ENSG00000129292

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000220847 ENSG00000129292 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF20L1 protein_coding protein_coding 12.69179 3.128667 23.52596 0.3184503 0.2710609 2.906643 2.3394278 0.5148078 1.051297 0.05962175 0.56984753 1.015967 0.16967917 0.1659333 0.04486667 -0.12106667 5.410044e-01 1.496132e-09 FALSE TRUE
ENST00000337920 ENSG00000129292 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF20L1 protein_coding protein_coding 12.69179 3.128667 23.52596 0.3184503 0.2710609 2.906643 1.6872144 0.3130464 3.284160 0.03821979 0.06080388 3.350098 0.13013750 0.1000000 0.13970000 0.03970000 5.475477e-01 1.496132e-09 FALSE TRUE
ENST00000395386 ENSG00000129292 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF20L1 protein_coding protein_coding 12.69179 3.128667 23.52596 0.3184503 0.2710609 2.906643 0.2243751 0.0000000 1.481956 0.00000000 0.09197583 7.221061 0.02153750 0.0000000 0.06293333 0.06293333 4.012270e-05 1.496132e-09 FALSE TRUE
ENST00000395390 ENSG00000129292 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF20L1 protein_coding protein_coding 12.69179 3.128667 23.52596 0.3184503 0.2710609 2.906643 3.0335500 1.2202493 4.851188 0.62554490 1.42109103 1.982358 0.28810417 0.3570000 0.20563333 -0.15136667 9.626426e-01 1.496132e-09 FALSE TRUE
ENST00000522253 ENSG00000129292 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF20L1 protein_coding retained_intron 12.69179 3.128667 23.52596 0.3184503 0.2710609 2.906643 1.1084551 0.0000000 3.026033 0.00000000 0.03338379 8.246043 0.04938750 0.0000000 0.12870000 0.12870000 1.496132e-09 1.496132e-09 FALSE FALSE
MSTRG.32112.10 ENSG00000129292 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF20L1 protein_coding   12.69179 3.128667 23.52596 0.3184503 0.2710609 2.906643 1.1771379 0.4671766 4.437706 0.23607303 0.89797601 3.220466 0.10758333 0.1563667 0.18783333 0.03146667 9.097423e-01 1.496132e-09 FALSE TRUE
MSTRG.32112.13 ENSG00000129292 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF20L1 protein_coding   12.69179 3.128667 23.52596 0.3184503 0.2710609 2.906643 0.3364801 0.1439746 2.547866 0.14397459 1.28632182 4.054176 0.02083333 0.0574000 0.10926667 0.05186667 8.011875e-01 1.496132e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000129292 E001 0.1614157 0.0334884432 1.000000000   8 132775358 132775371 14 + 0.057 0.000 -7.675
ENSG00000129292 E002 0.1614157 0.0334884432 1.000000000   8 132775372 132775374 3 + 0.057 0.000 -9.493
ENSG00000129292 E003 0.6731895 0.0345535369 0.669263485   8 132775375 132775387 13 + 0.152 0.242 0.832
ENSG00000129292 E004 1.1434572 0.0620732702 0.469844720   8 132775388 132775397 10 + 0.231 0.396 1.085
ENSG00000129292 E005 1.3158316 0.1084259770 0.209437140   8 132775398 132775399 2 + 0.231 0.510 1.666
ENSG00000129292 E006 1.3158316 0.1084259770 0.209437140   8 132775400 132775407 8 + 0.231 0.510 1.666
ENSG00000129292 E007 11.8157807 0.0032564817 0.299298765 0.53972237 8 132775408 132775579 172 + 0.959 1.112 0.561
ENSG00000129292 E008 20.2173270 0.0047196265 0.881912913 0.94233495 8 132775580 132775645 66 + 1.191 1.241 0.175
ENSG00000129292 E009 0.1426347 0.0316635970 1.000000000   8 132777789 132777791 3 + 0.057 0.000 -9.493
ENSG00000129292 E010 6.8955370 0.0042205106 0.310592115 0.55108176 8 132777792 132777795 4 + 0.809 0.675 -0.546
ENSG00000129292 E011 23.7090752 0.0047301904 0.659196304 0.80950763 8 132777796 132777822 27 + 1.266 1.259 -0.028
ENSG00000129292 E012 55.2847720 0.0081247431 0.145967728 0.35632811 8 132777823 132777911 89 + 1.631 1.555 -0.258
ENSG00000129292 E013 0.3559677 0.5410112547 1.000000000   8 132788804 132788999 196 + 0.110 0.000 -9.825
ENSG00000129292 E014 112.5558852 0.0061844659 0.033257242 0.13674502 8 132794410 132794581 172 + 1.936 1.846 -0.302
ENSG00000129292 E015 86.2046514 0.0018420101 0.246153510 0.48379755 8 132794733 132794817 85 + 1.814 1.788 -0.087
ENSG00000129292 E016 78.5806997 0.0004730564 0.011363030 0.06386485 8 132798772 132798860 89 + 1.786 1.681 -0.356
ENSG00000129292 E017 2.0342838 0.1363135385 0.097310909 0.27706712 8 132798861 132799082 222 + 0.297 0.682 1.954
ENSG00000129292 E018 1.9987470 0.0119863964 0.009438655 0.05569754 8 132799083 132799094 12 + 0.264 0.739 2.421
ENSG00000129292 E019 7.1141329 0.0054120603 0.815695040 0.90568024 8 132799095 132799158 64 + 0.780 0.843 0.250
ENSG00000129292 E020 4.8035132 0.0061393939 0.291478544 0.53210101 8 132799159 132799172 14 + 0.678 0.510 -0.751
ENSG00000129292 E021 4.2553718 0.0265603610 0.021625994 0.10137998 8 132799173 132799960 788 + 0.528 0.926 1.649
ENSG00000129292 E022 0.7448680 0.2498696433 0.181278170   8 132803541 132803818 278 + 0.108 0.405 2.452
ENSG00000129292 E023 143.0577113 0.0005785916 0.015646708 0.08052765 8 132803819 132804032 214 + 2.037 1.974 -0.211
ENSG00000129292 E024 0.9828494 0.0165605561 0.301829888   8 132804581 132804611 31 + 0.264 0.000 -11.991
ENSG00000129292 E025 18.3414406 0.0210899765 0.583616834 0.75935919 8 132804612 132804614 3 + 1.165 1.134 -0.112
ENSG00000129292 E026 124.1430425 0.0003993536 0.171772621 0.39291697 8 132804615 132804740 126 + 1.971 1.949 -0.075
ENSG00000129292 E027 7.7554426 0.0038247674 0.406931970 0.63368980 8 132806381 132807722 1342 + 0.836 0.739 -0.389
ENSG00000129292 E028 2.6376555 0.0089374607 0.633998097 0.79296689 8 132807723 132807783 61 + 0.470 0.397 -0.387
ENSG00000129292 E029 8.9177561 0.0300015801 0.911316050 0.95786017 8 132807784 132811045 3262 + 0.883 0.888 0.020
ENSG00000129292 E030 84.0683459 0.0006762128 0.534638538 0.72541512 8 132811046 132811128 83 + 1.790 1.856 0.223
ENSG00000129292 E031 81.8876280 0.0096775493 0.056136916 0.19393656 8 132811129 132813188 2060 + 1.800 1.696 -0.351
ENSG00000129292 E032 104.6826602 0.0047662219 0.773176508 0.88056732 8 132814637 132814889 253 + 1.887 1.939 0.175
ENSG00000129292 E033 24.2022923 0.0341900868 0.033227211 0.13666791 8 132814890 132816783 1894 + 1.304 1.032 -0.969
ENSG00000129292 E034 6.7132990 0.0335041625 0.417180962 0.64152886 8 132816784 132816887 104 + 0.797 0.675 -0.494
ENSG00000129292 E035 99.2924209 0.0059454538 0.748379530 0.86572323 8 132816888 132817076 189 + 1.866 1.885 0.064
ENSG00000129292 E036 1.2131104 0.0322575308 0.451442054   8 132817077 132817338 262 + 0.230 0.397 1.097
ENSG00000129292 E037 62.0054184 0.0086510074 0.621511887 0.78485908 8 132817339 132817407 69 + 1.655 1.725 0.239
ENSG00000129292 E038 71.5080461 0.0045538691 0.225301729 0.45970809 8 132817408 132817545 138 + 1.709 1.818 0.369
ENSG00000129292 E039 1.6266751 0.3402378476 0.695625743 0.83266955 8 132817546 132818970 1425 + 0.358 0.238 -0.812
ENSG00000129292 E040 44.5125773 0.0010148731 0.438544295 0.65768140 8 132824004 132824060 57 + 1.530 1.510 -0.071
ENSG00000129292 E041 3.1134600 0.0091351164 0.638419633 0.79598797 8 132824061 132825034 974 + 0.490 0.601 0.513
ENSG00000129292 E042 3.6232813 0.0078031818 0.298582379 0.53904297 8 132825035 132825157 123 + 0.579 0.397 -0.904
ENSG00000129292 E043 0.3228314 0.3883715613 1.000000000   8 132825158 132825263 106 + 0.107 0.000 -9.919
ENSG00000129292 E044 53.2480394 0.0096186620 0.556937913 0.74113527 8 132825264 132825371 108 + 1.594 1.667 0.251
ENSG00000129292 E045 86.1709479 0.0005654654 0.213584088 0.44587506 8 132832235 132832399 165 + 1.817 1.788 -0.096
ENSG00000129292 E046 0.3040503 0.0244411696 1.000000000   8 132836345 132836539 195 + 0.107 0.000 -10.477
ENSG00000129292 E047 105.0028509 0.0040710908 0.047287120 0.17323785 8 132836540 132836721 182 + 1.904 1.828 -0.254
ENSG00000129292 E048 65.2247728 0.0007175204 0.571411168 0.75132643 8 132837712 132837811 100 + 1.691 1.694 0.009
ENSG00000129292 E049 0.9915952 0.1176025879 1.000000000   8 132837812 132837816 5 + 0.231 0.243 0.095
ENSG00000129292 E050 66.6686539 0.0302988311 0.336523267 0.57496198 8 132839387 132839582 196 + 1.681 1.801 0.405
ENSG00000129292 E051 2.2718899 0.0097419736 0.095821187 0.27446110 8 132841553 132842514 962 + 0.353 0.675 1.569
ENSG00000129292 E052 102.8326988 1.4518108594 0.481487178 0.68808251 8 132842515 132842875 361 + 1.839 2.064 0.757
ENSG00000129292 E053 69.5641927 0.3554363594 0.242440364 0.47926963 8 132844156 132844318 163 + 1.670 1.905 0.792
ENSG00000129292 E054 489.1597566 0.0103844562 0.189819405 0.41673831 8 132845781 132848807 3027 + 2.541 2.634 0.312