ENSG00000127483

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312239 ENSG00000127483 HEK293_OSMI2_6hA HEK293_TMG_6hB HP1BP3 protein_coding protein_coding 59.61643 45.46406 70.54508 0.6604046 1.689768 0.6337063 17.015770 15.688397 12.924279 4.39354582 2.0376683 -0.2794176 0.32775000 0.34253333 0.18256667 -0.15996667 0.575079573 0.001296001 FALSE TRUE
ENST00000375003 ENSG00000127483 HEK293_OSMI2_6hA HEK293_TMG_6hB HP1BP3 protein_coding protein_coding 59.61643 45.46406 70.54508 0.6604046 1.689768 0.6337063 7.527612 6.435506 10.935623 1.70354276 0.9936507 0.7639886 0.13160417 0.14260000 0.15560000 0.01300000 0.938324886 0.001296001 FALSE TRUE
ENST00000424732 ENSG00000127483 HEK293_OSMI2_6hA HEK293_TMG_6hB HP1BP3 protein_coding protein_coding 59.61643 45.46406 70.54508 0.6604046 1.689768 0.6337063 8.621472 3.598397 10.588850 0.06195901 0.9348287 1.5544777 0.12358750 0.07916667 0.14970000 0.07053333 0.001296001 0.001296001 FALSE TRUE
ENST00000487117 ENSG00000127483 HEK293_OSMI2_6hA HEK293_TMG_6hB HP1BP3 protein_coding processed_transcript 59.61643 45.46406 70.54508 0.6604046 1.689768 0.6337063 4.592981 3.496564 8.541520 1.03797838 0.3972559 1.2861228 0.07425000 0.07760000 0.12126667 0.04366667 0.555338172 0.001296001 FALSE TRUE
ENST00000488722 ENSG00000127483 HEK293_OSMI2_6hA HEK293_TMG_6hB HP1BP3 protein_coding processed_transcript 59.61643 45.46406 70.54508 0.6604046 1.689768 0.6337063 4.932211 2.275468 7.133513 1.16130793 1.3701803 1.6441439 0.06569167 0.05066667 0.10033333 0.04966667 0.794107224 0.001296001 TRUE TRUE
MSTRG.478.3 ENSG00000127483 HEK293_OSMI2_6hA HEK293_TMG_6hB HP1BP3 protein_coding   59.61643 45.46406 70.54508 0.6604046 1.689768 0.6337063 4.849980 5.127874 5.840015 0.49635815 1.1034468 0.1872690 0.08409167 0.11270000 0.08353333 -0.02916667 0.710303456 0.001296001 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000127483 E001 9.9857814 0.0098714683 4.831254e-01 6.892469e-01 1 20740266 20742678 2413 - 0.985 1.073 0.320
ENSG00000127483 E002 4.1893039 0.0197177051 8.419561e-03 5.124306e-02 1 20742679 20742681 3 - 0.455 0.871 1.796
ENSG00000127483 E003 26.6547179 0.0162977403 1.572550e-02 8.081806e-02 1 20742682 20742730 49 - 1.322 1.547 0.777
ENSG00000127483 E004 203.4164005 0.0098824778 4.841012e-03 3.375273e-02 1 20742731 20742941 211 - 2.224 2.387 0.544
ENSG00000127483 E005 107.9712433 0.0065082571 2.764980e-03 2.196245e-02 1 20742942 20742943 2 - 1.950 2.118 0.563
ENSG00000127483 E006 155.6830929 0.0068983520 1.771288e-04 2.415720e-03 1 20742944 20742988 45 - 2.089 2.287 0.662
ENSG00000127483 E007 109.3124564 0.0014955592 3.985413e-08 1.626568e-06 1 20742989 20742989 1 - 1.921 2.144 0.747
ENSG00000127483 E008 230.2376602 0.0036698895 3.635308e-11 2.818991e-09 1 20742990 20743134 145 - 2.218 2.478 0.867
ENSG00000127483 E009 114.6155125 0.0045427189 1.782196e-08 7.910557e-07 1 20743135 20743174 40 - 1.908 2.182 0.919
ENSG00000127483 E010 1260.0804432 0.0014464324 1.126026e-10 7.898603e-09 1 20743175 20744625 1451 - 3.032 3.163 0.434
ENSG00000127483 E011 227.8179544 0.0004244172 1.449491e-01 3.548719e-01 1 20744626 20744743 118 - 2.334 2.381 0.158
ENSG00000127483 E012 483.1978281 0.0001303125 5.153240e-03 3.542203e-02 1 20744744 20745091 348 - 2.655 2.712 0.190
ENSG00000127483 E013 208.1493159 0.0002840551 5.262056e-02 1.857918e-01 1 20745543 20745591 49 - 2.288 2.348 0.201
ENSG00000127483 E014 237.0240734 0.0002097953 5.721512e-01 7.517928e-01 1 20745592 20745656 65 - 2.363 2.388 0.082
ENSG00000127483 E015 226.4683257 0.0002005995 7.490201e-01 8.661603e-01 1 20747544 20747614 71 - 2.347 2.366 0.063
ENSG00000127483 E016 179.9504208 0.0003107368 3.908665e-01 6.210354e-01 1 20747615 20747655 41 - 2.241 2.276 0.116
ENSG00000127483 E017 310.7327127 0.0002535507 7.618566e-01 8.737554e-01 1 20749723 20749882 160 - 2.487 2.505 0.060
ENSG00000127483 E018 22.7492129 0.0203040151 7.925330e-01 8.918987e-01 1 20749883 20749975 93 - 1.356 1.396 0.141
ENSG00000127483 E019 3.2778014 0.1023322198 4.797594e-01 6.869234e-01 1 20749976 20750251 276 - 0.542 0.705 0.713
ENSG00000127483 E020 20.6449739 0.6710171506 7.809200e-01 8.852496e-01 1 20755045 20755238 194 - 1.350 1.319 -0.108
ENSG00000127483 E021 18.6292465 0.6128195731 8.584017e-01 9.295309e-01 1 20755239 20755404 166 - 1.335 1.242 -0.326
ENSG00000127483 E022 198.4932302 0.0002828998 4.172740e-01 6.415964e-01 1 20757166 20757198 33 - 2.306 2.297 -0.030
ENSG00000127483 E023 240.9143908 0.0002633562 8.929670e-02 2.624502e-01 1 20757199 20757256 58 - 2.398 2.370 -0.094
ENSG00000127483 E024 336.1054927 0.0001693839 4.422488e-03 3.149940e-02 1 20765377 20765526 150 - 2.547 2.503 -0.149
ENSG00000127483 E025 129.8700365 0.0002970123 2.141470e-01 4.465398e-01 1 20765527 20765531 5 - 2.129 2.102 -0.092
ENSG00000127483 E026 242.5996129 0.0002149972 2.074511e-03 1.756493e-02 1 20767584 20767664 81 - 2.414 2.354 -0.200
ENSG00000127483 E027 337.1509853 0.0006445552 3.312841e-05 5.875683e-04 1 20770930 20771073 144 - 2.564 2.482 -0.275
ENSG00000127483 E028 337.1784385 0.0001504034 2.522722e-06 6.391410e-05 1 20773451 20773586 136 - 2.565 2.484 -0.269
ENSG00000127483 E029 151.0723469 0.0005461078 3.069823e-02 1.294522e-01 1 20773587 20773610 24 - 2.209 2.156 -0.179
ENSG00000127483 E030 291.7390438 0.0805078337 2.237913e-01 4.579747e-01 1 20773611 20775005 1395 - 2.519 2.401 -0.394
ENSG00000127483 E031 40.3938435 0.1062320498 1.481786e-01 3.597189e-01 1 20775450 20775654 205 - 1.694 1.511 -0.623
ENSG00000127483 E032 28.7257511 0.0702892630 1.800168e-01 4.040362e-01 1 20775655 20775723 69 - 1.539 1.383 -0.534
ENSG00000127483 E033 98.1081197 0.0241966983 4.071744e-03 2.957553e-02 1 20775724 20776005 282 - 2.091 1.866 -0.754
ENSG00000127483 E034 108.3674673 0.0501925459 2.396132e-02 1.089784e-01 1 20776006 20776596 591 - 2.133 1.907 -0.758
ENSG00000127483 E035 303.7173197 0.0009369260 6.198275e-06 1.386472e-04 1 20776597 20776697 101 - 2.530 2.431 -0.333
ENSG00000127483 E036 197.8094187 0.0003387727 3.198800e-07 1.043669e-05 1 20776698 20776712 15 - 2.355 2.233 -0.408
ENSG00000127483 E037 164.0467642 0.0004142524 2.524924e-05 4.651802e-04 1 20776713 20776719 7 - 2.268 2.158 -0.367
ENSG00000127483 E038 217.6086155 0.0002532606 2.459556e-08 1.057441e-06 1 20776720 20776750 31 - 2.397 2.270 -0.421
ENSG00000127483 E039 183.4763016 0.0008518220 4.238194e-06 9.979796e-05 1 20779812 20779835 24 - 2.323 2.201 -0.410
ENSG00000127483 E040 237.4655753 0.0002847934 1.726000e-05 3.370681e-04 1 20779836 20779911 76 - 2.421 2.330 -0.302
ENSG00000127483 E041 85.6765391 0.0005825491 6.344858e-02 2.104703e-01 1 20780345 20780349 5 - 1.968 1.908 -0.204
ENSG00000127483 E042 190.0266872 0.0003115477 4.831236e-05 8.076905e-04 1 20780350 20780540 191 - 2.327 2.231 -0.320
ENSG00000127483 E043 0.6434498 0.0195815826 4.326553e-02   1 20780541 20780541 1 - 0.349 0.000 -10.940
ENSG00000127483 E044 34.4523190 0.0014212338 5.366339e-01 7.267856e-01 1 20786186 20786252 67 - 1.524 1.573 0.166
ENSG00000127483 E045 62.2635078 0.0005971694 5.108744e-05 8.475794e-04 1 20786253 20786513 261 - 1.694 1.890 0.659
ENSG00000127483 E046 21.0696560 0.0032158846 3.798869e-07 1.214487e-05 1 20786514 20786648 135 - 1.083 1.506 1.483
ENSG00000127483 E047 23.8438548 0.0105551971 4.191894e-02 1.597218e-01 1 20786649 20786802 154 - 1.467 1.305 -0.561
ENSG00000127483 E048 41.2419643 0.0009977847 4.233156e-01 6.461026e-01 1 20787195 20787323 129 - 1.643 1.610 -0.111