ENSG00000127989

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351870 ENSG00000127989 HEK293_OSMI2_6hA HEK293_TMG_6hB MTERF1 protein_coding protein_coding 12.07037 8.159497 16.71693 1.471648 1.024703 1.033853 1.5988823 0.6843162 2.4830723 0.09566033 0.13481174 1.8442600 0.12422917 0.08703333 0.149766667 0.06273333 0.274269353 0.001055344 FALSE TRUE
ENST00000406735 ENSG00000127989 HEK293_OSMI2_6hA HEK293_TMG_6hB MTERF1 protein_coding protein_coding 12.07037 8.159497 16.71693 1.471648 1.024703 1.033853 3.9330999 1.5347146 6.2858401 0.26317327 0.52978977 2.0270586 0.29556667 0.19560000 0.375700000 0.18010000 0.045093575 0.001055344 FALSE TRUE
ENST00000442961 ENSG00000127989 HEK293_OSMI2_6hA HEK293_TMG_6hB MTERF1 protein_coding protein_coding 12.07037 8.159497 16.71693 1.471648 1.024703 1.033853 1.3412421 0.2416454 3.0039730 0.13693593 0.48892299 3.5822022 0.09079583 0.02486667 0.183366667 0.15850000 0.048490376 0.001055344 FALSE FALSE
MSTRG.30201.3 ENSG00000127989 HEK293_OSMI2_6hA HEK293_TMG_6hB MTERF1 protein_coding   12.07037 8.159497 16.71693 1.471648 1.024703 1.033853 0.6502623 0.7754411 0.2302159 0.29881055 0.12827038 -1.7091714 0.06727500 0.09203333 0.013100000 -0.07893333 0.147602304 0.001055344   FALSE
MSTRG.30201.4 ENSG00000127989 HEK293_OSMI2_6hA HEK293_TMG_6hB MTERF1 protein_coding   12.07037 8.159497 16.71693 1.471648 1.024703 1.033853 1.6863363 1.4697254 1.6494169 0.32127128 0.13018773 0.1653469 0.16530833 0.18550000 0.098666667 -0.08683333 0.267842268 0.001055344   FALSE
MSTRG.30201.5 ENSG00000127989 HEK293_OSMI2_6hA HEK293_TMG_6hB MTERF1 protein_coding   12.07037 8.159497 16.71693 1.471648 1.024703 1.033853 1.3625665 1.8928931 1.1942518 0.37526281 0.25346024 -0.6600574 0.12920000 0.23370000 0.070433333 -0.16326667 0.001055344 0.001055344   FALSE
MSTRG.30201.6 ENSG00000127989 HEK293_OSMI2_6hA HEK293_TMG_6hB MTERF1 protein_coding   12.07037 8.159497 16.71693 1.471648 1.024703 1.033853 0.5036653 1.2195926 0.1674018 0.76861654 0.08500498 -2.7930883 0.04944167 0.13036667 0.009733333 -0.12063333 0.148492725 0.001055344   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000127989 E001 0.0000000       7 91692008 91692166 159 -      
ENSG00000127989 E002 0.1308682 0.0326491905 1.868065e-01   7 91693398 91693459 62 - 0.000 0.183 10.868
ENSG00000127989 E003 1.5571215 0.2311232130 1.159801e-01 3.091134e-01 7 91800869 91800963 95 - 0.251 0.616 1.999
ENSG00000127989 E004 0.7547291 0.0172671820 1.470436e-01   7 91800994 91800994 1 - 0.145 0.410 1.986
ENSG00000127989 E005 4.7981446 0.0169087364 1.165073e-05 2.391589e-04 7 91800995 91801072 78 - 0.444 1.079 2.626
ENSG00000127989 E006 7.4199447 0.0046206906 8.403645e-08 3.177760e-06 7 91801073 91801090 18 - 0.599 1.237 2.452
ENSG00000127989 E007 20.2331372 0.0244428880 1.836427e-09 1.019175e-07 7 91801091 91801268 178 - 0.995 1.634 2.242
ENSG00000127989 E008 4.5556512 0.1823426947 2.554418e-05 4.698323e-04 7 91802482 91802599 118 - 0.200 1.145 4.471
ENSG00000127989 E009 0.3040503 0.0274424043 6.171092e-01   7 91824284 91824317 34 - 0.145 0.000 -12.428
ENSG00000127989 E010 8.7202266 0.0041904899 2.605705e-03 2.099706e-02 7 91827415 91827480 66 - 0.816 1.166 1.299
ENSG00000127989 E011 76.1897345 0.0023969445 5.465580e-01 7.338527e-01 7 91870929 91873321 2393 - 1.845 1.836 -0.032
ENSG00000127989 E012 188.7413781 0.0004191492 9.281024e-03 5.501523e-02 7 91873322 91874314 993 - 2.247 2.204 -0.145
ENSG00000127989 E013 19.0268407 0.0024778210 9.625487e-01 9.832290e-01 7 91874315 91874317 3 - 1.261 1.275 0.049
ENSG00000127989 E014 81.3632582 0.0006818674 8.455331e-08 3.196593e-06 7 91874318 91874653 336 - 1.924 1.706 -0.737
ENSG00000127989 E015 44.4417955 0.0008401505 8.133456e-05 1.258999e-03 7 91874654 91874764 111 - 1.665 1.443 -0.757
ENSG00000127989 E016 2.2612911 0.0094238414 2.513293e-01 4.894076e-01 7 91876878 91876894 17 - 0.413 0.618 0.991
ENSG00000127989 E017 3.5224450 0.0065927191 4.241971e-01 6.467167e-01 7 91876895 91876926 32 - 0.577 0.716 0.596
ENSG00000127989 E018 3.3750086 0.0068158706 6.219531e-01 7.851188e-01 7 91876927 91876978 52 - 0.577 0.670 0.404
ENSG00000127989 E019 37.7433923 0.0055532872 6.066802e-01 7.746835e-01 7 91880055 91880113 59 - 1.526 1.582 0.191
ENSG00000127989 E020 10.4184904 0.1030555080 8.150798e-01 9.052828e-01 7 91880114 91880642 529 - 1.001 1.059 0.213
ENSG00000127989 E021 4.5571956 0.0349768081 6.694842e-01 8.159512e-01 7 91880643 91880656 14 - 0.679 0.759 0.329
ENSG00000127989 E022 28.7461783 0.0055615739 9.890342e-01 9.962992e-01 7 91880657 91880720 64 - 1.422 1.443 0.072