ENSG00000126216

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261965 ENSG00000126216 HEK293_OSMI2_6hA HEK293_TMG_6hB TUBGCP3 protein_coding protein_coding 9.158477 5.969345 13.56501 0.50099 0.5379918 1.182894 5.578147 3.2853132 9.3754805 0.5292189 0.27928030 1.5100150 0.5978375 0.54436667 0.6931333 0.1487667 4.069903e-01 3.102996e-05 FALSE TRUE
ENST00000375669 ENSG00000126216 HEK293_OSMI2_6hA HEK293_TMG_6hB TUBGCP3 protein_coding protein_coding 9.158477 5.969345 13.56501 0.50099 0.5379918 1.182894 1.547256 0.4767498 2.3018234 0.1718482 0.71365617 2.2477788 0.1401250 0.07863333 0.1689333 0.0903000 5.841687e-01 3.102996e-05 FALSE TRUE
ENST00000464139 ENSG00000126216 HEK293_OSMI2_6hA HEK293_TMG_6hB TUBGCP3 protein_coding protein_coding 9.158477 5.969345 13.56501 0.50099 0.5379918 1.182894 1.134360 1.5592699 0.9223977 0.2991682 0.09265218 -0.7510762 0.1578917 0.25603333 0.0677000 -0.1883333 3.102996e-05 3.102996e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000126216 E001 2.2857837 0.0913528744 6.993426e-02 2.246689e-01 13 112485011 112485032 22 - 0.326 0.683 1.775
ENSG00000126216 E002 101.0209386 0.0224418828 3.759348e-01 6.089536e-01 13 112485033 112485843 811 - 1.952 2.027 0.254
ENSG00000126216 E003 93.0710776 0.0005633941 9.469249e-01 9.757688e-01 13 112485844 112486151 308 - 1.943 1.950 0.025
ENSG00000126216 E004 66.7818081 0.0007005947 8.452562e-01 9.222589e-01 13 112489581 112489697 117 - 1.808 1.805 -0.012
ENSG00000126216 E005 0.4576437 0.1917346752 9.322669e-01   13 112489698 112489823 126 - 0.158 0.168 0.102
ENSG00000126216 E006 3.3883001 0.0373739165 1.425399e-01 3.512369e-01 13 112498807 112498936 130 - 0.537 0.785 1.061
ENSG00000126216 E007 71.4972913 0.0006492081 7.127277e-01 8.434581e-01 13 112499045 112499185 141 - 1.835 1.824 -0.037
ENSG00000126216 E008 63.5334177 0.0005770201 4.066584e-01 6.335453e-01 13 112504032 112504163 132 - 1.794 1.761 -0.113
ENSG00000126216 E009 44.9696865 0.0169614059 8.902875e-01 9.468179e-01 13 112504626 112504714 89 - 1.634 1.653 0.064
ENSG00000126216 E010 70.1085120 0.0006079569 1.968669e-02 9.486021e-02 13 112516440 112516575 136 - 1.855 1.754 -0.341
ENSG00000126216 E011 52.1987852 0.0007490458 4.184553e-04 4.910401e-03 13 112518975 112519043 69 - 1.751 1.564 -0.635
ENSG00000126216 E012 70.1073938 0.0005535752 2.461517e-03 2.008057e-02 13 112519886 112520021 136 - 1.866 1.732 -0.452
ENSG00000126216 E013 1.4270612 0.3085978571 9.857252e-01 9.947086e-01 13 112521663 112521864 202 - 0.363 0.386 0.132
ENSG00000126216 E014 82.8798093 0.0006894290 7.346415e-02 2.317003e-01 13 112522320 112522509 190 - 1.920 1.850 -0.235
ENSG00000126216 E015 73.8790838 0.0027635859 3.020565e-01 5.426256e-01 13 112526942 112527050 109 - 1.862 1.817 -0.152
ENSG00000126216 E016 74.5784603 0.0056417164 1.337348e-01 3.376584e-01 13 112527374 112527484 111 - 1.874 1.795 -0.265
ENSG00000126216 E017 3.3893615 0.2549639741 6.086284e-01 7.759809e-01 13 112544556 112545698 1143 - 0.581 0.714 0.575
ENSG00000126216 E018 81.5982386 0.0011917391 1.260032e-02 6.884446e-02 13 112545699 112545865 167 - 1.919 1.814 -0.354
ENSG00000126216 E019 4.3559255 0.3851688139 3.579722e-01 5.941364e-01 13 112545866 112546203 338 - 0.570 0.899 1.348
ENSG00000126216 E020 45.2128395 0.0012223997 7.246111e-31 6.278348e-28 13 112546482 112547619 1138 - 1.327 1.952 2.131
ENSG00000126216 E021 77.9485854 0.0010763265 8.867440e-01 9.449913e-01 13 112547620 112547752 133 - 1.866 1.878 0.039
ENSG00000126216 E022 46.7681511 0.0008581743 5.923310e-01 7.651639e-01 13 112548108 112548176 69 - 1.638 1.672 0.115
ENSG00000126216 E023 71.0046097 0.0005476184 2.283296e-01 4.632690e-01 13 112554057 112554182 126 - 1.810 1.867 0.194
ENSG00000126216 E024 78.7095497 0.0005621459 3.235196e-01 5.628286e-01 13 112554887 112555005 119 - 1.858 1.904 0.156
ENSG00000126216 E025 86.0544260 0.0006608598 4.033704e-01 6.310193e-01 13 112556052 112556220 169 - 1.924 1.896 -0.095
ENSG00000126216 E026 24.5832715 0.0028505258 5.183222e-01 7.138965e-01 13 112556221 112556224 4 - 1.365 1.420 0.188
ENSG00000126216 E027 71.9821386 0.0055051765 3.378779e-01 5.761682e-01 13 112558196 112558413 218 - 1.818 1.875 0.192
ENSG00000126216 E028 42.6069788 0.0011321271 7.505366e-01 8.670524e-01 13 112559322 112559399 78 - 1.608 1.630 0.078
ENSG00000126216 E029 30.1315048 0.0013831642 4.831114e-01 6.892378e-01 13 112565111 112565178 68 - 1.452 1.504 0.179
ENSG00000126216 E030 32.2967883 0.0012291166 2.462840e-01 4.838960e-01 13 112569152 112569259 108 - 1.521 1.450 -0.245
ENSG00000126216 E031 0.2027342 0.0356192827 2.328053e-01   13 112584039 112584161 123 - 0.000 0.167 9.612
ENSG00000126216 E032 0.0000000       13 112587230 112587346 117 -      
ENSG00000126216 E033 22.8627196 0.0066555667 9.861412e-01 9.948924e-01 13 112587905 112588205 301 - 1.356 1.361 0.019