ENSG00000128881

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267890 ENSG00000128881 HEK293_OSMI2_6hA HEK293_TMG_6hB TTBK2 protein_coding protein_coding 2.605015 1.45626 3.916364 0.08802068 0.420723 1.421053 1.7544021 1.10053389 2.4949361 0.14406664 0.1958628 1.1735204 0.67142500 0.7503333 0.64290000 -0.10743333 0.6951353034 0.0008622897 FALSE TRUE
ENST00000567485 ENSG00000128881 HEK293_OSMI2_6hA HEK293_TMG_6hB TTBK2 protein_coding processed_transcript 2.605015 1.45626 3.916364 0.08802068 0.420723 1.421053 0.3959623 0.30069427 0.3657281 0.10331890 0.3657281 0.2741932 0.17679583 0.2123000 0.08146667 -0.13083333 0.4329019565 0.0008622897 FALSE TRUE
ENST00000567840 ENSG00000128881 HEK293_OSMI2_6hA HEK293_TMG_6hB TTBK2 protein_coding protein_coding 2.605015 1.45626 3.916364 0.08802068 0.420723 1.421053 0.1188016 0.01853013 0.2480687 0.01853013 0.1059146 3.1771968 0.05072083 0.0114000 0.06093333 0.04953333 0.4606545548 0.0008622897 FALSE TRUE
MSTRG.10631.2 ENSG00000128881 HEK293_OSMI2_6hA HEK293_TMG_6hB TTBK2 protein_coding   2.605015 1.45626 3.916364 0.08802068 0.420723 1.421053 0.2511915 0.00000000 0.5533888 0.00000000 0.1066041 5.8160590 0.07262083 0.0000000 0.14470000 0.14470000 0.0008622897 0.0008622897 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000128881 E001 250.9382767 1.130018912 0.27098654 0.51095015 15 42738730 42744895 6166 - 2.230 2.572 1.142
ENSG00000128881 E002 51.9778073 0.715783765 0.63989555 0.79686147 15 42744896 42746257 1362 - 1.668 1.720 0.175
ENSG00000128881 E003 69.8936047 0.053871110 0.01249275 0.06840860 15 42751974 42753247 1274 - 1.841 1.720 -0.409
ENSG00000128881 E004 29.3634426 0.056786360 0.01467718 0.07688223 15 42775135 42775723 589 - 1.486 1.322 -0.567
ENSG00000128881 E005 0.3393995 0.027128336 0.42051077   15 42776918 42776949 32 - 0.149 0.000 -14.036
ENSG00000128881 E006 1.5969194 0.011689204 0.07250363 0.22978724 15 42776950 42777030 81 - 0.453 0.179 -1.855
ENSG00000128881 E007 18.5350375 0.002374427 0.06083728 0.20467875 15 42777031 42777242 212 - 1.265 1.224 -0.142
ENSG00000128881 E008 22.2190857 0.002641854 0.05801023 0.19832249 15 42783419 42783635 217 - 1.336 1.308 -0.097
ENSG00000128881 E009 14.5626716 0.092920998 0.20276833 0.43303227 15 42794644 42794801 158 - 1.173 1.114 -0.214
ENSG00000128881 E010 12.7934823 0.102019784 0.40088733 0.62901230 15 42810614 42810739 126 - 1.101 1.100 -0.002
ENSG00000128881 E011 13.8394656 0.112742888 0.27519199 0.51521741 15 42811688 42811780 93 - 1.148 1.098 -0.180
ENSG00000128881 E012 16.7581021 0.032603650 0.43985898 0.65860369 15 42817032 42817097 66 - 1.198 1.247 0.173
ENSG00000128881 E013 14.9628091 0.002741287 0.83453695 0.91632012 15 42827928 42827976 49 - 1.136 1.237 0.358
ENSG00000128881 E014 12.7983227 0.012048990 0.92859409 0.96635537 15 42827977 42828032 56 - 1.058 1.197 0.497
ENSG00000128881 E015 6.5818810 0.005196407 0.90171044 0.95274674 15 42829938 42829940 3 - 0.815 0.909 0.365
ENSG00000128881 E016 7.9859095 0.004522846 0.52030773 0.71513653 15 42829941 42829969 29 - 0.901 0.936 0.134
ENSG00000128881 E017 13.7111617 0.006201924 0.19474899 0.42301311 15 42829970 42830078 109 - 1.130 1.121 -0.030
ENSG00000128881 E018 12.1603625 0.036186722 0.67777227 0.82131448 15 42840360 42840433 74 - 1.050 1.139 0.321
ENSG00000128881 E019 1.3745963 0.013481966 0.41412795   15 42855119 42855200 82 - 0.386 0.305 -0.494
ENSG00000128881 E020 0.0000000       15 42857395 42857516 122 -      
ENSG00000128881 E021 8.3664560 0.166192802 0.56497823 0.74677422 15 42872611 42872677 67 - 0.915 0.966 0.192
ENSG00000128881 E022 4.8866326 0.103846479 0.35298246 0.59000886 15 42872678 42872696 19 - 0.743 0.706 -0.152
ENSG00000128881 E023 7.1733097 0.059516202 0.12623672 0.32587362 15 42872697 42872758 62 - 0.902 0.787 -0.448
ENSG00000128881 E024 12.0121721 0.053670993 0.01132941 0.06372293 15 42878549 42878684 136 - 1.131 0.885 -0.909
ENSG00000128881 E025 0.1779838 0.142634914 0.81749542   15 42908216 42908275 60 - 0.081 0.000 -13.042
ENSG00000128881 E026 8.1881570 0.017118260 0.51850154 0.71405334 15 42919759 42919912 154 - 0.865 1.066 0.747
ENSG00000128881 E027 6.4318701 0.033438764 0.74368928 0.86277467 15 42920438 42920809 372 - 0.785 0.958 0.664