ENSG00000125447

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000537686 ENSG00000125447 HEK293_OSMI2_6hA HEK293_TMG_6hB GGA3 protein_coding protein_coding 34.03384 48.28694 31.21347 0.7592721 0.8475138 -0.6293007 11.748284 23.156730 8.787318 3.4450512 1.28774603 -1.3969188 0.33357083 0.48116667 0.28306667 -0.1981 3.489035e-01 1.368469e-22 FALSE TRUE
ENST00000538886 ENSG00000125447 HEK293_OSMI2_6hA HEK293_TMG_6hB GGA3 protein_coding protein_coding 34.03384 48.28694 31.21347 0.7592721 0.8475138 -0.6293007 4.213741 6.087321 0.000000 0.6053925 0.00000000 -9.2520318 0.11916250 0.12650000 0.00000000 -0.1265 1.368469e-22 1.368469e-22 FALSE TRUE
ENST00000578208 ENSG00000125447 HEK293_OSMI2_6hA HEK293_TMG_6hB GGA3 protein_coding retained_intron 34.03384 48.28694 31.21347 0.7592721 0.8475138 -0.6293007 4.799031 6.921075 4.415263 1.4217163 0.93628087 -0.6473161 0.13816667 0.14286667 0.14006667 -0.0028 1.000000e+00 1.368469e-22 FALSE TRUE
ENST00000613421 ENSG00000125447 HEK293_OSMI2_6hA HEK293_TMG_6hB GGA3 protein_coding retained_intron 34.03384 48.28694 31.21347 0.7592721 0.8475138 -0.6293007 2.042545 2.029764 2.827302 1.0596102 0.06118599 0.4761175 0.06085417 0.04156667 0.09076667 0.0492 3.612452e-01 1.368469e-22 TRUE TRUE
ENST00000621870 ENSG00000125447 HEK293_OSMI2_6hA HEK293_TMG_6hB GGA3 protein_coding nonsense_mediated_decay 34.03384 48.28694 31.21347 0.7592721 0.8475138 -0.6293007 1.875394 3.145115 2.355228 0.3346303 0.68158164 -0.4157131 0.05453750 0.06503333 0.07443333 0.0094 9.667716e-01 1.368469e-22 FALSE TRUE
MSTRG.15067.9 ENSG00000125447 HEK293_OSMI2_6hA HEK293_TMG_6hB GGA3 protein_coding   34.03384 48.28694 31.21347 0.7592721 0.8475138 -0.6293007 1.297987 0.000000 3.726306 0.0000000 0.69631420 8.5454688 0.04508333 0.00000000 0.11930000 0.1193 9.221462e-20 1.368469e-22 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000125447 E001 0.4756169 0.0240718864 2.791801e-01   17 75236599 75236599 1 - 0.001 0.219 8.920
ENSG00000125447 E002 0.6370325 0.0217681645 7.746116e-01   17 75236600 75236601 2 - 0.169 0.219 0.469
ENSG00000125447 E003 4.4455163 0.0057014019 6.738239e-01 8.188196e-01 17 75236602 75236620 19 - 0.759 0.694 -0.267
ENSG00000125447 E004 123.6573753 0.0030147385 4.194347e-04 4.920195e-03 17 75236621 75236790 170 - 1.953 2.105 0.507
ENSG00000125447 E005 491.3711614 0.0025126799 4.731087e-04 5.431521e-03 17 75236791 75237185 395 - 2.590 2.686 0.318
ENSG00000125447 E006 289.1238880 0.0081372872 5.236607e-01 7.175737e-01 17 75237186 75237283 98 - 2.414 2.436 0.074
ENSG00000125447 E007 331.3115760 0.0016007708 1.320392e-01 3.350238e-01 17 75237284 75237426 143 - 2.464 2.499 0.118
ENSG00000125447 E008 251.4486315 0.0003066354 1.778986e-02 8.832414e-02 17 75237427 75237521 95 - 2.332 2.385 0.178
ENSG00000125447 E009 121.4399249 0.0003666912 1.336135e-02 7.189459e-02 17 75237522 75237525 4 - 1.995 2.077 0.275
ENSG00000125447 E010 124.6096383 0.0003758065 7.999475e-04 8.281486e-03 17 75237526 75237532 7 - 1.982 2.096 0.381
ENSG00000125447 E011 270.5153702 0.0018630670 1.596182e-03 1.429912e-02 17 75237533 75237644 112 - 2.334 2.425 0.303
ENSG00000125447 E012 238.3610490 0.0003224254 9.370366e-05 1.416255e-03 17 75237645 75237777 133 - 2.277 2.373 0.320
ENSG00000125447 E013 107.1392218 0.0005027982 4.532360e-03 3.210959e-02 17 75237778 75237796 19 - 1.925 2.028 0.347
ENSG00000125447 E014 152.3565819 0.0004171740 6.626293e-05 1.059402e-03 17 75237797 75237981 185 - 2.062 2.187 0.417
ENSG00000125447 E015 217.9033325 0.0002545366 8.666984e-02 2.576674e-01 17 75237982 75238090 109 - 2.279 2.318 0.131
ENSG00000125447 E016 262.6103069 0.0002003147 5.047866e-01 7.041693e-01 17 75238091 75238178 88 - 2.379 2.389 0.032
ENSG00000125447 E017 225.2132299 0.0024879405 1.863709e-01 4.122712e-01 17 75238179 75238237 59 - 2.291 2.330 0.129
ENSG00000125447 E018 147.3708323 0.0024697910 7.688605e-01 8.779373e-01 17 75238238 75238245 8 - 2.132 2.136 0.013
ENSG00000125447 E019 250.5916954 0.0018203987 2.317904e-01 4.672540e-01 17 75238246 75238356 111 - 2.344 2.374 0.101
ENSG00000125447 E020 130.4658234 0.0003536858 4.698770e-01 6.799707e-01 17 75238357 75238389 33 - 2.105 2.074 -0.102
ENSG00000125447 E021 62.9965720 0.0563806500 7.194073e-01 8.478331e-01 17 75238390 75238651 262 - 1.804 1.755 -0.164
ENSG00000125447 E022 238.2489482 0.0002397968 7.732870e-01 8.806518e-01 17 75238652 75238762 111 - 2.353 2.339 -0.045
ENSG00000125447 E023 170.8490574 0.0003170551 7.446912e-01 8.635087e-01 17 75238914 75238964 51 - 2.197 2.200 0.011
ENSG00000125447 E024 160.8546449 0.0002672266 2.119477e-01 4.440365e-01 17 75238965 75239018 54 - 2.152 2.184 0.107
ENSG00000125447 E025 176.4239597 0.0003065862 1.952957e-02 9.428729e-02 17 75239019 75239079 61 - 2.171 2.234 0.212
ENSG00000125447 E026 111.3070085 0.0004535698 8.383118e-02 2.524330e-01 17 75239080 75239083 4 - 1.976 2.034 0.196
ENSG00000125447 E027 11.0288015 0.2705759629 7.137711e-01 8.442395e-01 17 75239084 75239374 291 - 1.024 1.058 0.125
ENSG00000125447 E028 240.2462391 0.0004010691 2.775537e-03 2.203291e-02 17 75239375 75239571 197 - 2.299 2.371 0.242
ENSG00000125447 E029 7.8343024 0.1481149492 3.478732e-01 5.853109e-01 17 75239572 75239788 217 - 1.016 0.868 -0.557
ENSG00000125447 E030 295.3708758 0.0009179916 2.721124e-03 2.169019e-02 17 75239789 75240108 320 - 2.386 2.459 0.243
ENSG00000125447 E031 16.5831445 0.2987457528 9.855524e-02 2.792982e-01 17 75240109 75240341 233 - 1.373 1.115 -0.911
ENSG00000125447 E032 176.7249299 0.0002916976 9.436312e-02 2.718502e-01 17 75240342 75240412 71 - 2.186 2.229 0.144
ENSG00000125447 E033 59.4440727 0.1646851783 5.895352e-02 2.004096e-01 17 75240413 75240793 381 - 1.914 1.646 -0.904
ENSG00000125447 E034 15.5985629 0.0895093121 3.949554e-02 1.534524e-01 17 75240794 75240811 18 - 1.381 1.062 -1.130
ENSG00000125447 E035 225.2934495 0.0014809466 8.432300e-01 9.212760e-01 17 75240812 75240948 137 - 2.323 2.324 0.004
ENSG00000125447 E036 188.9027253 0.0016107760 9.133023e-01 9.587314e-01 17 75240949 75241057 109 - 2.248 2.246 -0.005
ENSG00000125447 E037 207.2887623 0.0002733091 3.170610e-02 1.323540e-01 17 75241400 75241516 117 - 2.329 2.266 -0.210
ENSG00000125447 E038 19.5542178 0.0310575133 2.101697e-03 1.774644e-02 17 75241517 75241614 98 - 1.485 1.135 -1.223
ENSG00000125447 E039 187.1920154 0.0002871541 5.155410e-06 1.182638e-04 17 75241615 75241668 54 - 2.325 2.194 -0.439
ENSG00000125447 E040 153.9640883 0.0009886047 1.507506e-03 1.366987e-02 17 75241669 75241696 28 - 2.227 2.116 -0.371
ENSG00000125447 E041 47.3868304 0.0653955059 3.400111e-03 2.575800e-02 17 75241697 75241864 168 - 1.867 1.502 -1.240
ENSG00000125447 E042 80.1449516 0.1337871443 1.205897e-02 6.668047e-02 17 75241865 75242335 471 - 2.094 1.724 -1.245
ENSG00000125447 E043 288.2267037 0.0002328490 4.587540e-06 1.068683e-04 17 75242336 75242473 138 - 2.498 2.389 -0.363
ENSG00000125447 E044 202.1298997 0.0002156963 1.672179e-07 5.890366e-06 17 75242831 75242883 53 - 2.367 2.224 -0.476
ENSG00000125447 E045 131.9358759 0.0002955517 1.456100e-03 1.331248e-02 17 75242884 75242888 5 - 2.162 2.053 -0.366
ENSG00000125447 E046 135.4264403 0.0003359066 1.747918e-04 2.389412e-03 17 75242889 75242911 23 - 2.186 2.060 -0.422
ENSG00000125447 E047 160.7101680 0.0044781896 1.368411e-02 7.309506e-02 17 75243063 75243134 72 - 2.251 2.141 -0.368
ENSG00000125447 E048 129.0771793 0.0050453536 2.370089e-02 1.081696e-01 17 75243135 75243166 32 - 2.157 2.048 -0.365
ENSG00000125447 E049 6.4312972 0.0069712345 8.589145e-04 8.763725e-03 17 75243167 75243258 92 - 1.077 0.654 -1.641
ENSG00000125447 E050 179.5397758 0.0062514348 1.047139e-01 2.901378e-01 17 75243447 75243516 70 - 2.278 2.200 -0.263
ENSG00000125447 E051 167.3517937 0.0053034936 1.151012e-01 3.076255e-01 17 75243517 75243570 54 - 2.245 2.170 -0.250
ENSG00000125447 E052 1.9392446 0.0119564317 6.093412e-01 7.764583e-01 17 75244402 75244490 89 - 0.385 0.473 0.470
ENSG00000125447 E053 153.7377936 0.0009664990 4.851218e-01 6.906691e-01 17 75244619 75244717 99 - 2.179 2.150 -0.097
ENSG00000125447 E054 136.2603536 0.0003205096 2.082638e-01 4.397526e-01 17 75246509 75246584 76 - 2.138 2.091 -0.157
ENSG00000125447 E055 114.9047606 0.0004455774 4.059958e-01 6.330562e-01 17 75246712 75246796 85 - 2.057 2.021 -0.119
ENSG00000125447 E056 19.9454925 0.0150999821 2.894277e-01 5.299466e-01 17 75248840 75249008 169 - 1.361 1.251 -0.384
ENSG00000125447 E057 67.3279716 0.0006777818 4.904370e-01 6.943068e-01 17 75261548 75261631 84 - 1.829 1.792 -0.127
ENSG00000125447 E058 1.0719510 0.0157831260 5.470885e-01   17 75262282 75262363 82 - 0.385 0.273 -0.702