ENSG00000129003

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000249837 ENSG00000129003 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13C protein_coding protein_coding 2.486039 1.269932 3.832318 0.1411135 0.2649826 1.58591 1.1384174 0.29449336 2.2609841 0.10571717 0.17619836 2.8988349 0.35752083 0.22576667 0.60006667 0.37430000 0.111018968 0.007419841 FALSE TRUE
ENST00000559119 ENSG00000129003 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13C protein_coding retained_intron 2.486039 1.269932 3.832318 0.1411135 0.2649826 1.58591 0.3699123 0.16112963 0.3753993 0.11789717 0.31574602 1.1712642 0.14157083 0.15146667 0.08850000 -0.06296667 0.928769166 0.007419841   FALSE
ENST00000560637 ENSG00000129003 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13C protein_coding retained_intron 2.486039 1.269932 3.832318 0.1411135 0.2649826 1.58591 0.5018723 0.51617150 0.4222109 0.13764532 0.07655494 -0.2837977 0.31367917 0.39333333 0.10910000 -0.28423333 0.007419841 0.007419841 FALSE FALSE
ENST00000649766 ENSG00000129003 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13C protein_coding protein_coding 2.486039 1.269932 3.832318 0.1411135 0.2649826 1.58591 0.1616630 0.04742967 0.3188370 0.02869496 0.04417967 2.5175047 0.06467083 0.03313333 0.08536667 0.05223333 0.609287787 0.007419841 FALSE TRUE
ENST00000650094 ENSG00000129003 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13C protein_coding nonsense_mediated_decay 2.486039 1.269932 3.832318 0.1411135 0.2649826 1.58591 0.2250575 0.20696770 0.2591352 0.06377833 0.14876821 0.3108507 0.09428750 0.15556667 0.06533333 -0.09023333 0.604529039 0.007419841 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000129003 E001 0.2027342 0.036120579 0.1034448937   15 61852389 61852403 15 - 0.000 0.233 12.980
ENSG00000129003 E002 37.5674348 0.708550456 0.0533522996 0.187571372 15 61852404 61853451 1048 - 1.239 1.940 2.396
ENSG00000129003 E003 53.8989840 0.887647841 0.1671769617 0.386794373 15 61853452 61854412 961 - 1.477 1.993 1.746
ENSG00000129003 E004 22.3229259 0.290986925 0.0366299402 0.145900237 15 61854413 61854558 146 - 1.111 1.625 1.790
ENSG00000129003 E005 17.7026459 0.142882621 0.0549903431 0.191322141 15 61854871 61854954 84 - 1.069 1.445 1.326
ENSG00000129003 E006 21.5100028 0.021654637 0.0191247744 0.092887932 15 61856286 61856409 124 - 1.169 1.487 1.109
ENSG00000129003 E007 3.1385839 0.685818669 0.5100157483 0.707987382 15 61856410 61856793 384 - 0.429 0.833 1.784
ENSG00000129003 E008 15.6540880 0.002709048 0.2231159641 0.457103488 15 61863440 61863528 89 - 1.073 1.273 0.710
ENSG00000129003 E009 4.6912545 0.038057579 0.0673115688 0.219061219 15 61863529 61864305 777 - 0.697 0.383 -1.489
ENSG00000129003 E010 1.9645132 0.189644943 0.0893710654 0.262614200 15 61864306 61864640 335 - 0.303 0.715 2.051
ENSG00000129003 E011 3.1113670 0.008445553 0.1284989429 0.329479345 15 61864641 61864820 180 - 0.463 0.775 1.380
ENSG00000129003 E012 4.5677608 0.014869614 0.4483473685 0.664529873 15 61864821 61865557 737 - 0.656 0.585 -0.311
ENSG00000129003 E013 13.9844919 0.013142104 0.0124968145 0.068424249 15 61865558 61867743 2186 - 1.096 0.825 -1.015
ENSG00000129003 E014 3.4840433 0.076235052 0.0719926513 0.228797077 15 61867744 61867947 204 - 0.598 0.234 -2.052
ENSG00000129003 E015 2.9984248 0.022445325 0.7145961562 0.844696973 15 61867948 61868658 711 - 0.506 0.496 -0.048
ENSG00000129003 E016 17.0803072 0.003848062 0.0179144898 0.088748320 15 61868659 61868773 115 - 1.074 1.375 1.066
ENSG00000129003 E017 18.8390336 0.002157988 0.1547202861 0.369012615 15 61869500 61869623 124 - 1.139 1.348 0.739
ENSG00000129003 E018 13.2613404 0.002901885 0.1493030869 0.361233468 15 61871989 61872034 46 - 0.991 1.221 0.829
ENSG00000129003 E019 22.6525655 0.001571368 0.3607170790 0.596202872 15 61873246 61873409 164 - 1.230 1.388 0.552
ENSG00000129003 E020 12.9047840 0.002982228 0.6024864076 0.771873957 15 61874876 61874951 76 - 1.004 1.139 0.490
ENSG00000129003 E021 10.6697818 0.067181292 0.9434731782 0.974071322 15 61875732 61875786 55 - 0.943 1.008 0.241
ENSG00000129003 E022 12.3995609 0.030846322 0.4162102891 0.640770206 15 61875787 61875845 59 - 1.020 0.978 -0.157
ENSG00000129003 E023 15.8710189 0.002802193 0.6733687323 0.818517896 15 61876973 61877054 82 - 1.105 1.139 0.124
ENSG00000129003 E024 0.0000000       15 61877055 61877086 32 -      
ENSG00000129003 E025 21.2167888 0.010459824 0.3989956600 0.627377387 15 61878607 61878746 140 - 1.203 1.372 0.594
ENSG00000129003 E026 18.5944881 0.002068534 0.1051732684 0.290950022 15 61880609 61880722 114 - 1.134 1.361 0.802
ENSG00000129003 E027 15.0916251 0.002754877 0.1609308764 0.378184127 15 61880843 61880954 112 - 1.052 1.272 0.787
ENSG00000129003 E028 11.6803395 0.002957083 0.5219098548 0.716243735 15 61881563 61881632 70 - 0.964 1.116 0.554
ENSG00000129003 E029 8.4913726 0.013746374 0.1509732203 0.363680178 15 61881747 61881828 82 - 0.818 1.089 1.013
ENSG00000129003 E030 11.0390005 0.003333227 0.9699766775 0.986834266 15 61882596 61882736 141 - 0.964 1.038 0.273
ENSG00000129003 E031 14.5110034 0.008849008 0.9555123354 0.979627224 15 61884128 61884269 142 - 1.064 1.139 0.270
ENSG00000129003 E032 20.2253602 0.029906572 0.8213732185 0.908770454 15 61890165 61890400 236 - 1.199 1.256 0.200
ENSG00000129003 E033 0.1779838 0.044043896 1.0000000000   15 61906643 61907263 621 - 0.060 0.000 -8.558
ENSG00000129003 E034 17.0832195 0.002932489 0.5828170359 0.758883195 15 61907264 61907390 127 - 1.139 1.161 0.080
ENSG00000129003 E035 20.3053911 0.012949789 0.9812835953 0.992416084 15 61908992 61909125 134 - 1.202 1.273 0.251
ENSG00000129003 E036 17.1085198 0.002161003 0.4445390170 0.661808199 15 61910177 61910305 129 - 1.119 1.273 0.544
ENSG00000129003 E037 14.2645527 0.003822061 0.6626888986 0.811565709 15 61911840 61912004 165 - 1.057 1.181 0.448
ENSG00000129003 E038 9.7889888 0.004063652 0.8010109060 0.896871810 15 61913311 61913415 105 - 0.905 1.010 0.392
ENSG00000129003 E039 23.8562516 0.015401875 0.3046172457 0.545219955 15 61915633 61916022 390 - 1.242 1.414 0.601
ENSG00000129003 E040 17.8636472 0.009656316 0.1066294715 0.293358308 15 61917341 61917635 295 - 1.175 1.067 -0.386
ENSG00000129003 E041 8.0074376 0.003881762 0.9773625940 0.990432432 15 61918136 61918257 122 - 0.837 0.908 0.274
ENSG00000129003 E042 12.4874367 0.004495884 0.4829808116 0.689136775 15 61919289 61919449 161 - 1.016 1.010 -0.023
ENSG00000129003 E043 16.6286849 0.002010406 0.4645141745 0.676243281 15 61920067 61920331 265 - 1.105 1.256 0.538
ENSG00000129003 E044 9.2244785 0.004585680 0.1211280550 0.317659054 15 61920498 61920647 150 - 0.854 1.116 0.970
ENSG00000129003 E045 9.6685952 0.186341880 0.7038764997 0.838044090 15 61921947 61922033 87 - 0.907 1.005 0.365
ENSG00000129003 E046 17.0873372 0.281127253 0.9794922496 0.991566129 15 61922397 61922762 366 - 1.151 1.122 -0.103
ENSG00000129003 E047 3.2825806 0.009180922 0.9123648787 0.958321989 15 61925456 61925548 93 - 0.543 0.584 0.189
ENSG00000129003 E048 8.3231545 0.261277680 0.3672624149 0.601779251 15 61927091 61927320 230 - 0.810 1.064 0.956
ENSG00000129003 E049 15.7151940 0.002737238 0.7614624577 0.873482471 15 61929501 61929748 248 - 1.090 1.201 0.398
ENSG00000129003 E050 13.9223490 0.053068063 0.2834534684 0.523922140 15 61931090 61931259 170 - 1.079 1.000 -0.288
ENSG00000129003 E051 11.9083559 0.002847076 0.8502350822 0.925128767 15 61934219 61934331 113 - 0.991 1.091 0.367
ENSG00000129003 E052 10.7061500 0.048076984 0.8954198406 0.949455435 15 61936597 61936750 154 - 0.952 1.030 0.288
ENSG00000129003 E053 10.2345582 0.031623607 0.7693744321 0.878263297 15 61940647 61940794 148 - 0.917 1.037 0.446
ENSG00000129003 E054 16.7260181 0.010986793 0.4772680168 0.685195465 15 61941763 61942067 305 - 1.135 1.138 0.008
ENSG00000129003 E055 10.7948980 0.003312065 0.1284818473 0.329450433 15 61945715 61945882 168 - 0.991 0.868 -0.463
ENSG00000129003 E056 7.8045516 0.003861396 0.0051562576 0.035438550 15 61946307 61946410 104 - 0.897 0.495 -1.695
ENSG00000129003 E057 7.5145303 0.005195572 0.0743150926 0.233378552 15 61947193 61947309 117 - 0.864 0.657 -0.832
ENSG00000129003 E058 8.8237233 0.004032429 0.2621189206 0.501270483 15 61949443 61949605 163 - 0.905 0.824 -0.312
ENSG00000129003 E059 7.1712526 0.004248169 0.2165347732 0.449328374 15 61950358 61950417 60 - 0.836 0.721 -0.462
ENSG00000129003 E060 6.7074023 0.004516644 0.0037224036 0.027592743 15 61950945 61951024 80 - 0.846 0.384 -2.082
ENSG00000129003 E061 4.2584315 0.007072898 0.0689854765 0.222737429 15 61951824 61951859 36 - 0.669 0.383 -1.370
ENSG00000129003 E062 6.9940225 0.022523085 0.0195415846 0.094332306 15 61951860 61951980 121 - 0.847 0.494 -1.507
ENSG00000129003 E063 5.8541129 0.024006254 0.0654181037 0.214834055 15 61954421 61954466 46 - 0.768 0.495 -1.194
ENSG00000129003 E064 8.0247588 0.034975462 0.0406915336 0.156530644 15 61954467 61954554 88 - 0.884 0.584 -1.229
ENSG00000129003 E065 7.4863815 0.008568253 0.0386049438 0.151136610 15 61958608 61958716 109 - 0.856 0.584 -1.120
ENSG00000129003 E066 7.3207980 0.017097481 0.0142254817 0.075237907 15 61959448 61959595 148 - 0.864 0.495 -1.570
ENSG00000129003 E067 11.6353528 0.002979557 0.0404605178 0.155928074 15 61961589 61961893 305 - 1.022 0.825 -0.746
ENSG00000129003 E068 8.9631018 0.003465736 0.0017538273 0.015394646 15 61962371 61962538 168 - 0.943 0.495 -1.869
ENSG00000129003 E069 8.7704009 0.003744170 0.0623380167 0.208025375 15 61962749 61962852 104 - 0.921 0.720 -0.785
ENSG00000129003 E070 9.8261615 0.003606508 0.0276596807 0.120281931 15 61963835 61963951 117 - 0.965 0.720 -0.950
ENSG00000129003 E071 10.4223285 0.003366523 0.0044809164 0.031832783 15 61964699 61964861 163 - 1.004 0.658 -1.358
ENSG00000129003 E072 5.6866149 0.036348339 0.0040630582 0.029528854 15 61966083 61966142 60 - 0.794 0.232 -2.885
ENSG00000129003 E073 6.5102615 0.024452518 0.0012623756 0.011878037 15 61967368 61967447 80 - 0.844 0.233 -3.077
ENSG00000129003 E074 9.4026336 0.004517567 0.0011082384 0.010731845 15 61969299 61969452 154 - 0.964 0.495 -1.949
ENSG00000129003 E075 8.9302028 0.008090882 0.0263299313 0.116278839 15 61972625 61972764 140 - 0.929 0.657 -1.081
ENSG00000129003 E076 7.7794048 0.047261910 0.0444582961 0.166255621 15 61973454 61973532 79 - 0.883 0.580 -1.242
ENSG00000129003 E077 9.4993363 0.003205493 0.0008398329 0.008608858 15 61974288 61974417 130 - 0.971 0.495 -1.974
ENSG00000129003 E078 8.6991321 0.043564172 0.0289394816 0.124181059 15 61977082 61977199 118 - 0.918 0.584 -1.356
ENSG00000129003 E079 8.4468656 0.005242169 0.1057898921 0.291974359 15 61978626 61978749 124 - 0.889 0.721 -0.665
ENSG00000129003 E080 8.7037301 0.029636382 0.2395614339 0.476114612 15 61981342 61981478 137 - 0.892 0.777 -0.448
ENSG00000129003 E081 6.6827539 0.004457822 0.0662477121 0.216611830 15 61982459 61982573 115 - 0.818 0.584 -0.972
ENSG00000129003 E082 0.0000000       15 61983713 61983819 107 -      
ENSG00000129003 E083 8.9943851 0.006189373 0.0260358869 0.115422571 15 61983820 61984012 193 - 0.928 0.658 -1.075
ENSG00000129003 E084 7.9619487 0.004300726 0.0237184419 0.108213878 15 61984857 61984999 143 - 0.881 0.585 -1.216
ENSG00000129003 E085 6.6170448 0.004642958 0.0671436047 0.218711086 15 61991000 61991094 95 - 0.817 0.584 -0.972
ENSG00000129003 E086 8.4545344 0.004023128 0.0104955502 0.060235444 15 61991673 61991802 130 - 0.920 0.584 -1.369
ENSG00000129003 E087 4.1031728 0.010430728 0.0865010167 0.257414928 15 62000564 62000626 63 - 0.655 0.384 -1.309
ENSG00000129003 E088 9.7285683 0.039251485 0.0102689864 0.059268287 15 62007308 62007479 172 - 0.972 0.583 -1.568
ENSG00000129003 E089 8.5182183 0.005684249 0.0027983073 0.022180487 15 62008655 62008761 107 - 0.928 0.495 -1.812
ENSG00000129003 E090 9.0241950 0.005050458 0.0579921219 0.198272556 15 62010472 62010599 128 - 0.928 0.721 -0.812
ENSG00000129003 E091 4.9827145 0.005855371 0.9269242154 0.965516920 15 62012107 62012164 58 - 0.669 0.721 0.216
ENSG00000129003 E092 7.1887461 0.004094700 0.0124781786 0.068348088 15 62013039 62013119 81 - 0.855 0.495 -1.532
ENSG00000129003 E093 6.4453515 0.056677242 0.0210634918 0.099567593 15 62013933 62013992 60 - 0.819 0.385 -1.972
ENSG00000129003 E094 5.3430743 0.005911539 0.0244575745 0.110528711 15 62020479 62020538 60 - 0.744 0.384 -1.679
ENSG00000129003 E095 6.5460996 0.151944345 0.0993169371 0.280578635 15 62023411 62023520 110 - 0.818 0.487 -1.430
ENSG00000129003 E096 0.0000000       15 62023780 62023845 66 -      
ENSG00000129003 E097 0.0000000       15 62028358 62028420 63 -      
ENSG00000129003 E098 5.9061005 0.024722761 0.0548811843 0.191083288 15 62033441 62033542 102 - 0.778 0.494 -1.240
ENSG00000129003 E099 5.0445160 0.005848179 0.0282898321 0.122130924 15 62034957 62035052 96 - 0.732 0.384 -1.633
ENSG00000129003 E100 3.1796872 0.007267129 0.0057811628 0.038651014 15 62041324 62041366 43 - 0.595 0.000 -12.878
ENSG00000129003 E101 3.3366771 0.008094439 0.0045767824 0.032351422 15 62044212 62044255 44 - 0.611 0.000 -12.948
ENSG00000129003 E102 3.5326342 0.008014774 0.1641848153 0.382936300 15 62060275 62060473 199 - 0.595 0.384 -1.048