ENSG00000125895

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381894 ENSG00000125895 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM74B protein_coding protein_coding 4.06759 6.001803 1.487228 0.7653682 0.04311951 -2.005504 1.1165963 1.8032149 1.0522217 1.01452490 0.08543297 -0.7714650 0.33445833 0.29463333 0.70563333 0.411000000 0.186756506 0.004546446 FALSE TRUE
ENST00000429036 ENSG00000125895 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM74B protein_coding protein_coding 4.06759 6.001803 1.487228 0.7653682 0.04311951 -2.005504 0.1564628 0.3178846 0.1774133 0.16673950 0.17741333 -0.8069647 0.04751667 0.04683333 0.12520000 0.078366667 0.956903190 0.004546446 FALSE TRUE
ENST00000481747 ENSG00000125895 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM74B protein_coding processed_transcript 4.06759 6.001803 1.487228 0.7653682 0.04311951 -2.005504 0.4557566 0.5371457 0.1285229 0.06686655 0.08481537 -1.9818005 0.10655417 0.09276667 0.08330000 -0.009466667 0.907105605 0.004546446 FALSE FALSE
MSTRG.20237.1 ENSG00000125895 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM74B protein_coding   4.06759 6.001803 1.487228 0.7653682 0.04311951 -2.005504 0.8349886 1.0444796 0.1290700 0.47213248 0.08007015 -2.9226481 0.19139167 0.15833333 0.08586667 -0.072466667 0.826057627 0.004546446 FALSE TRUE
MSTRG.20237.2 ENSG00000125895 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM74B protein_coding   4.06759 6.001803 1.487228 0.7653682 0.04311951 -2.005504 0.1059336 0.3831503 0.0000000 0.09896119 0.00000000 -5.2970090 0.02193333 0.06880000 0.00000000 -0.068800000 0.074970899 0.004546446 FALSE TRUE
MSTRG.20237.3 ENSG00000125895 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM74B protein_coding   4.06759 6.001803 1.487228 0.7653682 0.04311951 -2.005504 0.9209224 1.1495404 0.0000000 0.46425172 0.00000000 -6.8574093 0.19585000 0.20706667 0.00000000 -0.207066667 0.054596513 0.004546446 FALSE TRUE
MSTRG.20237.4 ENSG00000125895 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM74B protein_coding   4.06759 6.001803 1.487228 0.7653682 0.04311951 -2.005504 0.3946267 0.7663872 0.0000000 0.20572743 0.00000000 -6.2787045 0.08515417 0.13153333 0.00000000 -0.131533333 0.004546446 0.004546446   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000125895 E001 1.713598 0.013454144 9.677181e-01 0.9857275656 20 1180171 1180325 155 - 0.393 0.356 -0.212
ENSG00000125895 E002 1.273877 0.013491371 7.059337e-01   20 1180326 1180506 181 - 0.239 0.299 0.430
ENSG00000125895 E003 0.000000       20 1180507 1180521 15 -      
ENSG00000125895 E004 0.000000       20 1180522 1180560 39 -      
ENSG00000125895 E005 0.000000       20 1180561 1180569 9 -      
ENSG00000125895 E006 25.517479 0.018277594 3.556269e-01 0.5922162491 20 1180570 1180788 219 - 1.414 1.273 -0.490
ENSG00000125895 E007 76.649473 0.027715017 8.710864e-03 0.0525327684 20 1180789 1181283 495 - 1.643 1.777 0.456
ENSG00000125895 E008 17.251933 0.002537285 2.778975e-02 0.1206714096 20 1181284 1181299 16 - 0.958 1.164 0.751
ENSG00000125895 E009 45.616114 0.001261281 1.422324e-05 0.0002844506 20 1181300 1181587 288 - 1.303 1.573 0.930
ENSG00000125895 E010 8.004224 0.004035161 6.407695e-01 0.7974212311 20 1183771 1183784 14 - 0.921 0.815 -0.410
ENSG00000125895 E011 13.753729 0.011427243 1.842246e-01 0.4094649484 20 1183785 1183885 101 - 1.195 1.005 -0.687
ENSG00000125895 E012 9.994789 0.004270897 5.299613e-02 0.1867173079 20 1183886 1183948 63 - 1.130 0.860 -1.001
ENSG00000125895 E013 18.756929 0.126743946 7.036768e-02 0.2254598767 20 1183949 1184301 353 - 1.373 1.112 -0.920
ENSG00000125895 E014 11.497465 0.070029162 1.169220e-02 0.0651997582 20 1184302 1184380 79 - 1.269 0.883 -1.407
ENSG00000125895 E015 23.346717 0.177560443 6.938287e-03 0.0443460367 20 1184381 1184981 601 - 1.567 1.161 -1.414
ENSG00000125895 E016 5.000048 0.077715048 1.026611e-01 0.2865344627 20 1185138 1185390 253 - 0.394 0.706 1.467
ENSG00000125895 E017 2.331969 0.237309415 3.804844e-01 0.6125979748 20 1185391 1185456 66 - 0.240 0.477 1.439