coding non_stop_decay 4.601562 0.5850154 8.756466 0.05333159 0.5699078 3.880996 0.4130222 0.00000000 0.9145235 0.00000000 0.1493212 6.530638 0.04360417 0.00000000 0.1073667 0.10736667 0.086763266 0.001440142 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000129317 E001 378.3520097 0.0092968892 0.0001290474 0.001849074 12 43718992 43728606 9615 - 2.338 2.523 0.618
ENSG00000129317 E002 62.8292444 0.0018885564 0.7629412729 0.874381497 12 43728607 43729257 651 - 1.582 1.660 0.265
ENSG00000129317 E003 60.7973578 0.0015346124 0.1520370516 0.365315282 12 43729258 43729762 505 - 1.580 1.532 -0.164
ENSG00000129317 E004 96.4091964 0.0006063392 0.0545870696 0.190422331 12 43729763 43730702 940 - 1.779 1.728 -0.175
ENSG00000129317 E005 21.3857609 0.0062094110 0.4192499958 0.643091278 12 43731705 43731758 54 - 1.151 1.103 -0.172
ENSG00000129317 E006 46.6546477 0.0670330726 0.8416239990 0.920394312 12 43736381 43736661 281 - 1.462 1.523 0.210
ENSG00000129317 E007 14.8342419 0.6131458410 0.4677377230 0.678522755 12 43738310 43738332 23 - 0.982 1.129 0.534
ENSG00000129317 E008 15.9689036 0.6626166309 0.6227581387 0.785690500 12 43738333 43738352 20 - 1.023 1.072 0.179
ENSG00000129317 E009 18.3806199 0.8095872900 0.7319852771 0.855412232 12 43738353 43738391 39 - 1.081 1.113 0.117
ENSG00000129317 E010 27.6177042 0.0594974339 0.6670464265 0.814388599 12 43742457 43742555 99 - 1.254 1.217 -0.131
ENSG00000129317 E011 29.1503945 0.0013445450 0.5297081267 0.721853118 12 43746046 43746213 168 - 1.274 1.267 -0.026
ENSG00000129317 E012 10.5734300 0.0036443843 0.8714810264 0.936752468 12 43746214 43746238 25 - 0.865 0.892 0.103
ENSG00000129317 E013 22.7659751 0.0017637516 0.3946048429 0.624019395 12 43748450 43748609 160 - 1.177 1.134 -0.153
ENSG00000129317 E014 21.1502436 0.0020170668 0.0060927597 0.040179211 12 43754336 43754442 107 - 1.165 0.834 -1.225
ENSG00000129317 E015 48.1949746 0.0166656332 0.0036842472 0.027388807 12 43754443 43754866 424 - 1.500 1.240 -0.903
ENSG00000129317 E016 49.0814912 0.0161813408 0.0923324675 0.268060118 12 43754867 43755216 350 - 1.497 1.384 -0.389
ENSG00000129317 E017 17.4919028 0.0019776137 0.0360592448 0.144382362 12 43755217 43755261 45 - 1.084 0.834 -0.936
ENSG00000129317 E018 7.1352697 0.0043923989 0.6604044259 0.810193611 12 43758286 43758607 322 - 0.714 0.834 0.480
ENSG00000129317 E019 1.6089232 0.0154531410 0.4259077715 0.647934565 12 43758608 43758692 85 - 0.269 0.468 1.177
ENSG00000129317 E020 0.3040503 0.0244411696 1.0000000000   12 43758693 43758700 8 - 0.084 0.000 -8.129
ENSG00000129317 E021 2.3801709 0.0093131637 0.7984540342 0.895409784 12 43758701 43758729 29 - 0.379 0.469 0.481
ENSG00000129317 E022 10.6642853 0.0032550874 0.0520514692 0.184518470 12 43758730 43758793 64 - 0.895 0.593 -1.234