ENSG00000129173

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000250024 ENSG00000129173 HEK293_OSMI2_6hA HEK293_TMG_6hB E2F8 protein_coding protein_coding 5.195864 4.333052 8.694839 0.956962 0.4518537 1.003109 1.8658161 0.9939186 4.1260228 0.2832963 0.1628071 2.0426018 0.31164583 0.22050000 0.47540000 0.25490000 0.0001490105 0.0001490105 FALSE TRUE
ENST00000527884 ENSG00000129173 HEK293_OSMI2_6hA HEK293_TMG_6hB E2F8 protein_coding protein_coding 5.195864 4.333052 8.694839 0.956962 0.4518537 1.003109 1.9796565 2.1301737 1.6191683 0.4010835 0.8115229 -0.3935922 0.45017083 0.51376667 0.17916667 -0.33460000 0.5729392690 0.0001490105 FALSE TRUE
ENST00000529188 ENSG00000129173 HEK293_OSMI2_6hA HEK293_TMG_6hB E2F8 protein_coding processed_transcript 5.195864 4.333052 8.694839 0.956962 0.4518537 1.003109 0.5584296 0.4110166 1.5333900 0.1749678 0.2652743 1.8741536 0.09939583 0.10393333 0.17420000 0.07026667 0.6640673705 0.0001490105   FALSE
ENST00000620009 ENSG00000129173 HEK293_OSMI2_6hA HEK293_TMG_6hB E2F8 protein_coding protein_coding 5.195864 4.333052 8.694839 0.956962 0.4518537 1.003109 0.2872360 0.6443085 0.4997852 0.3425153 0.3995653 -0.3600816 0.05381250 0.13296667 0.06193333 -0.07103333 0.6864181293 0.0001490105 FALSE TRUE
MSTRG.5270.4 ENSG00000129173 HEK293_OSMI2_6hA HEK293_TMG_6hB E2F8 protein_coding   5.195864 4.333052 8.694839 0.956962 0.4518537 1.003109 0.5047253 0.1536341 0.9164731 0.1536341 0.4800423 2.5012759 0.08498750 0.02883333 0.10930000 0.08046667 0.5516090399 0.0001490105 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000129173 E001 0.1614157 0.0375000933 7.464456e-01   11 19224063 19224065 3 - 0.100 0.000 -8.276
ENSG00000129173 E002 55.9252009 0.0048789485 2.807650e-01 0.5209999721 11 19224066 19224595 530 - 1.719 1.784 0.222
ENSG00000129173 E003 57.4038034 0.0186321154 6.158168e-02 0.2063492466 11 19224596 19224840 245 - 1.703 1.833 0.441
ENSG00000129173 E004 82.7486764 0.0151234501 1.054302e-01 0.2913856113 11 19225221 19225519 299 - 1.875 1.977 0.342
ENSG00000129173 E005 32.1150173 0.0016733192 7.795489e-01 0.8844572975 11 19225520 19225544 25 - 1.505 1.529 0.082
ENSG00000129173 E006 41.1290215 0.0010564483 4.922807e-01 0.6955140760 11 19225545 19225615 71 - 1.600 1.645 0.155
ENSG00000129173 E007 46.0894615 0.0009817381 1.649238e-01 0.3838945796 11 19225732 19225864 133 - 1.637 1.717 0.270
ENSG00000129173 E008 6.3975842 0.0136579437 3.564796e-02 0.1433167748 11 19225865 19226078 214 - 0.956 0.664 -1.157
ENSG00000129173 E009 95.0925407 0.0005231301 2.106763e-01 0.4426068208 11 19229454 19229988 535 - 1.954 2.007 0.178
ENSG00000129173 E010 29.2933208 0.0012603783 7.700643e-01 0.8787022738 11 19230241 19230328 88 - 1.483 1.474 -0.032
ENSG00000129173 E011 44.3334655 0.0013979547 4.768562e-01 0.6848828828 11 19230631 19230834 204 - 1.632 1.679 0.158
ENSG00000129173 E012 40.4548991 0.0012005638 8.218915e-01 0.9090417488 11 19232234 19232371 138 - 1.603 1.625 0.076
ENSG00000129173 E013 49.5828932 0.0016799517 1.410676e-01 0.3491339800 11 19234360 19234521 162 - 1.718 1.649 -0.234
ENSG00000129173 E014 76.7002509 0.0018855847 1.186079e-02 0.0658558657 11 19234744 19235058 315 - 1.919 1.818 -0.343
ENSG00000129173 E015 25.4711831 0.0195269223 1.373509e-01 0.3434650548 11 19237314 19237346 33 - 1.462 1.346 -0.402
ENSG00000129173 E016 48.1295894 0.0071316308 2.429209e-01 0.4798877274 11 19237347 19237470 124 - 1.706 1.644 -0.212
ENSG00000129173 E017 63.0240555 0.0008833817 1.358487e-01 0.3411140540 11 19237854 19238132 279 - 1.820 1.762 -0.196
ENSG00000129173 E018 27.1409468 0.0019808111 2.288949e-01 0.4638891412 11 19240107 19240230 124 - 1.475 1.404 -0.247
ENSG00000129173 E019 23.7226999 0.0015414596 5.163259e-05 0.0008553553 11 19240548 19240945 398 - 1.487 1.187 -1.045
ENSG00000129173 E020 2.2998829 0.0146154720 2.159750e-02 0.1012820571 11 19241407 19241496 90 - 0.310 0.699 1.940
ENSG00000129173 E021 5.2548082 0.0049167436 7.442524e-03 0.0467649226 11 19241497 19241620 124 - 0.615 0.973 1.426