ENSG00000128581

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000422177 ENSG00000128581 HEK293_OSMI2_6hA HEK293_TMG_6hB IFT22 protein_coding nonsense_mediated_decay 29.17713 24.05699 19.95622 4.425112 0.9253861 -0.2694944 3.652048 2.853692 4.121753 0.1897004 0.4328891 0.528877772 0.13265417 0.12426667 0.2093000 0.08503333 3.467984e-01 2.179176e-09 TRUE  
ENST00000430911 ENSG00000128581 HEK293_OSMI2_6hA HEK293_TMG_6hB IFT22 protein_coding nonsense_mediated_decay 29.17713 24.05699 19.95622 4.425112 0.9253861 -0.2694944 6.842299 4.558084 4.574965 1.7359528 1.1276394 0.005321536 0.23014167 0.17400000 0.2263667 0.05236667 8.616897e-01 2.179176e-09 FALSE  
ENST00000437644 ENSG00000128581 HEK293_OSMI2_6hA HEK293_TMG_6hB IFT22 protein_coding protein_coding 29.17713 24.05699 19.95622 4.425112 0.9253861 -0.2694944 8.310028 7.770397 5.189924 0.4342440 0.4207089 -0.581353160 0.28515000 0.34006667 0.2595000 -0.08056667 6.599660e-01 2.179176e-09 FALSE  
ENST00000495166 ENSG00000128581 HEK293_OSMI2_6hA HEK293_TMG_6hB IFT22 protein_coding processed_transcript 29.17713 24.05699 19.95622 4.425112 0.9253861 -0.2694944 1.626902 2.127483 0.000000 0.7743508 0.0000000 -7.739769468 0.05127917 0.08183333 0.0000000 -0.08183333 2.179176e-09 2.179176e-09 FALSE  
ENST00000498704 ENSG00000128581 HEK293_OSMI2_6hA HEK293_TMG_6hB IFT22 protein_coding protein_coding 29.17713 24.05699 19.95622 4.425112 0.9253861 -0.2694944 6.684369 5.458463 3.891921 1.1660662 0.1839242 -0.486950604 0.22456667 0.22436667 0.1964667 -0.02790000 8.011745e-01 2.179176e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000128581 E001 32.0436092 0.7209348303 0.924335902 0.96450523 7 101310914 101313366 2453 - 1.660 1.362 -1.021
ENSG00000128581 E002 7.2231673 0.5359733136 0.406743238 0.63357601 7 101313367 101313693 327 - 1.095 0.692 -1.546
ENSG00000128581 E003 16.5552644 0.4617041689 0.958440806 0.98110484 7 101313694 101314105 412 - 1.318 1.170 -0.521
ENSG00000128581 E004 7.8401501 0.1695526626 0.978184874 0.99085773 7 101314106 101314174 69 - 0.984 0.905 -0.295
ENSG00000128581 E005 12.2366050 0.3028144787 0.982701611 0.99310933 7 101314175 101314403 229 - 1.181 1.063 -0.423
ENSG00000128581 E006 25.7524910 0.5439491921 0.793458599 0.89237090 7 101314404 101314752 349 - 1.492 1.364 -0.440
ENSG00000128581 E007 12.6213510 0.3311611075 0.823763114 0.91015648 7 101314753 101314787 35 - 1.193 1.079 -0.411
ENSG00000128581 E008 12.8460026 0.3386263389 0.665448655 0.81332009 7 101314788 101314794 7 - 1.172 1.111 -0.218
ENSG00000128581 E009 46.0059106 0.0014662549 0.675358701 0.81978672 7 101314795 101314877 83 - 1.670 1.664 -0.019
ENSG00000128581 E010 140.1837245 0.0005031207 0.320446685 0.56009322 7 101314878 101315071 194 - 2.138 2.140 0.009
ENSG00000128581 E011 216.1061999 0.0004104166 0.003250596 0.02490755 7 101315072 101315282 211 - 2.303 2.345 0.141
ENSG00000128581 E012 2.9904166 0.1615580604 0.111105301 0.30079912 7 101315493 101315824 332 - 0.786 0.419 -1.651
ENSG00000128581 E013 4.6301075 0.0786071016 0.281005093 0.52126050 7 101315825 101316339 515 - 0.844 0.641 -0.825
ENSG00000128581 E014 231.3490818 0.0094621289 0.540645973 0.72948246 7 101316340 101316542 203 - 2.352 2.366 0.048
ENSG00000128581 E015 147.2424327 0.0077254766 0.377705455 0.61032996 7 101318124 101318213 90 - 2.195 2.139 -0.190
ENSG00000128581 E016 12.1470387 0.0501908763 0.136493993 0.34213264 7 101318214 101318955 742 - 1.229 1.002 -0.817
ENSG00000128581 E017 137.7547172 0.0049277320 0.740468762 0.86070244 7 101318956 101319032 77 - 2.155 2.119 -0.121
ENSG00000128581 E018 1.5076071 0.0712825064 0.236024131 0.47196301 7 101319033 101319063 31 - 0.509 0.267 -1.397
ENSG00000128581 E019 0.2027342 0.0321728977 0.588564942   7 101321427 101321499 73 - 0.001 0.108 7.785
ENSG00000128581 E020 130.9922786 0.0007734554 0.044594916 0.16659206 7 101321671 101321823 153 - 2.091 2.128 0.124