ENSG00000128191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351989 ENSG00000128191 HEK293_OSMI2_6hA HEK293_TMG_6hB DGCR8 protein_coding protein_coding 39.10326 46.00016 27.13055 9.85893 0.2498004 -0.7615026 15.255338 13.053485 9.4635123 1.5834904 0.65896954 -0.4635686 0.40155000 0.29673333 0.34860000 0.051866667 0.79742142 0.01597408 FALSE  
ENST00000407755 ENSG00000128191 HEK293_OSMI2_6hA HEK293_TMG_6hB DGCR8 protein_coding protein_coding 39.10326 46.00016 27.13055 9.85893 0.2498004 -0.7615026 1.995790 2.760375 1.4798970 0.5465663 0.40316996 -0.8948685 0.05018750 0.06643333 0.05480000 -0.011633333 0.95325448 0.01597408 FALSE  
ENST00000475941 ENSG00000128191 HEK293_OSMI2_6hA HEK293_TMG_6hB DGCR8 protein_coding retained_intron 39.10326 46.00016 27.13055 9.85893 0.2498004 -0.7615026 2.524311 3.992483 0.9212019 1.1146636 0.16590473 -2.1037294 0.05738750 0.08450000 0.03393333 -0.050566667 0.01597408 0.01597408 FALSE  
ENST00000491892 ENSG00000128191 HEK293_OSMI2_6hA HEK293_TMG_6hB DGCR8 protein_coding retained_intron 39.10326 46.00016 27.13055 9.85893 0.2498004 -0.7615026 5.890722 8.097635 5.1361583 2.8714772 0.13483650 -0.6557854 0.15059583 0.16680000 0.18936667 0.022566667 0.85740989 0.01597408 FALSE  
ENST00000495351 ENSG00000128191 HEK293_OSMI2_6hA HEK293_TMG_6hB DGCR8 protein_coding retained_intron 39.10326 46.00016 27.13055 9.85893 0.2498004 -0.7615026 2.100099 2.853537 1.8288641 1.0260009 0.40673134 -0.6389832 0.05416250 0.05846667 0.06726667 0.008800000 0.95697321 0.01597408 FALSE  
ENST00000495826 ENSG00000128191 HEK293_OSMI2_6hA HEK293_TMG_6hB DGCR8 protein_coding retained_intron 39.10326 46.00016 27.13055 9.85893 0.2498004 -0.7615026 2.946676 4.561983 2.5982859 1.5906468 0.11369929 -0.8097181 0.07553333 0.09403333 0.09570000 0.001666667 1.00000000 0.01597408 TRUE  
ENST00000498171 ENSG00000128191 HEK293_OSMI2_6hA HEK293_TMG_6hB DGCR8 protein_coding retained_intron 39.10326 46.00016 27.13055 9.85893 0.2498004 -0.7615026 6.893781 8.258205 4.6368577 0.9526431 0.07822997 -0.8313188 0.17425000 0.18653333 0.17096667 -0.015566667 0.91685025 0.01597408 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000128191 E001 0.5953387 0.2305337942 0.235944086   22 20080232 20080240 9 + 0.000 0.283 12.550
ENSG00000128191 E002 20.1351347 0.0222863010 0.148732804 0.36046410 22 20080241 20080383 143 + 1.363 1.277 -0.298
ENSG00000128191 E003 2.7940317 0.4985885369 0.601523899 0.77115503 22 20080569 20080685 117 + 0.377 0.624 1.217
ENSG00000128191 E004 29.6981797 0.0255687059 0.277142087 0.51719322 22 20085687 20085745 59 + 1.492 1.459 -0.113
ENSG00000128191 E005 31.3194554 0.0219351021 0.300676566 0.54114151 22 20085746 20085819 74 + 1.510 1.485 -0.086
ENSG00000128191 E006 16.2821731 0.0174650368 0.206086625 0.43712295 22 20085820 20085821 2 + 1.262 1.201 -0.214
ENSG00000128191 E007 131.8593418 0.0162392885 0.169864219 0.39030655 22 20085822 20086057 236 + 2.101 2.100 -0.003
ENSG00000128191 E008 114.5827903 0.0169141876 0.059518936 0.20172200 22 20086058 20086142 85 + 2.064 2.027 -0.124
ENSG00000128191 E009 162.5575038 0.0056289740 0.057905396 0.19808372 22 20086143 20086339 197 + 2.189 2.192 0.009
ENSG00000128191 E010 284.2059282 0.0123919927 0.006148697 0.04045722 22 20086340 20086683 344 + 2.468 2.413 -0.182
ENSG00000128191 E011 65.4150184 0.0260980691 0.373247752 0.60670741 22 20086684 20087035 352 + 1.774 1.812 0.128
ENSG00000128191 E012 43.3513384 0.0627034859 0.448427975 0.66455529 22 20087036 20087161 126 + 1.595 1.637 0.142
ENSG00000128191 E013 216.5990989 0.0100959274 0.002685217 0.02148649 22 20087162 20087321 160 + 2.362 2.288 -0.248
ENSG00000128191 E014 191.2574977 0.0098925810 0.011771976 0.06552533 22 20089669 20089811 143 + 2.293 2.243 -0.166
ENSG00000128191 E015 58.3807104 0.0280496844 0.052450921 0.18535402 22 20089812 20089975 164 + 1.796 1.725 -0.241
ENSG00000128191 E016 268.3082595 0.0232347595 0.217464153 0.45036059 22 20089976 20090258 283 + 2.410 2.406 -0.013
ENSG00000128191 E017 195.8175514 0.0158168936 0.310150713 0.55063797 22 20091435 20091632 198 + 2.263 2.276 0.042
ENSG00000128191 E018 143.1897925 0.0052589472 0.305484164 0.54612120 22 20091869 20091970 102 + 2.119 2.145 0.087
ENSG00000128191 E019 174.9662209 0.0071045294 0.225095516 0.45952367 22 20092809 20092907 99 + 2.211 2.228 0.057
ENSG00000128191 E020 1.8094740 0.1856859864 0.573724507 0.75280950 22 20094712 20094712 1 + 0.277 0.472 1.141
ENSG00000128191 E021 203.2284505 0.0061594795 0.025523877 0.11381827 22 20094713 20094795 83 + 2.301 2.279 -0.074
ENSG00000128191 E022 107.7672591 0.0036545000 0.015433130 0.07971836 22 20106177 20106181 5 + 2.033 2.001 -0.109
ENSG00000128191 E023 203.7515665 0.0081951748 0.045985170 0.17000848 22 20106182 20106277 96 + 2.302 2.281 -0.071
ENSG00000128191 E024 2.4807582 0.0236638646 0.766310562 0.87637401 22 20106567 20106591 25 + 0.443 0.555 0.545
ENSG00000128191 E025 241.0403576 0.0017820261 0.023962819 0.10897844 22 20106592 20106685 94 + 2.356 2.362 0.020
ENSG00000128191 E026 132.2530416 0.0008268416 0.006870774 0.04404240 22 20106686 20106698 13 + 2.112 2.094 -0.061
ENSG00000128191 E027 69.9589173 0.0422695665 0.388166038 0.61908471 22 20106699 20107036 338 + 1.801 1.841 0.133
ENSG00000128191 E028 252.8655224 0.0048173644 0.771135264 0.87934559 22 20107271 20107398 128 + 2.331 2.408 0.257
ENSG00000128191 E029 34.0952540 0.0550034023 0.539575777 0.72869973 22 20107399 20107571 173 + 1.498 1.533 0.120
ENSG00000128191 E030 176.3785431 0.0631391638 0.075547384 0.23594820 22 20107572 20108889 1318 + 2.002 2.309 1.027
ENSG00000128191 E031 248.7976211 1.2172936317 0.420049911 0.64368789 22 20108890 20109003 114 + 2.185 2.448 0.877
ENSG00000128191 E032 14.6131610 0.0242050391 0.004395873 0.03135586 22 20109004 20109184 181 + 0.828 1.280 1.658
ENSG00000128191 E033 1220.5027472 1.7833348518 0.445528708 0.66245028 22 20110025 20111877 1853 + 2.847 3.146 0.994