ENSG00000127586

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262315 ENSG00000127586 HEK293_OSMI2_6hA HEK293_TMG_6hB CHTF18 protein_coding protein_coding 48.89049 65.27853 43.70277 4.165703 3.373695 -0.5787749 14.529163 24.071451 4.278999 5.441497 0.5068186 -2.48920955 0.28184583 0.37846667 0.09766667 -0.28080000 0.02931258 1.206388e-06 FALSE TRUE
ENST00000464728 ENSG00000127586 HEK293_OSMI2_6hA HEK293_TMG_6hB CHTF18 protein_coding retained_intron 48.89049 65.27853 43.70277 4.165703 3.373695 -0.5787749 5.864979 6.666287 7.685210 3.513143 0.2428855 0.20491485 0.12147083 0.09703333 0.17726667 0.08023333 0.47995204 1.206388e-06 FALSE TRUE
ENST00000471202 ENSG00000127586 HEK293_OSMI2_6hA HEK293_TMG_6hB CHTF18 protein_coding retained_intron 48.89049 65.27853 43.70277 4.165703 3.373695 -0.5787749 3.119301 3.991176 3.070007 1.300986 0.2207105 -0.37749062 0.06771667 0.05903333 0.07100000 0.01196667 0.87600751 1.206388e-06 FALSE TRUE
ENST00000493715 ENSG00000127586 HEK293_OSMI2_6hA HEK293_TMG_6hB CHTF18 protein_coding processed_transcript 48.89049 65.27853 43.70277 4.165703 3.373695 -0.5787749 5.705001 6.024545 6.339038 2.338506 1.0283778 0.07329288 0.11782500 0.09050000 0.14390000 0.05340000 0.63980923 1.206388e-06 FALSE FALSE
ENST00000498439 ENSG00000127586 HEK293_OSMI2_6hA HEK293_TMG_6hB CHTF18 protein_coding retained_intron 48.89049 65.27853 43.70277 4.165703 3.373695 -0.5787749 6.187776 6.650106 7.864923 2.225302 0.8712980 0.24172065 0.12496667 0.09856667 0.17996667 0.08140000 0.33643797 1.206388e-06 FALSE TRUE
ENST00000567620 ENSG00000127586 HEK293_OSMI2_6hA HEK293_TMG_6hB CHTF18 protein_coding retained_intron 48.89049 65.27853 43.70277 4.165703 3.373695 -0.5787749 1.025743 0.000000 2.376290 0.000000 1.5143198 7.89862586 0.02466250 0.00000000 0.05020000 0.05020000 0.23663755 1.206388e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000127586 E001 1.0679030 1.2660779973 1.905606e-01   16 788046 788062 17 + 0.655 0.000 -14.913
ENSG00000127586 E002 1.0679030 1.2660779973 1.905606e-01   16 788063 788116 54 + 0.655 0.000 -15.523
ENSG00000127586 E003 1.3216133 0.0133747887 5.776982e-01   16 788165 788619 455 + 0.418 0.293 -0.750
ENSG00000127586 E004 0.1723744 0.0316513517 1.000000e+00   16 788620 788621 2 + 0.000 0.077 9.819
ENSG00000127586 E005 0.3032425 0.0244411696 5.984238e-01   16 788622 788623 2 + 0.000 0.141 10.816
ENSG00000127586 E006 0.3032425 0.0244411696 5.984238e-01   16 788624 788624 1 + 0.000 0.141 10.816
ENSG00000127586 E007 4.3967555 0.0320901962 2.829599e-01 5.233973e-01 16 788625 788634 10 + 0.841 0.645 -0.798
ENSG00000127586 E008 13.8105025 0.0180498528 7.724256e-01 8.801075e-01 16 788635 788646 12 + 1.177 1.112 -0.235
ENSG00000127586 E009 32.9043894 0.0013665373 6.018321e-01 7.713812e-01 16 788647 788664 18 + 1.487 1.483 -0.014
ENSG00000127586 E010 131.5652026 0.0006890500 1.966616e-02 9.477739e-02 16 788665 788756 92 + 2.038 2.081 0.146
ENSG00000127586 E011 99.8798317 0.0008072865 1.786256e-01 4.021574e-01 16 788757 788775 19 + 1.942 1.955 0.046
ENSG00000127586 E012 6.0014995 0.0057701394 3.758718e-01 6.089270e-01 16 788928 788930 3 + 0.726 0.819 0.371
ENSG00000127586 E013 218.5376843 0.0003364890 3.430633e-08 1.422364e-06 16 788931 789085 155 + 2.199 2.317 0.393
ENSG00000127586 E014 134.8293381 0.0027732793 1.501066e-08 6.767070e-07 16 789086 789125 40 + 1.914 2.125 0.709
ENSG00000127586 E015 12.0511509 0.0168135354 4.494862e-02 1.674816e-01 16 789126 789209 84 + 1.237 0.970 -0.967
ENSG00000127586 E016 103.8570909 0.0004224794 2.031319e-05 3.871224e-04 16 789210 789213 4 + 1.866 2.000 0.453
ENSG00000127586 E017 102.0978505 0.0003885967 2.743318e-05 4.989596e-04 16 789214 789216 3 + 1.859 1.992 0.447
ENSG00000127586 E018 204.3501524 0.0002982662 5.548787e-06 1.262386e-04 16 789217 789312 96 + 2.189 2.280 0.306
ENSG00000127586 E019 123.4097504 0.0003749501 7.577890e-02 2.363279e-01 16 789313 789318 6 + 2.022 2.046 0.078
ENSG00000127586 E020 168.3671484 0.0018988397 6.221536e-02 2.077675e-01 16 789319 789360 42 + 2.156 2.180 0.081
ENSG00000127586 E021 1.6306529 0.0113668625 1.523842e-01 3.658026e-01 16 789361 789362 2 + 0.569 0.293 -1.489
ENSG00000127586 E022 4.4608122 0.0531459109 4.957034e-03 3.440347e-02 16 789363 789546 184 + 0.988 0.495 -2.038
ENSG00000127586 E023 115.5766592 0.0023027552 1.999836e-01 4.296643e-01 16 789547 789548 2 + 2.005 2.016 0.039
ENSG00000127586 E024 189.5685301 0.0040110290 2.089307e-01 4.405965e-01 16 789549 789615 67 + 2.220 2.227 0.021
ENSG00000127586 E025 242.0224052 0.0015925978 2.937013e-01 5.343322e-01 16 789616 789715 100 + 2.339 2.327 -0.039
ENSG00000127586 E026 6.4639154 0.0047776263 2.531760e-01 4.914029e-01 16 790007 790081 75 + 0.959 0.778 -0.696
ENSG00000127586 E027 5.7811020 0.0051460556 9.655347e-01 9.846741e-01 16 790082 790176 95 + 0.807 0.778 -0.112
ENSG00000127586 E028 186.1486228 0.0002515671 2.528417e-01 4.910605e-01 16 790177 790250 74 + 2.225 2.217 -0.026
ENSG00000127586 E029 136.0596646 0.0010415511 4.476296e-01 6.640253e-01 16 790251 790269 19 + 2.094 2.081 -0.043
ENSG00000127586 E030 3.8344333 0.0076046812 9.605276e-03 5.640961e-02 16 790331 790346 16 + 0.904 0.494 -1.730
ENSG00000127586 E031 197.7007595 0.0011819794 6.764351e-01 8.204951e-01 16 790347 790399 53 + 2.266 2.237 -0.096
ENSG00000127586 E032 136.9452585 0.0004853163 2.518318e-01 4.898741e-01 16 790525 790530 6 + 2.144 2.064 -0.269
ENSG00000127586 E033 322.4159672 0.0031825546 5.428645e-01 7.311259e-01 16 790531 790666 136 + 2.502 2.436 -0.220
ENSG00000127586 E034 46.9863438 0.0294649894 1.260850e-05 2.564942e-04 16 790667 790671 5 + 1.913 1.456 -1.549
ENSG00000127586 E035 52.0464171 0.0800775982 1.795828e-03 1.567259e-02 16 790672 790698 27 + 1.956 1.496 -1.560
ENSG00000127586 E036 214.9801073 0.0563516225 9.048302e-05 1.374507e-03 16 790699 791136 438 + 2.563 2.107 -1.523
ENSG00000127586 E037 72.1745691 0.0784227506 9.186538e-04 9.250981e-03 16 791137 791160 24 + 2.094 1.635 -1.547
ENSG00000127586 E038 501.9630620 0.0011683028 3.138745e-03 2.423750e-02 16 791161 791370 210 + 2.727 2.613 -0.383
ENSG00000127586 E039 116.1040859 0.0790686625 4.943651e-03 3.432882e-02 16 791371 791457 87 + 2.251 1.883 -1.235
ENSG00000127586 E040 251.2899916 0.0962970951 1.037862e-02 5.976495e-02 16 791458 791850 393 + 2.569 2.228 -1.137
ENSG00000127586 E041 289.3228781 0.0021326725 5.459249e-01 7.333946e-01 16 791851 791948 98 + 2.452 2.388 -0.212
ENSG00000127586 E042 174.0949718 0.1170377275 3.661774e-02 1.458668e-01 16 791949 792223 275 + 2.377 2.093 -0.950
ENSG00000127586 E043 291.5895790 0.0005120324 1.856282e-01 4.113830e-01 16 792224 792347 124 + 2.417 2.407 -0.033
ENSG00000127586 E044 37.6247888 0.0338478260 1.277703e-01 3.283100e-01 16 792348 792367 20 + 1.656 1.478 -0.609
ENSG00000127586 E045 212.5091211 0.0072098457 4.181023e-02 1.594471e-01 16 792439 792523 85 + 2.235 2.285 0.169
ENSG00000127586 E046 183.9399914 0.0026407928 2.285391e-03 1.895726e-02 16 792524 792590 67 + 2.156 2.229 0.242
ENSG00000127586 E047 245.9540239 0.0045362587 7.880626e-02 2.424370e-01 16 792718 792811 94 + 2.317 2.343 0.087
ENSG00000127586 E048 1.8195955 0.0116006795 2.321648e-01 4.676977e-01 16 792812 792814 3 + 0.569 0.334 -1.226
ENSG00000127586 E049 144.5464408 0.0014533425 2.300597e-01 4.652152e-01 16 792966 792980 15 + 2.106 2.110 0.014
ENSG00000127586 E050 254.7879655 0.0014041611 3.447004e-02 1.401337e-01 16 792981 793064 84 + 2.336 2.360 0.081
ENSG00000127586 E051 320.3067423 0.0001962922 4.920725e-03 3.420145e-02 16 793144 793274 131 + 2.436 2.458 0.074
ENSG00000127586 E052 13.6206068 0.0081210935 4.556753e-03 3.224474e-02 16 793658 793802 145 + 1.323 1.002 -1.145
ENSG00000127586 E053 5.9997999 0.1986353944 4.009370e-01 6.290496e-01 16 794040 794053 14 + 0.925 0.742 -0.712
ENSG00000127586 E054 262.6457054 0.0046199422 3.657622e-02 1.457821e-01 16 794054 794141 88 + 2.338 2.375 0.122
ENSG00000127586 E055 230.6012241 0.0042268418 7.072740e-03 4.495875e-02 16 794142 794201 60 + 2.263 2.325 0.210
ENSG00000127586 E056 43.4230890 0.1678596278 7.013005e-03 4.470606e-02 16 794702 794844 143 + 1.886 1.410 -1.620
ENSG00000127586 E057 339.5683748 0.0043618468 1.064649e-02 6.088219e-02 16 795132 795356 225 + 2.441 2.488 0.157
ENSG00000127586 E058 348.4970596 0.0028561880 4.090120e-03 2.967853e-02 16 795685 795834 150 + 2.452 2.499 0.157
ENSG00000127586 E059 416.4521000 0.0017255098 1.247710e-01 3.233824e-01 16 795947 796077 131 + 2.569 2.563 -0.019
ENSG00000127586 E060 31.6951954 0.1145705662 8.129234e-03 4.991686e-02 16 796615 796716 102 + 1.729 1.304 -1.459
ENSG00000127586 E061 455.4215471 0.0016786441 1.070506e-01 2.940550e-01 16 796717 796861 145 + 2.607 2.604 -0.009
ENSG00000127586 E062 389.0526682 0.0013275694 1.645646e-02 8.348574e-02 16 796961 797092 132 + 2.523 2.541 0.060
ENSG00000127586 E063 310.4713842 0.0007297191 2.053140e-02 9.779280e-02 16 797694 797751 58 + 2.427 2.443 0.053
ENSG00000127586 E064 340.3262509 0.0056807317 8.871551e-01 9.451974e-01 16 797839 798040 202 + 2.510 2.466 -0.146
ENSG00000127586 E065 55.4255943 0.7168778199 6.261545e-01 7.880435e-01 16 798041 798186 146 + 1.732 1.682 -0.172
ENSG00000127586 E066 40.3348072 0.7271027515 9.264786e-01 9.653310e-01 16 800687 800815 129 + 1.667 1.516 -0.512