ENSG00000128573

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393489 ENSG00000128573 HEK293_OSMI2_6hA HEK293_TMG_6hB FOXP2 protein_coding nonsense_mediated_decay 2.436167 1.517854 4.077578 0.4350209 0.4697218 1.419739 0.03613302 0.00000000 0.19696960 0.00000000 0.19696960 4.3713470 0.01432500 0.00000000 0.051100000 0.05110000 0.975068747 0.007289173 FALSE TRUE
ENST00000408937 ENSG00000128573 HEK293_OSMI2_6hA HEK293_TMG_6hB FOXP2 protein_coding protein_coding 2.436167 1.517854 4.077578 0.4350209 0.4697218 1.419739 0.12041787 0.14050805 0.15436085 0.07307304 0.08425884 0.1270260 0.04484167 0.09913333 0.036400000 -0.06273333 0.720417299 0.007289173 FALSE TRUE
ENST00000412402 ENSG00000128573 HEK293_OSMI2_6hA HEK293_TMG_6hB FOXP2 protein_coding nonsense_mediated_decay 2.436167 1.517854 4.077578 0.4350209 0.4697218 1.419739 0.10638230 0.02053562 0.21839720 0.01028357 0.11185377 2.9029798 0.03636667 0.01050000 0.060933333 0.05043333 0.783027637 0.007289173 TRUE TRUE
ENST00000462331 ENSG00000128573 HEK293_OSMI2_6hA HEK293_TMG_6hB FOXP2 protein_coding protein_coding 2.436167 1.517854 4.077578 0.4350209 0.4697218 1.419739 0.10310487 0.10807747 0.01368338 0.04010984 0.01368338 -2.3177867 0.05080000 0.07326667 0.002733333 -0.07053333 0.007289173 0.007289173   FALSE
ENST00000495516 ENSG00000128573 HEK293_OSMI2_6hA HEK293_TMG_6hB FOXP2 protein_coding processed_transcript 2.436167 1.517854 4.077578 0.4350209 0.4697218 1.419739 0.06164457 0.00000000 0.40893503 0.00000000 0.40893503 5.3886546 0.01405417 0.00000000 0.082133333 0.08213333 0.970462543 0.007289173   FALSE
ENST00000634411 ENSG00000128573 HEK293_OSMI2_6hA HEK293_TMG_6hB FOXP2 protein_coding protein_coding 2.436167 1.517854 4.077578 0.4350209 0.4697218 1.419739 0.13749499 0.00000000 0.30233537 0.00000000 0.30233537 4.9650240 0.04147083 0.00000000 0.088933333 0.08893333 1.000000000 0.007289173 FALSE TRUE
ENST00000634664 ENSG00000128573 HEK293_OSMI2_6hA HEK293_TMG_6hB FOXP2 protein_coding processed_transcript 2.436167 1.517854 4.077578 0.4350209 0.4697218 1.419739 0.21268806 0.35015276 0.00000000 0.17867082 0.00000000 -5.1705371 0.15961667 0.17940000 0.000000000 -0.17940000 0.053305336 0.007289173   FALSE
ENST00000635109 ENSG00000128573 HEK293_OSMI2_6hA HEK293_TMG_6hB FOXP2 protein_coding nonsense_mediated_decay 2.436167 1.517854 4.077578 0.4350209 0.4697218 1.419739 0.02818343 0.10297113 0.00000000 0.10297113 0.00000000 -3.4978822 0.01075000 0.05253333 0.000000000 -0.05253333 0.654232013 0.007289173 FALSE TRUE
MSTRG.30535.10 ENSG00000128573 HEK293_OSMI2_6hA HEK293_TMG_6hB FOXP2 protein_coding   2.436167 1.517854 4.077578 0.4350209 0.4697218 1.419739 0.19424904 0.00000000 0.00000000 0.00000000 0.00000000 0.0000000 0.09727083 0.00000000 0.000000000 0.00000000   0.007289173 FALSE TRUE
MSTRG.30535.2 ENSG00000128573 HEK293_OSMI2_6hA HEK293_TMG_6hB FOXP2 protein_coding   2.436167 1.517854 4.077578 0.4350209 0.4697218 1.419739 0.59005889 0.40712871 0.49042754 0.23702665 0.24550737 0.2626686 0.21046250 0.34563333 0.120733333 -0.22490000 0.857249699 0.007289173 FALSE TRUE
MSTRG.30535.6 ENSG00000128573 HEK293_OSMI2_6hA HEK293_TMG_6hB FOXP2 protein_coding   2.436167 1.517854 4.077578 0.4350209 0.4697218 1.419739 0.27587755 0.03999710 0.96706522 0.03999710 0.49082282 4.2885385 0.10024167 0.02040000 0.219700000 0.19930000 0.658795678 0.007289173 FALSE TRUE
MSTRG.30535.7 ENSG00000128573 HEK293_OSMI2_6hA HEK293_TMG_6hB FOXP2 protein_coding   2.436167 1.517854 4.077578 0.4350209 0.4697218 1.419739 0.13721763 0.28573120 0.52964891 0.28573120 0.27411808 0.8677347 0.08504167 0.14683333 0.145233333 -0.00160000 0.857513057 0.007289173 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000128573 E001 0.4762370 0.021768165 0.259196857   7 114086327 114086398 72 + 0.081 0.306 2.326
ENSG00000128573 E002 0.4762370 0.021768165 0.259196857   7 114086399 114086438 40 + 0.081 0.306 2.326
ENSG00000128573 E003 0.4762370 0.021768165 0.259196857   7 114086439 114086443 5 + 0.081 0.306 2.326
ENSG00000128573 E004 0.7249894 0.030314902 0.809036774   7 114086444 114086498 55 + 0.207 0.305 0.736
ENSG00000128573 E005 0.7437705 0.017267182 0.803060647   7 114086499 114086500 2 + 0.207 0.305 0.736
ENSG00000128573 E006 2.3467089 0.009850654 0.345772876 0.58334596 7 114086501 114086559 59 + 0.420 0.660 1.129
ENSG00000128573 E007 4.2020518 0.009135924 0.218884440 0.45209940 7 114086560 114086611 52 + 0.706 0.609 -0.413
ENSG00000128573 E008 0.1614157 0.034414724 1.000000000   7 114087747 114087771 25 + 0.081 0.000 -28.822
ENSG00000128573 E009 0.4820342 0.021996257 0.256868622   7 114087772 114087838 67 + 0.207 0.000 -30.407
ENSG00000128573 E010 0.3228314 0.327536386 0.574606992   7 114088166 114088270 105 + 0.149 0.000 -29.827
ENSG00000128573 E011 5.9646704 0.052181304 0.920909456 0.96270136 7 114162944 114163040 97 + 0.773 0.856 0.327
ENSG00000128573 E012 5.1280400 0.082704943 0.878282828 0.94042676 7 114163041 114163088 48 + 0.725 0.790 0.262
ENSG00000128573 E013 0.3206185 0.026256384 0.469927199   7 114285405 114285456 52 + 0.148 0.000 -29.822
ENSG00000128573 E014 4.8682765 0.085057303 0.648799340 0.80273908 7 114288019 114288030 12 + 0.727 0.744 0.070
ENSG00000128573 E015 10.3425269 0.060317902 0.930604675 0.96731145 7 114288031 114288109 79 + 0.975 1.090 0.419
ENSG00000128573 E016 0.0000000       7 114366505 114366640 136 +      
ENSG00000128573 E017 0.0000000       7 114414274 114414542 269 +      
ENSG00000128573 E018 0.1614157 0.034414724 1.000000000   7 114414815 114414996 182 + 0.081 0.000 -28.822
ENSG00000128573 E019 0.3228314 0.327536386 0.574606992   7 114414997 114415057 61 + 0.149 0.000 -29.827
ENSG00000128573 E020 0.1614157 0.034414724 1.000000000   7 114415058 114415111 54 + 0.081 0.000 -28.822
ENSG00000128573 E021 0.5008152 0.060600799 0.264258038   7 114415112 114415219 108 + 0.208 0.000 -30.411
ENSG00000128573 E022 0.8096672 0.101543029 0.494901333   7 114415220 114415318 99 + 0.260 0.178 -0.696
ENSG00000128573 E023 0.1308682 0.032649190 0.254047876   7 114415319 114415322 4 + 0.000 0.179 31.434
ENSG00000128573 E024 0.1308682 0.032649190 0.254047876   7 114415323 114415360 38 + 0.000 0.179 31.434
ENSG00000128573 E025 0.0000000       7 114416286 114416427 142 +      
ENSG00000128573 E026 0.0000000       7 114426500 114426501 2 +      
ENSG00000128573 E027 7.8160014 0.071560217 0.663194431 0.81188737 7 114426502 114426514 13 + 0.893 0.935 0.160
ENSG00000128573 E028 16.5230578 0.053504508 0.185186867 0.41078109 7 114426515 114426679 165 + 1.221 1.163 -0.207
ENSG00000128573 E029 0.0000000       7 114463074 114463171 98 +      
ENSG00000128573 E030 0.9878233 0.017267182 0.114637489   7 114498883 114499093 211 + 0.148 0.483 2.325
ENSG00000128573 E031 1.7933384 0.138116931 0.011546319 0.06459024 7 114499094 114499728 635 + 0.148 0.719 3.385
ENSG00000128573 E032 14.8915295 0.002818990 0.254046908 0.49243264 7 114534617 114534706 90 + 1.166 1.170 0.013
ENSG00000128573 E033 0.9749096 0.622453915 1.000000000   7 114538326 114538383 58 + 0.293 0.293 -0.006
ENSG00000128573 E034 2.9766071 0.008891552 0.944712331 0.97468352 7 114570807 114570881 75 + 0.537 0.610 0.328
ENSG00000128573 E035 14.0316757 0.010932154 0.156505298 0.37158275 7 114628540 114628677 138 + 1.158 1.105 -0.190
ENSG00000128573 E036 0.1779838 0.110495966 1.000000000   7 114628678 114628982 305 + 0.081 0.000 -28.828
ENSG00000128573 E037 0.6482515 0.133186313 0.691482447   7 114629592 114629642 51 + 0.209 0.178 -0.287
ENSG00000128573 E038 0.6544085 0.019387492 0.719405773   7 114629787 114629804 18 + 0.207 0.179 -0.259
ENSG00000128573 E039 7.8168273 0.004820397 0.132180205 0.33524456 7 114629805 114629853 49 + 0.941 0.853 -0.336
ENSG00000128573 E040 4.7215966 0.085504678 0.596428934 0.76797176 7 114629854 114629855 2 + 0.735 0.707 -0.115
ENSG00000128573 E041 5.3594369 0.061036175 0.532747935 0.72404691 7 114629856 114629864 9 + 0.781 0.749 -0.131
ENSG00000128573 E042 5.4087655 0.022723375 0.247154828 0.48485092 7 114629865 114629867 3 + 0.798 0.707 -0.366
ENSG00000128573 E043 7.6038000 0.017853639 0.364673906 0.59964339 7 114629868 114629944 77 + 0.909 0.883 -0.099
ENSG00000128573 E044 5.3493357 0.005640605 0.333155186 0.57176624 7 114629945 114630005 61 + 0.785 0.748 -0.149
ENSG00000128573 E045 0.0000000       7 114630611 114630613 3 +      
ENSG00000128573 E046 1.6009132 0.011702797 0.715336684 0.84513773 7 114631528 114631530 3 + 0.347 0.483 0.739
ENSG00000128573 E047 2.0663792 0.009865512 0.790098887 0.89059663 7 114631531 114631536 6 + 0.452 0.483 0.155
ENSG00000128573 E048 2.1972474 0.009480094 0.917084284 0.96074176 7 114631537 114631542 6 + 0.452 0.550 0.476
ENSG00000128573 E049 2.1972474 0.009480094 0.917084284 0.96074176 7 114631543 114631545 3 + 0.452 0.550 0.476
ENSG00000128573 E050 8.5768060 0.003999602 0.047763706 0.17446275 7 114631546 114631705 160 + 0.989 0.853 -0.517
ENSG00000128573 E051 17.0377194 0.006307654 0.002384595 0.01959068 7 114642410 114642623 214 + 1.272 1.086 -0.660
ENSG00000128573 E052 15.8418316 0.012939978 0.073938285 0.23264264 7 114644685 114644789 105 + 1.216 1.151 -0.229
ENSG00000128573 E053 0.0000000       7 114644790 114645830 1041 +      
ENSG00000128573 E054 13.6258368 0.002938899 0.238323211 0.47469813 7 114652203 114652290 88 + 1.141 1.138 -0.010
ENSG00000128573 E055 14.4422609 0.002989174 0.334990819 0.57356602 7 114653926 114654009 84 + 1.153 1.170 0.060
ENSG00000128573 E056 0.1723744 0.178760057 0.260523541   7 114654010 114654143 134 + 0.000 0.180 31.444
ENSG00000128573 E057 0.6709767 0.250414195 0.760248243   7 114656440 114656594 155 + 0.209 0.180 -0.262
ENSG00000128573 E058 23.2003065 0.013617062 0.396271539 0.62537785 7 114658066 114658267 202 + 1.330 1.370 0.139
ENSG00000128573 E059 19.3650567 0.077261495 0.703362205 0.83775480 7 114659356 114659432 77 + 1.244 1.313 0.241
ENSG00000128573 E060 23.0672028 0.074229642 0.209206347 0.44093996 7 114659572 114659673 102 + 1.356 1.296 -0.211
ENSG00000128573 E061 0.0000000       7 114661792 114661913 122 +      
ENSG00000128573 E062 22.3415867 0.057495558 0.031975406 0.13313782 7 114662065 114662186 122 + 1.368 1.227 -0.494
ENSG00000128573 E063 13.2576228 0.002731111 0.057542018 0.19726790 7 114663450 114663519 70 + 1.147 1.069 -0.283
ENSG00000128573 E064 17.5334600 0.004918398 0.726176590 0.85186187 7 114664273 114664436 164 + 1.194 1.331 0.481
ENSG00000128573 E065 0.1779838 0.110495966 1.000000000   7 114664437 114669984 5548 + 0.081 0.000 -28.828
ENSG00000128573 E066 166.6727058 1.475092775 0.379047963 0.61145049 7 114689782 114693772 3991 + 2.054 2.394 1.137