ENSG00000125952

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358402 ENSG00000125952 HEK293_OSMI2_6hA HEK293_TMG_6hB MAX protein_coding protein_coding 66.10373 70.95693 47.40759 6.6414 1.790212 -0.5817244 48.66681 55.20331 28.91123 6.6334134 1.687121 -0.9328873 0.7200125 0.7742667 0.6088667 -0.1654 2.786224e-03 4.769583e-05 FALSE TRUE
ENST00000358664 ENSG00000125952 HEK293_OSMI2_6hA HEK293_TMG_6hB MAX protein_coding protein_coding 66.10373 70.95693 47.40759 6.6414 1.790212 -0.5817244 13.00726 11.51910 14.05483 0.6108281 0.173355 0.2868123 0.2076375 0.1638000 0.2971000 0.1333 4.769583e-05 4.769583e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000125952 E001 0.1723744 0.0338722262 0.92023621   14 65006174 65006284 111 - 0.000 0.096 10.589
ENSG00000125952 E002 7.4248543 0.0040637799 0.00226099 0.01880350 14 65060918 65062002 1085 - 1.091 0.775 -1.194
ENSG00000125952 E003 0.3337900 0.0286595624 0.64736633   14 65065537 65065602 66 - 0.152 0.096 -0.761
ENSG00000125952 E004 3.4492598 0.0081041507 0.11252425 0.30336405 14 65069694 65070369 676 - 0.749 0.542 -0.895
ENSG00000125952 E005 0.6672048 0.0253467364 0.13516638   14 65075124 65075126 3 - 0.000 0.299 12.589
ENSG00000125952 E006 9.8150385 0.0039869080 0.59504674 0.76707960 14 65075127 65075157 31 - 1.028 1.008 -0.073
ENSG00000125952 E007 93.3866701 0.0028821538 0.67764325 0.82124492 14 65075158 65075201 44 - 1.910 1.976 0.223
ENSG00000125952 E008 1474.4658544 0.0136974699 0.77332957 0.88067076 14 65075202 65076085 884 - 3.105 3.177 0.241
ENSG00000125952 E009 713.0499292 0.0123280952 0.96166892 0.98285710 14 65076086 65076457 372 - 2.801 2.857 0.185
ENSG00000125952 E010 227.1580879 0.0069182469 0.20771346 0.43906213 14 65076458 65076461 4 - 2.343 2.339 -0.012
ENSG00000125952 E011 541.6621784 0.0010290800 0.00308742 0.02394338 14 65076462 65076608 147 - 2.724 2.712 -0.041
ENSG00000125952 E012 393.7327917 0.0002163205 0.01052493 0.06035800 14 65076609 65076663 55 - 2.582 2.577 -0.017
ENSG00000125952 E013 35.0823315 0.1020251952 0.07112441 0.22698941 14 65076664 65077192 529 - 1.669 1.445 -0.765
ENSG00000125952 E014 7.2902521 0.0430447157 0.51965891 0.71478386 14 65077193 65077286 94 - 0.934 0.885 -0.186
ENSG00000125952 E015 3.7027909 0.0075703988 0.66553402 0.81336661 14 65077287 65077300 14 - 0.596 0.696 0.429
ENSG00000125952 E016 4.8148431 0.0061096991 0.56699006 0.74800702 14 65077301 65077327 27 - 0.781 0.737 -0.177
ENSG00000125952 E017 5.1416186 0.0062614450 0.31448808 0.55471977 14 65077328 65077343 16 - 0.837 0.737 -0.398
ENSG00000125952 E018 6.5469093 0.1149232184 0.49740596 0.69913600 14 65077344 65077384 41 - 0.888 0.838 -0.192
ENSG00000125952 E019 8.5082862 0.0845501809 0.20165478 0.43169649 14 65077385 65077428 44 - 1.060 0.893 -0.621
ENSG00000125952 E020 12.2427727 0.0498151580 0.86835209 0.93504322 14 65077429 65077562 134 - 1.087 1.112 0.089
ENSG00000125952 E021 12.3032525 0.0045824605 0.85340471 0.92684155 14 65077563 65077643 81 - 1.091 1.111 0.073
ENSG00000125952 E022 13.6707665 0.0033393638 0.61711378 0.78184441 14 65077644 65077773 130 - 1.159 1.150 -0.031
ENSG00000125952 E023 11.3014204 0.0031436842 0.18120122 0.40555822 14 65077774 65077912 139 - 1.133 1.038 -0.345
ENSG00000125952 E024 496.9025304 0.0264227744 0.42942800 0.65059676 14 65077913 65078036 124 - 2.624 2.711 0.289
ENSG00000125952 E025 11.6780929 0.0062253837 0.13298720 0.33647940 14 65083744 65083993 250 - 1.160 1.047 -0.405
ENSG00000125952 E026 23.4513289 0.0028718400 0.02645198 0.11663780 14 65083994 65084299 306 - 1.452 1.328 -0.427
ENSG00000125952 E027 0.4873834 0.2341283648 1.00000000   14 65093498 65093702 205 - 0.151 0.176 0.266
ENSG00000125952 E028 1.7138376 0.0461067041 0.32078471 0.56037835 14 65093703 65093707 5 - 0.264 0.478 1.259
ENSG00000125952 E029 396.6853990 1.4988825661 0.52905678 0.72136499 14 65093708 65093815 108 - 2.463 2.640 0.590
ENSG00000125952 E030 99.7706409 0.0984697929 0.91739046 0.96092025 14 65101546 65101572 27 - 2.011 1.974 -0.123
ENSG00000125952 E031 0.9006742 0.1753136143 0.85998830   14 65101573 65101685 113 - 0.265 0.246 -0.141
ENSG00000125952 E032 317.3533105 0.0370937480 0.45776663 0.67161266 14 65102304 65102508 205 - 2.428 2.517 0.296
ENSG00000125952 E033 19.9125058 0.0225452753 0.43377412 0.65405867 14 65102509 65102695 187 - 1.339 1.298 -0.145