ENSG00000126858

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333942 ENSG00000126858 HEK293_OSMI2_6hA HEK293_TMG_6hB RHOT1 protein_coding protein_coding 8.811067 3.791167 16.81476 0.7489533 0.6971579 2.146072 2.9576032 1.49152713 6.482192 0.37947570 0.7732696 2.112275 0.29812083 0.40233333 0.38760000 -0.014733333 0.9997367 0.0292402 FALSE TRUE
ENST00000354266 ENSG00000126858 HEK293_OSMI2_6hA HEK293_TMG_6hB RHOT1 protein_coding protein_coding 8.811067 3.791167 16.81476 0.7489533 0.6971579 2.146072 0.4501115 0.08249438 0.861795 0.08249438 0.4352319 3.236551 0.07182083 0.01783333 0.05256667 0.034733333 0.8366058 0.0292402 FALSE TRUE
ENST00000358365 ENSG00000126858 HEK293_OSMI2_6hA HEK293_TMG_6hB RHOT1 protein_coding protein_coding 8.811067 3.791167 16.81476 0.7489533 0.6971579 2.146072 0.5577639 0.11820398 0.466504 0.06463167 0.2434570 1.894047 0.06787083 0.02590000 0.02863333 0.002733333 0.9882125 0.0292402 FALSE TRUE
ENST00000394692 ENSG00000126858 HEK293_OSMI2_6hA HEK293_TMG_6hB RHOT1 protein_coding protein_coding 8.811067 3.791167 16.81476 0.7489533 0.6971579 2.146072 2.7905839 0.75937346 6.356704 0.24528854 0.6005995 3.048791 0.30984583 0.20706667 0.37660000 0.169533333 0.2879105 0.0292402 FALSE TRUE
ENST00000545287 ENSG00000126858 HEK293_OSMI2_6hA HEK293_TMG_6hB RHOT1 protein_coding protein_coding 8.811067 3.791167 16.81476 0.7489533 0.6971579 2.146072 1.0875851 0.90892859 1.268728 0.29088826 0.2832823 0.476685 0.12888333 0.23093333 0.07443333 -0.156500000 0.0292402 0.0292402 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000126858 E001 0.0000000       17 32142454 32142465 12 +      
ENSG00000126858 E002 0.0000000       17 32142466 32142474 9 +      
ENSG00000126858 E003 1.3945947 0.0149275778 0.0390231159 0.152250380 17 32142475 32142501 27 + 0.227 0.605 2.141
ENSG00000126858 E004 7.1562800 0.2524526645 0.1200962813 0.316011167 17 32142502 32142559 58 + 0.740 1.092 1.338
ENSG00000126858 E005 7.5191447 0.3300494224 0.1643391716 0.383170450 17 32142560 32142567 8 + 0.751 1.123 1.404
ENSG00000126858 E006 13.5963163 0.4267383849 0.1197681957 0.315500866 17 32142568 32142629 62 + 0.966 1.367 1.435
ENSG00000126858 E007 14.6488661 0.4401060134 0.0921056150 0.267611548 17 32142630 32142672 43 + 0.981 1.417 1.551
ENSG00000126858 E008 13.1657173 0.4341395566 0.1311876219 0.333677948 17 32142673 32142676 4 + 0.965 1.337 1.333
ENSG00000126858 E009 13.8142266 0.4870050161 0.1826054622 0.407433879 17 32142677 32142679 3 + 1.001 1.330 1.176
ENSG00000126858 E010 23.5270138 0.1055697363 0.1074500248 0.294791275 17 32142680 32142729 50 + 1.249 1.494 0.849
ENSG00000126858 E011 17.1488598 0.0394363089 0.2514097245 0.489477376 17 32171043 32171046 4 + 1.150 1.296 0.517
ENSG00000126858 E012 34.1019723 0.0012877905 0.7932758491 0.892315793 17 32171047 32171101 55 + 1.464 1.504 0.136
ENSG00000126858 E013 1.2910658 0.0131422092 0.0021882900   17 32172937 32173060 124 + 0.128 0.666 3.405
ENSG00000126858 E014 52.4406033 0.0011757063 0.7802415567 0.884934162 17 32173831 32173912 82 + 1.646 1.684 0.129
ENSG00000126858 E015 50.6036939 0.0007296162 0.3686909323 0.602963164 17 32175319 32175362 44 + 1.644 1.613 -0.106
ENSG00000126858 E016 53.4329527 0.0006879239 0.1266904387 0.326544398 17 32175962 32176015 54 + 1.674 1.607 -0.228
ENSG00000126858 E017 53.2485687 0.0012868030 0.0258951284 0.114957609 17 32176161 32176213 53 + 1.680 1.566 -0.390
ENSG00000126858 E018 60.5365247 0.0033800104 0.2850312858 0.525641219 17 32182757 32182865 109 + 1.723 1.678 -0.151
ENSG00000126858 E019 52.3035922 0.0009574142 0.2720257429 0.511892247 17 32183171 32183272 102 + 1.662 1.619 -0.146
ENSG00000126858 E020 60.8472085 0.0005946105 0.1314015808 0.334004731 17 32192201 32192299 99 + 1.727 1.667 -0.203
ENSG00000126858 E021 62.6442067 0.0026356369 0.0322150028 0.133859761 17 32193136 32193244 109 + 1.748 1.644 -0.352
ENSG00000126858 E022 77.5426855 0.0060630605 0.0759868338 0.236750304 17 32193987 32194107 121 + 1.837 1.749 -0.297
ENSG00000126858 E023 72.5816163 0.0033722841 0.0455870790 0.168989228 17 32198947 32199031 85 + 1.809 1.716 -0.314
ENSG00000126858 E024 91.6180396 0.0018321715 0.7948125968 0.893217313 17 32199405 32199550 146 + 1.887 1.896 0.029
ENSG00000126858 E025 83.2282559 0.0004926375 0.2307825053 0.466052006 17 32200956 32201056 101 + 1.856 1.823 -0.111
ENSG00000126858 E026 60.9413519 0.0005871604 0.4376972105 0.657008843 17 32202770 32202823 54 + 1.701 1.763 0.210
ENSG00000126858 E027 63.9645256 0.0028957965 0.9024499194 0.953078726 17 32202824 32202900 77 + 1.729 1.758 0.098
ENSG00000126858 E028 0.1723744 0.0495087271 0.1318210526   17 32202901 32202906 6 + 0.000 0.206 11.575
ENSG00000126858 E029 0.2922838 0.0257602873 0.3750609764   17 32203860 32203889 30 + 0.069 0.206 1.818
ENSG00000126858 E030 54.9878972 0.0017530565 0.5391146926 0.728381374 17 32203890 32203936 47 + 1.674 1.661 -0.044
ENSG00000126858 E031 49.3899982 0.0008157220 0.8368858452 0.917710325 17 32203937 32203973 37 + 1.622 1.632 0.034
ENSG00000126858 E032 42.9469884 0.0022119061 0.6333560421 0.792536299 17 32206910 32206924 15 + 1.567 1.558 -0.031
ENSG00000126858 E033 50.5489346 0.0087582720 0.4550846463 0.669560425 17 32206925 32206949 25 + 1.640 1.606 -0.115
ENSG00000126858 E034 70.4886916 0.0012148958 0.8672243602 0.934448197 17 32206950 32207029 80 + 1.771 1.786 0.048
ENSG00000126858 E035 0.1723744 0.0495087271 0.1318210526   17 32207030 32207511 482 + 0.000 0.206 11.575
ENSG00000126858 E036 0.7850890 0.0172671820 0.0810779746   17 32207512 32207563 52 + 0.128 0.450 2.404
ENSG00000126858 E037 55.3117077 0.0008467713 0.7245772298 0.850855551 17 32208107 32208147 41 + 1.671 1.673 0.008
ENSG00000126858 E038 83.8452220 0.0044217069 0.4137222653 0.638781310 17 32208148 32208301 154 + 1.834 1.898 0.217
ENSG00000126858 E039 39.6656270 0.0012741160 0.8900751448 0.946702354 17 32208302 32208309 8 + 1.527 1.558 0.107
ENSG00000126858 E040 1.7437355 0.0114978018 0.7382846438 0.859440214 17 32208310 32209349 1040 + 0.375 0.450 0.406
ENSG00000126858 E041 20.2469923 0.0017001951 0.1368329790 0.342633250 17 32209350 32209387 38 + 1.275 1.157 -0.420
ENSG00000126858 E042 21.0452168 0.0016880349 0.1911260617 0.418322023 17 32209388 32209445 58 + 1.291 1.192 -0.349
ENSG00000126858 E043 0.1723744 0.0495087271 0.1318210526   17 32209446 32209738 293 + 0.000 0.206 11.575
ENSG00000126858 E044 12.0053258 0.0027497982 0.0004225768 0.004950556 17 32211116 32211238 123 + 0.923 1.297 1.350
ENSG00000126858 E045 0.0000000       17 32211239 32211435 197 +      
ENSG00000126858 E046 1.0431212 0.0625069680 0.0312208210   17 32221049 32221186 138 + 0.128 0.538 2.837
ENSG00000126858 E047 0.9716304 0.4044692375 0.6031732411   17 32222759 32222828 70 + 0.226 0.349 0.852
ENSG00000126858 E048 0.6566214 0.5309399881 0.7609584654   17 32222829 32222902 74 + 0.181 0.208 0.245
ENSG00000126858 E049 237.7673513 0.0038129053 0.5317751324 0.723288629 17 32224616 32225770 1155 + 2.289 2.335 0.155
ENSG00000126858 E050 0.0000000       17 32241795 32242162 368 +      
ENSG00000126858 E051 1.2563522 0.0132259896 0.4608744021   17 32253085 32253374 290 + 0.343 0.206 -0.988