ENSG00000125703

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317868 ENSG00000125703 HEK293_OSMI2_6hA HEK293_TMG_6hB ATG4C protein_coding protein_coding 13.80998 4.294336 21.59277 1.214678 0.7911803 2.327354 5.469193 2.14715801 8.257376 0.55227722 0.6245367 1.938298 0.45502917 0.542000000 0.38326667 -0.15873333 6.516611e-01 9.235688e-10 FALSE TRUE
ENST00000371118 ENSG00000125703 HEK293_OSMI2_6hA HEK293_TMG_6hB ATG4C protein_coding protein_coding 13.80998 4.294336 21.59277 1.214678 0.7911803 2.327354 2.857668 0.00000000 5.288793 0.00000000 1.1698308 9.049520 0.12082500 0.000000000 0.24203333 0.24203333 9.235688e-10 9.235688e-10 FALSE FALSE
ENST00000371120 ENSG00000125703 HEK293_OSMI2_6hA HEK293_TMG_6hB ATG4C protein_coding protein_coding 13.80998 4.294336 21.59277 1.214678 0.7911803 2.327354 4.065497 2.12870479 6.197611 0.79833752 0.5785832 1.537301 0.33817083 0.455033333 0.28880000 -0.16623333 5.916154e-01 9.235688e-10 FALSE TRUE
MSTRG.1319.1 ENSG00000125703 HEK293_OSMI2_6hA HEK293_TMG_6hB ATG4C protein_coding   13.80998 4.294336 21.59277 1.214678 0.7911803 2.327354 1.006643 0.01847301 1.848989 0.01847301 0.3908111 6.028780 0.06009583 0.002966667 0.08593333 0.08296667 3.785290e-04 9.235688e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000125703 E001 6.1744257 0.0048296367 0.002211107 0.01846918 1 62783765 62783977 213 + 0.878 0.338 -2.478
ENSG00000125703 E002 2.9006092 0.0086298761 0.149111859 0.36096795 1 62784132 62784134 3 + 0.469 0.709 1.079
ENSG00000125703 E003 39.1780541 0.0012652196 0.149393658 0.36138225 1 62784135 62784225 91 + 1.519 1.612 0.317
ENSG00000125703 E004 24.6584920 0.0052333418 0.611222903 0.77775191 1 62784226 62784273 48 + 1.337 1.378 0.142
ENSG00000125703 E005 1.0478208 0.0149274325 0.755339919   1 62785233 62785260 28 + 0.275 0.337 0.408
ENSG00000125703 E006 58.4274779 0.0045831892 0.811317566 0.90303381 1 62803719 62803777 59 + 1.713 1.699 -0.047
ENSG00000125703 E007 79.5725268 0.0006327569 0.250234399 0.48821898 1 62803778 62803862 85 + 1.852 1.801 -0.171
ENSG00000125703 E008 80.8613254 0.0012257916 0.472173077 0.68167276 1 62805172 62805255 84 + 1.850 1.817 -0.111
ENSG00000125703 E009 128.7601188 0.0017793712 0.852933470 0.92663614 1 62816575 62816808 234 + 2.046 2.039 -0.024
ENSG00000125703 E010 178.2140815 0.0003865018 0.700323093 0.83584679 1 62819005 62819335 331 + 2.188 2.180 -0.029
ENSG00000125703 E011 70.4063138 0.0006741241 0.919918182 0.96216519 1 62821139 62821182 44 + 1.785 1.793 0.025
ENSG00000125703 E012 52.1931523 0.0032240748 0.625302754 0.78750261 1 62821183 62821209 27 + 1.667 1.636 -0.107
ENSG00000125703 E013 103.7301871 0.0037179024 0.799726938 0.89620649 1 62829040 62829176 137 + 1.950 1.959 0.030
ENSG00000125703 E014 104.1365697 0.0008336154 0.133449328 0.33720840 1 62834038 62834116 79 + 1.968 1.908 -0.204
ENSG00000125703 E015 103.4270807 0.0004378469 0.425278482 0.64747302 1 62834776 62834852 77 + 1.959 1.929 -0.098
ENSG00000125703 E016 0.5173834 0.0487111687 0.539676801   1 62835386 62835529 144 + 0.186 0.000 -9.202
ENSG00000125703 E017 137.3532033 0.0004316317 0.353930676 0.59078083 1 62841428 62841547 120 + 2.067 2.102 0.117
ENSG00000125703 E018 277.8565708 0.0014629802 0.060927150 0.20486341 1 62863992 62865516 1525 + 2.364 2.411 0.155