ENSG00000128487

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395525 ENSG00000128487 HEK293_OSMI2_6hA HEK293_TMG_6hB SPECC1 protein_coding protein_coding 7.454935 7.358953 7.692374 1.458535 0.2792785 0.06384365 0.4437993 0.4253063 1.2354713 0.2543835 0.09729529 1.5165890 0.05964583 0.06586667 0.16066667 0.09480000 6.306056e-01 1.077813e-21 FALSE TRUE
ENST00000395530 ENSG00000128487 HEK293_OSMI2_6hA HEK293_TMG_6hB SPECC1 protein_coding protein_coding 7.454935 7.358953 7.692374 1.458535 0.2792785 0.06384365 0.9652736 0.9067756 0.3312835 0.2380052 0.16564778 -1.4255981 0.12639167 0.11970000 0.04296667 -0.07673333 5.159870e-01 1.077813e-21 FALSE TRUE
ENST00000580934 ENSG00000128487 HEK293_OSMI2_6hA HEK293_TMG_6hB SPECC1 protein_coding protein_coding 7.454935 7.358953 7.692374 1.458535 0.2792785 0.06384365 1.1927069 0.0000000 2.6691968 0.0000000 0.20378116 8.0656568 0.14478750 0.00000000 0.34736667 0.34736667 1.077813e-21 1.077813e-21 FALSE TRUE
ENST00000581399 ENSG00000128487 HEK293_OSMI2_6hA HEK293_TMG_6hB SPECC1 protein_coding protein_coding 7.454935 7.358953 7.692374 1.458535 0.2792785 0.06384365 1.1463192 1.8467954 1.4670549 0.1484332 0.17182596 -0.3300914 0.16746250 0.26563333 0.19063333 -0.07500000 6.420456e-01 1.077813e-21 FALSE TRUE
ENST00000583482 ENSG00000128487 HEK293_OSMI2_6hA HEK293_TMG_6hB SPECC1 protein_coding protein_coding 7.454935 7.358953 7.692374 1.458535 0.2792785 0.06384365 1.4478243 2.6487395 0.3521009 0.9223829 0.35210089 -2.8762788 0.19308333 0.33680000 0.04286667 -0.29393333 1.200684e-01 1.077813e-21 FALSE TRUE
ENST00000679740 ENSG00000128487 HEK293_OSMI2_6hA HEK293_TMG_6hB SPECC1 protein_coding protein_coding 7.454935 7.358953 7.692374 1.458535 0.2792785 0.06384365 0.8196708 0.2553184 0.0000000 0.2553184 0.00000000 -4.7296527 0.10612500 0.02663333 0.00000000 -0.02663333 8.647535e-01 1.077813e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000128487 E001 0.0000000       17 20008262 20008864 603 +      
ENSG00000128487 E002 0.0000000       17 20008865 20008869 5 +      
ENSG00000128487 E003 0.4646582 0.0213381096 7.163087e-01   17 20008870 20009319 450 + 0.134 0.198 0.683
ENSG00000128487 E004 0.3447487 0.6798567827 4.385849e-01   17 20009320 20009343 24 + 0.000 0.202 12.137
ENSG00000128487 E005 0.3447487 0.6798567827 4.385849e-01   17 20009344 20009345 2 + 0.000 0.202 12.137
ENSG00000128487 E006 0.3447487 0.6798567827 4.385849e-01   17 20009346 20009346 1 + 0.000 0.202 12.137
ENSG00000128487 E007 0.3447487 0.6798567827 4.385849e-01   17 20009347 20009352 6 + 0.000 0.202 12.137
ENSG00000128487 E008 0.3447487 0.6798567827 4.385849e-01   17 20009353 20009358 6 + 0.000 0.202 12.137
ENSG00000128487 E009 0.3447487 0.6798567827 4.385849e-01   17 20009359 20009359 1 + 0.000 0.202 12.137
ENSG00000128487 E010 0.3447487 0.6798567827 4.385849e-01   17 20009360 20009363 4 + 0.000 0.202 12.137
ENSG00000128487 E011 0.5227326 0.5024411787 7.972489e-01   17 20009364 20009365 2 + 0.135 0.201 0.689
ENSG00000128487 E012 0.5227326 0.5024411787 7.972489e-01   17 20009366 20009367 2 + 0.135 0.201 0.689
ENSG00000128487 E013 3.1105414 0.0985426881 7.403418e-01 8.606323e-01 17 20009368 20009378 11 + 0.630 0.565 -0.287
ENSG00000128487 E014 5.5979094 0.0157964694 7.354935e-01 8.576137e-01 17 20009379 20009424 46 + 0.831 0.793 -0.152
ENSG00000128487 E015 0.0000000       17 20009863 20010217 355 +      
ENSG00000128487 E016 0.8080019 0.2711279901 5.847427e-01   17 20010335 20010652 318 + 0.316 0.200 -0.872
ENSG00000128487 E017 1.6063823 0.1481260571 1.633494e-01 3.817103e-01 17 20017145 20017605 461 + 0.235 0.546 1.810
ENSG00000128487 E018 4.4906564 0.0312058012 2.575626e-01 4.963128e-01 17 20017987 20018102 116 + 0.629 0.811 0.749
ENSG00000128487 E019 0.8572626 0.1410862754 2.352737e-01   17 20057677 20057771 95 + 0.134 0.381 1.963
ENSG00000128487 E020 0.1614157 0.0337431060 3.922876e-01   17 20057772 20057817 46 + 0.134 0.000 -13.238
ENSG00000128487 E021 1.3983512 0.0354161086 5.331254e-01 7.242942e-01 17 20067194 20067378 185 + 0.317 0.437 0.688
ENSG00000128487 E022 0.0000000       17 20073538 20073555 18 +      
ENSG00000128487 E023 0.0000000       17 20073556 20073564 9 +      
ENSG00000128487 E024 0.0000000       17 20073565 20073701 137 +      
ENSG00000128487 E025 0.0000000       17 20087021 20087021 1 +      
ENSG00000128487 E026 0.0000000       17 20087022 20087051 30 +      
ENSG00000128487 E027 0.0000000       17 20095692 20095692 1 +      
ENSG00000128487 E028 0.0000000       17 20095693 20095912 220 +      
ENSG00000128487 E029 0.0000000       17 20095913 20096037 125 +      
ENSG00000128487 E030 5.2274826 0.0816622013 4.423671e-01 6.603025e-01 17 20096631 20096635 5 + 0.859 0.706 -0.610
ENSG00000128487 E031 5.7511428 0.0652412380 5.437967e-01 7.317751e-01 17 20096636 20096651 16 + 0.880 0.770 -0.429
ENSG00000128487 E032 9.2428999 0.0498313227 9.013149e-01 9.525265e-01 17 20096652 20096798 147 + 1.019 1.004 -0.055
ENSG00000128487 E033 9.9578405 0.0752048885 6.492801e-01 8.030165e-01 17 20110427 20110562 136 + 0.997 1.084 0.320
ENSG00000128487 E034 0.4397201 0.0855123702 7.456445e-01   17 20124900 20124997 98 + 0.134 0.196 0.663
ENSG00000128487 E035 0.0000000       17 20155338 20155511 174 +      
ENSG00000128487 E036 0.0000000       17 20155742 20155877 136 +      
ENSG00000128487 E037 0.0000000       17 20155989 20155993 5 +      
ENSG00000128487 E038 0.3641499 0.0286367145 8.593199e-01   17 20155994 20156014 21 + 0.134 0.111 -0.313
ENSG00000128487 E039 1.1318630 0.0142490617 9.740991e-02   17 20156015 20156050 36 + 0.134 0.437 2.268
ENSG00000128487 E040 1.4053658 0.0127737840 1.826578e-01 4.074895e-01 17 20156051 20156057 7 + 0.235 0.480 1.490
ENSG00000128487 E041 3.1148839 0.0085208868 1.854445e-03 1.608578e-02 17 20156058 20156082 25 + 0.235 0.772 2.772
ENSG00000128487 E042 5.9535902 0.0065784209 1.779863e-02 8.835738e-02 17 20156083 20156088 6 + 0.627 0.958 1.320
ENSG00000128487 E043 34.9410182 0.0018587156 3.300769e-01 5.690236e-01 17 20156089 20156236 148 + 1.573 1.524 -0.167
ENSG00000128487 E044 246.4323525 0.0002922630 2.435005e-07 8.196626e-06 17 20204333 20205739 1407 + 2.441 2.341 -0.332
ENSG00000128487 E045 38.5003609 0.0012124072 5.994062e-01 7.698290e-01 17 20205740 20205795 56 + 1.597 1.577 -0.067
ENSG00000128487 E046 47.3728995 0.0008380233 9.025772e-03 5.394028e-02 17 20205796 20205912 117 + 1.740 1.618 -0.415
ENSG00000128487 E047 127.0084519 0.0034363627 2.497518e-01 4.875843e-01 17 20227413 20227620 208 + 2.117 2.085 -0.107
ENSG00000128487 E048 83.1584545 0.0008590656 6.479685e-01 8.021804e-01 17 20231758 20231831 74 + 1.904 1.933 0.098
ENSG00000128487 E049 114.9748913 0.0044045200 6.767332e-01 8.206606e-01 17 20232200 20232405 206 + 2.064 2.061 -0.011
ENSG00000128487 E050 1.9670884 0.0570160654 6.841929e-01 8.254185e-01 17 20232406 20232414 9 + 0.500 0.437 -0.317
ENSG00000128487 E051 0.1723744 0.0438593106 5.969863e-01   17 20232415 20232451 37 + 0.000 0.110 12.008
ENSG00000128487 E052 14.4706908 0.0154433366 4.838641e-01 6.896759e-01 17 20236860 20236899 40 + 1.225 1.169 -0.197
ENSG00000128487 E053 58.6789282 0.0008497286 1.297456e-05 2.630586e-04 17 20236900 20239427 2528 + 1.870 1.680 -0.642
ENSG00000128487 E054 0.4764247 0.0227829133 4.392732e-01   17 20244124 20245925 1802 + 0.235 0.110 -1.314
ENSG00000128487 E055 55.3106602 0.0010427339 4.403787e-02 1.652082e-01 17 20245926 20246071 146 + 1.676 1.787 0.373
ENSG00000128487 E056 0.5365243 0.0235071624 7.135701e-01   17 20246072 20246197 126 + 0.134 0.199 0.688
ENSG00000128487 E057 0.1614157 0.0337431060 3.922876e-01   17 20246198 20246574 377 + 0.134 0.000 -13.238
ENSG00000128487 E058 0.1723744 0.0438593106 5.969863e-01   17 20246575 20247218 644 + 0.000 0.110 12.008
ENSG00000128487 E059 47.2253639 0.0010624463 3.563648e-01 5.928521e-01 17 20247219 20247319 101 + 1.646 1.705 0.202
ENSG00000128487 E060 1.0843377 0.0206986210 1.506956e-01   17 20247320 20248932 1613 + 0.447 0.198 -1.635
ENSG00000128487 E061 41.9808946 0.0017933572 7.440967e-01 8.630587e-01 17 20253505 20253586 82 + 1.638 1.632 -0.021
ENSG00000128487 E062 61.6970299 0.0075359453 2.898344e-01 5.304167e-01 17 20257451 20257607 157 + 1.823 1.772 -0.174
ENSG00000128487 E063 61.8368632 0.0007245966 3.677345e-01 6.021872e-01 17 20260192 20260294 103 + 1.811 1.782 -0.097
ENSG00000128487 E064 52.2457722 0.0007292996 3.175211e-02 1.325005e-01 17 20296961 20297077 117 + 1.652 1.770 0.397
ENSG00000128487 E065 0.3040503 0.0274424043 1.447270e-01   17 20305652 20306000 349 + 0.235 0.000 -14.278
ENSG00000128487 E066 0.0000000       17 20306001 20306022 22 +      
ENSG00000128487 E067 44.7334319 0.0009142062 2.893733e-02 1.241750e-01 17 20306023 20306082 60 + 1.577 1.705 0.438
ENSG00000128487 E068 6.0632685 0.2490980691 1.450199e-01 3.549427e-01 17 20306083 20308261 2179 + 0.987 0.685 -1.182
ENSG00000128487 E069 275.1302882 0.0033153854 2.418614e-07 8.152763e-06 17 20313976 20319026 5051 + 2.335 2.502 0.557