ENSG00000127419

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264771 ENSG00000127419 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM175 protein_coding protein_coding 28.2346 41.97219 16.15218 1.495636 1.012633 -1.377156 5.710486 10.298361 1.1507879 0.7371039 0.6040212 -3.1506386 0.18971667 0.24690000 0.07233333 -0.174566667 0.54493445 3.965865e-08 FALSE TRUE
ENST00000452360 ENSG00000127419 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM175 protein_coding retained_intron 28.2346 41.97219 16.15218 1.495636 1.012633 -1.377156 1.661809 2.329695 1.2737608 0.3490065 0.1011729 -0.8659442 0.05922917 0.05516667 0.08033333 0.025166667 0.63055317 3.965865e-08 FALSE TRUE
ENST00000506669 ENSG00000127419 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM175 protein_coding retained_intron 28.2346 41.97219 16.15218 1.495636 1.012633 -1.377156 1.981489 4.023623 0.2506043 1.6412719 0.2506043 -3.9521435 0.06423333 0.09423333 0.01770000 -0.076533333 0.33473958 3.965865e-08   FALSE
ENST00000508204 ENSG00000127419 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM175 protein_coding protein_coding 28.2346 41.97219 16.15218 1.495636 1.012633 -1.377156 2.141197 2.664299 1.1103971 1.3372431 0.7423696 -1.2551509 0.07480417 0.06583333 0.06523333 -0.000600000 1.00000000 3.965865e-08 FALSE TRUE
ENST00000515876 ENSG00000127419 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM175 protein_coding retained_intron 28.2346 41.97219 16.15218 1.495636 1.012633 -1.377156 3.417648 3.176021 3.6070644 1.0495408 0.1987369 0.1830635 0.13540417 0.07416667 0.22406667 0.149900000 0.01045564 3.965865e-08 FALSE TRUE
MSTRG.24429.1 ENSG00000127419 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM175 protein_coding   28.2346 41.97219 16.15218 1.495636 1.012633 -1.377156 2.711492 4.919108 2.0894906 1.2265454 0.3788888 -1.2312874 0.09654167 0.11950000 0.12730000 0.007800000 0.96044145 3.965865e-08 FALSE TRUE
MSTRG.24429.16 ENSG00000127419 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM175 protein_coding   28.2346 41.97219 16.15218 1.495636 1.012633 -1.377156 2.920087 3.564876 1.3807688 0.8692641 0.7266671 -1.3620106 0.10079583 0.08370000 0.08813333 0.004433333 0.95134953 3.965865e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000127419 E001 1.1849480 0.0182475695 5.447157e-01   4 932387 932403 17 + 0.199 0.317 0.891
ENSG00000127419 E002 2.8631964 0.0081356192 4.795232e-01 6.868259e-01 4 932404 932425 22 + 0.438 0.566 0.624
ENSG00000127419 E003 3.7442817 0.0066568348 2.098750e-01 4.416829e-01 4 932426 932431 6 + 0.438 0.661 1.040
ENSG00000127419 E004 5.2077219 0.0052035442 2.735414e-01 5.133927e-01 4 932432 932443 12 + 0.592 0.766 0.736
ENSG00000127419 E005 5.6418325 0.0048051447 1.778459e-01 4.008940e-01 4 932444 932445 2 + 0.592 0.804 0.887
ENSG00000127419 E006 8.9908350 0.0032625061 8.077749e-01 9.008834e-01 4 932446 932459 14 + 0.961 0.930 -0.113
ENSG00000127419 E007 9.4670721 0.0032403599 7.476582e-01 8.653107e-01 4 932460 932460 1 + 0.987 0.948 -0.145
ENSG00000127419 E008 9.4670721 0.0032403599 7.476582e-01 8.653107e-01 4 932461 932461 1 + 0.987 0.948 -0.145
ENSG00000127419 E009 11.7331649 0.0027776919 2.113447e-01 4.433747e-01 4 932462 932464 3 + 1.139 1.006 -0.485
ENSG00000127419 E010 17.2464441 0.0021164124 6.471543e-01 8.015701e-01 4 932465 932471 7 + 1.157 1.201 0.154
ENSG00000127419 E011 20.0390596 0.0018411605 5.229098e-01 7.169826e-01 4 932472 932473 2 + 1.207 1.264 0.203
ENSG00000127419 E012 25.9687227 0.0017265309 4.447963e-01 6.619924e-01 4 932474 932474 1 + 1.405 1.345 -0.208
ENSG00000127419 E013 36.0785158 0.0011397852 7.162570e-01 8.457763e-01 4 932475 932477 3 + 1.478 1.502 0.084
ENSG00000127419 E014 42.4817527 0.0015560846 6.081157e-01 7.756417e-01 4 932478 932479 2 + 1.589 1.556 -0.113
ENSG00000127419 E015 46.8721203 0.0009261634 9.023476e-01 9.530537e-01 4 932480 932481 2 + 1.601 1.608 0.024
ENSG00000127419 E016 51.5862292 0.0008318622 4.525382e-01 6.675473e-01 4 932482 932486 5 + 1.614 1.657 0.147
ENSG00000127419 E017 81.3647044 0.0005897118 4.603665e-01 6.733979e-01 4 932487 932516 30 + 1.816 1.850 0.114
ENSG00000127419 E018 87.9086975 0.0004757138 3.886771e-01 6.194082e-01 4 932517 932540 24 + 1.846 1.884 0.128
ENSG00000127419 E019 0.1723744 0.0323683906 1.000000e+00   4 945999 946126 128 + 0.001 0.072 6.725
ENSG00000127419 E020 131.7041573 0.0003764037 2.956716e-01 5.361707e-01 4 947709 947892 184 + 2.021 2.059 0.126
ENSG00000127419 E021 32.3039239 0.0724394282 1.818809e-01 4.064513e-01 4 947893 948115 223 + 1.563 1.409 -0.529
ENSG00000127419 E022 90.2006056 0.0004797412 2.650449e-01 5.043851e-01 4 948116 948154 39 + 1.925 1.877 -0.161
ENSG00000127419 E023 32.9538739 0.0917648221 6.255155e-02 2.085048e-01 4 948155 948410 256 + 1.630 1.391 -0.823
ENSG00000127419 E024 19.4997000 0.0829420458 1.442602e-01 3.537668e-01 4 948411 948510 100 + 1.377 1.191 -0.652
ENSG00000127419 E025 20.8199247 0.0403981916 4.330892e-01 6.535205e-01 4 948511 948615 105 + 1.332 1.243 -0.313
ENSG00000127419 E026 77.0601870 0.0007115925 5.428090e-01 7.310815e-01 4 950421 950423 3 + 1.839 1.809 -0.099
ENSG00000127419 E027 101.7407716 0.0004168925 3.991964e-01 6.275711e-01 4 950424 950450 27 + 1.965 1.930 -0.116
ENSG00000127419 E028 137.3149025 0.0003759602 8.190794e-02 2.485936e-01 4 950451 950518 68 + 2.116 2.056 -0.200
ENSG00000127419 E029 131.0519037 0.0003823394 8.064899e-02 2.461386e-01 4 951207 951258 52 + 2.096 2.034 -0.206
ENSG00000127419 E030 0.8259751 0.0949285477 8.856566e-01   4 951259 951259 1 + 0.200 0.235 0.299
ENSG00000127419 E031 18.0123528 0.0020444254 3.484516e-01 5.859036e-01 4 951646 951681 36 + 1.279 1.195 -0.296
ENSG00000127419 E032 118.1021259 0.0004257599 2.296170e-01 4.646789e-01 4 951682 951717 36 + 2.040 1.995 -0.150
ENSG00000127419 E033 7.5555230 0.0121310363 4.406067e-04 5.132492e-03 4 951718 951973 256 + 1.157 0.724 -1.636
ENSG00000127419 E034 86.3173019 0.0007491604 4.424080e-01 6.603264e-01 4 952367 952410 44 + 1.897 1.863 -0.114
ENSG00000127419 E035 77.9692718 0.0033911881 9.734060e-01 9.886348e-01 4 952411 952450 40 + 1.827 1.828 0.001
ENSG00000127419 E036 203.1574443 0.0002960406 6.204400e-01 7.841041e-01 4 953190 953354 165 + 2.226 2.240 0.047
ENSG00000127419 E037 148.4442895 0.0006336252 8.744455e-02 2.590334e-01 4 955405 955483 79 + 2.051 2.111 0.201
ENSG00000127419 E038 4.3788093 0.0080958791 2.197612e-01 4.531772e-01 4 955484 955491 8 + 0.795 0.608 -0.777
ENSG00000127419 E039 200.3332149 0.0070843276 4.901824e-01 6.941301e-01 4 955755 955890 136 + 2.207 2.236 0.096
ENSG00000127419 E040 12.1938870 0.0599098522 2.389534e-02 1.087573e-01 4 955891 955944 54 + 1.269 0.948 -1.161
ENSG00000127419 E041 48.8001800 0.0107563353 7.199322e-04 7.610720e-03 4 956297 956892 596 + 1.796 1.558 -0.809
ENSG00000127419 E042 400.0375637 0.0016701196 2.846226e-07 9.409280e-06 4 957824 958656 833 + 2.421 2.559 0.457