ENSG00000128591

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325888 ENSG00000128591 HEK293_OSMI2_6hA HEK293_TMG_6hB FLNC protein_coding protein_coding 7.104526 12.37921 2.46944 2.626932 0.1517304 -2.320997 5.2381877 9.8720070 2.1504390 1.9097449 0.3490281 -2.1934796 0.75551667 0.80603333 0.8685667 0.06253333 6.623622e-01 7.146192e-07 FALSE TRUE
ENST00000346177 ENSG00000128591 HEK293_OSMI2_6hA HEK293_TMG_6hB FLNC protein_coding protein_coding 7.104526 12.37921 2.46944 2.626932 0.1517304 -2.320997 0.4222152 0.5484103 0.3012134 0.2759195 0.3012134 -0.8434212 0.08405833 0.03716667 0.1234333 0.08626667 9.379968e-01 7.146192e-07 FALSE TRUE
MSTRG.30655.6 ENSG00000128591 HEK293_OSMI2_6hA HEK293_TMG_6hB FLNC protein_coding   7.104526 12.37921 2.46944 2.626932 0.1517304 -2.320997 1.0232459 1.6353864 0.0000000 0.3216678 0.0000000 -7.3622826 0.10337500 0.13513333 0.0000000 -0.13513333 7.146192e-07 7.146192e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000128591 E001 6.8814111 0.0146732638 2.172977e-01 0.4501854533 7 128830406 128830425 20 + 0.908 0.720 -0.741
ENSG00000128591 E002 12.2982664 0.0030202766 8.960305e-01 0.9498194002 7 128830426 128830492 67 + 0.986 0.975 -0.039
ENSG00000128591 E003 10.4116743 0.0038639577 7.431075e-01 0.8624179259 7 128830493 128830498 6 + 0.864 0.917 0.202
ENSG00000128591 E004 10.9998262 0.0034465078 3.982320e-01 0.6268440511 7 128830499 128830541 43 + 1.020 0.917 -0.384
ENSG00000128591 E005 16.6000505 0.0019785598 8.889517e-02 0.2617229903 7 128830542 128830620 79 + 1.245 1.072 -0.615
ENSG00000128591 E006 46.8368012 0.0012368636 1.325949e-01 0.3358790563 7 128830621 128830989 369 + 1.615 1.520 -0.326
ENSG00000128591 E007 40.6347265 0.0009749446 1.721406e-01 0.3933900330 7 128835326 128835574 249 + 1.553 1.461 -0.314
ENSG00000128591 E008 27.9553280 0.0014086251 1.738252e-01 0.3956333918 7 128837160 128837257 98 + 1.406 1.295 -0.385
ENSG00000128591 E009 37.5027962 0.0082058361 6.556932e-01 0.8071372315 7 128837398 128837548 151 + 1.469 1.430 -0.131
ENSG00000128591 E010 31.5337967 0.0074107386 3.812098e-02 0.1499402109 7 128837637 128837755 119 + 1.513 1.333 -0.621
ENSG00000128591 E011 27.5392114 0.0117973711 2.779845e-02 0.1207007338 7 128837987 128838064 78 + 1.478 1.264 -0.743
ENSG00000128591 E012 45.0041320 0.0056920768 7.273319e-02 0.2302544289 7 128838267 128838429 163 + 1.623 1.486 -0.469
ENSG00000128591 E013 50.7061476 0.0040880721 1.068546e-01 0.2937827270 7 128838603 128838803 201 + 1.655 1.542 -0.384
ENSG00000128591 E014 43.0366605 0.0009070232 3.805598e-05 0.0006605459 7 128840023 128840160 138 + 1.712 1.449 -0.895
ENSG00000128591 E015 44.4352522 0.0010429521 4.135832e-03 0.0299245595 7 128840548 128840674 127 + 1.662 1.475 -0.638
ENSG00000128591 E016 50.6191956 0.0023996445 9.466421e-03 0.0558083743 7 128840834 128840970 137 + 1.698 1.530 -0.574
ENSG00000128591 E017 53.7228888 0.0037357444 1.941873e-01 0.4223602339 7 128841170 128841330 161 + 1.655 1.569 -0.293
ENSG00000128591 E018 26.9650804 0.0110288582 4.614145e-01 0.6741468998 7 128841331 128841363 33 + 1.348 1.282 -0.232
ENSG00000128591 E019 0.1308682 0.0326491905 9.622497e-01   7 128841364 128841453 90 + 0.001 0.054 5.651
ENSG00000128591 E020 42.7090471 0.0082692354 8.815925e-02 0.2603088941 7 128841454 128841567 114 + 1.598 1.462 -0.467
ENSG00000128591 E021 49.2350982 0.0015092947 3.843997e-02 0.1507271126 7 128842231 128842374 144 + 1.662 1.529 -0.454
ENSG00000128591 E022 44.2677428 0.0009748615 2.356964e-02 0.1077621844 7 128842575 128842698 124 + 1.631 1.483 -0.508
ENSG00000128591 E023 51.4343369 0.0013975119 1.236757e-02 0.0679026785 7 128842794 128842954 161 + 1.698 1.541 -0.534
ENSG00000128591 E024 40.5806378 0.0012645185 3.116980e-02 0.1308500703 7 128843229 128843319 91 + 1.589 1.442 -0.507
ENSG00000128591 E025 59.5248511 0.0006105395 2.619273e-02 0.1158939885 7 128843408 128843577 170 + 1.737 1.612 -0.425
ENSG00000128591 E026 47.5082350 0.0011106158 2.616260e-01 0.5007061479 7 128843796 128843913 118 + 1.598 1.527 -0.243
ENSG00000128591 E027 75.3481387 0.0092168304 9.475733e-01 0.9761112309 7 128844004 128844266 263 + 1.732 1.730 -0.009
ENSG00000128591 E028 60.1076092 0.0006918726 9.118127e-01 0.9580620289 7 128844658 128844824 167 + 1.623 1.637 0.046
ENSG00000128591 E029 57.1374184 0.0006757911 4.105942e-01 0.6364861638 7 128844825 128844936 112 + 1.655 1.609 -0.155
ENSG00000128591 E030 98.6700524 0.0005139345 1.552196e-01 0.3697657977 7 128844937 128845255 319 + 1.902 1.842 -0.204
ENSG00000128591 E031 65.5244054 0.0007282094 5.774043e-01 0.7553783094 7 128845990 128846163 174 + 1.698 1.673 -0.086
ENSG00000128591 E032 61.2333666 0.0009559764 9.515581e-01 0.9777197500 7 128846301 128846463 163 + 1.639 1.651 0.040
ENSG00000128591 E033 63.8284393 0.0006350654 1.805567e-01 0.4046651027 7 128846745 128846905 161 + 1.725 1.653 -0.243
ENSG00000128591 E034 61.5382089 0.0031779481 2.216439e-01 0.4554668125 7 128847697 128847864 168 + 1.711 1.641 -0.240
ENSG00000128591 E035 57.8597735 0.0014400645 2.113097e-01 0.4433397559 7 128847945 128848068 124 + 1.543 1.636 0.319
ENSG00000128591 E036 64.0658407 0.0018636490 9.002500e-01 0.9519855134 7 128848561 128848717 157 + 1.670 1.669 -0.003
ENSG00000128591 E037 72.0393096 0.0012917441 7.780373e-01 0.8835324512 7 128848793 128848982 190 + 1.725 1.713 -0.040
ENSG00000128591 E038 36.7669689 0.0061202658 9.269130e-01 0.9655169199 7 128849181 128849204 24 + 1.432 1.424 -0.028
ENSG00000128591 E039 84.7595125 0.0051896721 2.264133e-01 0.4611162418 7 128849331 128849578 248 + 1.712 1.792 0.270
ENSG00000128591 E040 41.4821959 0.0027917226 2.285002e-02 0.1054787892 7 128849976 128850074 99 + 1.299 1.501 0.698
ENSG00000128591 E041 60.2085058 0.0009587400 1.281912e-01 0.3289180603 7 128850384 128850483 100 + 1.543 1.652 0.372
ENSG00000128591 E042 77.4737850 0.0006622097 9.708002e-02 0.2766595542 7 128850803 128850943 141 + 1.655 1.761 0.359
ENSG00000128591 E043 76.0762324 0.0251026137 5.233694e-01 0.7173695195 7 128851232 128851360 129 + 1.685 1.742 0.193
ENSG00000128591 E044 84.8382119 0.0006750528 3.219246e-01 0.5613820867 7 128851455 128851628 174 + 1.731 1.794 0.213
ENSG00000128591 E045 89.2864823 0.0004878629 4.274458e-01 0.6490643208 7 128852591 128852752 162 + 1.762 1.812 0.170
ENSG00000128591 E046 111.5662403 0.0004712801 4.931147e-01 0.6960534281 7 128852828 128853031 204 + 1.919 1.894 -0.084
ENSG00000128591 E047 97.4985616 0.0003950365 2.035870e-01 0.4340329150 7 128853469 128853621 153 + 1.889 1.835 -0.184
ENSG00000128591 E048 86.3116456 0.0005899083 6.906495e-01 0.8294836743 7 128853715 128853837 123 + 1.768 1.795 0.093
ENSG00000128591 E049 109.2051637 0.0005029200 4.607376e-02 0.1702137308 7 128853974 128854216 243 + 1.801 1.909 0.361
ENSG00000128591 E050 111.0978262 0.0007850313 3.637406e-04 0.0043753727 7 128854413 128854682 270 + 1.725 1.923 0.670
ENSG00000128591 E051 85.5288547 0.0004938827 9.593188e-02 0.2746365382 7 128854775 128854912 138 + 1.698 1.800 0.344
ENSG00000128591 E052 85.9088174 0.0005106082 5.146313e-02 0.1832090977 7 128855199 128855314 116 + 1.684 1.803 0.400
ENSG00000128591 E053 103.0226666 0.0004446798 1.481769e-01 0.3597189442 7 128856518 128856650 133 + 1.796 1.877 0.275
ENSG00000128591 E054 117.3850224 0.0004600212 2.763138e-03 0.0219519278 7 128856745 128856921 177 + 1.785 1.943 0.531
ENSG00000128591 E055 119.8022751 0.0014264665 4.110104e-03 0.0297828221 7 128857118 128857336 219 + 1.790 1.945 0.522
ENSG00000128591 E056 96.8453397 0.0034837292 3.771316e-03 0.0278613704 7 128858008 128858217 210 + 1.670 1.855 0.625
ENSG00000128591 E057 257.2559339 0.0096798026 9.200700e-03 0.0547186270 7 128858336 128859274 939 + 2.109 2.276 0.559