ENSG00000125648

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301454 ENSG00000125648 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC25A23 protein_coding protein_coding 70.75606 109.6463 44.07468 22.33587 3.732873 -1.314639 43.600527 68.385168 27.910424 13.5563950 1.3747980 -1.2925735 0.62542917 0.6262 0.63736667 0.011166667 0.968916482 0.002166728 FALSE  
ENST00000595810 ENSG00000125648 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC25A23 protein_coding protein_coding 70.75606 109.6463 44.07468 22.33587 3.732873 -1.314639 6.524167 8.726437 2.268408 2.1228345 0.8764596 -1.9390186 0.08301250 0.0781 0.04980000 -0.028300000 0.640437327 0.002166728 FALSE  
ENST00000598908 ENSG00000125648 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC25A23 protein_coding protein_coding 70.75606 109.6463 44.07468 22.33587 3.732873 -1.314639 6.125299 8.721364 3.415113 1.8423942 0.4657607 -1.3500556 0.08273333 0.0792 0.07686667 -0.002333333 0.979370619 0.002166728 FALSE  
ENST00000600682 ENSG00000125648 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC25A23 protein_coding protein_coding 70.75606 109.6463 44.07468 22.33587 3.732873 -1.314639 1.779897 2.954412 3.986565 0.9868912 0.8652576 0.4310146 0.03276667 0.0251 0.08883333 0.063733333 0.002166728 0.002166728 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000125648 E001 0.1426347 0.0317159014 1.537981e-01   19 6436079 6436080 2 - 0.193 0.000 -10.160
ENSG00000125648 E002 18.2392634 0.0020810931 4.676076e-01 6.784499e-01 19 6436081 6436117 37 - 1.176 1.248 0.252
ENSG00000125648 E003 19.7442097 0.0019670274 4.527535e-01 6.677374e-01 19 6436118 6436120 3 - 1.208 1.278 0.249
ENSG00000125648 E004 21.9290550 0.0018193585 4.239115e-01 6.464885e-01 19 6436121 6436130 10 - 1.251 1.323 0.252
ENSG00000125648 E005 44.9287202 0.0008584009 9.118798e-01 9.581029e-01 19 6436131 6436173 43 - 1.605 1.602 -0.010
ENSG00000125648 E006 54.9495570 0.0006607742 9.208834e-01 9.626966e-01 19 6436174 6436191 18 - 1.687 1.686 -0.005
ENSG00000125648 E007 64.1859011 0.0014736186 7.438893e-01 8.629068e-01 19 6436192 6436217 26 - 1.734 1.756 0.073
ENSG00000125648 E008 187.9689725 0.0004448250 2.356883e-01 4.716238e-01 19 6436218 6436420 203 - 2.183 2.223 0.134
ENSG00000125648 E009 111.4393910 0.0111490246 3.096634e-01 5.501247e-01 19 6436421 6436464 44 - 1.935 2.001 0.221
ENSG00000125648 E010 23.5213296 0.0016455786 9.807654e-01 9.921395e-01 19 6436465 6436468 4 - 1.326 1.327 0.004
ENSG00000125648 E011 2.4050003 0.1896522349 7.788818e-01 8.840691e-01 19 6438191 6438312 122 - 0.431 0.491 0.308
ENSG00000125648 E012 74.6012686 0.0005869696 1.184575e-01 3.133360e-01 19 6438447 6438534 88 - 1.756 1.837 0.272
ENSG00000125648 E013 14.4016483 0.0106457665 8.970296e-02 2.632603e-01 19 6438724 6438771 48 - 0.974 1.172 0.720
ENSG00000125648 E014 11.9500774 0.0128546229 9.856656e-02 2.793134e-01 19 6438772 6438821 50 - 0.888 1.096 0.771
ENSG00000125648 E015 0.1308682 0.0326491905 1.000000e+00   19 6440064 6440064 1 - 0.000 0.074 9.876
ENSG00000125648 E016 1.7785690 0.0238925241 1.585847e-01 3.746447e-01 19 6440065 6440066 2 - 0.193 0.481 1.856
ENSG00000125648 E017 31.5671155 0.0021576530 8.634156e-01 9.322432e-01 19 6440067 6440099 33 - 1.463 1.456 -0.023
ENSG00000125648 E018 66.0147626 0.0015541528 6.893428e-01 8.286528e-01 19 6440100 6440122 23 - 1.747 1.774 0.091
ENSG00000125648 E019 104.1030428 0.0026523748 5.505524e-02 1.914577e-01 19 6440123 6440184 62 - 1.884 1.983 0.333
ENSG00000125648 E020 315.0233211 0.0012656828 6.890351e-02 2.225736e-01 19 6440185 6440322 138 - 2.393 2.452 0.195
ENSG00000125648 E021 305.4256613 0.0002803069 2.292978e-01 4.643264e-01 19 6440323 6440378 56 - 2.401 2.435 0.113
ENSG00000125648 E022 1119.0095731 0.0005044709 2.633456e-01 5.025412e-01 19 6440379 6441123 745 - 2.972 2.990 0.060
ENSG00000125648 E023 372.7078128 0.0003269401 6.732014e-01 8.183731e-01 19 6441124 6441180 57 - 2.502 2.514 0.040
ENSG00000125648 E024 591.2126816 0.0022313903 6.112946e-01 7.777954e-01 19 6441181 6441341 161 - 2.700 2.710 0.032
ENSG00000125648 E025 435.6375615 0.0005488290 2.270935e-01 4.618591e-01 19 6441342 6441437 96 - 2.595 2.569 -0.084
ENSG00000125648 E026 358.8345193 0.0006419116 6.040922e-02 2.037472e-01 19 6441438 6441473 36 - 2.524 2.480 -0.146
ENSG00000125648 E027 272.7574039 0.0001856021 4.308595e-03 3.088163e-02 19 6441474 6441484 11 - 2.425 2.359 -0.219
ENSG00000125648 E028 966.5310178 0.0001090136 4.319405e-07 1.360917e-05 19 6441485 6441929 445 - 2.970 2.908 -0.206
ENSG00000125648 E029 260.9423891 0.0001883768 2.383152e-01 4.746933e-01 19 6441930 6441978 49 - 2.377 2.351 -0.087
ENSG00000125648 E030 510.7642730 0.0001194569 3.710881e-01 6.047910e-01 19 6441979 6442159 181 - 2.632 2.652 0.067
ENSG00000125648 E031 6.7337299 0.0719719874 9.285348e-01 9.663056e-01 19 6443562 6443656 95 - 0.820 0.826 0.022
ENSG00000125648 E032 581.1629797 0.0001956818 3.477699e-04 4.216415e-03 19 6444151 6444301 151 - 2.650 2.718 0.226
ENSG00000125648 E033 465.7696967 0.0002127064 8.300410e-04 8.526243e-03 19 6452312 6452479 168 - 2.553 2.625 0.238
ENSG00000125648 E034 4.8742051 0.0698852831 5.040867e-01 7.036678e-01 19 6452480 6452601 122 - 0.818 0.687 -0.526
ENSG00000125648 E035 410.6297866 0.0001726062 8.525067e-01 9.264680e-01 19 6453981 6454088 108 - 2.555 2.554 -0.001
ENSG00000125648 E036 581.5819933 0.0001371341 5.133194e-01 7.104600e-01 19 6454323 6454475 153 - 2.710 2.703 -0.024
ENSG00000125648 E037 646.2730444 0.0001912797 2.445500e-03 1.998018e-02 19 6454559 6454717 159 - 2.783 2.737 -0.153
ENSG00000125648 E038 21.6930845 0.0140113916 2.081218e-02 9.870934e-02 19 6455952 6456092 141 - 1.448 1.234 -0.743
ENSG00000125648 E039 0.7204775 0.0994032379 1.000000e+00   19 6456303 6456419 117 - 0.193 0.195 0.019
ENSG00000125648 E040 574.4314943 0.0001489165 7.732460e-03 4.806189e-02 19 6456420 6456531 112 - 2.729 2.687 -0.140
ENSG00000125648 E041 433.6391964 0.0001909161 5.218195e-02 1.848266e-01 19 6457503 6457590 88 - 2.601 2.567 -0.116
ENSG00000125648 E042 412.8496626 0.0004118295 5.682065e-01 7.489485e-01 19 6458198 6458324 127 - 2.544 2.561 0.056
ENSG00000125648 E043 310.6032647 0.0048958296 1.392651e-03 1.284511e-02 19 6459473 6459844 372 - 2.318 2.461 0.479
ENSG00000125648 E044 0.0000000       19 6460745 6460851 107 -      
ENSG00000125648 E045 0.0000000       19 6465081 6465203 123 -