ENSG00000126217

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375597 ENSG00000126217 HEK293_OSMI2_6hA HEK293_TMG_6hB MCF2L protein_coding protein_coding 2.017615 2.616045 1.498078 0.500757 0.113268 -0.8001808 0.0980949 0.1620888 0.1405955 0.16208880 0.08200887 -0.19247443 0.05181667 0.07906667 0.1019333 0.02286667 0.80060792 0.02840143 FALSE  
ENST00000375608 ENSG00000126217 HEK293_OSMI2_6hA HEK293_TMG_6hB MCF2L protein_coding protein_coding 2.017615 2.616045 1.498078 0.500757 0.113268 -0.8001808 0.2928261 0.2130552 0.2082228 0.14185169 0.04355336 -0.03159873 0.15622917 0.06846667 0.1454000 0.07693333 0.71158785 0.02840143 FALSE  
ENST00000421756 ENSG00000126217 HEK293_OSMI2_6hA HEK293_TMG_6hB MCF2L protein_coding protein_coding 2.017615 2.616045 1.498078 0.500757 0.113268 -0.8001808 0.3098604 0.3357337 0.3862426 0.17819310 0.19633237 0.19672240 0.15228750 0.11706667 0.2409667 0.12390000 0.91806013 0.02840143 FALSE  
ENST00000441756 ENSG00000126217 HEK293_OSMI2_6hA HEK293_TMG_6hB MCF2L protein_coding protein_coding 2.017615 2.616045 1.498078 0.500757 0.113268 -0.8001808 0.1967226 0.2153363 0.0000000 0.04348306 0.00000000 -4.49400764 0.08868750 0.08973333 0.0000000 -0.08973333 0.02840143 0.02840143    
ENST00000491028 ENSG00000126217 HEK293_OSMI2_6hA HEK293_TMG_6hB MCF2L protein_coding retained_intron 2.017615 2.616045 1.498078 0.500757 0.113268 -0.8001808 0.1961689 0.3746470 0.0393476 0.22212636 0.03934760 -2.96248335 0.08442917 0.12343333 0.0308000 -0.09263333 0.54286396 0.02840143 FALSE  
ENST00000535094 ENSG00000126217 HEK293_OSMI2_6hA HEK293_TMG_6hB MCF2L protein_coding protein_coding 2.017615 2.616045 1.498078 0.500757 0.113268 -0.8001808 0.5106574 0.8121787 0.3723010 0.11684014 0.02791685 -1.10474285 0.27230833 0.34566667 0.2535333 -0.09213333 0.86105865 0.02840143 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000126217 E001 1.8553045 0.0113777458 0.641949796 0.79810291 13 112894378 112894431 54 + 0.373 0.453 0.433
ENSG00000126217 E002 0.0000000       13 112902195 112902198 4 +      
ENSG00000126217 E003 1.6525703 0.0125575533 0.799282955 0.89589813 13 112902199 112902199 1 + 0.373 0.416 0.239
ENSG00000126217 E004 3.5987096 0.0721056914 0.965251187 0.98452746 13 112902200 112902371 172 + 0.623 0.630 0.031
ENSG00000126217 E005 1.2611538 0.0452630884 0.023657906   13 112909253 112910619 1367 + 0.572 0.163 -2.582
ENSG00000126217 E006 0.1308682 0.0327207284 0.936595550   13 112917114 112917524 411 + 0.000 0.090 12.277
ENSG00000126217 E007 0.7962354 0.0172671820 0.776501408   13 112956043 112958164 2122 + 0.280 0.227 -0.399
ENSG00000126217 E008 0.0000000       13 112968500 112968714 215 +      
ENSG00000126217 E009 7.9341098 0.0047849238 0.243136236 0.48016240 13 112969214 112969458 245 + 0.839 0.977 0.524
ENSG00000126217 E010 0.0000000       13 112979312 112979758 447 +      
ENSG00000126217 E011 0.0000000       13 112985118 112985479 362 +      
ENSG00000126217 E012 0.0000000       13 113001270 113001425 156 +      
ENSG00000126217 E013 0.0000000       13 113001714 113001753 40 +      
ENSG00000126217 E014 0.0000000       13 113001754 113001784 31 +      
ENSG00000126217 E015 0.2617363 0.3330448190 0.545970658   13 113001785 113001892 108 + 0.000 0.159 12.728
ENSG00000126217 E016 0.2617363 0.3330448190 0.545970658   13 113001893 113001983 91 + 0.000 0.159 12.728
ENSG00000126217 E017 9.1285406 0.0039202115 0.592016194 0.76503682 13 113014763 113014846 84 + 0.940 0.998 0.215
ENSG00000126217 E018 5.9778011 0.0113880341 0.872166326 0.93710948 13 113024644 113024663 20 + 0.838 0.814 -0.095
ENSG00000126217 E019 5.8578917 0.0075185670 0.951667035 0.97774239 13 113024664 113024697 34 + 0.809 0.814 0.020
ENSG00000126217 E020 6.6799226 0.0545323076 0.862289751 0.93158205 13 113024698 113024758 61 + 0.839 0.872 0.129
ENSG00000126217 E021 0.0000000       13 113024759 113024908 150 +      
ENSG00000126217 E022 0.3447487 0.1651587624 0.504790889   13 113026869 113027068 200 + 0.000 0.165 12.981
ENSG00000126217 E023 0.0000000       13 113033872 113034137 266 +      
ENSG00000126217 E024 0.0000000       13 113040348 113041008 661 +      
ENSG00000126217 E025 0.1614157 0.0373691701 0.253343399   13 113042276 113044461 2186 + 0.162 0.000 -14.317
ENSG00000126217 E026 0.1426347 0.0310893015 0.254221395   13 113044462 113044661 200 + 0.162 0.000 -14.339
ENSG00000126217 E027 0.1426347 0.0310893015 0.254221395   13 113044662 113044687 26 + 0.162 0.000 -14.339
ENSG00000126217 E028 0.1426347 0.0310893015 0.254221395   13 113044688 113044850 163 + 0.162 0.000 -14.339
ENSG00000126217 E029 0.0000000       13 113044851 113044888 38 +      
ENSG00000126217 E030 0.0000000       13 113044889 113045025 137 +      
ENSG00000126217 E031 0.0000000       13 113045026 113045270 245 +      
ENSG00000126217 E032 5.4101769 0.0582259447 0.520508119 0.71526221 13 113045271 113045361 91 + 0.837 0.752 -0.340
ENSG00000126217 E033 0.0000000       13 113045362 113046597 1236 +      
ENSG00000126217 E034 0.0000000       13 113046598 113047341 744 +      
ENSG00000126217 E035 0.1723744 0.0304506677 0.936783829   13 113052507 113052753 247 + 0.000 0.090 12.285
ENSG00000126217 E036 0.0000000       13 113054302 113054905 604 +      
ENSG00000126217 E037 8.6627376 0.0034773151 0.391463594 0.62159290 13 113060593 113060712 120 + 1.022 0.921 -0.375
ENSG00000126217 E038 5.5212711 0.0058720042 0.948394170 0.97648886 13 113064304 113064311 8 + 0.778 0.782 0.017
ENSG00000126217 E039 13.0597202 0.0257172771 0.793075652 0.89224426 13 113064312 113064420 109 + 1.151 1.105 -0.167
ENSG00000126217 E040 0.0000000       13 113064690 113064754 65 +      
ENSG00000126217 E041 15.7102716 0.0263682533 0.791485435 0.89131617 13 113064936 113065085 150 + 1.226 1.179 -0.166
ENSG00000126217 E042 0.1723744 0.0304506677 0.936783829   13 113065086 113065303 218 + 0.000 0.090 12.285
ENSG00000126217 E043 14.9096731 0.0030212123 0.717387512 0.84651019 13 113066046 113066170 125 + 1.203 1.163 -0.144
ENSG00000126217 E044 12.2161921 0.0028600995 0.246698034 0.48439680 13 113070059 113070173 115 + 1.165 1.046 -0.429
ENSG00000126217 E045 0.1779838 0.0345056061 0.253434993   13 113070174 113070394 221 + 0.163 0.000 -14.329
ENSG00000126217 E046 7.1880159 0.0082035941 0.481795082 0.68830243 13 113074444 113074466 23 + 0.940 0.844 -0.364
ENSG00000126217 E047 9.0961885 0.0533465533 0.260959863 0.49994909 13 113074467 113074563 97 + 1.091 0.903 -0.696
ENSG00000126217 E048 13.8332779 0.0164959479 0.641153912 0.79762504 13 113074998 113075189 192 + 1.177 1.117 -0.218
ENSG00000126217 E049 16.2745754 0.0032807018 0.893701520 0.94852772 13 113075966 113076157 192 + 1.215 1.220 0.017
ENSG00000126217 E050 15.5223394 0.0025437267 0.055383275 0.19220096 13 113077052 113077211 160 + 1.075 1.249 0.622
ENSG00000126217 E051 11.6317915 0.0026682218 0.553404010 0.73862736 13 113078363 113078436 74 + 1.041 1.096 0.201
ENSG00000126217 E052 10.4338596 0.0034061145 0.794808926 0.89321731 13 113078666 113078739 74 + 1.058 1.027 -0.115
ENSG00000126217 E053 12.7889790 0.0164166449 0.827813699 0.91251738 13 113081213 113081279 67 + 1.122 1.106 -0.059
ENSG00000126217 E054 16.5890768 0.0024388561 0.922358777 0.96345623 13 113082427 113082542 116 + 1.227 1.215 -0.044
ENSG00000126217 E055 12.9331503 0.0033301309 0.922298836 0.96343500 13 113083998 113084067 70 + 1.122 1.127 0.017
ENSG00000126217 E056 0.6479912 0.0296409289 0.148182957   13 113084567 113084891 325 + 0.000 0.283 14.099
ENSG00000126217 E057 11.8008967 0.0119646404 0.229426577 0.46447367 13 113084892 113084984 93 + 1.002 1.126 0.453
ENSG00000126217 E058 13.5488137 0.0030356865 0.520478976 0.71526009 13 113085086 113085178 93 + 1.107 1.162 0.199
ENSG00000126217 E059 12.5696137 0.0080618092 0.419426435 0.64320840 13 113086124 113086187 64 + 1.058 1.140 0.295
ENSG00000126217 E060 14.2085739 0.0028268176 0.679654291 0.82247889 13 113086188 113086249 62 + 1.137 1.169 0.116
ENSG00000126217 E061 16.3161812 0.0022348524 0.733994117 0.85663739 13 113087235 113087349 115 + 1.191 1.215 0.085
ENSG00000126217 E062 10.4344011 0.0049884894 0.764256565 0.87520065 13 113087350 113087398 49 + 1.058 1.018 -0.145
ENSG00000126217 E063 10.2931715 0.0046261749 0.711251338 0.84257751 13 113087399 113087456 58 + 1.003 1.037 0.124
ENSG00000126217 E064 11.1564189 0.0044169183 0.882001978 0.94236176 13 113087707 113087795 89 + 1.075 1.054 -0.075
ENSG00000126217 E065 6.8146199 0.0043013816 0.937132200 0.97076509 13 113087796 113087799 4 + 0.866 0.871 0.017
ENSG00000126217 E066 9.0399759 0.0047659078 0.156547996 0.37164775 13 113088327 113088405 79 + 0.866 1.027 0.602
ENSG00000126217 E067 8.2814566 0.0044014869 0.923718408 0.96423581 13 113088562 113088628 67 + 0.940 0.945 0.017
ENSG00000126217 E068 6.9951428 0.0046038862 0.460038314 0.67318259 13 113089610 113089635 26 + 0.940 0.843 -0.368
ENSG00000126217 E069 9.5166224 0.0040102266 0.253897348 0.49228735 13 113089636 113089690 55 + 1.075 0.945 -0.478
ENSG00000126217 E070 8.6486384 0.0042606549 0.220087663 0.45362462 13 113089691 113089728 38 + 1.041 0.897 -0.534
ENSG00000126217 E071 0.5963342 0.0367412075 0.100970364   13 113089875 113090067 193 + 0.373 0.090 -2.571
ENSG00000126217 E072 0.9357337 0.0387390861 0.015575059   13 113090068 113090151 84 + 0.515 0.089 -3.310
ENSG00000126217 E073 0.7860845 0.0174861308 0.002121668   13 113090152 113090160 9 + 0.514 0.000 -16.442
ENSG00000126217 E074 0.6081007 0.0249321861 0.006950945   13 113090161 113090183 23 + 0.449 0.000 -16.148
ENSG00000126217 E075 1.0121411 0.0162692071 0.354212268   13 113090969 113091120 152 + 0.162 0.332 1.341
ENSG00000126217 E076 1.1356349 0.0149480382 0.213914668   13 113091121 113091195 75 + 0.450 0.227 -1.399
ENSG00000126217 E077 6.6720617 0.2277810166 0.325040418 0.56424311 13 113093601 113094513 913 + 0.936 0.816 -0.461
ENSG00000126217 E078 16.3621945 0.0026208493 0.765829338 0.87615206 13 113094514 113094635 122 + 1.227 1.196 -0.109
ENSG00000126217 E079 2.5224367 0.0107854284 0.013011538 0.07050151 13 113094636 113094859 224 + 0.162 0.625 2.828
ENSG00000126217 E080 1.1539680 0.0149895183 0.032883526   13 113094969 113095178 210 + 0.000 0.416 14.808
ENSG00000126217 E081 3.1850589 0.3804877820 0.554633616 0.73953616 13 113095222 113096370 1149 + 0.678 0.551 -0.562
ENSG00000126217 E082 12.6168265 0.0033087245 0.228928878 0.46390792 13 113096371 113096483 113 + 1.022 1.142 0.433
ENSG00000126217 E083 3.1512870 0.0341301818 0.110219353 0.29934560 13 113096484 113096549 66 + 0.373 0.671 1.436
ENSG00000126217 E084 7.5080385 0.0046720708 0.036761964 0.14629237 13 113096550 113096653 104 + 0.706 0.978 1.057
ENSG00000126217 E085 3.3129605 0.2911376114 0.932445403 0.96836944 13 113096654 113096773 120 + 0.563 0.647 0.370
ENSG00000126217 E086 65.7825708 0.0007615447 0.776086843 0.88239655 13 113096774 113099742 2969 + 1.806 1.788 -0.061