ENSG00000128731

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261609 ENSG00000128731 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC2 protein_coding protein_coding 19.14768 27.3815 13.96755 2.731406 1.193835 -0.9706169 4.6370200 6.7700523 5.342728 0.6772671 0.1375897 -0.34102209 0.26481250 0.24806667 0.3862333 0.13816667 0.029406814 0.001371476 FALSE TRUE
ENST00000562136 ENSG00000128731 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC2 protein_coding retained_intron 19.14768 27.3815 13.96755 2.731406 1.193835 -0.9706169 5.0710589 6.7794495 1.650599 0.8206349 0.5748343 -2.03159088 0.24508333 0.24663333 0.1137333 -0.13290000 0.233629569 0.001371476 FALSE TRUE
ENST00000563945 ENSG00000128731 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC2 protein_coding processed_transcript 19.14768 27.3815 13.96755 2.731406 1.193835 -0.9706169 2.2933311 2.0377661 1.966350 0.6559426 0.1434211 -0.05121225 0.12888333 0.07180000 0.1432333 0.07143333 0.389692687 0.001371476 FALSE FALSE
ENST00000564383 ENSG00000128731 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC2 protein_coding retained_intron 19.14768 27.3815 13.96755 2.731406 1.193835 -0.9706169 0.9256639 0.7452056 1.488982 0.1562882 0.5157333 0.98904222 0.05460417 0.02733333 0.1033667 0.07603333 0.083127275 0.001371476 FALSE TRUE
ENST00000650509 ENSG00000128731 HEK293_OSMI2_6hA HEK293_TMG_6hB HERC2 protein_coding nonsense_mediated_decay 19.14768 27.3815 13.96755 2.731406 1.193835 -0.9706169 5.2535028 9.9975817 2.638196 1.1778967 0.1842499 -1.91801174 0.25302500 0.36373333 0.1912333 -0.17250000 0.001371476 0.001371476 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000128731 E001 2.1837478 0.1097783083 8.427580e-01 9.209937e-01 15 28111040 28111078 39 - 0.455 0.528 0.359
ENSG00000128731 E002 35.9527279 0.3257803360 1.203921e-01 3.164612e-01 15 28111079 28111278 200 - 1.260 1.624 1.259
ENSG00000128731 E003 221.2202324 1.2180268719 3.325213e-01 5.712730e-01 15 28111279 28111761 483 - 2.042 2.402 1.201
ENSG00000128731 E004 209.1693471 1.2055495362 3.400138e-01 5.779576e-01 15 28111762 28112035 274 - 2.029 2.375 1.157
ENSG00000128731 E005 189.0974163 0.0242529738 3.900005e-04 4.635174e-03 15 28113071 28113283 213 - 2.023 2.324 1.007
ENSG00000128731 E006 120.7364538 0.0069684384 1.800074e-04 2.448686e-03 15 28113573 28113678 106 - 1.886 2.116 0.775
ENSG00000128731 E007 0.4873834 0.3070803717 9.225756e-01   15 28113679 28113717 39 - 0.165 0.162 -0.032
ENSG00000128731 E008 174.1072088 0.0041295853 8.281838e-03 5.062074e-02 15 28114612 28114802 191 - 2.116 2.252 0.455
ENSG00000128731 E009 2.1017578 0.1250364406 6.720348e-01 8.176105e-01 15 28115281 28115428 148 - 0.382 0.486 0.549
ENSG00000128731 E010 135.2695610 0.0003675483 2.703229e-04 3.430507e-03 15 28115429 28115541 113 - 1.998 2.150 0.510
ENSG00000128731 E011 159.8290559 0.0011294877 1.030330e-03 1.014399e-02 15 28116665 28116859 195 - 2.079 2.219 0.468
ENSG00000128731 E012 2.2386858 0.0554598873 4.595106e-01 6.727834e-01 15 28116860 28117012 153 - 0.580 0.473 -0.507
ENSG00000128731 E013 138.8232421 0.0003085256 2.292924e-02 1.057065e-01 15 28117013 28117154 142 - 2.048 2.150 0.343
ENSG00000128731 E014 11.5037591 0.3392507151 7.938343e-01 8.926306e-01 15 28117155 28118421 1267 - 0.852 1.141 1.072
ENSG00000128731 E015 110.2962141 0.0003717505 4.571282e-03 3.232061e-02 15 28121346 28121429 84 - 1.925 2.058 0.448
ENSG00000128731 E016 167.2617342 0.0002797582 9.991050e-04 9.907773e-03 15 28124037 28124234 198 - 2.109 2.236 0.426
ENSG00000128731 E017 159.2643939 0.0025519167 2.645032e-03 2.123757e-02 15 28125006 28125193 188 - 2.075 2.220 0.483
ENSG00000128731 E018 146.4458822 0.0008503361 1.934921e-03 1.663182e-02 15 28130163 28130299 137 - 2.048 2.182 0.450
ENSG00000128731 E019 68.9738316 0.0006135442 4.384548e-02 1.647197e-01 15 28130300 28130302 3 - 1.734 1.856 0.412
ENSG00000128731 E020 118.4307190 0.0004633189 6.041996e-03 3.992800e-02 15 28130503 28130594 92 - 1.962 2.089 0.427
ENSG00000128731 E021 149.0800060 0.0013011764 3.027259e-03 2.357492e-02 15 28132100 28132261 162 - 2.053 2.186 0.445
ENSG00000128731 E022 0.6564337 0.0642971484 4.532421e-01   15 28132262 28132397 136 - 0.287 0.160 -1.067
ENSG00000128731 E023 156.2561283 0.0011362132 6.856061e-04 7.318145e-03 15 28132653 28132830 178 - 2.066 2.211 0.486
ENSG00000128731 E024 177.4599303 0.0032883220 1.973794e-03 1.689351e-02 15 28135478 28135692 215 - 2.115 2.265 0.500
ENSG00000128731 E025 178.0430738 0.0038182778 1.249163e-01 3.236083e-01 15 28141432 28141630 199 - 2.163 2.252 0.298
ENSG00000128731 E026 73.9577752 0.0064723323 5.603433e-01 7.435759e-01 15 28141731 28141738 8 - 1.809 1.869 0.202
ENSG00000128731 E027 125.1914872 0.0009791511 9.529345e-01 9.784371e-01 15 28141739 28141846 108 - 2.057 2.085 0.095
ENSG00000128731 E028 110.1107955 0.0004015930 2.876486e-01 5.283809e-01 15 28142238 28142393 156 - 1.973 2.038 0.221
ENSG00000128731 E029 0.6785387 0.5873076108 1.000000e+00   15 28142394 28142452 59 - 0.167 0.227 0.554
ENSG00000128731 E030 76.4829400 0.0005524184 1.279526e-01 3.285846e-01 15 28142827 28142952 126 - 1.797 1.891 0.318
ENSG00000128731 E031 80.8714333 0.0006140129 1.697057e-01 3.901122e-01 15 28143873 28143991 119 - 1.828 1.914 0.290
ENSG00000128731 E032 94.9825279 0.0003950506 3.922509e-01 6.221929e-01 15 28144077 28144235 159 - 1.913 1.973 0.202
ENSG00000128731 E033 90.9725532 0.0033011947 3.998037e-01 6.280839e-01 15 28144673 28144804 132 - 1.890 1.953 0.213
ENSG00000128731 E034 96.6102802 0.0111162580 1.069763e-01 2.939603e-01 15 28146237 28146344 108 - 1.870 1.997 0.427
ENSG00000128731 E035 87.7318844 0.0036417480 5.478613e-02 1.908619e-01 15 28152677 28152758 82 - 1.834 1.955 0.409
ENSG00000128731 E036 75.7921566 0.0028846779 1.219511e-02 6.723406e-02 15 28152759 28152830 72 - 1.746 1.901 0.524
ENSG00000128731 E037 125.1744947 0.0003269303 7.284178e-03 4.598933e-02 15 28163094 28163285 192 - 1.988 2.109 0.406
ENSG00000128731 E038 96.1593772 0.0004066590 1.629191e-01 3.811090e-01 15 28167687 28167827 141 - 1.902 1.984 0.274
ENSG00000128731 E039 97.9285442 0.0004223207 2.961140e-01 5.366518e-01 15 28168407 28168590 184 - 1.920 1.987 0.225
ENSG00000128731 E040 100.0337423 0.0004438508 2.463778e-01 4.840143e-01 15 28169484 28169655 172 - 1.925 1.996 0.239
ENSG00000128731 E041 113.4894608 0.0033673193 9.745666e-01 9.891219e-01 15 28174395 28174620 226 - 2.010 2.034 0.078
ENSG00000128731 E042 107.7982481 0.0029680122 5.479915e-01 7.348744e-01 15 28175512 28175656 145 - 1.971 2.023 0.172
ENSG00000128731 E043 121.3218788 0.0006534111 5.387485e-01 7.281196e-01 15 28176428 28176599 172 - 2.026 2.074 0.162
ENSG00000128731 E044 83.8917721 0.0005755743 1.947417e-01 4.230027e-01 15 28176687 28176768 82 - 1.917 1.889 -0.095
ENSG00000128731 E045 119.2001948 0.0004651709 7.852458e-03 4.864050e-02 15 28176950 28177127 178 - 2.096 2.030 -0.222
ENSG00000128731 E046 94.3154089 0.0004435323 6.031530e-01 7.723223e-01 15 28177419 28177509 91 - 1.951 1.957 0.021
ENSG00000128731 E047 104.7406558 0.0032763896 3.624045e-01 5.976592e-01 15 28178887 28179030 144 - 1.951 2.019 0.227
ENSG00000128731 E048 70.4807096 0.0005791135 4.757318e-02 1.739631e-01 15 28179142 28179223 82 - 1.742 1.860 0.401
ENSG00000128731 E049 76.4142995 0.0040169597 8.989160e-01 9.513275e-01 15 28182401 28182512 112 - 1.846 1.862 0.052
ENSG00000128731 E050 95.7038434 0.0025002933 5.198128e-01 7.148950e-01 15 28186577 28186752 176 - 1.957 1.951 -0.021
ENSG00000128731 E051 0.4756169 0.0269221267 2.952260e-01   15 28190201 28190964 764 - 0.001 0.222 8.682
ENSG00000128731 E052 65.9150605 0.0097622555 7.267496e-01 8.522809e-01 15 28190965 28191056 92 - 1.797 1.795 -0.007
ENSG00000128731 E053 55.8212354 0.0011322548 1.818633e-01 4.064437e-01 15 28191139 28191244 106 - 1.752 1.709 -0.147
ENSG00000128731 E054 77.5472900 0.0030614890 1.454831e-01 3.556307e-01 15 28191961 28192151 191 - 1.896 1.846 -0.166
ENSG00000128731 E055 70.3462714 0.0159881599 3.960375e-01 6.252208e-01 15 28196215 28196354 140 - 1.859 1.806 -0.178
ENSG00000128731 E056 68.8341044 0.0063135872 1.470311e-01 3.580487e-01 15 28196461 28196569 109 - 1.859 1.796 -0.212
ENSG00000128731 E057 79.3916614 0.0005124837 1.140260e-02 6.400344e-02 15 28198378 28198503 126 - 1.932 1.852 -0.268
ENSG00000128731 E058 100.6998366 0.0003873996 6.538398e-04 7.041476e-03 15 28198601 28198769 169 - 2.044 1.944 -0.336
ENSG00000128731 E059 76.4094283 0.0005417074 2.358852e-06 6.026588e-05 15 28201456 28201554 99 - 1.968 1.796 -0.580
ENSG00000128731 E060 64.8692076 0.0052044838 1.037289e-02 5.973889e-02 15 28202113 28202249 137 - 1.867 1.745 -0.412
ENSG00000128731 E061 34.6052699 0.0072412228 6.006944e-02 2.029963e-01 15 28202347 28202614 268 - 1.596 1.484 -0.383
ENSG00000128731 E062 2.2844259 0.0097106262 4.293179e-01 6.505134e-01 15 28202615 28203936 1322 - 0.380 0.538 0.810
ENSG00000128731 E063 10.8229818 0.0034067538 3.249390e-01 5.641436e-01 15 28206240 28206382 143 - 0.951 1.084 0.490
ENSG00000128731 E064 30.0804881 0.0017389523 7.116960e-01 8.428689e-01 15 28211002 28211145 144 - 1.434 1.486 0.179
ENSG00000128731 E065 39.5662279 0.0010594241 7.035641e-02 2.254537e-01 15 28212445 28212583 139 - 1.634 1.553 -0.274
ENSG00000128731 E066 70.3851200 0.0005218930 5.721378e-03 3.834122e-02 15 28213742 28213972 231 - 1.890 1.794 -0.322
ENSG00000128731 E067 53.5343982 0.0008435898 5.028870e-05 8.360429e-04 15 28214076 28214272 197 - 1.822 1.646 -0.597
ENSG00000128731 E068 41.1171759 0.0069260834 1.202704e-02 6.655807e-02 15 28214655 28214802 148 - 1.691 1.548 -0.488
ENSG00000128731 E069 52.1866011 0.0091378470 5.085744e-02 1.817365e-01 15 28215621 28215802 182 - 1.766 1.656 -0.374
ENSG00000128731 E070 56.2270328 0.0058298390 2.329847e-01 4.685841e-01 15 28218489 28218671 183 - 1.760 1.712 -0.164
ENSG00000128731 E071 59.3812497 0.0077176539 7.260269e-02 2.299956e-01 15 28220452 28220644 193 - 1.811 1.723 -0.298
ENSG00000128731 E072 37.1584854 0.0009477946 2.641977e-01 5.034374e-01 15 28222028 28222147 120 - 1.584 1.542 -0.142
ENSG00000128731 E073 27.8384376 0.0013467924 2.152139e-02 1.010374e-01 15 28222148 28222215 68 - 1.521 1.391 -0.449
ENSG00000128731 E074 54.1452848 0.0012890331 3.280326e-03 2.507426e-02 15 28228218 28228409 192 - 1.794 1.669 -0.423
ENSG00000128731 E075 40.5422983 0.0101369489 9.459655e-02 2.722595e-01 15 28229195 28229346 152 - 1.654 1.552 -0.348
ENSG00000128731 E076 0.3503582 0.0305151864 5.610544e-01   15 28229347 28229459 113 - 0.167 0.087 -1.067
ENSG00000128731 E077 46.8905849 0.0035338619 2.394347e-03 1.964989e-02 15 28229460 28229596 137 - 1.750 1.596 -0.522
ENSG00000128731 E078 41.4232379 0.0013378524 2.855030e-03 2.252706e-02 15 28229674 28229847 174 - 1.695 1.550 -0.493
ENSG00000128731 E079 33.9997648 0.0010450170 3.604451e-06 8.684998e-05 15 28230367 28230500 134 - 1.674 1.418 -0.876
ENSG00000128731 E080 38.9018745 0.0009002118 2.608076e-06 6.570408e-05 15 28233146 28233341 196 - 1.723 1.480 -0.828
ENSG00000128731 E081 21.4421663 0.0018983823 1.067839e-02 6.102424e-02 15 28233434 28233561 128 - 1.434 1.264 -0.591
ENSG00000128731 E082 21.8679588 0.0015963156 5.536016e-03 3.739630e-02 15 28233664 28233796 133 - 1.448 1.264 -0.640
ENSG00000128731 E083 22.9141321 0.0020584792 1.381291e-03 1.276457e-02 15 28234070 28234284 215 - 1.490 1.279 -0.729
ENSG00000128731 E084 34.1438487 0.0160116188 7.693150e-03 4.790708e-02 15 28236963 28237113 151 - 1.643 1.445 -0.680
ENSG00000128731 E085 33.3460886 0.0018577692 3.006632e-02 1.275369e-01 15 28238114 28238217 104 - 1.584 1.470 -0.390
ENSG00000128731 E086 51.0188584 0.0033999481 2.680900e-03 2.146527e-02 15 28238602 28238757 156 - 1.781 1.634 -0.497
ENSG00000128731 E087 29.4766910 0.0013627573 4.089984e-04 4.817070e-03 15 28238758 28238772 15 - 1.589 1.383 -0.707
ENSG00000128731 E088 50.6419155 0.0008322608 5.498437e-06 1.252323e-04 15 28245881 28246066 186 - 1.816 1.611 -0.693
ENSG00000128731 E089 42.5709078 0.0008732136 5.352939e-04 5.995200e-03 15 28246742 28246897 156 - 1.719 1.553 -0.564
ENSG00000128731 E090 51.3875624 0.0095700310 2.575319e-03 2.081620e-02 15 28248552 28248736 185 - 1.806 1.621 -0.624
ENSG00000128731 E091 51.2844171 0.0031821868 4.692291e-05 7.874100e-04 15 28254340 28254487 148 - 1.817 1.615 -0.684
ENSG00000128731 E092 27.4993378 0.0013972654 4.087162e-02 1.569674e-01 15 28254488 28254518 31 - 1.503 1.387 -0.398
ENSG00000128731 E093 39.1443141 0.0009091780 2.421066e-04 3.132901e-03 15 28255872 28255996 125 - 1.695 1.511 -0.629
ENSG00000128731 E094 38.9613837 0.0012948927 7.532313e-03 4.717485e-02 15 28256089 28256317 229 - 1.661 1.531 -0.445
ENSG00000128731 E095 38.0426385 0.0275619981 4.482029e-02 1.671795e-01 15 28257061 28257261 201 - 1.674 1.501 -0.591
ENSG00000128731 E096 50.4008286 0.0028622430 9.848854e-07 2.802081e-05 15 28260777 28260970 194 - 1.835 1.591 -0.827
ENSG00000128731 E097 62.8811823 0.0022004425 2.560545e-09 1.374334e-07 15 28262918 28263169 252 - 1.940 1.671 -0.909
ENSG00000128731 E098 41.3022958 0.0009022150 6.559555e-04 7.059337e-03 15 28265618 28265731 114 - 1.703 1.537 -0.567
ENSG00000128731 E099 39.6974547 0.0010128082 8.340068e-04 8.556884e-03 15 28265817 28265974 158 - 1.687 1.520 -0.569
ENSG00000128731 E100 36.1581671 0.0046444546 1.973403e-06 5.159009e-05 15 28268465 28268616 152 - 1.715 1.426 -0.988
ENSG00000128731 E101 39.8908916 0.0015122130 9.806724e-11 6.959496e-09 15 28269248 28269436 189 - 1.787 1.443 -1.173
ENSG00000128731 E102 38.6426172 0.0052281805 2.419676e-09 1.309486e-07 15 28270695 28270868 174 - 1.781 1.417 -1.241
ENSG00000128731 E103 0.0000000       15 28272044 28272214 171 -      
ENSG00000128731 E104 28.4849626 0.0013883521 8.193263e-06 1.763956e-04 15 28272215 28272386 172 - 1.610 1.341 -0.924
ENSG00000128731 E105 20.2058752 0.0137365623 2.696558e-01 5.095486e-01 15 28272894 28273004 111 - 1.353 1.276 -0.270
ENSG00000128731 E106 0.2735028 0.0261152517 5.585405e-01   15 28273005 28273168 164 - 0.166 0.087 -1.067
ENSG00000128731 E107 24.5048855 0.0017115472 8.874052e-02 2.614762e-01 15 28274291 28274447 157 - 1.448 1.350 -0.340
ENSG00000128731 E108 21.9339959 0.0017264720 1.631138e-03 1.453941e-02 15 28274905 28275005 101 - 1.469 1.259 -0.731
ENSG00000128731 E109 5.8247808 0.0239668804 2.989100e-02 1.270092e-01 15 28280034 28280067 34 - 0.973 0.683 -1.137
ENSG00000128731 E110 46.4445166 0.0013987415 2.620456e-08 1.119250e-06 15 28280068 28280287 220 - 1.813 1.537 -0.935
ENSG00000128731 E111 34.5491431 0.0013036138 1.728379e-05 3.374552e-04 15 28292888 28293022 135 - 1.670 1.433 -0.811
ENSG00000128731 E112 0.4458772 0.0217681645 9.316799e-01   15 28298517 28298629 113 - 0.166 0.160 -0.066
ENSG00000128731 E113 22.7302821 0.0244531763 5.998006e-03 3.971612e-02 15 28299402 28299516 115 - 1.510 1.245 -0.921
ENSG00000128731 E114 22.4084673 0.0571074270 1.943980e-01 4.226185e-01 15 28320122 28320464 343 - 1.431 1.290 -0.490
ENSG00000128731 E115 15.6754396 0.0025783253 1.403071e-02 7.445982e-02 15 28321362 28321464 103 - 1.314 1.122 -0.679
ENSG00000128731 E116 5.2775333 0.0055712879 5.208962e-01 7.155055e-01 15 28322075 28322179 105 - 0.820 0.754 -0.259