ENSG00000126016

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304758 ENSG00000126016 HEK293_OSMI2_6hA HEK293_TMG_6hB AMOT protein_coding protein_coding 114.0675 91.12766 115.7753 22.12086 3.062838 0.3453329 14.92581 10.38897 10.09093 3.133505 0.7824458 -0.04195254 0.1334625 0.1093000 0.08710000 -0.0222000 0.668631249 0.0002291321 FALSE TRUE
ENST00000371959 ENSG00000126016 HEK293_OSMI2_6hA HEK293_TMG_6hB AMOT protein_coding protein_coding 114.0675 91.12766 115.7753 22.12086 3.062838 0.3453329 71.27402 47.28394 83.77017 8.867035 2.0447428 0.82495338 0.6041875 0.5385333 0.72383333 0.1853000 0.038933792 0.0002291321 FALSE TRUE
MSTRG.34738.4 ENSG00000126016 HEK293_OSMI2_6hA HEK293_TMG_6hB AMOT protein_coding   114.0675 91.12766 115.7753 22.12086 3.062838 0.3453329 19.84751 28.32025 11.13752 10.422277 1.4867672 -1.34561979 0.1947250 0.2874333 0.09596667 -0.1914667 0.006918797 0.0002291321 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000126016 E001 1.372709e+01 0.0026235120 6.993368e-06 1.537391e-04 X 112774503 112774876 374 - 0.874 1.388 1.854
ENSG00000126016 E002 9.429259e+01 0.0102121981 2.743365e-06 6.874523e-05 X 112774877 112774919 43 - 1.766 2.161 1.327
ENSG00000126016 E003 1.522981e+02 0.0075150301 4.778868e-08 1.913683e-06 X 112774920 112774937 18 - 1.973 2.365 1.313
ENSG00000126016 E004 8.406156e+02 0.0145373629 3.946533e-06 9.390670e-05 X 112774938 112775088 151 - 2.704 3.107 1.339
ENSG00000126016 E005 1.171962e+04 0.0057649351 1.525851e-05 3.026803e-04 X 112775089 112778511 3423 - 3.971 4.165 0.644
ENSG00000126016 E006 7.859930e+02 0.0011251401 5.033114e-03 3.481056e-02 X 112778512 112778664 153 - 2.874 2.909 0.116
ENSG00000126016 E007 1.418008e+03 0.0031148056 2.641587e-01 5.034082e-01 X 112778997 112779680 684 - 3.121 3.179 0.194
ENSG00000126016 E008 9.930002e-01 0.1241241685 8.570485e-01   X 112780355 112780717 363 - 0.260 0.333 0.492
ENSG00000126016 E009 1.477607e+00 0.1873658090 5.914431e-01 7.646795e-01 X 112780718 112780885 168 - 0.318 0.469 0.851
ENSG00000126016 E010 8.167747e+02 0.0014862692 2.205137e-04 2.898924e-03 X 112780886 112781118 233 - 2.902 2.913 0.034
ENSG00000126016 E011 6.670956e+02 0.0002835693 1.714538e-06 4.558046e-05 X 112782540 112782662 123 - 2.810 2.830 0.067
ENSG00000126016 E012 2.397626e+00 0.1785907767 5.303498e-01 7.222871e-01 X 112790422 112790446 25 - 0.422 0.619 0.943
ENSG00000126016 E013 8.278053e+02 0.0033798749 3.164264e-03 2.439684e-02 X 112790592 112790782 191 - 2.913 2.911 -0.008
ENSG00000126016 E014 7.737086e+02 0.0043737246 1.848745e-02 9.067420e-02 X 112791832 112791981 150 - 2.880 2.887 0.023
ENSG00000126016 E015 7.268535e+02 0.0011155853 1.204363e-05 2.462420e-04 X 112804947 112805092 146 - 2.855 2.857 0.006
ENSG00000126016 E016 5.282285e+02 0.0006654776 2.529888e-10 1.648631e-08 X 112809894 112809984 91 - 2.731 2.700 -0.102
ENSG00000126016 E017 2.995456e+02 0.0039513590 1.378983e-05 2.769104e-04 X 112809985 112809986 2 - 2.502 2.428 -0.245
ENSG00000126016 E018 7.286281e+02 0.0004319630 2.593716e-16 4.661086e-14 X 112811249 112811393 145 - 2.873 2.832 -0.134
ENSG00000126016 E019 1.343127e+03 0.0042642797 2.566140e-05 4.715828e-04 X 112815358 112815877 520 - 3.142 3.094 -0.162
ENSG00000126016 E020 1.678409e+03 0.0063644189 9.440424e-05 1.424688e-03 X 112822255 112823136 882 - 3.245 3.181 -0.211
ENSG00000126016 E021 2.887580e+02 0.0034908654 1.833868e-06 4.832448e-05 X 112823137 112823188 52 - 2.489 2.406 -0.276
ENSG00000126016 E022 3.887920e+02 0.0030811804 1.293304e-09 7.407511e-08 X 112825072 112825220 149 - 2.628 2.517 -0.368
ENSG00000126016 E023 3.932768e+02 0.0001808243 5.402647e-27 3.385586e-24 X 112832294 112832370 77 - 2.632 2.522 -0.365
ENSG00000126016 E024 1.803337e+01 0.0024387928 1.977166e-03 1.691613e-02 X 112840242 112840315 74 - 1.339 1.171 -0.591
ENSG00000126016 E025 7.397811e+02 0.0012224449 5.138531e-13 5.561764e-11 X 112840452 112840898 447 - 2.888 2.826 -0.205