ENSG00000126787

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000247191 ENSG00000126787 HEK293_OSMI2_6hA HEK293_TMG_6hB DLGAP5 protein_coding protein_coding 29.80212 7.385231 59.07729 1.423921 2.072431 2.998181 20.615489 4.5853355 44.856559 1.10108100 1.3366215 3.287398 0.66738750 0.6058667 0.76136667 0.15550000 0.2755609343 0.0002678237 FALSE TRUE
ENST00000395425 ENSG00000126787 HEK293_OSMI2_6hA HEK293_TMG_6hB DLGAP5 protein_coding protein_coding 29.80212 7.385231 59.07729 1.423921 2.072431 2.998181 5.405821 2.0791081 7.707796 0.38775673 0.2394512 1.885302 0.22678333 0.2850000 0.13106667 -0.15393333 0.0002678237 0.0002678237 FALSE TRUE
MSTRG.9584.2 ENSG00000126787 HEK293_OSMI2_6hA HEK293_TMG_6hB DLGAP5 protein_coding   29.80212 7.385231 59.07729 1.423921 2.072431 2.998181 2.556830 0.3025664 4.106073 0.05584274 2.8042925 3.719034 0.05655833 0.0480000 0.06686667 0.01886667 0.9771609328 0.0002678237 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000126787 E001 0.2852693 0.3174490275 1.000000e+00   14 55132315 55132441 127 - 0.096 0.001 -6.684
ENSG00000126787 E002 0.4576437 0.2588003240 3.331706e-01   14 55145248 55145272 25 - 0.097 0.262 1.733
ENSG00000126787 E003 1.2379310 0.0824558973 9.743519e-02   14 55146446 55146549 104 - 0.211 0.541 1.981
ENSG00000126787 E004 0.9523018 0.0160206356 8.254092e-01   14 55148112 55148134 23 - 0.213 0.260 0.375
ENSG00000126787 E005 3.8734233 0.0064817707 1.366601e-02 7.303309e-02 14 55148135 55148176 42 - 0.481 0.880 1.700
ENSG00000126787 E006 106.3436216 0.0021911589 1.580774e-03 1.418195e-02 14 55148177 55148394 218 - 1.846 2.001 0.524
ENSG00000126787 E007 173.1771947 0.0003368680 1.987714e-02 9.543943e-02 14 55148395 55148473 79 - 2.068 2.153 0.286
ENSG00000126787 E008 36.4781181 0.0032194948 2.534875e-07 8.505830e-06 14 55148594 55148684 91 - 1.343 1.715 1.274
ENSG00000126787 E009 11.3632445 0.0534130231 4.475560e-02 1.670092e-01 14 55150328 55150798 471 - 0.889 1.177 1.055
ENSG00000126787 E010 147.7930636 0.0003622558 1.619252e-02 8.250163e-02 14 55150799 55150848 50 - 1.997 2.092 0.318
ENSG00000126787 E011 332.8895726 0.0001714094 5.312870e-02 1.870835e-01 14 55151695 55151941 247 - 2.353 2.404 0.168
ENSG00000126787 E012 164.8193861 0.0002669109 6.589727e-01 8.093844e-01 14 55152590 55152647 58 - 2.055 2.071 0.054
ENSG00000126787 E013 294.9463218 0.0001896540 1.518570e-02 7.879138e-02 14 55154617 55154806 190 - 2.300 2.367 0.225
ENSG00000126787 E014 316.6333590 0.0001690334 1.285213e-03 1.205117e-02 14 55158522 55158741 220 - 2.327 2.412 0.285
ENSG00000126787 E015 231.0517615 0.0002006846 3.581634e-02 1.437623e-01 14 55162971 55163075 105 - 2.194 2.260 0.220
ENSG00000126787 E016 268.2877823 0.0002140097 3.071982e-02 1.295070e-01 14 55169399 55169559 161 - 2.259 2.322 0.210
ENSG00000126787 E017 201.2214280 0.0002731626 2.478184e-01 4.856421e-01 14 55170702 55170787 86 - 2.138 2.178 0.132
ENSG00000126787 E018 219.5153348 0.0003598832 7.622716e-02 2.371777e-01 14 55175346 55175472 127 - 2.175 2.233 0.196
ENSG00000126787 E019 232.8518557 0.0002224734 1.864682e-01 4.123952e-01 14 55175894 55176018 125 - 2.202 2.244 0.140
ENSG00000126787 E020 328.3289914 0.0002360259 7.579763e-01 8.713151e-01 14 55177062 55177336 275 - 2.354 2.361 0.024
ENSG00000126787 E021 166.6372247 0.0002853607 1.566404e-01 3.717321e-01 14 55179629 55179699 71 - 2.072 2.013 -0.198
ENSG00000126787 E022 219.0642903 0.0114042269 1.477014e-01 3.589851e-01 14 55180656 55180778 123 - 2.193 2.102 -0.307
ENSG00000126787 E023 183.5507194 0.0002855132 1.670255e-05 3.277270e-04 14 55181213 55181297 85 - 2.126 1.945 -0.606
ENSG00000126787 E024 177.6228421 0.0002522754 4.042700e-04 4.770976e-03 14 55182370 55182432 63 - 2.109 1.961 -0.495
ENSG00000126787 E025 155.1176359 0.0002709900 5.478865e-03 3.710687e-02 14 55183560 55183605 46 - 2.047 1.925 -0.412
ENSG00000126787 E026 270.3942426 0.0002625591 2.088693e-06 5.424501e-05 14 55183606 55183753 148 - 2.290 2.128 -0.543
ENSG00000126787 E027 322.8475761 0.0001740088 2.375181e-12 2.291821e-10 14 55188942 55189180 239 - 2.372 2.146 -0.755
ENSG00000126787 E028 3.8676621 0.0368796739 8.949785e-01 9.491949e-01 14 55191069 55191176 108 - 0.576 0.540 -0.165
ENSG00000126787 E029 157.9405526 0.0016820946 2.045045e-05 3.893450e-04 14 55191463 55191608 146 - 2.063 1.846 -0.729