ENSG00000125351

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276201 ENSG00000125351 HEK293_OSMI2_6hA HEK293_TMG_6hB UPF3B protein_coding protein_coding 29.76587 27.48967 34.7129 2.903441 1.778385 0.3364732 1.680602 2.595730 1.248009 0.36686914 0.08274789 -1.0505447 0.05775833 0.09436667 0.03603333 -0.05833333 0.0005503302 0.0005503302 FALSE  
ENST00000345865 ENSG00000125351 HEK293_OSMI2_6hA HEK293_TMG_6hB UPF3B protein_coding protein_coding 29.76587 27.48967 34.7129 2.903441 1.778385 0.3364732 25.003063 21.998725 30.155060 2.62679144 1.58996683 0.4548029 0.83719583 0.79780000 0.86860000 0.07080000 0.1337952747 0.0005503302 FALSE  
MSTRG.34799.4 ENSG00000125351 HEK293_OSMI2_6hA HEK293_TMG_6hB UPF3B protein_coding   29.76587 27.48967 34.7129 2.903441 1.778385 0.3364732 1.554997 1.488152 1.288152 0.08208868 0.23323776 -0.2067247 0.05238750 0.05563333 0.03666667 -0.01896667 0.5662211486 0.0005503302 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000125351 E001 2.042211 0.0103018939 8.208275e-03 5.029312e-02 X 119805311 119805393 83 - 0.209 0.672 2.578
ENSG00000125351 E002 2.030444 0.0102762927 9.051692e-04 9.134146e-03 X 119805394 119805435 42 - 0.117 0.701 3.701
ENSG00000125351 E003 2.615831 0.0452059095 5.903155e-01 7.639485e-01 X 119807475 119807524 50 - 0.502 0.605 0.477
ENSG00000125351 E004 3.418036 0.0939440680 3.265206e-01 5.657297e-01 X 119807525 119807581 57 - 0.541 0.731 0.825
ENSG00000125351 E005 2.472599 0.0345623633 2.747839e-01 5.147668e-01 X 119815200 119815274 75 - 0.613 0.429 -0.878
ENSG00000125351 E006 1.407662 0.3448918934 4.548655e-01 6.693757e-01 X 119815275 119815307 33 - 0.465 0.229 -1.469
ENSG00000125351 E007 2.403378 0.0091320969 2.355279e-01 4.714444e-01 X 119822935 119822941 7 - 0.612 0.428 -0.881
ENSG00000125351 E008 7.409262 0.0045244605 8.814681e-01 9.420787e-01 X 119822942 119823043 102 - 0.910 0.941 0.118
ENSG00000125351 E009 16.257820 0.0026134939 4.070833e-03 2.957017e-02 X 119831518 119831651 134 - 1.084 1.346 0.928
ENSG00000125351 E010 26.139187 0.0014599019 5.640524e-02 1.945785e-01 X 119831652 119831759 108 - 1.355 1.500 0.498
ENSG00000125351 E011 6.226181 0.0053552587 8.548450e-02 2.555026e-01 X 119834022 119834025 4 - 0.727 0.958 0.896
ENSG00000125351 E012 727.263826 0.0027309234 1.378746e-03 1.275079e-02 X 119834026 119834919 894 - 2.820 2.905 0.282
ENSG00000125351 E013 266.868362 0.0001867059 9.395853e-05 1.419096e-03 X 119834920 119835027 108 - 2.382 2.479 0.325
ENSG00000125351 E014 413.914379 0.0012440184 1.980245e-01 4.271579e-01 X 119837757 119838051 295 - 2.600 2.640 0.135
ENSG00000125351 E015 9.308669 0.1406981074 8.314286e-01 9.146458e-01 X 119838266 119838366 101 - 1.000 1.024 0.089
ENSG00000125351 E016 269.681756 0.0024364551 1.462647e-01 3.568152e-01 X 119838367 119838527 161 - 2.450 2.420 -0.100
ENSG00000125351 E017 1.146854 0.0896206826 7.590857e-02   X 119840594 119840645 52 - 0.459 0.125 -2.488
ENSG00000125351 E018 8.840826 0.0034339354 1.217119e-03 1.156063e-02 X 119840646 119840684 39 - 0.775 1.149 1.404
ENSG00000125351 E019 232.891103 0.0026237827 7.408258e-01 8.609432e-01 X 119841076 119841258 183 - 2.370 2.372 0.007
ENSG00000125351 E020 121.552086 0.0033902215 9.365684e-01 9.704995e-01 X 119841735 119841778 44 - 2.085 2.094 0.030
ENSG00000125351 E021 183.509290 0.0002775318 2.710191e-02 1.185861e-01 X 119843191 119843301 111 - 2.290 2.247 -0.143
ENSG00000125351 E022 171.287413 0.0024021017 1.463859e-02 7.672510e-02 X 119845198 119845296 99 - 2.271 2.199 -0.240
ENSG00000125351 E023 155.220501 0.0003642997 1.306393e-06 3.582939e-05 X 119851495 119851601 107 - 2.252 2.127 -0.417
ENSG00000125351 E024 168.346495 0.0003058707 2.487817e-05 4.596000e-04 X 119851767 119851873 107 - 2.279 2.178 -0.335
ENSG00000125351 E025 189.117543 0.0005603145 3.503646e-05 6.157956e-04 X 119852773 119853051 279 - 2.329 2.232 -0.322