ENSG00000127314

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000250559 ENSG00000127314 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1B protein_coding protein_coding 62.89587 20.94043 103.9374 5.603858 7.566869 2.310802 2.498217 1.207167 3.179025 0.2677288 1.518738 1.389589 0.05556667 0.05980000 0.02863333 -0.03116667 6.677422e-01 1.483807e-07 FALSE TRUE
ENST00000341355 ENSG00000127314 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1B protein_coding protein_coding 62.89587 20.94043 103.9374 5.603858 7.566869 2.310802 39.074829 15.471378 59.236723 4.0773879 8.555714 1.936201 0.66466250 0.74293333 0.56363333 -0.17930000 3.322108e-01 1.483807e-07 FALSE TRUE
ENST00000535492 ENSG00000127314 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1B protein_coding protein_coding 62.89587 20.94043 103.9374 5.603858 7.566869 2.310802 5.074307 1.219253 6.944616 1.0241888 2.087548 2.500189 0.06531250 0.05106667 0.06450000 0.01343333 8.598585e-01 1.483807e-07 FALSE TRUE
ENST00000540781 ENSG00000127314 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1B protein_coding protein_coding 62.89587 20.94043 103.9374 5.603858 7.566869 2.310802 3.685385 0.000000 13.243763 0.0000000 4.447958 10.372186 0.04165417 0.00000000 0.13503333 0.13503333 1.483807e-07 1.483807e-07 FALSE FALSE
ENST00000541216 ENSG00000127314 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1B protein_coding protein_coding 62.89587 20.94043 103.9374 5.603858 7.566869 2.310802 1.852934 0.000000 6.483760 0.0000000 1.828754 9.342910 0.01832083 0.00000000 0.06583333 0.06583333 3.347687e-07 1.483807e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000127314 E001 0.8192208 0.0833061612 0.2905526896   12 68610855 68610857 3 + 0.267 0.000 -10.976
ENSG00000127314 E002 6.4523301 0.0586249390 0.6327045844 0.792135590 12 68610858 68610898 41 + 0.777 0.854 0.305
ENSG00000127314 E003 10.2235995 0.0173932746 0.7986811302 0.895550384 12 68610899 68610907 9 + 0.978 0.953 -0.095
ENSG00000127314 E004 13.6974535 0.0199039568 0.7462930288 0.864560965 12 68610908 68610912 5 + 1.076 1.123 0.168
ENSG00000127314 E005 20.4880360 0.0214989306 0.8985574744 0.951113669 12 68610913 68610917 5 + 1.253 1.244 -0.034
ENSG00000127314 E006 22.2481520 0.0198403117 0.8857336353 0.944395408 12 68610918 68610918 1 + 1.281 1.301 0.068
ENSG00000127314 E007 45.6996374 0.0189013944 0.7499232439 0.866744355 12 68610919 68610924 6 + 1.584 1.599 0.054
ENSG00000127314 E008 54.8466310 0.0191873185 0.4255978135 0.647714800 12 68610925 68610928 4 + 1.653 1.705 0.177
ENSG00000127314 E009 62.9927007 0.0227926603 0.3093505267 0.549843890 12 68610929 68610932 4 + 1.709 1.780 0.241
ENSG00000127314 E010 74.7871680 0.0100382850 0.3595186252 0.595447866 12 68610933 68610937 5 + 1.786 1.842 0.188
ENSG00000127314 E011 76.3279816 0.0105551863 0.3406543277 0.578601975 12 68610938 68610938 1 + 1.794 1.852 0.196
ENSG00000127314 E012 102.5484841 0.0016086673 0.0164524408 0.083477827 12 68610939 68610960 22 + 1.909 2.020 0.372
ENSG00000127314 E013 145.9306457 0.0003280423 0.0670826340 0.218592642 12 68610961 68611024 64 + 2.072 2.142 0.234
ENSG00000127314 E014 105.5366926 0.0005616008 0.9999951046 1.000000000 12 68611025 68611028 4 + 1.947 1.955 0.025
ENSG00000127314 E015 115.5039262 0.0003778886 0.9606008644 0.982179278 12 68611029 68611035 7 + 1.986 1.992 0.019
ENSG00000127314 E016 123.7102677 0.0003132284 0.8140152599 0.904659717 12 68611036 68611043 8 + 2.012 2.029 0.055
ENSG00000127314 E017 38.1948860 0.0009786509 0.5113224315 0.708975069 12 68611044 68611052 9 + 1.523 1.485 -0.130
ENSG00000127314 E018 0.3088520 0.0253652966 0.3479354400   12 68611053 68611056 4 + 0.068 0.208 1.859
ENSG00000127314 E019 0.1614157 0.0359924891 1.0000000000   12 68621446 68621491 46 + 0.068 0.000 -10.994
ENSG00000127314 E020 0.5421338 0.0217502897 0.6270508134   12 68624508 68624670 163 + 0.127 0.209 0.864
ENSG00000127314 E021 2.0803586 0.0619263629 0.8877577969 0.945454119 12 68624671 68624674 4 + 0.430 0.455 0.132
ENSG00000127314 E022 6.4831896 0.0047925647 0.9816282476 0.992608186 12 68624675 68624753 79 + 0.807 0.815 0.034
ENSG00000127314 E023 7.6287423 0.0319123446 0.6896307330 0.828787692 12 68624754 68624873 120 + 0.859 0.921 0.235
ENSG00000127314 E024 0.1723744 0.1066471684 0.1219026914   12 68641034 68641037 4 + 0.000 0.209 11.869
ENSG00000127314 E025 1.7489691 0.5750847097 0.6891589401 0.828535489 12 68641038 68641056 19 + 0.428 0.210 -1.431
ENSG00000127314 E026 2.5979296 0.2057862246 0.5467491996 0.733996754 12 68641057 68641153 97 + 0.529 0.351 -0.938
ENSG00000127314 E027 0.4873834 0.6332344215 0.2058460643   12 68647993 68648095 103 + 0.067 0.354 2.924
ENSG00000127314 E028 0.4764247 0.0217681645 0.6223808250   12 68648670 68648698 29 + 0.126 0.208 0.865
ENSG00000127314 E029 125.3215242 0.0003166720 0.5826029180 0.758768769 12 68648699 68648705 7 + 2.024 2.011 -0.045
ENSG00000127314 E030 246.4080117 0.0001925087 0.8091523245 0.901679927 12 68648706 68648781 76 + 2.310 2.324 0.046
ENSG00000127314 E031 5.2717173 0.1454672991 0.1921543967 0.419577701 12 68648782 68650041 1260 + 0.658 0.923 1.055
ENSG00000127314 E032 0.7912460 0.0231929883 0.0688957945   12 68650244 68650399 156 + 0.126 0.454 2.452
ENSG00000127314 E033 304.8873358 0.0002052558 0.1903483528 0.417395009 12 68650400 68650468 69 + 2.409 2.384 -0.082
ENSG00000127314 E034 0.7804750 0.0324836453 1.0000000000   12 68650469 68650882 414 + 0.224 0.208 -0.133
ENSG00000127314 E035 0.4654660 0.0317928324 0.5761296303   12 68651682 68651994 313 + 0.178 0.000 -12.617
ENSG00000127314 E036 227.5994133 0.0002588929 0.3088197838 0.549334478 12 68651995 68651998 4 + 2.281 2.260 -0.072
ENSG00000127314 E037 265.6980922 0.0002339361 0.5285499946 0.720998430 12 68651999 68652018 20 + 2.346 2.336 -0.031
ENSG00000127314 E038 316.7897293 0.0002516268 0.0605968395 0.204185343 12 68652019 68652051 33 + 2.428 2.390 -0.128
ENSG00000127314 E039 286.6634173 0.0002741888 0.0818311738 0.248450235 12 68654112 68654124 13 + 2.385 2.348 -0.123
ENSG00000127314 E040 398.3457502 0.0004317424 0.0208644199 0.098901870 12 68654125 68654252 128 + 2.530 2.485 -0.150
ENSG00000127314 E041 240.7704618 0.0019493673 0.0984500130 0.279069763 12 68656306 68656449 144 + 2.314 2.266 -0.158
ENSG00000127314 E042 0.8461841 0.0172671820 1.0000000000   12 68656450 68656637 188 + 0.224 0.208 -0.135
ENSG00000127314 E043 181.8525534 0.0054300316 0.4205337391 0.644059702 12 68657101 68657217 117 + 2.189 2.163 -0.087
ENSG00000127314 E044 1.6072579 0.4358120568 0.7173742161 0.846506261 12 68657218 68657713 496 + 0.337 0.461 0.691
ENSG00000127314 E045 415.6418570 0.0027695816 0.0009005802 0.009099734 12 68659280 68671901 12622 + 2.515 2.619 0.346