ENSG00000127511

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000248054 ENSG00000127511 HEK293_OSMI2_6hA HEK293_TMG_6hB SIN3B protein_coding protein_coding 36.70877 51.78398 26.44091 1.504438 0.7809902 -0.969467 12.269278 20.459194 8.654809 3.2576326 0.37714247 -1.2402144 0.33238333 0.39246667 0.32730000 -0.065166667 7.941072e-01 9.409557e-11 FALSE TRUE
ENST00000595049 ENSG00000127511 HEK293_OSMI2_6hA HEK293_TMG_6hB SIN3B protein_coding retained_intron 36.70877 51.78398 26.44091 1.504438 0.7809902 -0.969467 4.820905 7.510813 1.187899 0.3015846 0.03907126 -2.6503830 0.11757083 0.14496667 0.04506667 -0.099900000 9.409557e-11 9.409557e-11 FALSE TRUE
ENST00000595900 ENSG00000127511 HEK293_OSMI2_6hA HEK293_TMG_6hB SIN3B protein_coding processed_transcript 36.70877 51.78398 26.44091 1.504438 0.7809902 -0.969467 3.281059 4.895026 2.307220 0.5343727 0.40339128 -1.0818658 0.08887083 0.09513333 0.08816667 -0.006966667 9.592036e-01 9.409557e-11 FALSE TRUE
ENST00000596802 ENSG00000127511 HEK293_OSMI2_6hA HEK293_TMG_6hB SIN3B protein_coding protein_coding 36.70877 51.78398 26.44091 1.504438 0.7809902 -0.969467 8.630951 9.112602 7.494342 1.2417824 0.37587763 -0.2817198 0.24155417 0.17620000 0.28330000 0.107100000 1.392664e-01 9.409557e-11 FALSE TRUE
ENST00000602204 ENSG00000127511 HEK293_OSMI2_6hA HEK293_TMG_6hB SIN3B protein_coding retained_intron 36.70877 51.78398 26.44091 1.504438 0.7809902 -0.969467 1.992362 3.181766 1.984218 0.5755804 0.13365482 -0.6785314 0.05559167 0.06153333 0.07533333 0.013800000 8.389801e-01 9.409557e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000127511 E001 1.5489103 0.2790858445 3.287776e-01 5.677591e-01 19 16829387 16829397 11 + 0.175 0.434 1.794
ENSG00000127511 E002 1.5489103 0.2790858445 3.287776e-01 5.677591e-01 19 16829398 16829398 1 + 0.175 0.434 1.796
ENSG00000127511 E003 2.1560155 0.4148558428 4.641277e-01 6.759471e-01 19 16829399 16829401 3 + 0.296 0.524 1.265
ENSG00000127511 E004 5.0303582 0.0070276688 9.563323e-02 2.741598e-01 19 16829402 16829406 5 + 0.543 0.808 1.122
ENSG00000127511 E005 68.0716638 0.0033075062 2.881298e-05 5.210422e-04 19 16829407 16829540 134 + 1.612 1.860 0.837
ENSG00000127511 E006 143.8837577 0.0029877246 6.799373e-01 8.226455e-01 19 16829791 16829897 107 + 2.128 2.116 -0.041
ENSG00000127511 E007 248.4043890 0.0028595171 6.555188e-04 7.055978e-03 19 16831494 16831647 154 + 2.431 2.317 -0.378
ENSG00000127511 E008 316.0423163 0.0019603560 3.727690e-06 8.931256e-05 19 16841768 16841951 184 + 2.546 2.415 -0.437
ENSG00000127511 E009 156.3550401 0.0006620164 1.710923e-05 3.346626e-04 19 16841952 16841968 17 + 2.242 2.110 -0.441
ENSG00000127511 E010 277.2754421 0.0003010222 7.968076e-07 2.332637e-05 19 16846970 16847113 144 + 2.478 2.368 -0.368
ENSG00000127511 E011 216.5599470 0.0003480232 1.342041e-03 1.247861e-02 19 16851412 16851534 123 + 2.352 2.271 -0.270
ENSG00000127511 E012 150.4290158 0.0003134089 3.852874e-04 4.589370e-03 19 16853069 16853158 90 + 2.211 2.106 -0.353
ENSG00000127511 E013 166.1991167 0.0009802822 7.858650e-02 2.419471e-01 19 16854143 16854261 119 + 2.218 2.164 -0.179
ENSG00000127511 E014 254.7185624 0.0080271042 1.437975e-04 2.026062e-03 19 16854262 16855114 853 + 2.483 2.304 -0.597
ENSG00000127511 E015 124.3236391 0.0055180484 1.265524e-03 1.189762e-02 19 16855115 16855745 631 + 2.156 2.003 -0.515
ENSG00000127511 E016 171.2446717 0.0043554632 9.117719e-01 9.580402e-01 19 16862352 16862559 208 + 2.187 2.198 0.036
ENSG00000127511 E017 15.8837355 0.0093677043 6.784617e-03 4.363011e-02 19 16862884 16862979 96 + 1.352 1.096 -0.906
ENSG00000127511 E018 9.4340978 0.2382584261 3.698973e-01 6.038931e-01 19 16862980 16863096 117 + 1.101 0.924 -0.650
ENSG00000127511 E019 16.7407392 0.2410637956 2.457644e-01 4.833012e-01 19 16863097 16863273 177 + 1.333 1.148 -0.651
ENSG00000127511 E020 15.2148072 0.2975276314 3.013653e-01 5.418551e-01 19 16863274 16863362 89 + 1.239 1.140 -0.352
ENSG00000127511 E021 22.4328539 0.2627109774 1.739791e-01 3.958528e-01 19 16863363 16863679 317 + 1.465 1.261 -0.708
ENSG00000127511 E022 156.9846367 0.0004691147 9.686150e-01 9.861342e-01 19 16863680 16863796 117 + 2.158 2.161 0.011
ENSG00000127511 E023 0.9706349 0.0155802299 4.821480e-01   19 16865122 16865409 288 + 0.176 0.310 1.062
ENSG00000127511 E024 64.8915566 0.0005600003 5.651690e-01 7.468449e-01 19 16865410 16865413 4 + 1.755 1.787 0.108
ENSG00000127511 E025 250.3424615 0.0002125751 5.496175e-01 7.360321e-01 19 16865414 16865648 235 + 2.368 2.357 -0.035
ENSG00000127511 E026 212.4321316 0.0005737013 7.529662e-01 8.685090e-01 19 16866373 16866556 184 + 2.293 2.288 -0.017
ENSG00000127511 E027 183.0745772 0.0122245184 1.438646e-01 3.531995e-01 19 16869460 16869739 280 + 2.162 2.247 0.285
ENSG00000127511 E028 113.2777001 0.0135979357 3.060817e-01 5.467394e-01 19 16869740 16869881 142 + 1.969 2.035 0.221
ENSG00000127511 E029 106.4953638 0.0045855093 1.744208e-01 3.964251e-01 19 16869882 16869968 87 + 1.941 2.013 0.240
ENSG00000127511 E030 127.8627182 0.0022054149 7.821179e-02 2.412132e-01 19 16869969 16870075 107 + 2.016 2.094 0.261
ENSG00000127511 E031 162.9786564 0.0016929439 1.043002e-01 2.893643e-01 19 16871229 16871398 170 + 2.130 2.194 0.214
ENSG00000127511 E032 27.0678459 0.0235504132 1.232701e-01 3.209276e-01 19 16871399 16871638 240 + 1.506 1.360 -0.504
ENSG00000127511 E033 34.4470506 0.0567678972 7.651382e-01 8.757390e-01 19 16872468 16872666 199 + 1.523 1.498 -0.084
ENSG00000127511 E034 35.6558284 0.0482704840 2.035719e-01 4.340224e-01 19 16875931 16876054 124 + 1.390 1.565 0.602
ENSG00000127511 E035 202.3085075 0.0004053969 1.001379e-02 5.821882e-02 19 16876055 16876228 174 + 2.213 2.291 0.262
ENSG00000127511 E036 145.2067791 0.0026951978 1.037212e-01 2.884083e-01 19 16876486 16876578 93 + 2.075 2.147 0.240
ENSG00000127511 E037 12.1670935 0.0833217386 3.850239e-01 6.165225e-01 19 16876939 16877161 223 + 1.158 1.042 -0.421
ENSG00000127511 E038 12.4962751 0.0401555919 5.864618e-01 7.612375e-01 19 16877162 16877335 174 + 1.145 1.067 -0.279
ENSG00000127511 E039 10.2807844 0.0288350568 5.241117e-02 1.852675e-01 19 16877336 16877544 209 + 1.175 0.937 -0.867
ENSG00000127511 E040 123.6366479 0.0012721625 3.677096e-03 2.735241e-02 19 16877545 16877639 95 + 1.970 2.089 0.400
ENSG00000127511 E041 221.5126280 0.0004665212 4.387122e-05 7.445131e-04 19 16878183 16878390 208 + 2.219 2.340 0.401
ENSG00000127511 E042 1089.3226158 0.0011276311 2.930995e-16 5.228471e-14 19 16878497 16880353 1857 + 2.885 3.035 0.499