ENSG00000126391

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317568 ENSG00000126391 HEK293_OSMI2_6hA HEK293_TMG_6hB FRMD8 protein_coding protein_coding 20.71315 32.35968 10.33096 5.887283 0.5633887 -1.646273 6.343252 12.237369 2.3864374 1.6948213 0.4671952 -2.3535088 0.30091250 0.38886667 0.23476667 -0.15410000 0.3807708356 0.0007733192 FALSE TRUE
ENST00000416776 ENSG00000126391 HEK293_OSMI2_6hA HEK293_TMG_6hB FRMD8 protein_coding protein_coding 20.71315 32.35968 10.33096 5.887283 0.5633887 -1.646273 5.863404 8.793406 4.6657805 1.7376583 0.2901941 -0.9128547 0.28909583 0.26970000 0.45263333 0.18293333 0.0007733192 0.0007733192 FALSE TRUE
ENST00000528854 ENSG00000126391 HEK293_OSMI2_6hA HEK293_TMG_6hB FRMD8 protein_coding retained_intron 20.71315 32.35968 10.33096 5.887283 0.5633887 -1.646273 1.719233 3.367313 0.7523810 1.1393426 0.1690758 -2.1472917 0.08420833 0.09653333 0.07320000 -0.02333333 0.8817711727 0.0007733192 FALSE FALSE
ENST00000531296 ENSG00000126391 HEK293_OSMI2_6hA HEK293_TMG_6hB FRMD8 protein_coding protein_coding 20.71315 32.35968 10.33096 5.887283 0.5633887 -1.646273 2.360914 2.558914 0.9663509 1.1797843 0.4906607 -1.3956871 0.10682083 0.07510000 0.08876667 0.01366667 0.9833357528 0.0007733192 FALSE FALSE
MSTRG.5719.1 ENSG00000126391 HEK293_OSMI2_6hA HEK293_TMG_6hB FRMD8 protein_coding   20.71315 32.35968 10.33096 5.887283 0.5633887 -1.646273 3.751087 4.588366 1.2891231 0.9636066 0.6704861 -1.8235831 0.18693750 0.14396667 0.12423333 -0.01973333 0.8778873743 0.0007733192 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000126391 E001 2.7016085 0.0084900624 0.36539386 0.60025693 11 65386603 65386620 18 + 0.630 0.464 -0.771
ENSG00000126391 E002 4.2661771 0.0058551226 0.24339469 0.48046453 11 65386621 65386625 5 + 0.794 0.605 -0.786
ENSG00000126391 E003 10.9563178 0.0516248608 0.31537266 0.55539813 11 65386626 65386636 11 + 1.106 0.946 -0.585
ENSG00000126391 E004 34.5918240 0.0013488045 0.04705013 0.17265612 11 65386637 65386656 20 + 1.340 1.486 0.504
ENSG00000126391 E005 35.0315442 0.0015744332 0.05966063 0.20200800 11 65386657 65386659 3 + 1.353 1.490 0.474
ENSG00000126391 E006 85.2902845 0.0035168044 0.32234630 0.56180767 11 65386660 65386761 102 + 1.804 1.850 0.156
ENSG00000126391 E007 0.3032425 0.0274424043 1.00000000   11 65386928 65387036 109 + 0.000 0.120 8.660
ENSG00000126391 E008 108.2129837 0.0046607278 0.75010408 0.86683537 11 65387037 65387121 85 + 1.937 1.945 0.026
ENSG00000126391 E009 5.6017155 0.1326777826 0.65078761 0.80404138 11 65387122 65387261 140 + 0.833 0.722 -0.443
ENSG00000126391 E010 63.1318051 0.0008826624 0.86973003 0.93569841 11 65389361 65389384 24 + 1.731 1.711 -0.066
ENSG00000126391 E011 105.8477032 0.0021273702 0.66547303 0.81332009 11 65389385 65389528 144 + 1.927 1.934 0.025
ENSG00000126391 E012 43.9194426 0.0036578091 0.02303065 0.10604742 11 65393573 65393674 102 + 1.422 1.578 0.536
ENSG00000126391 E013 3.3805071 0.0557438030 0.88745655 0.94529664 11 65393675 65393755 81 + 0.556 0.570 0.062
ENSG00000126391 E014 66.3111379 0.0005962787 0.15554716 0.37023318 11 65394041 65394099 59 + 1.675 1.742 0.227
ENSG00000126391 E015 40.9439157 0.0008945328 0.15045658 0.36296079 11 65394259 65394261 3 + 1.453 1.543 0.310
ENSG00000126391 E016 92.3409731 0.0004699372 0.01835231 0.09018852 11 65394262 65394425 164 + 1.790 1.891 0.341
ENSG00000126391 E017 119.0195380 0.0055517020 0.34608007 0.58363593 11 65396799 65397020 222 + 1.951 1.989 0.129
ENSG00000126391 E018 124.7136444 0.0012861906 0.07332532 0.23144728 11 65399736 65399859 124 + 2.069 1.985 -0.280
ENSG00000126391 E019 2.6177362 0.1661222192 0.03705815 0.14705750 11 65399860 65399897 38 + 0.798 0.335 -2.181
ENSG00000126391 E020 136.4090477 0.0003575370 0.17097440 0.39185874 11 65400724 65400867 144 + 2.090 2.030 -0.201
ENSG00000126391 E021 193.2049608 0.0002789776 0.74576845 0.86418906 11 65404864 65405068 205 + 2.208 2.187 -0.071
ENSG00000126391 E022 1186.3965235 0.0037356017 0.30371060 0.54427984 11 65411242 65413525 2284 + 3.001 2.964 -0.121