ENSG00000127663

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000159111 ENSG00000127663 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM4B protein_coding protein_coding 16.84404 29.48069 10.99827 4.405677 0.4086669 -1.421671 2.091797 3.023260 0.7052906 0.8447995 0.3944193 -2.0842679 0.1227750 0.0980000 0.0618 -0.03620000 8.052617e-01 1.355798e-08 FALSE TRUE
ENST00000536461 ENSG00000127663 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM4B protein_coding protein_coding 16.84404 29.48069 10.99827 4.405677 0.4086669 -1.421671 3.919655 8.347905 0.0000000 2.9937128 0.0000000 -9.7069975 0.1781042 0.2624333 0.0000 -0.26243333 1.355798e-08 1.355798e-08 FALSE TRUE
ENST00000611640 ENSG00000127663 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM4B protein_coding protein_coding 16.84404 29.48069 10.99827 4.405677 0.4086669 -1.421671 7.138116 11.858982 8.0654010 1.2425913 0.2451440 -0.5555903 0.4744000 0.4292667 0.7350 0.30573333 1.305970e-01 1.355798e-08 FALSE TRUE
MSTRG.16238.4 ENSG00000127663 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM4B protein_coding   16.84404 29.48069 10.99827 4.405677 0.4086669 -1.421671 2.449248 4.219562 1.1582619 1.0285478 0.2139347 -1.8561447 0.1479000 0.1382333 0.1070 -0.03123333 7.918403e-01 1.355798e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000127663 E001 0.1723744 0.0419028293 1.000000e+00   19 4969113 4969113 1 + 0.000 0.072 7.824
ENSG00000127663 E002 0.1723744 0.0419028293 1.000000e+00   19 4969114 4969116 3 + 0.000 0.072 10.068
ENSG00000127663 E003 8.5711028 0.0109632745 1.122636e-02 0.0632987138 19 4969117 4969131 15 + 0.588 0.992 1.619
ENSG00000127663 E004 43.1994376 0.0013438243 8.391171e-01 0.9189013677 19 4969132 4969230 99 + 1.584 1.584 -0.001
ENSG00000127663 E005 64.5495857 0.0019132957 2.742636e-03 0.0218203176 19 5016257 5016324 68 + 1.856 1.712 -0.486
ENSG00000127663 E006 54.8433148 0.0010509952 1.375477e-03 0.0127295699 19 5016325 5016339 15 + 1.796 1.638 -0.536
ENSG00000127663 E007 113.0438379 0.0004825119 1.246028e-03 0.0117655917 19 5032866 5033031 166 + 2.071 1.962 -0.367
ENSG00000127663 E008 146.4742505 0.0003045551 1.211493e-02 0.0669179994 19 5039836 5040011 176 + 2.154 2.083 -0.238
ENSG00000127663 E009 150.0277333 0.0002978757 6.438362e-04 0.0069518185 19 5041137 5041251 115 + 2.186 2.088 -0.329
ENSG00000127663 E010 0.3751086 0.0298065335 7.906654e-01   19 5046998 5047140 143 + 0.000 0.134 11.205
ENSG00000127663 E011 202.3635602 0.0002557777 4.439470e-05 0.0007523442 19 5047476 5047669 194 + 2.316 2.214 -0.341
ENSG00000127663 E012 0.0000000       19 5070618 5071009 392 +      
ENSG00000127663 E013 85.0412341 0.0010735578 7.845966e-02 0.2417099190 19 5071010 5071059 50 + 1.917 1.849 -0.231
ENSG00000127663 E014 4.8940972 0.1752199818 6.706976e-01 0.8167793740 19 5074091 5077366 3276 + 0.785 0.694 -0.370
ENSG00000127663 E015 131.0860160 0.0003769785 1.005650e-03 0.0099581682 19 5077367 5077470 104 + 2.127 2.024 -0.345
ENSG00000127663 E016 33.0697580 0.0223854434 1.090221e-01 0.2974496177 19 5077471 5079166 1696 + 1.576 1.427 -0.510
ENSG00000127663 E017 4.2023555 0.0980689792 6.493002e-01 0.8030165417 19 5080688 5080996 309 + 0.702 0.623 -0.334
ENSG00000127663 E018 132.1887119 0.0003011439 2.017894e-03 0.0171823551 19 5082367 5082451 85 + 2.127 2.033 -0.315
ENSG00000127663 E019 111.2739313 0.0003761477 7.497533e-03 0.0470164905 19 5082452 5082504 53 + 2.049 1.961 -0.298
ENSG00000127663 E020 191.6756912 0.0002847789 4.220722e-02 0.1604530170 19 5110622 5110818 197 + 2.252 2.205 -0.159
ENSG00000127663 E021 1.9260731 0.0248428416 4.599001e-01 0.6730675056 19 5111375 5111544 170 + 0.519 0.389 -0.670
ENSG00000127663 E022 10.5644587 0.0034880901 3.227702e-01 0.5621288481 19 5111775 5112357 583 + 1.077 0.977 -0.365
ENSG00000127663 E023 6.8249633 0.0044113445 7.326829e-01 0.8557769791 19 5112358 5112636 279 + 0.865 0.831 -0.132
ENSG00000127663 E024 4.6891407 0.2726178998 5.884701e-01 0.7626587523 19 5112637 5113340 704 + 0.864 0.637 -0.921
ENSG00000127663 E025 135.4651010 0.0003742311 6.598915e-01 0.8099150983 19 5119118 5119219 102 + 2.069 2.066 -0.012
ENSG00000127663 E026 175.8403129 0.0003399584 6.149952e-01 0.7802555835 19 5119653 5119852 200 + 2.157 2.186 0.097
ENSG00000127663 E027 292.4139683 0.0002140330 2.496149e-02 0.1121111664 19 5131076 5131545 470 + 2.346 2.415 0.229
ENSG00000127663 E028 126.6809914 0.0003733409 2.489948e-01 0.4867682331 19 5131887 5132007 121 + 1.997 2.054 0.189
ENSG00000127663 E029 160.3010614 0.0002907292 2.024377e-01 0.4326961318 19 5133883 5134061 179 + 2.163 2.134 -0.094
ENSG00000127663 E030 213.5116767 0.0003629300 9.936193e-01 0.9984344301 19 5135339 5135535 197 + 2.257 2.269 0.043
ENSG00000127663 E031 92.3048039 0.0071346666 2.505098e-01 0.4885318545 19 5135536 5135561 26 + 1.844 1.921 0.260
ENSG00000127663 E032 137.5158675 0.0008500047 3.586905e-01 0.5947345025 19 5137262 5137338 77 + 2.040 2.086 0.155
ENSG00000127663 E033 123.2412185 0.0004169311 3.908274e-01 0.6210138382 19 5137621 5137676 56 + 1.992 2.037 0.150
ENSG00000127663 E034 162.2691532 0.0003225178 1.675975e-01 0.3873773038 19 5137962 5138070 109 + 2.098 2.156 0.195
ENSG00000127663 E035 0.7076135 0.0231220378 8.778981e-01   19 5138262 5138470 209 + 0.197 0.236 0.326
ENSG00000127663 E036 13.9813294 0.0023927076 1.706064e-01 0.3912718376 19 5140252 5141503 1252 + 0.984 1.147 0.592
ENSG00000127663 E037 240.0788936 0.0002928248 4.202693e-02 0.1600004149 19 5143967 5144152 186 + 2.259 2.328 0.229
ENSG00000127663 E038 265.7686701 0.0001961473 1.562746e-01 0.3712842319 19 5144248 5144412 165 + 2.320 2.369 0.164
ENSG00000127663 E039 240.4947184 0.0002197248 8.977881e-01 0.9507081403 19 5144783 5144902 120 + 2.304 2.320 0.054
ENSG00000127663 E040 201.2474595 0.0005479216 1.793744e-01 0.4031538661 19 5150358 5150450 93 + 2.197 2.252 0.182
ENSG00000127663 E041 1119.4474661 0.0018584508 3.546845e-05 0.0006221867 19 5151335 5153598 2264 + 2.902 2.999 0.322