ENSG00000129055

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354910 ENSG00000129055 HEK293_OSMI2_6hA HEK293_TMG_6hB ANAPC13 protein_coding protein_coding 46.32659 23.61581 52.94726 2.590493 1.691795 1.164465 32.13525 14.463643 37.12377 1.5397542 1.5349670 1.3593038 0.6848250 0.6129667 0.7007000 0.08773333 0.0422017 0.0002646695    
ENST00000510994 ENSG00000129055 HEK293_OSMI2_6hA HEK293_TMG_6hB ANAPC13 protein_coding protein_coding 46.32659 23.61581 52.94726 2.590493 1.691795 1.164465 11.15706 6.987313 11.63107 0.8626553 0.8991946 0.7343505 0.2466042 0.2948333 0.2191667 -0.07566667 0.1435483 0.0002646695    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000129055 E001 2.306848 0.0120276622 0.3675584266 0.6020493512 3 134477706 134477710 5 - 0.469 0.553 0.405
ENSG00000129055 E002 229.687886 0.7446926912 0.3883220678 0.6191533050 3 134477711 134478075 365 - 2.381 2.345 -0.120
ENSG00000129055 E003 392.251063 1.0653176601 0.5300130729 0.7220949232 3 134478076 134478477 402 - 2.645 2.540 -0.352
ENSG00000129055 E004 348.837346 0.9885562149 0.4781996387 0.6859318243 3 134478478 134478715 238 - 2.582 2.504 -0.259
ENSG00000129055 E005 1.541621 0.0866666013 0.0220995943 0.1029324319 3 134482742 134482805 64 - 0.592 0.121 -3.184
ENSG00000129055 E006 234.023700 0.0324125428 0.2916207861 0.5322691309 3 134482806 134482931 126 - 2.420 2.321 -0.329
ENSG00000129055 E007 8.702746 0.3174568249 0.4113468433 0.6370597969 3 134482932 134483253 322 - 1.055 0.903 -0.565
ENSG00000129055 E008 112.700408 0.3879353837 0.4055203699 0.6327099866 3 134485320 134485563 244 - 2.119 1.984 -0.452
ENSG00000129055 E009 55.876789 0.1284280316 0.4110908108 0.6369086388 3 134485564 134485700 137 - 1.799 1.709 -0.302
ENSG00000129055 E010 61.520540 0.0007884458 0.0000437158 0.0007424692 3 134485701 134485951 251 - 1.760 1.849 0.299
ENSG00000129055 E011 57.584540 0.0202504455 0.2338680495 0.4695989736 3 134485952 134486023 72 - 1.784 1.765 -0.065
ENSG00000129055 E012 0.000000       3 134486587 134486716 130 -