ENSG00000125755

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000245934 ENSG00000125755 HEK293_OSMI2_6hA HEK293_TMG_6hB SYMPK protein_coding protein_coding 67.40541 92.28608 45.26316 15.16155 1.385969 -1.027613 15.225731 30.234742 8.155518 8.5641082 2.8124795 -1.8890679 0.21521250 0.31230000 0.1785667 -0.13373333 5.013410e-01 2.382378e-18 FALSE TRUE
MSTRG.17344.10 ENSG00000125755 HEK293_OSMI2_6hA HEK293_TMG_6hB SYMPK protein_coding   67.40541 92.28608 45.26316 15.16155 1.385969 -1.027613 3.014031 3.386788 0.000000 0.3990522 0.0000000 -8.4080274 0.05005833 0.03736667 0.0000000 -0.03736667 2.382378e-18 2.382378e-18 FALSE TRUE
MSTRG.17344.7 ENSG00000125755 HEK293_OSMI2_6hA HEK293_TMG_6hB SYMPK protein_coding   67.40541 92.28608 45.26316 15.16155 1.385969 -1.027613 23.750470 33.878124 18.094529 5.1167566 1.8105695 -0.9044292 0.35032500 0.36923333 0.4002000 0.03096667 9.130388e-01 2.382378e-18 FALSE TRUE
MSTRG.17344.9 ENSG00000125755 HEK293_OSMI2_6hA HEK293_TMG_6hB SYMPK protein_coding   67.40541 92.28608 45.26316 15.16155 1.385969 -1.027613 5.590137 3.329897 7.580161 1.2217453 0.8909972 1.1843270 0.10205417 0.03536667 0.1690000 0.13363333 8.971634e-04 2.382378e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000125755 E001 0.0000000       19 45815410 45815427 18 -      
ENSG00000125755 E002 0.1614157 0.0336357533 1.859451e-01   19 45815428 45815447 20 - 0.179 0.000 -11.656
ENSG00000125755 E003 0.1614157 0.0336357533 1.859451e-01   19 45815448 45815467 20 - 0.179 0.000 -11.704
ENSG00000125755 E004 1.3277703 0.0167094597 5.710639e-01   19 45815468 45815537 70 - 0.402 0.306 -0.576
ENSG00000125755 E005 2.5119105 0.0189196064 1.830414e-01 4.078677e-01 19 45815538 45815543 6 - 0.305 0.564 1.390
ENSG00000125755 E006 2.8455129 0.0151655668 1.132755e-01 3.046111e-01 19 45815544 45815544 1 - 0.305 0.610 1.595
ENSG00000125755 E007 409.8918761 0.0033382389 1.420252e-04 2.004751e-03 19 45815545 45815697 153 - 2.455 2.608 0.510
ENSG00000125755 E008 360.9978846 0.0038530982 2.835541e-04 3.563268e-03 19 45815851 45815895 45 - 2.397 2.554 0.524
ENSG00000125755 E009 781.4900968 0.0071488232 1.007707e-04 1.504588e-03 19 45815896 45816183 288 - 2.703 2.894 0.637
ENSG00000125755 E010 225.9416010 0.0050437388 1.340433e-05 2.702557e-04 19 45816482 45816482 1 - 2.145 2.364 0.733
ENSG00000125755 E011 465.5432605 0.0064050711 4.944955e-05 8.237048e-04 19 45816483 45816577 95 - 2.471 2.672 0.668
ENSG00000125755 E012 7.6349560 0.0043499954 4.630253e-02 1.707951e-01 19 45816578 45816614 37 - 1.049 0.827 -0.834
ENSG00000125755 E013 551.9529870 0.0029359757 1.707692e-05 3.340691e-04 19 45816798 45816974 177 - 2.582 2.737 0.517
ENSG00000125755 E014 4.2965842 0.0211465054 1.132936e-01 3.046403e-01 19 45816975 45817133 159 - 0.482 0.768 1.257
ENSG00000125755 E015 620.9297414 0.0001219149 1.780768e-05 3.463696e-04 19 45817959 45818146 188 - 2.688 2.776 0.295
ENSG00000125755 E016 9.9040766 0.0467393566 6.201084e-01 7.839231e-01 19 45818913 45818954 42 - 0.938 1.016 0.287
ENSG00000125755 E017 239.0661922 0.0713182024 9.130424e-01 9.586245e-01 19 45818955 45821383 2429 - 2.303 2.346 0.143
ENSG00000125755 E018 548.0270029 0.0001388144 5.432892e-04 6.066742e-03 19 45821384 45821485 102 - 2.642 2.720 0.261
ENSG00000125755 E019 489.0508475 0.0002605775 1.467069e-03 1.338610e-02 19 45822756 45822846 91 - 2.592 2.670 0.261
ENSG00000125755 E020 496.9150776 0.0015872186 1.733186e-01 3.949319e-01 19 45823372 45823472 101 - 2.616 2.667 0.168
ENSG00000125755 E021 522.1130608 0.0006052919 2.443781e-02 1.104720e-01 19 45823767 45823875 109 - 2.630 2.692 0.205
ENSG00000125755 E022 13.0912668 0.1156000087 2.936752e-01 5.343176e-01 19 45823876 45824012 137 - 1.223 1.054 -0.607
ENSG00000125755 E023 11.2134744 0.1449612242 3.186382e-01 5.584679e-01 19 45824044 45824161 118 - 1.156 0.997 -0.578
ENSG00000125755 E024 598.8245106 0.0001280071 4.359934e-02 1.641395e-01 19 45825171 45825331 161 - 2.700 2.750 0.169
ENSG00000125755 E025 3.1354294 0.0609840113 3.312690e-01 5.701152e-01 19 45826215 45826225 11 - 0.705 0.555 -0.652
ENSG00000125755 E026 372.1391833 0.0003527949 1.089041e-01 2.972520e-01 19 45826226 45826280 55 - 2.492 2.545 0.174
ENSG00000125755 E027 438.0883904 0.0001417206 9.957788e-01 9.994807e-01 19 45826281 45826373 93 - 2.589 2.606 0.056
ENSG00000125755 E028 530.5453019 0.0001296607 4.848483e-01 6.904282e-01 19 45827510 45827623 114 - 2.680 2.685 0.016
ENSG00000125755 E029 399.8746364 0.0008537561 2.758429e-01 5.159318e-01 19 45827837 45827918 82 - 2.566 2.556 -0.035
ENSG00000125755 E030 56.0133278 0.0512944509 5.716004e-01 7.514065e-01 19 45827919 45828969 1051 - 1.752 1.694 -0.197
ENSG00000125755 E031 409.1650930 0.0001576186 2.976421e-01 5.381522e-01 19 45828970 45829054 85 - 2.545 2.583 0.128
ENSG00000125755 E032 493.8233090 0.0015641904 1.350827e-02 7.240068e-02 19 45829055 45829205 151 - 2.593 2.674 0.271
ENSG00000125755 E033 500.0482125 0.0629018456 1.089131e-01 2.972670e-01 19 45830054 45830204 151 - 2.519 2.698 0.596
ENSG00000125755 E034 5.7878159 0.0063240984 1.382528e-01 3.448967e-01 19 45831170 45831383 214 - 0.910 0.724 -0.730
ENSG00000125755 E035 701.2312374 0.0079424307 1.262817e-01 3.259379e-01 19 45831384 45831588 205 - 2.746 2.821 0.250
ENSG00000125755 E036 339.3245376 0.0007402825 5.223126e-01 7.165450e-01 19 45835078 45835095 18 - 2.490 2.488 -0.006
ENSG00000125755 E037 566.4019226 0.0011309812 3.182184e-02 1.326806e-01 19 45835096 45835228 133 - 2.735 2.698 -0.122
ENSG00000125755 E038 465.3600997 0.0001992116 1.993305e-03 1.701905e-02 19 45838461 45838554 94 - 2.656 2.616 -0.135
ENSG00000125755 E039 359.1065439 0.0003949708 3.771052e-02 1.488671e-01 19 45838555 45838592 38 - 2.538 2.509 -0.098
ENSG00000125755 E040 293.9473726 0.0006092155 1.624000e-01 3.803377e-01 19 45838593 45838615 23 - 2.444 2.425 -0.064
ENSG00000125755 E041 638.9070574 0.0007372850 4.452900e-02 1.664330e-01 19 45842250 45842489 240 - 2.782 2.756 -0.087
ENSG00000125755 E042 0.5115862 0.0217681645 8.248544e-01   19 45842490 45842708 219 - 0.179 0.149 -0.319
ENSG00000125755 E043 0.0000000       19 45842709 45843037 329 -      
ENSG00000125755 E044 0.3337900 0.0329534791 4.929167e-01   19 45843043 45843072 30 - 0.179 0.081 -1.317
ENSG00000125755 E045 498.3423230 0.0001182361 1.034961e-05 2.160543e-04 19 45844030 45844200 171 - 2.699 2.639 -0.200
ENSG00000125755 E046 631.2540689 0.0010250567 1.849174e-11 1.520952e-09 19 45847752 45848001 250 - 2.847 2.716 -0.434
ENSG00000125755 E047 268.0782390 0.0105411679 1.622821e-03 1.448235e-02 19 45848750 45848762 13 - 2.499 2.330 -0.562
ENSG00000125755 E048 379.2753906 0.0019668154 3.224966e-10 2.053518e-08 19 45848763 45848829 67 - 2.650 2.482 -0.562
ENSG00000125755 E049 321.7865656 0.0001978630 1.683233e-16 3.127480e-14 19 45848830 45848876 47 - 2.577 2.417 -0.531
ENSG00000125755 E050 412.7193268 0.0016977614 1.431440e-11 1.198676e-09 19 45852312 45852385 74 - 2.687 2.517 -0.568
ENSG00000125755 E051 374.4758078 0.0021430153 2.078766e-09 1.140990e-07 19 45852482 45852535 54 - 2.641 2.476 -0.551
ENSG00000125755 E052 260.3176427 0.0034253093 4.963861e-07 1.537719e-05 19 45854175 45854194 20 - 2.489 2.315 -0.581
ENSG00000125755 E053 317.4085906 0.0015392806 7.648886e-10 4.559343e-08 19 45854195 45854240 46 - 2.566 2.406 -0.533
ENSG00000125755 E054 2.5263514 0.1954252675 4.166036e-01 6.411509e-01 19 45854241 45854390 150 - 0.655 0.453 -0.936
ENSG00000125755 E055 336.5683708 0.0001609760 7.657134e-07 2.251846e-05 19 45854391 45854497 107 - 2.548 2.460 -0.291
ENSG00000125755 E056 146.7856351 0.0005675440 3.545373e-01 5.913450e-01 19 45854498 45854507 10 - 2.141 2.128 -0.044
ENSG00000125755 E057 11.5707029 0.0913426510 4.678627e-02 1.720302e-01 19 45854508 45854585 78 - 0.748 1.136 1.462
ENSG00000125755 E058 13.2045321 0.2138468906 2.492916e-01 4.870734e-01 19 45854586 45854808 223 - 0.824 1.183 1.328
ENSG00000125755 E059 27.2569709 0.1724940431 1.965464e-01 4.252307e-01 19 45854809 45855807 999 - 1.146 1.476 1.154
ENSG00000125755 E060 14.6173028 0.0026238377 9.261693e-01 9.652219e-01 19 45861900 45862027 128 - 1.154 1.160 0.024
ENSG00000125755 E061 3.6047988 0.0837057269 3.681524e-01 6.025225e-01 19 45862487 45862551 65 - 0.483 0.671 0.851
ENSG00000125755 E062 178.5251038 0.0010065388 9.779154e-01 9.907316e-01 19 45863058 45863194 137 - 2.204 2.220 0.055