ENSG00000125746

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000245925 ENSG00000125746 HEK293_OSMI2_6hA HEK293_TMG_6hB EML2 protein_coding protein_coding 21.221 26.06889 17.8402 0.7995243 0.9027192 -0.5469426 2.829966 4.039550 2.0618225 0.7195511 1.0657031 -0.9668612 0.13037917 0.15360000 0.12200000 -0.03160000 0.89980622 0.002372858 FALSE  
ENST00000586195 ENSG00000125746 HEK293_OSMI2_6hA HEK293_TMG_6hB EML2 protein_coding nonsense_mediated_decay 21.221 26.06889 17.8402 0.7995243 0.9027192 -0.5469426 1.228405 1.722071 0.8596462 0.7390553 0.3044415 -0.9939975 0.05705000 0.06483333 0.04673333 -0.01810000 0.97238144 0.002372858 FALSE  
ENST00000592433 ENSG00000125746 HEK293_OSMI2_6hA HEK293_TMG_6hB EML2 protein_coding retained_intron 21.221 26.06889 17.8402 0.7995243 0.9027192 -0.5469426 8.031354 7.647830 7.0173787 0.1047817 0.3423609 -0.1239490 0.38355417 0.29383333 0.39343333 0.09960000 0.04042931 0.002372858 FALSE  
ENST00000592482 ENSG00000125746 HEK293_OSMI2_6hA HEK293_TMG_6hB EML2 protein_coding retained_intron 21.221 26.06889 17.8402 0.7995243 0.9027192 -0.5469426 1.621821 1.834236 2.0571645 0.6133530 0.2884104 0.1646302 0.07615417 0.07113333 0.11513333 0.04400000 0.60479184 0.002372858    
MSTRG.17328.7 ENSG00000125746 HEK293_OSMI2_6hA HEK293_TMG_6hB EML2 protein_coding   21.221 26.06889 17.8402 0.7995243 0.9027192 -0.5469426 2.917531 4.173513 1.9165812 0.4838070 0.7548301 -1.1186718 0.13769167 0.16126667 0.10373333 -0.05753333 0.71922857 0.002372858 FALSE  
MSTRG.17328.8 ENSG00000125746 HEK293_OSMI2_6hA HEK293_TMG_6hB EML2 protein_coding   21.221 26.06889 17.8402 0.7995243 0.9027192 -0.5469426 2.061478 3.469971 1.4831054 0.1554954 0.7449814 -1.2207592 0.09700000 0.13323333 0.08300000 -0.05023333 0.82041144 0.002372858 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000125746 E001 4.5250465 0.0084113795 0.050335131 0.18047976 19 45606994 45607506 513 - 0.462 0.782 1.411
ENSG00000125746 E002 0.8682213 0.0356265812 0.073728649   19 45609400 45609401 2 - 0.000 0.363 13.015
ENSG00000125746 E003 8.2461749 0.0139793545 0.909130427 0.95664292 19 45609402 45609556 155 - 0.935 0.956 0.077
ENSG00000125746 E004 17.2468309 0.0022525547 0.126871170 0.32680616 19 45609557 45609578 22 - 1.312 1.183 -0.453
ENSG00000125746 E005 21.1197378 0.0018039541 0.034613961 0.14054721 19 45609579 45609581 3 - 1.418 1.257 -0.561
ENSG00000125746 E006 99.7971492 0.0014785770 0.391858524 0.62191005 19 45609582 45609661 80 - 1.995 1.961 -0.114
ENSG00000125746 E007 121.4011338 0.0004783612 0.122898105 0.32031255 19 45609662 45609719 58 - 2.092 2.041 -0.169
ENSG00000125746 E008 145.0346701 0.0003550173 0.010406787 0.05989754 19 45609720 45609788 69 - 2.185 2.108 -0.257
ENSG00000125746 E009 175.4632015 0.0003146512 0.080781083 0.24638528 19 45613541 45613671 131 - 2.245 2.198 -0.159
ENSG00000125746 E010 128.9399427 0.0003700675 0.500124018 0.70083888 19 45614605 45614700 96 - 2.097 2.076 -0.069
ENSG00000125746 E011 2.1530102 0.0111882957 0.958194200 0.98102199 19 45614826 45615036 211 - 0.463 0.473 0.052
ENSG00000125746 E012 103.2606436 0.0012880401 0.132440507 0.33565918 19 45615802 45615858 57 - 2.027 1.971 -0.188
ENSG00000125746 E013 79.2196299 0.0005370041 0.415011430 0.63980125 19 45615859 45615889 31 - 1.895 1.862 -0.109
ENSG00000125746 E014 41.8201997 0.0015840601 0.009769584 0.05712761 19 45615890 45616152 263 - 1.694 1.546 -0.503
ENSG00000125746 E015 29.7995509 0.0208131864 0.153595632 0.36744856 19 45616461 45616484 24 - 1.353 1.498 0.499
ENSG00000125746 E016 28.8093949 0.0097770442 0.143520017 0.35267768 19 45616485 45616495 11 - 1.352 1.479 0.441
ENSG00000125746 E017 26.3413554 0.0014089266 0.015825707 0.08117191 19 45616496 45616499 4 - 1.269 1.456 0.649
ENSG00000125746 E018 34.8988428 0.0010615590 0.054047412 0.18917937 19 45616500 45616517 18 - 1.433 1.562 0.440
ENSG00000125746 E019 42.3279129 0.0009477822 0.191682055 0.41900426 19 45616518 45616558 41 - 1.552 1.631 0.269
ENSG00000125746 E020 66.2688277 0.0050941857 0.394412535 0.62392241 19 45616765 45616853 89 - 1.761 1.811 0.168
ENSG00000125746 E021 48.8047578 0.0242236569 0.125850746 0.32524871 19 45617630 45617676 47 - 1.567 1.700 0.452
ENSG00000125746 E022 37.4050754 0.0058089504 0.008702819 0.05249863 19 45617677 45617697 21 - 1.410 1.604 0.662
ENSG00000125746 E023 1.5218220 0.0945881606 0.161477952 0.37895989 19 45618822 45618943 122 - 0.169 0.468 2.022
ENSG00000125746 E024 72.5563751 0.0024136846 0.008909122 0.05341102 19 45619060 45619191 132 - 1.738 1.871 0.449
ENSG00000125746 E025 22.9721426 0.0598320053 0.038661030 0.15127257 19 45619192 45619494 303 - 1.512 1.247 -0.921
ENSG00000125746 E026 12.6816144 0.0821829125 0.122186448 0.31930653 19 45620812 45621162 351 - 1.246 1.021 -0.808
ENSG00000125746 E027 4.5626605 0.0168131567 0.128076711 0.32874416 19 45621163 45621206 44 - 0.856 0.633 -0.906
ENSG00000125746 E028 63.3382252 0.0006022861 0.029258372 0.12514784 19 45621207 45621332 126 - 1.698 1.807 0.366
ENSG00000125746 E029 50.5436538 0.0010962764 0.574357305 0.75324988 19 45621483 45621553 71 - 1.659 1.692 0.109
ENSG00000125746 E030 48.7112248 0.0150747927 0.869378562 0.93555514 19 45621554 45621637 84 - 1.655 1.673 0.061
ENSG00000125746 E031 0.1779838 0.0343326937 0.224734160   19 45623456 45623521 66 - 0.169 0.000 -12.732
ENSG00000125746 E032 28.5192493 0.0016077733 0.969711831 0.98668751 19 45624719 45624719 1 - 1.441 1.446 0.017
ENSG00000125746 E033 65.8306956 0.0006570181 0.549781745 0.73612761 19 45624720 45624818 99 - 1.774 1.804 0.100
ENSG00000125746 E034 76.5317467 0.0025199434 0.584556847 0.76004653 19 45626705 45626839 135 - 1.838 1.865 0.091
ENSG00000125746 E035 0.1779838 0.0343326937 0.224734160   19 45628698 45628795 98 - 0.169 0.000 -12.732
ENSG00000125746 E036 36.6966249 0.0013946150 0.408317003 0.63471791 19 45629951 45629963 13 - 1.575 1.524 -0.173
ENSG00000125746 E037 58.2118489 0.0061003559 0.417905658 0.64207054 19 45629964 45630046 83 - 1.702 1.752 0.168
ENSG00000125746 E038 0.4880035 0.1908656284 0.281168088   19 45632521 45632860 340 - 0.288 0.087 -2.080
ENSG00000125746 E039 50.4404261 0.0016600771 0.052815655 0.18628630 19 45632861 45632905 45 - 1.596 1.707 0.378
ENSG00000125746 E040 50.7600710 0.0008319287 0.946969039 0.97580168 19 45632906 45632971 66 - 1.677 1.682 0.017
ENSG00000125746 E041 1.1547758 0.0188738359 0.865389914   19 45632972 45633069 98 - 0.290 0.322 0.208
ENSG00000125746 E042 40.7929147 0.0013749085 0.908716726 0.95644642 19 45633070 45633107 38 - 1.580 1.588 0.026
ENSG00000125746 E043 41.2799112 0.0009799327 0.567028621 0.74800742 19 45633108 45633139 32 - 1.617 1.585 -0.108
ENSG00000125746 E044 75.7270984 0.0006636051 0.830529333 0.91408284 19 45634322 45634471 150 - 1.856 1.848 -0.027
ENSG00000125746 E045 1.2804824 0.0224936066 0.079468639   19 45634472 45634496 25 - 0.528 0.219 -1.855
ENSG00000125746 E046 66.2573991 0.0006291303 0.954831197 0.97930012 19 45638505 45638634 130 - 1.794 1.799 0.015
ENSG00000125746 E047 1.0719510 0.0180555408 0.532780217   19 45638635 45638844 210 - 0.385 0.273 -0.704
ENSG00000125746 E048 38.8648603 0.0034320756 0.846686583 0.92311896 19 45638845 45638873 29 - 1.564 1.580 0.055
ENSG00000125746 E049 1.6497938 0.0117781232 0.917986972 0.96119105 19 45638874 45638993 120 - 0.385 0.404 0.107
ENSG00000125746 E050 0.1723744 0.0338685696 1.000000000   19 45638994 45639104 111 - 0.000 0.086 10.545
ENSG00000125746 E051 0.2027342 0.0372272125 1.000000000   19 45639207 45639294 88 - 0.000 0.086 10.522
ENSG00000125746 E052 2.6610823 0.0114965482 0.481955082 0.68836307 19 45639295 45639356 62 - 0.462 0.585 0.583
ENSG00000125746 E053 29.2766753 0.0015493835 0.370199944 0.60411931 19 45639357 45639403 47 - 1.410 1.475 0.224
ENSG00000125746 E054 0.0000000       19 45640024 45640131 108 -      
ENSG00000125746 E055 0.4646582 0.0217681645 0.949013074   19 45640417 45640929 513 - 0.169 0.158 -0.119
ENSG00000125746 E056 0.0000000       19 45640930 45641640 711 -      
ENSG00000125746 E057 1.2028192 0.0192776675 0.717306417   19 45641641 45641671 31 - 0.385 0.321 -0.384
ENSG00000125746 E058 1.4645555 0.0825477639 0.982038675 0.99277612 19 45641672 45641745 74 - 0.384 0.398 0.078
ENSG00000125746 E059 0.3926045 0.4404732834 0.502873924   19 45641746 45641748 3 - 0.000 0.209 11.045
ENSG00000125746 E060 0.0000000       19 45641749 45641917 169 -      
ENSG00000125746 E061 1.3336873 0.0347032246 0.890531989   19 45641918 45642041 124 - 0.385 0.363 -0.127
ENSG00000125746 E062 0.0000000       19 45642042 45642133 92 -      
ENSG00000125746 E063 1.3642348 0.0839828762 0.451472354   19 45642134 45642352 219 - 0.462 0.319 -0.810
ENSG00000125746 E064 0.4646582 0.0217681645 0.949013074   19 45642353 45642471 119 - 0.169 0.158 -0.119
ENSG00000125746 E065 0.3032425 0.0244411696 0.507512663   19 45642472 45642778 307 - 0.000 0.158 11.593
ENSG00000125746 E066 0.0000000       19 45643579 45643727 149 -      
ENSG00000125746 E067 0.0000000       19 45644709 45644917 209 -      
ENSG00000125746 E068 0.0000000       19 45645273 45645602 330 -