ENSG00000128789

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317615 ENSG00000128789 HEK293_OSMI2_6hA HEK293_TMG_6hB PSMG2 protein_coding protein_coding 31.59563 24.04639 40.68592 4.900835 1.720502 0.7584638 21.648536 14.933931 29.03074870 3.2610979 1.96985511 0.9585189 0.67394583 0.61703333 0.711933333 0.09490000 0.3496922036 0.0008986702 FALSE  
ENST00000586587 ENSG00000128789 HEK293_OSMI2_6hA HEK293_TMG_6hB PSMG2 protein_coding nonsense_mediated_decay 31.59563 24.04639 40.68592 4.900835 1.720502 0.7584638 1.665255 2.604373 3.22008732 1.3079266 0.48746617 0.3051081 0.05519167 0.08993333 0.079633333 -0.01030000 0.9626426198 0.0008986702 TRUE  
ENST00000590217 ENSG00000128789 HEK293_OSMI2_6hA HEK293_TMG_6hB PSMG2 protein_coding protein_coding 31.59563 24.04639 40.68592 4.900835 1.720502 0.7584638 4.256575 2.279603 5.90652443 0.4661806 0.30396981 1.3696524 0.13027917 0.10640000 0.146333333 0.03993333 0.7520075636 0.0008986702 FALSE  
MSTRG.15523.2 ENSG00000128789 HEK293_OSMI2_6hA HEK293_TMG_6hB PSMG2 protein_coding   31.59563 24.04639 40.68592 4.900835 1.720502 0.7584638 1.502568 2.334178 0.08735615 0.5732869 0.08735615 -4.5896663 0.05214583 0.09480000 0.002066667 -0.09273333 0.0008986702 0.0008986702    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000128789 E001 0.0000000       18 12658043 12658129 87 +      
ENSG00000128789 E002 4.0600284 0.0107880594 2.031393e-04 2.709954e-03 18 12658130 12658192 63 + 0.367 0.928 2.492
ENSG00000128789 E003 5.0826509 0.0060683414 5.039166e-05 8.375906e-04 18 12658193 12658205 13 + 0.456 1.018 2.342
ENSG00000128789 E004 7.7049308 0.0484973983 7.045691e-06 1.546491e-04 18 12658206 12658245 40 + 0.528 1.211 2.684
ENSG00000128789 E005 13.0451861 0.0042661352 7.018733e-13 7.403369e-11 18 12658246 12658343 98 + 0.697 1.429 2.700
ENSG00000128789 E006 0.1426347 0.0323137147 7.039560e-01   18 12658551 12658573 23 + 0.102 0.000 -10.455
ENSG00000128789 E007 25.2494472 0.0015396965 1.980174e-20 6.192984e-18 18 12658574 12658737 164 + 1.001 1.689 2.406
ENSG00000128789 E008 13.8496289 0.0045885815 3.544308e-12 3.318109e-10 18 12658738 12658773 36 + 0.762 1.452 2.514
ENSG00000128789 E009 1.7541467 0.0123001009 3.554913e-01 5.921536e-01 18 12658774 12658893 120 + 0.495 0.337 -0.856
ENSG00000128789 E010 11.3500876 0.0616360918 4.853280e-09 2.450784e-07 18 12663458 12663738 281 + 0.416 1.410 3.945
ENSG00000128789 E011 2.8985456 0.0077159318 2.729526e-04 3.457678e-03 18 12665065 12665139 75 + 0.254 0.837 2.884
ENSG00000128789 E012 1.1359948 0.1984324993 1.440556e-01   18 12686275 12686491 217 + 0.183 0.475 1.922
ENSG00000128789 E013 0.3926045 0.3219180362 1.131389e-01   18 12686653 12686752 100 + 0.000 0.326 11.889
ENSG00000128789 E014 15.7140333 0.0154486249 8.443215e-01 9.217417e-01 18 12703023 12703025 3 + 1.229 1.218 -0.041
ENSG00000128789 E015 46.6505927 0.0028026330 6.032061e-01 7.723496e-01 18 12703026 12703041 16 + 1.662 1.700 0.131
ENSG00000128789 E016 154.5251816 0.0003069269 1.920036e-01 4.193669e-01 18 12703042 12703164 123 + 2.198 2.169 -0.096
ENSG00000128789 E017 246.2052701 0.0002302152 1.779629e-06 4.703112e-05 18 12706550 12706721 172 + 2.424 2.328 -0.322
ENSG00000128789 E018 141.8910705 0.0003417436 1.429534e-04 2.015339e-03 18 12712702 12712760 59 + 2.192 2.087 -0.352
ENSG00000128789 E019 180.6935761 0.0003499683 5.058271e-04 5.733236e-03 18 12718517 12718635 119 + 2.286 2.202 -0.280
ENSG00000128789 E020 209.8084648 0.0002667669 7.324601e-01 8.556594e-01 18 12720510 12720683 174 + 2.318 2.317 -0.002
ENSG00000128789 E021 6.3286438 0.1078807059 8.176345e-01 9.067250e-01 18 12724128 12724498 371 + 0.848 0.884 0.138
ENSG00000128789 E022 181.0100391 0.0003109930 5.385459e-01 7.280110e-01 18 12724499 12724619 121 + 2.245 2.269 0.078
ENSG00000128789 E023 3.2475371 0.0079495258 1.475322e-01 3.587875e-01 18 12724620 12724868 249 + 0.697 0.471 -1.022
ENSG00000128789 E024 188.7593261 0.0003425775 9.024131e-01 9.530681e-01 18 12725439 12725740 302 + 2.270 2.281 0.037