ENSG00000127720

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000248306 ENSG00000127720 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL25 protein_coding protein_coding 4.389832 1.696816 6.204822 0.09493282 0.1365071 1.864405 3.2813863 0.91854855 4.7389045 0.37001925 0.21674795 2.354546 0.74230833 0.52420000 0.7633000 0.23910000 0.72633717 0.04204353 FALSE TRUE
ENST00000547357 ENSG00000127720 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL25 protein_coding processed_transcript 4.389832 1.696816 6.204822 0.09493282 0.1365071 1.864405 0.2057790 0.27448096 0.0000000 0.27448096 0.00000000 -4.830260 0.04967500 0.17806667 0.0000000 -0.17806667 0.75539060 0.04204353 FALSE TRUE
ENST00000548569 ENSG00000127720 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL25 protein_coding processed_transcript 4.389832 1.696816 6.204822 0.09493282 0.1365071 1.864405 0.1829320 0.00000000 0.3293156 0.00000000 0.19967468 5.084556 0.02752500 0.00000000 0.0545000 0.05450000 0.58246831 0.04204353 FALSE TRUE
ENST00000551645 ENSG00000127720 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL25 protein_coding retained_intron 4.389832 1.696816 6.204822 0.09493282 0.1365071 1.864405 0.1282346 0.27086572 0.1218846 0.09811702 0.03418259 -1.090604 0.04819167 0.15550000 0.0199000 -0.13560000 0.04204353 0.04204353 FALSE TRUE
ENST00000552741 ENSG00000127720 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL25 protein_coding processed_transcript 4.389832 1.696816 6.204822 0.09493282 0.1365071 1.864405 0.1210719 0.09735136 0.0000000 0.09735136 0.00000000 -3.424269 0.04425417 0.06316667 0.0000000 -0.06316667 0.69688165 0.04204353 FALSE FALSE
MSTRG.7711.5 ENSG00000127720 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL25 protein_coding   4.389832 1.696816 6.204822 0.09493282 0.1365071 1.864405 0.2116002 0.02643907 0.7373724 0.02643907 0.34352833 4.358269 0.03769583 0.01716667 0.1168667 0.09970000 0.30317203 0.04204353 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000127720 E001 2.5865390 0.0368749748 0.9038683848 0.95383811 12 82358528 82358528 1 + 0.495 0.526 0.147
ENSG00000127720 E002 3.1643819 0.0150765033 0.2066153923 0.43766506 12 82358529 82358539 11 + 0.494 0.711 0.965
ENSG00000127720 E003 18.9164368 0.0746144730 0.2335080859 0.46917386 12 82358540 82358824 285 + 1.190 1.351 0.567
ENSG00000127720 E004 0.4764247 0.0217681645 0.6800718165   12 82358825 82358893 69 + 0.131 0.202 0.745
ENSG00000127720 E005 0.3228314 0.3434372548 1.0000000000   12 82358894 82358916 23 + 0.132 0.000 -10.398
ENSG00000127720 E006 0.8569551 0.0188465679 0.0852214531   12 82369449 82369560 112 + 0.131 0.443 2.330
ENSG00000127720 E007 0.3559677 0.5613258695 1.0000000000   12 82374027 82374310 284 + 0.135 0.000 -10.225
ENSG00000127720 E008 20.5179544 0.0036250952 0.8187426405 0.90729598 12 82386803 82386967 165 + 1.269 1.258 -0.039
ENSG00000127720 E009 0.0000000       12 82386968 82386972 5 +      
ENSG00000127720 E010 0.0000000       12 82388802 82388902 101 +      
ENSG00000127720 E011 26.1472281 0.0014552293 0.1040991422 0.28896709 12 82389816 82389922 107 + 1.391 1.272 -0.415
ENSG00000127720 E012 62.7457606 0.0007888272 0.0007513313 0.00787273 12 82398795 82399358 564 + 1.768 1.608 -0.544
ENSG00000127720 E013 15.4249198 0.0029430194 0.0860592605 0.25653575 12 82399359 82399394 36 + 1.189 1.019 -0.614
ENSG00000127720 E014 29.9037185 0.0079807450 0.6664265265 0.81394776 12 82402983 82403130 148 + 1.415 1.457 0.146
ENSG00000127720 E015 27.4587957 0.0034631645 0.3861871533 0.61745950 12 82430893 82430987 95 + 1.366 1.440 0.257
ENSG00000127720 E016 14.4969962 0.0294220956 0.8027397372 0.89788073 12 82434695 82434724 30 + 1.110 1.147 0.133
ENSG00000127720 E017 0.0000000       12 82438515 82438717 203 +      
ENSG00000127720 E018 17.5622824 0.0044029673 0.3931994216 0.62293631 12 82438718 82438791 74 + 1.169 1.259 0.317
ENSG00000127720 E019 0.0000000       12 82438792 82439087 296 +      
ENSG00000127720 E020 17.8493066 0.0773793608 0.9355095805 0.96990869 12 82456727 82456820 94 + 1.190 1.240 0.178
ENSG00000127720 E021 0.1308682 0.0311134369 0.1382265785   12 82459876 82459931 56 + 0.000 0.201 11.890
ENSG00000127720 E022 0.4576437 0.1681064493 0.6668419554   12 82474499 82474583 85 + 0.130 0.202 0.765
ENSG00000127720 E023 2.2563515 0.0105774954 0.0014707432 0.01341074 12 82476299 82476643 345 + 0.275 0.800 2.589
ENSG00000127720 E024 20.8390192 0.0619967427 0.8205363269 0.90840661 12 82476644 82476718 75 + 1.247 1.321 0.260
ENSG00000127720 E025 18.2534054 0.0028426273 0.2352358842 0.47116915 12 82477281 82477352 72 + 1.184 1.299 0.405
ENSG00000127720 E026 20.1183198 0.0020008763 0.9244656402 0.96455929 12 82478932 82479239 308 + 1.253 1.272 0.066