ENSG00000125375

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000426751 ENSG00000125375 HEK293_OSMI2_6hA HEK293_TMG_6hB DMAC2L protein_coding protein_coding 11.84614 7.32156 10.17487 0.5295319 0.8366329 0.4742362 0.9848571 1.1668396 0.5568166 0.03317263 0.07523442 -1.0539638 0.09196250 0.16063333 0.05673333 -0.10390000 7.790988e-03 4.502282e-11 FALSE TRUE
ENST00000554438 ENSG00000125375 HEK293_OSMI2_6hA HEK293_TMG_6hB DMAC2L protein_coding protein_coding 11.84614 7.32156 10.17487 0.5295319 0.8366329 0.4742362 0.1930418 0.4872085 0.0000000 0.30077351 0.00000000 -5.6357790 0.02401250 0.07066667 0.00000000 -0.07066667 2.478717e-01 4.502282e-11 FALSE TRUE
ENST00000555939 ENSG00000125375 HEK293_OSMI2_6hA HEK293_TMG_6hB DMAC2L protein_coding processed_transcript 11.84614 7.32156 10.17487 0.5295319 0.8366329 0.4742362 5.0842503 2.8938150 4.9847321 0.51172548 0.20177530 0.7824578 0.42360417 0.38963333 0.49360000 0.10396667 5.109096e-01 4.502282e-11 FALSE TRUE
ENST00000556962 ENSG00000125375 HEK293_OSMI2_6hA HEK293_TMG_6hB DMAC2L protein_coding retained_intron 11.84614 7.32156 10.17487 0.5295319 0.8366329 0.4742362 0.6852595 0.3143488 0.9146405 0.25332351 0.29160504 1.5113462 0.05822917 0.03903333 0.08636667 0.04733333 6.008876e-01 4.502282e-11 FALSE FALSE
ENST00000557421 ENSG00000125375 HEK293_OSMI2_6hA HEK293_TMG_6hB DMAC2L protein_coding protein_coding 11.84614 7.32156 10.17487 0.5295319 0.8366329 0.4742362 2.3288056 0.3035171 2.3991160 0.30351709 0.20666827 2.9418879 0.17373750 0.03636667 0.23813333 0.20176667 1.500527e-01 4.502282e-11 FALSE TRUE
MSTRG.9517.1 ENSG00000125375 HEK293_OSMI2_6hA HEK293_TMG_6hB DMAC2L protein_coding   11.84614 7.32156 10.17487 0.5295319 0.8366329 0.4742362 0.6202383 0.4501871 0.6621108 0.02273197 0.13452591 0.5464787 0.05312500 0.06210000 0.06370000 0.00160000 1.000000e+00 4.502282e-11 FALSE TRUE
MSTRG.9517.9 ENSG00000125375 HEK293_OSMI2_6hA HEK293_TMG_6hB DMAC2L protein_coding   11.84614 7.32156 10.17487 0.5295319 0.8366329 0.4742362 1.3427013 1.3946519 0.0000000 0.20046908 0.00000000 -7.1340688 0.12375833 0.19603333 0.00000000 -0.19603333 4.502282e-11 4.502282e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000125375 E001 0.3393995 0.0258473830 2.793564e-01   14 50312314 50312323 10 + 0.199 0.000 -11.716
ENSG00000125375 E002 0.3393995 0.0258473830 2.793564e-01   14 50312324 50312326 3 + 0.199 0.000 -11.715
ENSG00000125375 E003 0.3393995 0.0258473830 2.793564e-01   14 50312327 50312328 2 + 0.199 0.000 -11.715
ENSG00000125375 E004 20.6476101 0.0022240668 8.691991e-02 2.580955e-01 14 50312329 50312389 61 + 1.286 1.391 0.369
ENSG00000125375 E005 4.9205832 0.0939318508 3.770024e-01 6.098526e-01 14 50312390 50313060 671 + 0.684 0.835 0.606
ENSG00000125375 E006 9.5685688 0.0132925852 5.824254e-01 7.586568e-01 14 50314591 50314626 36 + 1.049 0.967 -0.302
ENSG00000125375 E007 0.8209858 0.0172671820 9.809166e-02   14 50319234 50319301 68 + 0.111 0.386 2.304
ENSG00000125375 E008 2.4026854 0.1432596693 6.523667e-01 8.049626e-01 14 50321319 50321376 58 + 0.481 0.588 0.500
ENSG00000125375 E009 37.9892788 0.0012447967 4.508018e-02 1.678172e-01 14 50321483 50321532 50 + 1.547 1.636 0.302
ENSG00000125375 E010 57.5119618 0.0037369989 1.209134e-02 6.682172e-02 14 50321533 50321594 62 + 1.712 1.819 0.363
ENSG00000125375 E011 54.0983761 0.0081819761 2.823886e-01 5.227954e-01 14 50322511 50322541 31 + 1.713 1.761 0.164
ENSG00000125375 E012 96.5920909 0.0007829315 3.609015e-01 5.963684e-01 14 50322542 50322719 178 + 1.982 1.990 0.028
ENSG00000125375 E013 18.9642520 0.0021054097 5.689326e-05 9.317053e-04 14 50322720 50322806 87 + 1.148 1.439 1.019
ENSG00000125375 E014 7.6835812 0.0064721993 4.811394e-05 8.049308e-04 14 50322807 50322892 86 + 0.679 1.142 1.767
ENSG00000125375 E015 48.3925152 0.0019079394 4.268593e-08 1.730084e-06 14 50323945 50324116 172 + 1.806 1.488 -1.082
ENSG00000125375 E016 3.2568871 0.0325378434 2.796096e-01 5.197159e-01 14 50324117 50324291 175 + 0.703 0.501 -0.902
ENSG00000125375 E017 3.8178103 0.3104307813 4.171957e-01 6.415429e-01 14 50324547 50324706 160 + 0.765 0.544 -0.945
ENSG00000125375 E018 32.3298932 0.0011656705 3.027320e-04 3.757829e-03 14 50325609 50325645 37 + 1.620 1.372 -0.850
ENSG00000125375 E019 118.5828392 0.0582534810 4.450195e-01 6.621444e-01 14 50325646 50327957 2312 + 2.128 2.006 -0.409
ENSG00000125375 E020 5.2785712 0.2524244265 2.493533e-01 4.871582e-01 14 50332022 50332236 215 + 0.643 0.935 1.166
ENSG00000125375 E021 0.1308682 0.0314489703 3.844263e-01   14 50335459 50335558 100 + 0.000 0.133 11.279