ENSG00000126001

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397527 ENSG00000126001 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP250 protein_coding protein_coding 11.69535 15.20649 12.26768 1.289473 0.3107818 -0.3095982 0.6672682 0.9444549 0.2707478 0.1260221 0.13975061 -1.7654024 0.05691667 0.06243333 0.02150000 -0.040933333 5.086642e-01 5.646287e-14 FALSE TRUE
ENST00000425096 ENSG00000126001 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP250 protein_coding protein_coding 11.69535 15.20649 12.26768 1.289473 0.3107818 -0.3095982 0.3964561 0.2060547 0.9567437 0.2060547 0.50630463 2.1617366 0.03505000 0.01213333 0.07596667 0.063833333 6.547372e-01 5.646287e-14 FALSE FALSE
ENST00000425525 ENSG00000126001 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP250 protein_coding nonsense_mediated_decay 11.69535 15.20649 12.26768 1.289473 0.3107818 -0.3095982 0.9328138 1.5399927 0.5323348 0.3326818 0.29943796 -1.5150057 0.07395417 0.10103333 0.04253333 -0.058500000 6.609167e-01 5.646287e-14 FALSE FALSE
ENST00000446710 ENSG00000126001 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP250 protein_coding protein_coding 11.69535 15.20649 12.26768 1.289473 0.3107818 -0.3095982 0.1715433 0.0000000 1.3723468 0.0000000 0.17847266 7.1109758 0.01403750 0.00000000 0.11230000 0.112300000 5.646287e-14 5.646287e-14 FALSE FALSE
ENST00000487467 ENSG00000126001 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP250 protein_coding retained_intron 11.69535 15.20649 12.26768 1.289473 0.3107818 -0.3095982 2.0887609 2.5514728 2.2071042 1.1553689 0.41601803 -0.2082970 0.17220000 0.15896667 0.17946667 0.020500000 9.274651e-01 5.646287e-14   FALSE
MSTRG.20627.1 ENSG00000126001 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP250 protein_coding   11.69535 15.20649 12.26768 1.289473 0.3107818 -0.3095982 1.9479867 3.6096201 0.8207391 0.5090800 0.43006475 -2.1233709 0.16594583 0.24323333 0.06863333 -0.174600000 5.159805e-01 5.646287e-14 FALSE TRUE
MSTRG.20627.13 ENSG00000126001 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP250 protein_coding   11.69535 15.20649 12.26768 1.289473 0.3107818 -0.3095982 1.4241349 1.0500955 3.0060291 0.2231879 0.43465208 1.5084561 0.12695000 0.07073333 0.24576667 0.175033333 1.738342e-02 5.646287e-14 FALSE TRUE
MSTRG.20627.5 ENSG00000126001 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP250 protein_coding   11.69535 15.20649 12.26768 1.289473 0.3107818 -0.3095982 0.6132502 0.7904562 0.5810789 0.3953712 0.30416845 -0.4374718 0.05551250 0.04810000 0.04640000 -0.001700000 1.000000e+00 5.646287e-14 FALSE TRUE
MSTRG.20627.7 ENSG00000126001 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP250 protein_coding   11.69535 15.20649 12.26768 1.289473 0.3107818 -0.3095982 1.3268515 2.2243315 0.7971168 0.5611192 0.31080241 -1.4689939 0.11394167 0.15366667 0.06600000 -0.087666667 6.112795e-01 5.646287e-14 FALSE TRUE
MSTRG.20627.9 ENSG00000126001 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP250 protein_coding   11.69535 15.20649 12.26768 1.289473 0.3107818 -0.3095982 1.1837762 1.2384447 0.9976151 0.2548582 0.09548042 -0.3091873 0.10266250 0.08000000 0.08176667 0.001766667 1.000000e+00 5.646287e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000126001 E001 0.0000000       20 35455162 35455163 2 +      
ENSG00000126001 E002 0.2922838 0.0263083421 5.117024e-01   20 35455164 35455169 6 + 0.166 0.088 -1.055
ENSG00000126001 E003 0.4231520 0.0711339209 8.538754e-01   20 35455170 35455174 5 + 0.166 0.160 -0.066
ENSG00000126001 E004 1.6010331 0.1315274908 5.373768e-01 7.272345e-01 20 35455175 35455186 12 + 0.457 0.399 -0.303
ENSG00000126001 E005 5.7940068 0.0053869207 3.385332e-02 1.384678e-01 20 35455187 35455200 14 + 0.949 0.738 -0.820
ENSG00000126001 E006 13.2031754 0.0172067314 1.719470e-01 3.931516e-01 20 35455201 35455237 37 + 1.187 1.111 -0.271
ENSG00000126001 E007 9.5370188 0.0081437708 9.768572e-02 2.777565e-01 20 35455238 35455242 5 + 1.085 0.966 -0.435
ENSG00000126001 E008 13.0522337 0.0406216555 6.836684e-02 2.214262e-01 20 35455243 35455516 274 + 1.225 1.067 -0.568
ENSG00000126001 E009 5.1844782 0.1604052053 8.130491e-01 9.040600e-01 20 35455597 35455597 1 + 0.756 0.777 0.084
ENSG00000126001 E010 5.6794962 0.0755400227 7.680173e-01 8.774181e-01 20 35455598 35455606 9 + 0.789 0.812 0.092
ENSG00000126001 E011 12.3413306 0.0036739576 2.628933e-01 5.021237e-01 20 35455607 35455723 117 + 1.132 1.086 -0.165
ENSG00000126001 E012 8.2253054 0.0035006682 1.548424e-01 3.691572e-01 20 35455724 35455751 28 + 1.012 0.912 -0.375
ENSG00000126001 E013 25.1710157 0.0015672842 3.458639e-03 2.609430e-02 20 35458304 35458374 71 + 1.487 1.348 -0.483
ENSG00000126001 E014 52.6340288 0.0007167049 1.589496e-05 3.138027e-04 20 35459983 35460105 123 + 1.801 1.654 -0.496
ENSG00000126001 E015 96.1131218 0.0022554812 9.159711e-10 5.393653e-08 20 35462265 35462553 289 + 2.079 1.890 -0.632
ENSG00000126001 E016 38.4462472 0.0068369075 1.253360e-05 2.551539e-04 20 35463575 35463631 57 + 1.708 1.477 -0.788
ENSG00000126001 E017 34.4658918 0.0021766385 2.865805e-07 9.464855e-06 20 35465743 35465763 21 + 1.676 1.421 -0.872
ENSG00000126001 E018 52.0962711 0.0007205233 5.922096e-07 1.799764e-05 20 35465764 35465825 62 + 1.813 1.632 -0.614
ENSG00000126001 E019 76.3776392 0.0121525423 4.174603e-03 3.013191e-02 20 35466039 35466204 166 + 1.936 1.820 -0.390
ENSG00000126001 E020 56.7634862 0.0183710252 5.780197e-02 1.978934e-01 20 35466966 35467072 107 + 1.785 1.706 -0.267
ENSG00000126001 E021 1.2617014 0.0137788222 5.458213e-02   20 35467272 35467303 32 + 0.521 0.223 -1.789
ENSG00000126001 E022 88.9627708 0.0138841182 3.720974e-03 2.758520e-02 20 35467304 35467555 252 + 2.003 1.884 -0.401
ENSG00000126001 E023 0.1426347 0.0308897167 1.964354e-01   20 35469846 35469889 44 + 0.166 0.000 -9.331
ENSG00000126001 E024 53.4302043 0.0274976046 3.529570e-03 2.651752e-02 20 35469890 35469986 97 + 1.829 1.634 -0.663
ENSG00000126001 E025 2.6654043 0.0838893413 2.753789e-01 5.154235e-01 20 35469987 35470132 146 + 0.631 0.481 -0.693
ENSG00000126001 E026 33.7701101 0.0410774125 8.847785e-03 5.313709e-02 20 35472050 35472052 3 + 1.650 1.430 -0.753
ENSG00000126001 E027 61.8931082 0.0215450683 2.849357e-03 2.249588e-02 20 35472053 35472151 99 + 1.879 1.710 -0.571
ENSG00000126001 E028 75.7226794 0.0060967293 2.408039e-04 3.118588e-03 20 35472673 35472831 159 + 1.943 1.813 -0.439
ENSG00000126001 E029 76.8852639 0.0008825030 3.756307e-03 2.777737e-02 20 35473374 35473552 179 + 1.903 1.846 -0.190
ENSG00000126001 E030 43.3860453 0.0017398678 1.584037e-02 8.121947e-02 20 35473870 35473954 85 + 1.667 1.597 -0.240
ENSG00000126001 E031 42.6050651 0.0017085547 6.045207e-02 2.038432e-01 20 35473955 35474000 46 + 1.641 1.599 -0.140
ENSG00000126001 E032 39.1289350 0.0011853348 1.700105e-01 3.904588e-01 20 35474001 35474052 52 + 1.587 1.572 -0.051
ENSG00000126001 E033 3.2250762 0.1239419062 8.738920e-01 9.381267e-01 20 35474794 35474852 59 + 0.578 0.617 0.176
ENSG00000126001 E034 57.3475859 0.0364140230 9.803133e-01 9.919492e-01 20 35475502 35475646 145 + 1.714 1.751 0.125
ENSG00000126001 E035 63.4773614 0.5749327351 5.312631e-01 7.229512e-01 20 35476449 35476595 147 + 1.731 1.802 0.239
ENSG00000126001 E036 1.1477613 0.4168017590 7.309499e-01   20 35477868 35477870 3 + 0.371 0.286 -0.532
ENSG00000126001 E037 73.2218484 0.0027674537 2.638106e-01 5.030756e-01 20 35477871 35478101 231 + 1.839 1.848 0.030
ENSG00000126001 E038 26.6381289 0.0067502963 3.206958e-03 2.464434e-02 20 35479231 35479245 15 + 1.513 1.350 -0.562
ENSG00000126001 E039 72.7348900 0.0006591879 2.654810e-02 1.169181e-01 20 35479246 35479424 179 + 1.860 1.832 -0.095
ENSG00000126001 E040 84.0293829 0.0034377253 2.688421e-02 1.179530e-01 20 35479646 35479773 128 + 1.925 1.890 -0.118
ENSG00000126001 E041 94.9150114 0.0027953162 1.398695e-04 1.978927e-03 20 35479976 35480145 170 + 2.019 1.923 -0.324
ENSG00000126001 E042 79.1223641 0.0193029025 6.334738e-02 2.102469e-01 20 35490637 35490804 168 + 1.919 1.853 -0.222
ENSG00000126001 E043 75.3170107 0.0264243200 2.935595e-01 5.342306e-01 20 35491212 35491346 135 + 1.864 1.849 -0.050
ENSG00000126001 E044 80.1575529 0.0044754867 2.252093e-01 4.596123e-01 20 35493429 35493572 144 + 1.874 1.885 0.035
ENSG00000126001 E045 14.5182529 0.1520958203 1.603602e-01 3.773275e-01 20 35494378 35494523 146 + 1.258 1.109 -0.532
ENSG00000126001 E046 83.3513833 0.0020263042 4.278725e-01 6.493950e-01 20 35494524 35494657 134 + 1.874 1.909 0.117
ENSG00000126001 E047 80.7806747 0.0055903350 2.742161e-01 5.141907e-01 20 35496577 35496715 139 + 1.876 1.888 0.040
ENSG00000126001 E048 68.4931487 0.0009370224 9.341347e-01 9.691992e-01 20 35497719 35497808 90 + 1.771 1.836 0.221
ENSG00000126001 E049 98.4515738 0.0009930518 1.403572e-01 3.480554e-01 20 35497809 35498067 259 + 1.964 1.976 0.042
ENSG00000126001 E050 67.0213149 0.0062557625 2.249920e-02 1.042191e-01 20 35498595 35498716 122 + 1.844 1.786 -0.194
ENSG00000126001 E051 84.4772687 0.0013285345 2.406167e-01 4.772791e-01 20 35500049 35500169 121 + 1.890 1.908 0.059
ENSG00000126001 E052 89.8290367 0.0008302863 7.387497e-01 8.596829e-01 20 35501845 35501966 122 + 1.874 1.956 0.277
ENSG00000126001 E053 207.1742496 1.1637038450 4.641002e-01 6.759471e-01 20 35502390 35502905 516 + 2.137 2.345 0.695
ENSG00000126001 E054 328.4571663 1.3094778477 4.369611e-01 6.564351e-01 20 35502906 35503664 759 + 2.299 2.555 0.853
ENSG00000126001 E055 394.5184728 1.3113383254 3.509773e-01 5.881101e-01 20 35503665 35504654 990 + 2.304 2.651 1.160
ENSG00000126001 E056 105.4468979 0.5875346311 2.292865e-01 4.643119e-01 20 35504655 35504802 148 + 1.754 2.077 1.087
ENSG00000126001 E057 137.8768917 0.9016318966 2.944613e-01 5.350280e-01 20 35504803 35505005 203 + 1.857 2.196 1.137
ENSG00000126001 E058 108.6400456 0.0003873497 3.686482e-07 1.182117e-05 20 35507738 35507851 114 + 1.810 2.084 0.919
ENSG00000126001 E059 134.1868954 0.0004015940 4.022352e-06 9.543000e-05 20 35508035 35508190 156 + 1.932 2.167 0.788
ENSG00000126001 E060 110.1724882 0.0019267135 7.179241e-05 1.133929e-03 20 35508943 35509044 102 + 1.840 2.086 0.826
ENSG00000126001 E061 88.5736051 0.0127722402 2.472470e-02 1.113657e-01 20 35509998 35510054 57 + 1.751 1.987 0.796
ENSG00000126001 E062 300.6083307 0.0080507070 1.035426e-02 5.965706e-02 20 35511363 35516981 5619 + 2.304 2.505 0.670
ENSG00000126001 E063 49.2699276 0.0099928873 1.162268e-01 3.095359e-01 20 35516982 35519280 2299 + 1.532 1.725 0.654